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  1. Article ; Online: Reply.

    Norsa, Lorenzo

    Gastroenterology

    2021  Volume 160, Issue 6, Page(s) 2192

    Language English
    Publishing date 2021-01-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.01.197
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  2. Article ; Online: Reply.

    Norsa, Lorenzo / D'Antiga, Lorenzo

    Gastroenterology

    2020  Volume 160, Issue 1, Page(s) 474–475

    MeSH term(s) COVID-19 ; Disease Outbreaks ; Humans ; Inflammatory Bowel Diseases ; Italy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-11-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2020.11.001
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  3. Article ; Online: Gastrointestinal coronavirus disease 2019 manifestations in childhood.

    Sansotta, Naire / Norsa, Lorenzo / D'Antiga, Lorenzo

    Current opinion in clinical nutrition and metabolic care

    2022  Volume 25, Issue 3, Page(s) 195–202

    Abstract: Purpose of the review: The pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged and caused a massive global health crisis. The aim of this review is first, to provide the ... ...

    Abstract Purpose of the review: The pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged and caused a massive global health crisis. The aim of this review is first, to provide the latest evidence on what is known about the pathophysiology and the transmission of SARS-CoV-2 and then to focus on the manifestations of the gastrointestinal (GI) tract in children with COVID-19. Lastly, we summarise the impact of COVID-19 on patients with preexisting GI diseases.
    Recent findings: Even though the virus is mostly transmitted from human to human via respiratory droplets, ACE2 is known to be expressed throughout the GI tract, and SARS-CoV-2 ribonucleic acid has been isolated from patients' stools. GI symptoms including abdominal pain, diarrhoea and vomiting are frequently reported in paediatric patients. Interestingly, a small number of patients seem to exhibit solely GI symptoms. In addition, a multisystem inflammatory syndrome in children (MIS-C) related to SARS-COV-2 described in children, has a high rate of GI involvement. Several etiopathogenetic mechanisms have been postulated to explain the GI involvement of COVID-19.
    Summary: Clinicians should not underestimate or disregard these early or mild GI symptoms, because the patients may be infected and transmit the virus, or develop a more severe condition such as MIS-C.
    MeSH term(s) COVID-19/complications ; Child ; Gastrointestinal Diseases ; Humans ; Pandemics ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
    Language English
    Publishing date 2022-02-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1460178-3
    ISSN 1473-6519 ; 1363-1950
    ISSN (online) 1473-6519
    ISSN 1363-1950
    DOI 10.1097/MCO.0000000000000825
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    Zs.A 5586: Show issues Location:
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  4. Article ; Online: Vitamin B

    Morotti, Francesco / Terruzzi, Jacopo / Cavalleri, Laura / Betalli, Pietro / D'Antiga, Lorenzo / Norsa, Lorenzo

    Nutrition (Burbank, Los Angeles County, Calif.)

    2022  Volume 106, Page(s) 111895

    Abstract: Bowel obstruction and nutrient deficiencies are commonly encountered complications seen during follow-up of patients with short bowel syndrome. It is rare to see vitamin ... ...

    Abstract Bowel obstruction and nutrient deficiencies are commonly encountered complications seen during follow-up of patients with short bowel syndrome. It is rare to see vitamin B
    MeSH term(s) Humans ; Vitamin B 12 ; Vitamin B 12 Deficiency/complications ; Vitamin B 12 Deficiency/diagnosis ; Short Bowel Syndrome/complications ; Intestinal Obstruction ; Intestinal Pseudo-Obstruction/etiology ; Intestinal Pseudo-Obstruction/complications ; Vitamins
    Chemical Substances Vitamin B 12 (P6YC3EG204) ; Vitamins
    Language English
    Publishing date 2022-10-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2022.111895
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  5. Article ; Online: Prevalence and clinical features of chronic uveitis in pediatric inflammatory bowel diseases: A nationwide study.

    Maniscalco, Valerio / Scarallo, Luca / Aloi, Marina / Alvisi, Patrizia / Norsa, Lorenzo / Zuin, Giovanna / Simonini, Gabriele / Lionetti, Paolo

    Journal of pediatric gastroenterology and nutrition

    2024  

    Abstract: Inflammatory bowel diseases (IBD) encompass a group of chronic inflammatory disorders primarily affecting the gastrointestinal tract but capable of impacting various organs, including the eye, with uveitis being the most common ocular condition. We ... ...

    Abstract Inflammatory bowel diseases (IBD) encompass a group of chronic inflammatory disorders primarily affecting the gastrointestinal tract but capable of impacting various organs, including the eye, with uveitis being the most common ocular condition. We assessed uveitis prevalence and clinical features in a nationwide cohort of pediatric IBD. Among 4229 cases, six patients (four Crohn's disease, one ulcerative colitis, and one unclassified IBD) were identified, resulting in an overall prevalence rate of 141.8 per 100,000 patients. Uveitis onset varied: two before IBD, two after, and two concomitantly. Symptomatic uveitis occurred in 2/6 patients, with anterior involvement in all cases. Median follow-up was 3 years (interquartile range [IQR]: 2-4.75 years). At the last follow-up, 5/6 patients exhibited quiescent IBD, while 4/6 had inactive uveitis. One patient had ocular complications. Uveitis is a rare but potentially complicating manifestation of pediatric IBD.
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603201-1
    ISSN 1536-4801 ; 0277-2116
    ISSN (online) 1536-4801
    ISSN 0277-2116
    DOI 10.1002/jpn3.12216
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  6. Article: Use of oral vancomycin in children with autoimmune liver disease: A single centre experience.

