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  1. Article ; Online: Effect of Starch Noodle (

    Kim, Youngmin / Jang, Hyejin / Lim, Sangdong / Hong, Sangpil

    Food science of animal resources

    2021  Volume 41, Issue 1, Page(s) 153–163

    Abstract: This study was conducted to examine the effects of starch noodles ( ...

    Abstract This study was conducted to examine the effects of starch noodles (
    Language English
    Publishing date 2021-01-01
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 3016289-0
    ISSN 2636-0780 ; 2636-0772
    ISSN (online) 2636-0780
    ISSN 2636-0772
    DOI 10.5851/kosfa.2020.e87
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  2. Article ; Online: Improving the Work Efficiency of Therapeutic Drug Monitoring Reports Through the Establishment of an Automated Data Transfer System.

    Lee, Seunghoo / Yoon, Sangpil / Kim, Hyun-Ki / Kim, Sollip / Lee, Woochang / Chun, Sail / Min, Won-Ki

    Annals of laboratory medicine

    2023  Volume 43, Issue 6, Page(s) 628–631

    MeSH term(s) Humans ; Drug Monitoring
    Language English
    Publishing date 2023-06-30
    Publishing country Korea (South)
    Document type Letter
    ZDB-ID 2677441-0
    ISSN 2234-3814 ; 2234-3814
    ISSN (online) 2234-3814
    ISSN 2234-3814
    DOI 10.3343/alm.2023.43.6.628
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  3. Article ; Online: Skeletal Muscle Mass Measurement via Bioelectrical Impedance Analysis as an Aid to Screen for Chronic Kidney Disease in Routine Health Checkups.

    Lee, Seunghoo / Yoon, Sangpil / Kim, Sollip / Lee, Woochang / Chun, Sail / Min, Won-Ki

    Annals of laboratory medicine

    2023  Volume 44, Issue 1, Page(s) 100–102

    MeSH term(s) Humans ; Electric Impedance ; Renal Insufficiency, Chronic/diagnosis ; Muscle, Skeletal
    Language English
    Publishing date 2023-09-04
    Publishing country Korea (South)
    Document type Letter
    ZDB-ID 2677441-0
    ISSN 2234-3814 ; 2234-3814
    ISSN (online) 2234-3814
    ISSN 2234-3814
    DOI 10.3343/alm.2024.44.1.100
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  4. Article ; Online: Event fusion photometric stereo network.

    Ryoo, Wonjeong / Nam, Giljoo / Hyun, Jae-Sang / Kim, Sangpil

    Neural networks : the official journal of the International Neural Network Society

    2023  Volume 167, Page(s) 141–158

    Abstract: Photometric stereo methods typically rely on RGB cameras and are usually performed in a dark room to avoid ambient illumination. Ambient illumination poses a great challenge in photometric stereo due to the restricted dynamic range of the RGB cameras. To ...

    Abstract Photometric stereo methods typically rely on RGB cameras and are usually performed in a dark room to avoid ambient illumination. Ambient illumination poses a great challenge in photometric stereo due to the restricted dynamic range of the RGB cameras. To address this limitation, we present a novel method, namely Event Fusion Photometric Stereo Network (EFPS-Net), which estimates the surface normals of an object in an ambient light environment by utilizing a deep fusion of RGB and event cameras. The high dynamic range of event cameras provides a broader perspective of light representations that RGB cameras cannot provide. Specifically, we propose an event interpolation method to obtain ample light information, which enables precise estimation of the surface normals of an object. By using RGB-event fused observation maps, our EFPS-Net outperforms previous state-of-the-art methods that depend only on RGB frames, resulting in a 7.94% reduction in mean average error. In addition, we curate a novel photometric stereo dataset by capturing objects with RGB and event cameras under numerous ambient light environments.
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 740542-x
    ISSN 1879-2782 ; 0893-6080
    ISSN (online) 1879-2782
    ISSN 0893-6080
    DOI 10.1016/j.neunet.2023.08.009
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2365: Show issues Location:
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  5. Article ; Online: Robust sound-guided image manipulation.

