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  1. Article ; Online: Meningitis and brain abscess: First but fatal presentation in a child with tetralogy of fallot.

    Adebayo, Bosede Ehelamioke / Ogunkunle, Oluwatoyin Oluwafunmilayo / Ayun, Felix Olugbenga

    Journal of cardiology cases

    2015  Volume 13, Issue 3, Page(s) 72–74

    Abstract: Brain abscess is a known complication of cyanotic congenital heart diseases. We report the case of a four-year-old girl whose first presentation in the hospital was because of symptoms referable to the neurological system. These symptoms are similar to ... ...

    Abstract Brain abscess is a known complication of cyanotic congenital heart diseases. We report the case of a four-year-old girl whose first presentation in the hospital was because of symptoms referable to the neurological system. These symptoms are similar to those seen in cerebral malaria as well as other infections of the central nervous system, e.g. meningitis and encephalitis. Detailed history, painstaking examination, and investigations will however help in differentiating these conditions. In the index case however, the illness was fatal due to the late presentation, which is not uncommon in this environment. In a resource-poor environment such as Nigeria, this is a reminder that proper history taking, clinical examination, and subsequent investigations will aid in early diagnosis and subsequent management of such cases to reduce childhood mortality. It also underscores the need for increased awareness among primary health care providers. <
    Language English
    Publishing date 2015-12-30
    Publishing country Japan
    Document type Journal Article
    ISSN 1878-5409
    ISSN (online) 1878-5409
    DOI 10.1016/j.jccase.2015.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Intracardiac bronchogenic cyst in a 2-year-old Nigerian boy.

    Ogunkunle, Oluwatoyin Oluwafunmilayo / Animashaun, Deola

    BMJ case reports

    2012  Volume 2012

    Abstract: Primary cardiac tumours are rare in the paediatric age group. Bronchogenic cysts, although relatively rare, represent the most common cystic lesion of the mediastinum. Intracardiac bronchogenic cysts however, are extremely rare. The authors are unaware ... ...

    Abstract Primary cardiac tumours are rare in the paediatric age group. Bronchogenic cysts, although relatively rare, represent the most common cystic lesion of the mediastinum. Intracardiac bronchogenic cysts however, are extremely rare. The authors are unaware of any case previously reported in a Nigerian child and hence report the case of a 2-year-old boy for its rarity and interest. The boy was referred for evaluation of a cardiac murmur. Clinical, radiological and electrographic findings were suggestive of mild pulmonary stenosis or an atrial septal defect (ASD). 2-dimensional echocardiography however, revealed in addition to a small ASD, an intracardiac mass attached to the tricuspid valve. The mass was surgically removed and found on histology to be a bronchogenic cyst. Our experience highlights the importance of echocardiography in the evaluation of asymptomatic patients with cardiac murmurs, in whom a rare lesion might have otherwise been missed.
    MeSH term(s) Bronchogenic Cyst/diagnosis ; Bronchogenic Cyst/surgery ; Diagnosis, Differential ; Echocardiography ; Electrocardiography ; Heart Neoplasms/diagnosis ; Heart Neoplasms/surgery ; Humans ; Infant ; Male ; Nigeria ; Radiography, Thoracic
    Language English
    Publishing date 2012-03-27
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr.09.2011.4785
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Consequences of restricting antimalarial drugs to rapid diagnostic test-positive febrile children in south-west Nigeria.

    Falade, Catherine Olufunke / Orimadegun, Adebola Emanuel / Michael, Obaro Stanley / Dada-Adegbola, Hannah Odunola / Ogunkunle, Oluwatoyin Oluwafunmilayo / Badejo, Joseph Ayotunde / Funwei, Roland Ibenipere / Ajayi, IkeOluwapo Oyeneye / Jegede, Ayodele Samuel / Ojurongbe, Olusola Daniel / Ssekitooleko, James / Baba, Ebenezer / Hamade, Prudence / Webster, Jayne / Chandramohan, Daniel

    Tropical medicine & international health : TM & IH

    2019  Volume 24, Issue 11, Page(s) 1291–1300

    Abstract: Objectives: To investigate the consequence of restricting antimalarial treatment to febrile children that test positive to a malaria rapid diagnostic test (MRDT) only in an area of intense malaria transmission.: Methods: Febrile children aged 3-59 ... ...

    Abstract Objectives: To investigate the consequence of restricting antimalarial treatment to febrile children that test positive to a malaria rapid diagnostic test (MRDT) only in an area of intense malaria transmission.
    Methods: Febrile children aged 3-59 months were screened with an MRDT at health facilities in south-west Nigeria. MRDT-positive children received artesunate-amodiaquine (ASAQ), while MRDT-negative children were treated based on the clinical diagnosis of non-malaria febrile illness. The primary endpoint was the risk of developing microscopy-positive malaria within 28 days post-treatment.
    Results: 309 (60.5%) of 511 children were MRDT-positive while 202 (39.5%) were MRDT-negative at enrolment. 18.5% (50/275) of MRDT-positive children and 7.6% (14/184) of MRDT-negative children developed microscopy-positive malaria by day 28 post-treatment (ρ = 0.001). The risk of developing clinical malaria by day 28 post-treatment was higher among the MRDT-positive group than the MRDT-negative group (adjusted OR 2.74; 95% CI, 1.4, 5.4). A higher proportion of children who were MRDT-positive at enrolment were anaemic on day 28 compared with the MRDT-negative group (12.6% vs. 3.1%; ρ = 0.001). Children in the MRDT-negative group made more unscheduled visits because of febrile illness than those in MRDT-positive group (23.2% vs. 12.0%; ρ = 0.001).
    Conclusion: Restricting ACT treatment to MRDT-positive febrile children only did not result in significant adverse outcomes. However, the risk of re-infection within 28 days was significantly higher among MRDT-positive children despite ASAQ treatment. A longer-acting ACT may be needed as the first-line drug of choice for treating uncomplicated malaria in high-transmission settings to prevent frequent re-infections.
    MeSH term(s) Amodiaquine/administration & dosage ; Amodiaquine/adverse effects ; Amodiaquine/therapeutic use ; Antimalarials/administration & dosage ; Antimalarials/adverse effects ; Antimalarials/therapeutic use ; Artemisinins/administration & dosage ; Artemisinins/adverse effects ; Artemisinins/therapeutic use ; Child, Preschool ; Cross-Sectional Studies ; Drug Combinations ; Female ; Fever/epidemiology ; Fever/therapy ; Humans ; Malaria/diagnosis ; Malaria/drug therapy ; Malaria/epidemiology ; Male ; Microbiological Techniques ; Nigeria ; Prospective Studies ; Socioeconomic Factors
    Chemical Substances Antimalarials ; Artemisinins ; Drug Combinations ; amodiaquine, artesunate drug combination ; Amodiaquine (220236ED28)
    Language English
    Publishing date 2019-10-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1314080-2
    ISSN 1365-3156 ; 1360-2276
    ISSN (online) 1365-3156
    ISSN 1360-2276
    DOI 10.1111/tmi.13304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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