    Di Giorgio, Angelo / Tulone, Anna / Nicastro, Emanuele / Norsa, Lorenzo / Sonzogni, Aurelio / D'Antiga, Lorenzo

    World journal of hepatology

    2022  Volume 13, Issue 12, Page(s) 2113–2127

    Abstract: Background: Previous reports showed some beneficial effect of oral vancomycin treatment (OVT) in children with primary sclerosing cholangitis; conversely, the experience in patients with other autoimmune liver diseases (AILD), including autoimmune ... ...

    Abstract Background: Previous reports showed some beneficial effect of oral vancomycin treatment (OVT) in children with primary sclerosing cholangitis; conversely, the experience in patients with other autoimmune liver diseases (AILD), including autoimmune hepatitis (AIH) and autoimmune sclerosing cholangitis (ASC), is scant.
    Aim: To assess the response to immunosuppressive treatment (IS) and to OVT in children diagnosed with AILD.
    Methods: Retrospective study of children diagnosed with AIH (normal biliary tree at cholangiography) and ASC (abnormal biliary tree at cholangiography) in the last 10 years. All underwent standard immunosuppressive therapy (IS), but non-responders received also OVT. Biochemical remission [normal aspartate aminotransferase (AST)] and immunological remission (normal IgG and negative autoantibodies) rates and Sclerosing Cholangitis Outcomes in Pediatrics (SCOPE) index were assessed and compared during the follow up.
    Results: 75 children were included [69% female, median age 10.5 years (5.6-13.4 years), AIH = 54, ASC= 21]. Sixty-three patients (84%, AIH = 52, ASC = 11) were treated with standard IS and 61 achieved biochemical remission, whereas 12 not responding to IS [16%, F = 75%, median age 13.5 years, (12.2-15.7), 10 with ASC] required OVT and 8 achieved biochemical remission. Overall OVT increased the biochemical remission rate of the whole group of AILD patients from 81% (61/75) to 92% (69/75). Median values of AST, alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) decreased significantly after OVT start (
    Conclusion: Children with AIH and ASC respond well to IS treatment. OVT may represent a valuable treatment option to achieve biochemical remission in patients not responding to standard IS. These promising preliminary results suggest that a prospective study is indicated to define the efficacy of OVT in AILD.
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573703-X
    ISSN 1948-5182
    ISSN 1948-5182
    DOI 10.4254/wjh.v13.i12.2113
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  8. Article ; Online: Give Gluten a Chance! Time to Schedule Gluten Re-introduction in Celiac Patients on a Long-term Gluten-free Diet?

    Elli, Luca / Norsa, Lorenzo / Roncoroni, Leda / Vecchi, Maurizio

    Journal of pediatric gastroenterology and nutrition

    2020  Volume 71, Issue 6, Page(s) e147

    MeSH term(s) Celiac Disease/diet therapy ; Diet, Gluten-Free ; Glutens/adverse effects ; Humans ; Patient Compliance ; Probability
    Chemical Substances Glutens (8002-80-0)
    Language English
    Publishing date 2020-08-11
    Publishing country United States
    Document type Letter
    ZDB-ID 603201-1
    ISSN 1536-4801 ; 0277-2116
    ISSN (online) 1536-4801
    ISSN 0277-2116
    DOI 10.1097/MPG.0000000000002898
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  9. Article ; Online: Breakthroughs and challenges in the management of pediatric viral hepatitis.

    Nicastro, Emanuele / Norsa, Lorenzo / Di Giorgio, Angelo / Indolfi, Giuseppe / D'Antiga, Lorenzo

    World journal of gastroenterology

    2021  Volume 27, Issue 20, Page(s) 2474–2494

    Abstract: Chronic infections by hepatitis B virus (HBV) and hepatitis C virus (HCV) major causes of advanced liver disease and mortality worldwide. Although regarded as benign infections in children, their persistence through adulthood is undoubtedly of concern. ... ...

    Abstract Chronic infections by hepatitis B virus (HBV) and hepatitis C virus (HCV) major causes of advanced liver disease and mortality worldwide. Although regarded as benign infections in children, their persistence through adulthood is undoubtedly of concern. Recent advances in HCV treatment have restored the visibility of these conditions and raised expectations for HBV treatment, which is currently far from being curative. Herein we describe direct-acting antivirals available for pediatric HCV (sofosbuvir/ledipasvir, sofosbuvir/velpatasvir, glecaprevir/pibrentasvir) and their real-world use. A critical review of the HBV pediatric classification is provided. Anti-HBV investigational compounds are reviewed in light of the pathophysiology in the pediatric population, including capsid assembly modulators, antigen secretion inhibitors, silencing RNAs, and immune modifiers. Recommendations for screening and management of immunosuppressed children or those with other risk factors or comorbidities are also summarized.
    MeSH term(s) Adult ; Antiviral Agents/therapeutic use ; Child ; Hepacivirus/genetics ; Hepatitis C/drug therapy ; Hepatitis C, Chronic/diagnosis ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/epidemiology ; Humans ; Sofosbuvir/therapeutic use
    Chemical Substances Antiviral Agents ; Sofosbuvir (WJ6CA3ZU8B)
    Language English
    Publishing date 2021-03-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v27.i20.2474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Colon importance in short bowel syndrome.

    Lambe, Cecile / Goulet, Olivier / Norsa, Lorenzo

    Aging

    2019  Volume 11, Issue 22, Page(s) 9961–9962

    MeSH term(s) Colon/microbiology ; Gastrointestinal Microbiome ; Humans ; Short Bowel Syndrome/microbiology
    Language English
    Publishing date 2019-11-15
    Publishing country United States
    Document type Editorial
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.102447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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