    Lee, Seung Hyun / Chi, Hyung-Gun / Oh, Gyeongrok / Byeon, Wonmin / Yoon, Sang Ho / Park, Hyunje / Cho, Wonjun / Kim, Jinkyu / Kim, Sangpil

    Neural networks : the official journal of the International Neural Network Society

    2024  Volume 175, Page(s) 106271

    Abstract: Recent successes suggest that an image can be manipulated by a text prompt, e.g., a landscape scene on a sunny day is manipulated into the same scene on a rainy day driven by a text input "raining". These approaches often utilize a StyleCLIP-based image ... ...

    Abstract Recent successes suggest that an image can be manipulated by a text prompt, e.g., a landscape scene on a sunny day is manipulated into the same scene on a rainy day driven by a text input "raining". These approaches often utilize a StyleCLIP-based image generator, which leverages multi-modal (text and image) embedding space. However, we observe that such text inputs are often bottlenecked in providing and synthesizing rich semantic cues, e.g., differentiating heavy rain from rain with thunderstorms. To address this issue, we advocate leveraging an additional modality, sound, which has notable advantages in image manipulation as it can convey more diverse semantic cues (vivid emotions or dynamic expressions of the natural world) than texts. In this paper, we propose a novel approach that first extends the image-text joint embedding space with sound and applies a direct latent optimization method to manipulate a given image based on audio input, e.g., the sound of rain. Our extensive experiments show that our sound-guided image manipulation approach produces semantically and visually more plausible manipulation results than the state-of-the-art text and sound-guided image manipulation methods, which are further confirmed by our human evaluations. Our downstream task evaluations also show that our learned image-text-sound joint embedding space effectively encodes sound inputs. Examples are provided in our project page: https://kuai-lab.github.io/robust-demo/.
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 740542-x
    ISSN 1879-2782 ; 0893-6080
    ISSN (online) 1879-2782
    ISSN 0893-6080
    DOI 10.1016/j.neunet.2024.106271
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    Zs.A 2365: Show issues Location:
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  6. Book ; Online: FPANet

    Oh, Gyeongrok / Gu, Heon / Kim, Jinkyu / Kim, Sangpil

    Frequency-based Video Demoireing using Frame-level Post Alignment

    2023  

    Abstract: Interference between overlapping gird patterns creates moire patterns, degrading the visual quality of an image that captures a screen of a digital display device by an ordinary digital camera. Removing such moire patterns is challenging due to their ... ...

    Abstract Interference between overlapping gird patterns creates moire patterns, degrading the visual quality of an image that captures a screen of a digital display device by an ordinary digital camera. Removing such moire patterns is challenging due to their complex patterns of diverse sizes and color distortions. Existing approaches mainly focus on filtering out in the spatial domain, failing to remove a large-scale moire pattern. In this paper, we propose a novel model called FPANet that learns filters in both frequency and spatial domains, improving the restoration quality by removing various sizes of moire patterns. To further enhance, our model takes multiple consecutive frames, learning to extract frame-invariant content features and outputting better quality temporally consistent images. We demonstrate the effectiveness of our proposed method with a publicly available large-scale dataset, observing that ours outperforms the state-of-the-art approaches, including ESDNet, VDmoire, MBCNN, WDNet, UNet, and DMCNN, in terms of the image and video quality metrics, such as PSNR, SSIM, LPIPS, FVD, and FSIM.
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Artificial Intelligence
    Subject code 006
    Publishing date 2023-01-18
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Multiplexed Ultrasound Imaging Using Spectral Analysis on Gas Vesicles.

    Kim, Sangnam / Zhang, Siyuan / Yoon, Sangpil

    Advanced healthcare materials

    2022  Volume 11, Issue 17, Page(s) e2200568

    Abstract: Current advances in ultrasound imaging techniques combined with the next generation contrast agents such as gas vesicles (GV) revolutionize the visualization of biological tissues with spatiotemporal precision. In optics, fluorescent proteins enable ... ...

