Article ; Online: Effect of non-pharmacological interventions on the prevention of sarcopenia in menopausal women: a systematic review and meta-analysis of randomized controlled trials.
2023 Volume 23, Issue 1, Page(s) 606
Abstract: Background: Sarcopenia is a chronic disease marked by gradual muscle system and functional decline. Prior research indicates its prevalence in those under 60 varies from 8 to 36%. There is limited evidence on the effectiveness of non-pharmacological ... ...
| Abstract | Background: Sarcopenia is a chronic disease marked by gradual muscle system and functional decline. Prior research indicates its prevalence in those under 60 varies from 8 to 36%. There is limited evidence on the effectiveness of non-pharmacological interventions for sarcopenia prevention in menopausal women aged 40-60. This study examines the influence of such interventions for sarcopenia prevention on these women. Methods: PubMed, EMBASE, Medline, Cochrane Library, CINAHL, PEDro, and Airiti Library were searched from inception until May 5, 2023. Randomized controlled trials that examined exercise, vitamin D and protein supplementation effects on muscle mass, strength, and physical function. Quality assessment used the Cochrane risk of bias tool, and analysis employed Comprehensive Meta-Analysis version 2.0. Results: A total of 27 randomized controlled trials, involving 1,989 participants were identified. Meta-analysis results showed exercise improved lean body mass (SMD = 0.232, 95% CI: 0.097, 0.366), handgrip strength (SMD = 0.901, 95% CI: 0.362, 1.441), knee extension strength (SMD = 0.698, 95% CI: 0.384, 1.013). Resistance training had a small effect on lean body mass, longer exercise duration (> 12 weeks) and higher frequency (60-90 min, 3 sessions/week) showed small to moderate effects on lean body mass. Vitamin D supplementation improved handgrip strength (SMD = 0.303, 95% CI: 0.130, 0.476), but not knee extension strength. There was insufficient data to assess the impact of protein supplementation on muscle strength. Conclusions: Exercise effectively improves muscle mass, and strength in menopausal women. Resistance training with 3 sessions per week, lasting 20-90 min for at least 6 weeks, is most effective. Vitamin D supplementation enhances small muscle group strength. Further trials are needed to assess the effects of vitamin D and protein supplementation on sarcopenia prevention. Registration number: This review was registered on PROSPERO CRD42022329273. |
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| MeSH term(s) | Humans ; Female ; Sarcopenia/prevention & control ; Hand Strength ; Randomized Controlled Trials as Topic ; Muscle Strength ; Vitamin D/therapeutic use ; Menopause |
| Chemical Substances | Vitamin D (1406-16-2) |
| Language | English |
| Publishing date | 2023-11-14 |
| Publishing country | England |
| Document type | Meta-Analysis ; Systematic Review ; Journal Article |
| ZDB-ID | 2050444-5 |
| ISSN | 1472-6874 ; 1472-6874 |
| ISSN (online) | 1472-6874 |
| ISSN | 1472-6874 |
| DOI | 10.1186/s12905-023-02749-7 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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