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  1. Article ; Online: Breakthrough Technologies in Diagnosis and Therapy of Chronic Wounds.

    Matoori, Simon

    ACS pharmacology & translational science

    2023  Volume 6, Issue 6, Page(s) 854–856

    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Editorial
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.3c00060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Breakthrough Technologies in Diagnosis and Therapy of Chronic Wounds.

    Matoori, Simon

    ACS applied bio materials

    2023  Volume 6, Issue 6, Page(s) 2014–2016

    MeSH term(s) Wounds and Injuries/diagnosis ; Wounds and Injuries/therapy ; Humans
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Editorial
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.3c00225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Vesicular Diagnostics: A Spotlight on Lactate- and Ammonia-Sensing Systems.

    Matoori, Simon

    ACS applied bio materials

    2023  Volume 6, Issue 4, Page(s) 1315–1322

    Abstract: Liposomes are a highly successful drug delivery system with over 15 FDA-approved formulations. Beyond delivering drugs, lipid and polymer vesicles have successfully been used for diagnostic applications. These applications range from more traditional ... ...

    Abstract Liposomes are a highly successful drug delivery system with over 15 FDA-approved formulations. Beyond delivering drugs, lipid and polymer vesicles have successfully been used for diagnostic applications. These applications range from more traditional uses, such as releasing diagnostic agents in a controlled manner, to leveraging the unique membrane properties to separate analytes and provide isolated reaction compartments in complex biological matrices. In this Spotlight on Applications, I highlight the complexities in the development and translation of diagnostic vesicles with two case studies, a liposomal reaction compartment for lactate sensing and a transmembrane pH-gradient polymersome for ammonia sensing.
    MeSH term(s) Ammonia ; Lactic Acid ; Liposomes ; Drug Delivery Systems
    Chemical Substances Ammonia (7664-41-7) ; Lactic Acid (33X04XA5AT) ; Liposomes
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.3c00042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Diabetes and its Complications.

    Matoori, Simon

    ACS pharmacology & translational science

    2022  Volume 5, Issue 8, Page(s) 513–515

    Language English
    Publishing date 2022-07-12
    Publishing country United States
    Document type Editorial
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.2c00122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Development of a liposomal near-infrared fluorescence lactate assay for human blood.

    Matoori, Simon / Mooney, David J

    Biomaterials

    2022  Volume 283, Page(s) 121475

    Abstract: In emergency medicine, blood lactate is a commonly used biomarker of hypoxia (e.g., sepsis, trauma, cardiac arrest) but the median time to obtain the results from a clinical lactate test is 3 h. We recently developed a near-infrared fluorescent blood ... ...

    Abstract In emergency medicine, blood lactate is a commonly used biomarker of hypoxia (e.g., sepsis, trauma, cardiac arrest) but the median time to obtain the results from a clinical lactate test is 3 h. We recently developed a near-infrared fluorescent blood lactate assay based on a two-step enzymatic cascade in a vesicular reaction compartment. Previously, we reported a response of this assay to lactate-spiked bovine blood after 10 min. To develop a point-of-care test, we optimized this assay in commercial human blood, validated it in fresh capillary blood of healthy volunteers in an institutional review board-approved study, and improved the stability of the formulation. External pH and luminal enzyme concentrations were identified as key parameters of sensor response and kinetics, as they impact transmembrane lactate diffusion and turnover rate. The preparation process was also simplified and the stability was improved to allow storage at 4 °C for at least 5 days. The final formulation exhibited a strong and linear response to lactate-spiked human blood in a clinically relevant range, and accurately quantified a lactate standard at a clinically used cut-off in fresh capillary blood after 2 min. These findings motivate a clinical evaluation of this rapid and easy-to-use lactate assay.
    MeSH term(s) Animals ; Cattle ; Fluorescence ; Humans ; Kinetics ; Lactic Acid ; Liposomes ; Sepsis
    Chemical Substances Liposomes ; Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2022-03-18
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603079-8
    ISSN 1878-5905 ; 0142-9612
    ISSN (online) 1878-5905
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2022.121475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2371: Show issues Location:
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  6. Article ; Online: Real-Time Tracking of In Situ-Forming Alginate Hydrogel by Contrast-Enhanced Computed Tomography.