    Abstract Current advances in ultrasound imaging techniques combined with the next generation contrast agents such as gas vesicles (GV) revolutionize the visualization of biological tissues with spatiotemporal precision. In optics, fluorescent proteins enable understanding of molecular and cellular functions in biological systems due to their multiplexed imaging capability. Here, a panel of GVs is investigated using mid-band fit (MBF) spectral imaging to realize multiplexed ultrasound imaging to uniquely visualize locations of different types of stationary GVs. The MBF spectral imaging technique demonstrates that stationary clustered GVs are efficiently localized and distinguished from unclustered GVs in agarose gel phantom and 3D vessel structures are visualized in ex vivo mouse liver specimens. Mouse macrophages serve as carriers of clustered and unclustered GVs and multiplexing beacons to report cells' spatial locations by emitting distinct spectral signals. 2D MBF spectral images are reconstructed, and pixels in these images are classified depending on MBF values by comparing predetermined filters that predict the existence of cells with clustered and unclustered GVs. This pseudo-coloring scheme clearly distinguishes the locations of two classes of cells like pseudo-color images in fluorescence microscopy.
    MeSH term(s) Animals ; Contrast Media ; Mice ; Microscopy, Fluorescence ; Proteins/chemistry ; Ultrasonography/methods
    Chemical Substances Contrast Media ; Proteins
    Language English
    Publishing date 2022-07-12
    Publishing country Germany
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202200568
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    Zs.A 6966: Show issues Location:
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  8. Article ; Online: Drug-Loaded Nanogel for Efficient Orchestration of Cell Death Pathways by Intramitochondrial Disulfide Polymerization.

    Choi, Eun Seong / Kim, Sangpil / Kim, Dohyun / Choi, Eunshil / Ryu, Ja-Hyoung

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 20, Issue 15, Page(s) e2308872

    Abstract: Chemotherapy using a nanoscaled drug delivery system is an effective cancer therapy, but its high drug concentration often causes drug resistance in cancer cells and normal cell damage. Combination therapy involving two or more different cell signaling ... ...

    Abstract Chemotherapy using a nanoscaled drug delivery system is an effective cancer therapy, but its high drug concentration often causes drug resistance in cancer cells and normal cell damage. Combination therapy involving two or more different cell signaling pathways can be a powerful tool to overcome the limitations of chemotherapy. Herein, this article presents nanogel (NG)-mediated co-delivery of a chemodrug camptothecin (CPT) and mitochondria-targeting monomer (MT monomer) for efficient activation of two modes of the programmed cell death pathway (apoptosis and necroptosis) and synergistic enhancement of cancer therapy. CPT and the monomer are incorporated together into the redox-degradable polymeric NGs for release in response to the intracellular glutathione. The MT monomer is shown to undergo reactive oxygen species (ROS)-triggered disulfide polymerization inside the cancerous mitochondria in cooperation with the chemotherapeutic CPT elevating the intracellular ROS level. The CPT/monomer interconnection in cell death mechanisms for mitochondrial dysfunction and enhanced cell death is evidenced by a series of cell analyses showing ROS generation, mitochondria damage, impacts on (non)cancerous or drug-resistant cells, and cell death modes. The presented work provides beneficial insights for utilizing combination therapy to facilitate a desired cell death mechanism and developing a novel nanosystem for more efficacious cancer treatment.
    MeSH term(s) Humans ; Nanogels ; Pharmaceutical Preparations ; Disulfides/pharmacology ; Reactive Oxygen Species/metabolism ; Polymerization ; Cell Death ; Neoplasms/drug therapy ; Cell Line, Tumor ; Camptothecin/pharmacology ; Camptothecin/therapeutic use ; Polyethylene Glycols ; Polyethyleneimine
    Chemical Substances polyethylene glycol polyethyleneimine nanogel ; Nanogels ; Pharmaceutical Preparations ; Disulfides ; Reactive Oxygen Species ; Camptothecin (XT3Z54Z28A) ; Polyethylene Glycols (3WJQ0SDW1A) ; Polyethyleneimine (9002-98-6)
    Language English
    Publishing date 2023-11-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202308872
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  9. Article ; Online: Comparison of intermittent theta burst stimulation and high-frequency repetitive transcranial magnetic stimulation on spinal cord injury-related neuropathic pain: A sham-controlled study.

    Kim, Jong Keun / You, JaeIn / Son, Sangpil / Suh, InHyuk / Lim, Jong Youb

    The journal of spinal cord medicine

    2023  , Page(s) 1–7

    Abstract: Objective: To compare the effects of intermittent theta burst stimulation (iTBS) and high-frequency repetitive transcranial magnetic stimulation (rTMS) on spinal cord injury-related neuropathic pain with sham controls, using neuropathic pain-specific ... ...

    Abstract Objective: To compare the effects of intermittent theta burst stimulation (iTBS) and high-frequency repetitive transcranial magnetic stimulation (rTMS) on spinal cord injury-related neuropathic pain with sham controls, using neuropathic pain-specific evaluation tools.
    Design: A randomized, double-blind, sham-controlled trial.
    Setting: Rehabilitation medicine department of a university hospital.
    Participants: Thirty-three patients with spinal cord injury-related neuropathic pain.
    Interventions: Patients were randomly allocated to one of three groups (real iTBS, real rTMS, and sham rTMS). Each patient underwent five sessions of assigned stimulation.
    Outcome measures: Before and after completion of the five sessions, patients were evaluated using the self-completed Leeds Assessment of Neuropathic Symptoms and Signs, Numeric Rating Scale, Neuropathic Pain Symptom Inventory, and Neuropathic Pain Scale.
    Results: Real iTBS and real rTMS reduced pain levels after stimulation according to all the evaluation tools, and the changes were significant when compared to the values of the sham rTMS group. No significant differences were found between the real iTBS and real rTMS groups.
    Conclusion: Both iTBS and rTMS were effective in reducing spinal cord injury-related neuropathic pain. When safety, convenience, and compliance are considered, iTBS would have an advantage over rTMS in clinical situations with spinal cord injury-related neuropathic pain.
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1223949-5
    ISSN 2045-7723 ; 1079-0268
    ISSN (online) 2045-7723
    ISSN 1079-0268
    DOI 10.1080/10790268.2023.2277964
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2416: Show issues Location:
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  10. Article ; Online: Spatiotemporal Self-Assembly of Peptide Amphiphiles by Carbonic Anhydrase IX-Targeting Induces Cancer-Lysosomal Membrane Disruption.

    Kim, Dohyun / Kim, Sangpil / Park, Gaeun / Choi, Huyeon / Ryu, Ja-Hyoung

    JACS Au

    2022  Volume 2, Issue 11, Page(s) 2539–2547

    Abstract: To achieve spatiotemporal control, an enzyme-instructed self-assembly system is widely used, but this approach typically has a small effect on cellular fate. In this study, we show that the intralysosomal assembly by a carbonic anhydrase IX (CAIX)- ... ...

    Abstract To achieve spatiotemporal control, an enzyme-instructed self-assembly system is widely used, but this approach typically has a small effect on cellular fate. In this study, we show that the intralysosomal assembly by a carbonic anhydrase IX (CAIX)-targeting peptide amphiphile (Pep-AT) can control cellular fate with a low therapeutic dose by tuning the surface charge based on pH change. Pep-AT self-assembles into a fibrous aggregate with a negative surface charge in an extracellular environment near CAIX. During endocytosis, it changes into a nanofiber with a positive surface charge at the lysosome. Then, it can disrupt the lysosomal membrane and induce cellular apoptosis. This study demonstrates that a spatiotemporal assembly induced by a cancer enzyme and specific organelle can control the cellular fate of cancer.
    Language English
    Publishing date 2022-11-01
    Publishing country United States
    Document type Journal Article
    ISSN 2691-3704
    ISSN (online) 2691-3704
    DOI 10.1021/jacsau.2c00422
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