    Guirguis, Natalie / Zellagui, Yanis / Matoori, Simon

    The AAPS journal

    2023  Volume 25, Issue 5, Page(s) 79

    Abstract: Hydrogel-based biomaterials have gained broad acceptance for tissue engineering and drug delivery applications. As their function generally depends on their localization, identifying the hydrogel position in the body is relevant and will alert physicians ...

    Abstract Hydrogel-based biomaterials have gained broad acceptance for tissue engineering and drug delivery applications. As their function generally depends on their localization, identifying the hydrogel position in the body is relevant and will alert physicians about potentially dangerous hydrogel migration. Monitoring the localization of hydrogels by imaging is challenging due to their high water content. Here, we developed a method to render alginate hydrogels visible on computed tomography (CT) and X-ray for real-time tracking of hydrogels inside the body. This method is based on physically immobilizing emulsion droplets of ethiodized oil, an FDA-approved positive CT contrast agent, in calcium-crosslinked alginate hydrogels. We prepared an oil-in-water emulsion of ethiodized oil with micron-sized emulsion droplets and encapsulated it in a calcium-crosslinked alginate hydrogel. This injectable in situ-forming hydrogel was stable for at least 2 weeks in vitro, visible on CT and X-ray in mice, and showed contrast agent concentration-dependent signal intensities. Hydrogels retrieved from mice after imaging had suitable rheological properties with a storage modulus of about 2 kPa and a loss modulus of about 0.35 kPa. This proof-of-concept study highlights the potential of ethiodized oil to localize hydrogels in real time inside the body and identifies a new use of this FDA-approved contrast agent.
    MeSH term(s) Mice ; Animals ; Hydrogels ; Alginates ; Contrast Media ; Calcium ; Ethiodized Oil ; Emulsions ; Tomography, X-Ray Computed
    Chemical Substances Hydrogels ; Alginates ; Contrast Media ; Calcium (SY7Q814VUP) ; Ethiodized Oil (8008-53-5) ; Emulsions
    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1550-7416
    ISSN (online) 1550-7416
    DOI 10.1208/s12248-023-00843-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Portable Near-Infrared Fluorometer for a Liposomal Blood Lactate Assay.

    Guirguis, Natalie / Machuca-Parra, Arturo Israel / Matoori, Simon

    ACS pharmacology & translational science

    2023  Volume 6, Issue 6, Page(s) 907–912

    Abstract: In sepsis, plasma lactate is a key biomarker of disease severity, prognosis, and treatment success. However, the median time to result for clinical lactate tests is 3 h. We recently reported a near-infrared fluorescent (NIRF) blood lactate assay that ... ...

    Abstract In sepsis, plasma lactate is a key biomarker of disease severity, prognosis, and treatment success. However, the median time to result for clinical lactate tests is 3 h. We recently reported a near-infrared fluorescent (NIRF) blood lactate assay that relies on a two-step enzymatic reaction in a liposomal reaction compartment. This assay was optimized in human blood and was capable of quantifying lactate in fresh capillary blood from human volunteers at clinically relevant concentrations in 2 min. However, these studies were performed with a tabletop fluorescence plate reader. For translation to the point of care, the liposomal lactate assay needs to be combined with a small portable NIR fluorometer. Portable NIR fluorometers were successfully used for the analysis of skin and soil samples, but reports for blood metabolite assays are scarce. We aimed at testing the performance of the liposomal lactate assay in combination with a commercial small portable NIR fluorometer. First, we tested the fluorophore of the liposomal lactate assay using the NIR dye sulfo-cyanine 7; we observed strong fluorescence signals and high linearity. Second, we performed the liposomal lactate assay in lactate-spiked human arterial blood using the portable fluorometer as the detector and observed strong and highly linear lactate sensing at clinically relevant lactate concentrations after 2 min. Finally, spiking fresh mouse blood with three clinically relevant lactate concentrations led to a significantly different response to all three concentrations after 5 min. These results highlight the usefulness of the tested portable NIR fluorometer for the liposomal lactate assay and motivate a clinical evaluation of this rapid and easy-to-use lactate assay.
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.3c00055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Development of a liposomal near-infrared fluorescence lactate assay for human blood

    Matoori, Simon / Mooney, David J.

    Biomaterials. 2022 Apr., v. 283

    2022  

    Abstract: In emergency medicine, blood lactate is a commonly used biomarker of hypoxia (e.g., sepsis, trauma, cardiac arrest) but the median time to obtain the results from a clinical lactate test is 3 h. We recently developed a near-infrared fluorescent blood ... ...

    Abstract In emergency medicine, blood lactate is a commonly used biomarker of hypoxia (e.g., sepsis, trauma, cardiac arrest) but the median time to obtain the results from a clinical lactate test is 3 h. We recently developed a near-infrared fluorescent blood lactate assay based on a two-step enzymatic cascade in a vesicular reaction compartment. Previously, we reported a response of this assay to lactate-spiked bovine blood after 10 min. To develop a point-of-care test, we optimized this assay in commercial human blood, validated it in fresh capillary blood of healthy volunteers in an institutional review board-approved study, and improved the stability of the formulation. External pH and luminal enzyme concentrations were identified as key parameters of sensor response and kinetics, as they impact transmembrane lactate diffusion and turnover rate. The preparation process was also simplified and the stability was improved to allow storage at 4 °C for at least 5 days. The final formulation exhibited a strong and linear response to lactate-spiked human blood in a clinically relevant range, and accurately quantified a lactate standard at a clinically used cut-off in fresh capillary blood after 2 min. These findings motivate a clinical evaluation of this rapid and easy-to-use lactate assay.
    Keywords biocompatible materials ; biomarkers ; blood ; cardiac arrest ; cattle ; clinical examination ; enzymes ; fluorescence ; humans ; hypoxia ; lactic acid ; medicine ; pH ; point-of-care systems
    Language English
    Dates of publication 2022-04
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 603079-8
    ISSN 0142-9612
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2022.121475
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2371: Show issues Location:
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  9. Article ; Online: 175 Years of Bilirubin Testing: Ready for Point-of-Care?

    Guirguis, Natalie / Bertrand, Antoine-Xavier / Rose, Christopher F / Matoori, Simon

    Advanced healthcare materials

    2023  Volume 12, Issue 18, Page(s) e2203380

    Abstract: Bilirubin was first detected in blood in 1847 and since then has become one of the most widely used biomarkers for liver disease. Clinical routine bilirubin testing is performed at the hospital laboratory, and the gold standard colorimetric test is prone ...

    Abstract Bilirubin was first detected in blood in 1847 and since then has become one of the most widely used biomarkers for liver disease. Clinical routine bilirubin testing is performed at the hospital laboratory, and the gold standard colorimetric test is prone to interferences. The absence of a bedside test for bilirubin delays critical clinical decisions for patients with liver disease. This clinical care gap has motivated the development of a new generation of bioengineered point-of-care bilirubin assays. In this Perspective, recently developed bilirubin assays are critically discussed, and their translational potential evaluated.
    MeSH term(s) Humans ; Bilirubin ; Point-of-Care Systems ; Biomarkers
    Chemical Substances Bilirubin (RFM9X3LJ49) ; Biomarkers
    Language English
    Publishing date 2023-04-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202203380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6966: Show issues Location:
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  10. Article ; Online: Breakthrough treatments for accelerated wound healing.

    Freedman, Benjamin R / Hwang, Charles / Talbot, Simon / Hibler, Brian / Matoori, Simon / Mooney, David J

    Science advances

    2023  Volume 9, Issue 20, Page(s) eade7007

    Abstract: Skin injuries across the body continue to disrupt everyday life for millions of patients and result in prolonged hospital stays, infection, and death. Advances in wound healing devices have improved clinical practice but have mainly focused on treating ... ...

    Abstract Skin injuries across the body continue to disrupt everyday life for millions of patients and result in prolonged hospital stays, infection, and death. Advances in wound healing devices have improved clinical practice but have mainly focused on treating macroscale healing versus underlying microscale pathophysiology. Consensus is lacking on optimal treatment strategies using a spectrum of wound healing products, which has motivated the design of new therapies. We summarize advances in the development of novel drug, biologic products, and biomaterial therapies for wound healing for marketed therapies and those in clinical trials. We also share perspectives for successful and accelerated translation of novel integrated therapies for wound healing.
    MeSH term(s) Humans ; Wound Healing/physiology ; Biocompatible Materials
    Chemical Substances Biocompatible Materials
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.ade7007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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