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  1. Article: Academician Wen-Rui Hu - Eminent Pioneer and Prominent Leader of Microgravity Science in China.

    Li, Kai / Zhao, Jian-Fu / Kang, Qi / Wang, Shuang-Feng

    Microgravity science and technology

    2022  Volume 34, Issue 2, Page(s) 19

    Abstract: ... Academician Wen-Rui Hu. In addition to his innovative contributions to cosmic magnetohydrodynamics (MHD ... to provide a brief historical perspective of the tireless explorations of Academician Wen-Rui Hu in the field ...

    Abstract In 2021, the scientific community celebrated the 85th anniversary of the Chinese scientist Academician Wen-Rui Hu. In addition to his innovative contributions to cosmic magnetohydrodynamics (MHD) during his early scientific career, he has initiated microgravity science research in China from the middle of 1980s, and made many pioneering contributions to microgravity fluid physics. He has also promoted researches in China in the fields of space material science, space biotechnology, space fundamental physics, and relevant applications. He is respected as the founder of microgravity science in China because of his eminent pioneering contributions and prominent leadership. This article tries to provide a brief historical perspective of the tireless explorations of Academician Wen-Rui Hu in the field of microgravity science and other relevant disciplines till today based on personal views of his former students and colleagues.
    Language English
    Publishing date 2022-03-15
    Publishing country Germany
    Document type Editorial
    ZDB-ID 2403671-7
    ISSN 1875-0494 ; 0938-0108
    ISSN (online) 1875-0494
    ISSN 0938-0108
    DOI 10.1007/s12217-022-09934-7
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  2. Article: Tarlatamab: the promising immunotherapy on its way from the lab to the clinic.

    Tang, Daolin / Kang, Rui

    Translational lung cancer research

    2023  Volume 12, Issue 6, Page(s) 1355–1357

    Language English
    Publishing date 2023-03-20
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-23-115
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  3. Article ; Online: Unusual Band Gap Bowing in CsCd

    Gao, Rui / Kang, Jun

    The journal of physical chemistry letters

    2023  Volume 14, Issue 47, Page(s) 10670–10676

    Abstract: In this work, the band structure of ... ...

    Abstract In this work, the band structure of CsCd
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c02813
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  4. Article ; Online: Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice.

    Wang, Pingping / Kang, Qianqian / Wu, Wen-Shu / Rui, Liangyou

    Cell reports

    2024  Volume 43, Issue 3, Page(s) 113875

    Abstract: Liver injury stimulates hepatocyte replication and hepatic stellate cell (HSC) activation, thereby driving liver regeneration. Aberrant HSC activation induces liver fibrosis. However, mechanisms underlying liver regeneration and fibrosis remain poorly ... ...

    Abstract Liver injury stimulates hepatocyte replication and hepatic stellate cell (HSC) activation, thereby driving liver regeneration. Aberrant HSC activation induces liver fibrosis. However, mechanisms underlying liver regeneration and fibrosis remain poorly understood. Here, we identify hepatic Snai1 and Snai2 as important transcriptional regulators for liver regeneration and fibrosis. Partial hepatectomy or CCl4 treatment increases occupancies of Snai1 and Snai2 on cyclin A2 and D1 promoters in the liver. Snai1 and Snai2 in turn increase promoter H3K27 acetylation and cyclin A2/D1 expressions. Hepatocyte-specific deletion of both Snai1 and Snai2, but not one alone, suppresses liver cyclin A2/D1 expression and regenerative hepatocyte proliferation after hepatectomy or CCl4 treatments but augments CCl4-stimulated HSC activation and liver fibrosis. Conversely, Snai2 overexpression in the liver enhances hepatocyte replication and suppresses liver fibrosis after CCl4 treatment. These results suggest that hepatic Snai1 and Snai2 directly promote, via histone modifications, reparative hepatocyte replication and indirectly inhibit liver fibrosis.
    MeSH term(s) Animals ; Mice ; Cyclin A2/metabolism ; Hepatectomy ; Liver/metabolism ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; Liver Regeneration/physiology
    Chemical Substances Cyclin A2 ; Snai1 protein, mouse ; Snai2 protein, mouse
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.113875
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  5. Article ; Online: From Oxytosis to Ferroptosis: 10 Years of Research on Oxidative Cell Death.

    Tang, Daolin / Kang, Rui

    Antioxidants & redox signaling

    2023  Volume 39, Issue 1-3, Page(s) 162–165

    Abstract: Over the past decade, extensive research has been dedicated to understanding oxidative cell death, specifically the transition from oxytosis to ferroptosis. Oxytosis was initially characterized in 1989 as a calcium-dependent form of nerve cell death ... ...

    Abstract Over the past decade, extensive research has been dedicated to understanding oxidative cell death, specifically the transition from oxytosis to ferroptosis. Oxytosis was initially characterized in 1989 as a calcium-dependent form of nerve cell death induced by glutamate. It was associated with intracellular glutathione depletion and the inhibition of cystine uptake through system xc
    MeSH term(s) Ferroptosis ; Cystine ; Cell Death/physiology ; Oxidation-Reduction ; Oxidative Stress ; Glutamates
    Chemical Substances Cystine (48TCX9A1VT) ; Glutamates
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Review ; Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2023.0356
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Adverse effects of ferroptotic therapy: mechanisms and management.

    Liu, Jiao / Kang, Rui / Tang, Daolin

    Trends in cancer

    2024  

    Abstract: Ferroptosis, a nonapoptotic form of cell death characterized by iron accumulation and uncontrolled lipid peroxidation, holds promise as a therapeutic approach in cancer treatment, alongside established modalities, such as chemotherapy, immunotherapy, and ...

    Abstract Ferroptosis, a nonapoptotic form of cell death characterized by iron accumulation and uncontrolled lipid peroxidation, holds promise as a therapeutic approach in cancer treatment, alongside established modalities, such as chemotherapy, immunotherapy, and radiotherapy. However, recent research has raised concerns about its side effects, including damage to immune cells, hematopoietic stem cells, liver, and kidneys, the development of cachexia, and the risk of secondary tumor formation. In this review, we provide an overview of these emerging findings, with a specific emphasis on elucidating the underlying mechanisms, and underscore the critical significance of effectively managing side effects associated with targeted ferroptosis-based therapy.
    Language English
    Publishing date 2024-01-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2024.01.002
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  7. Article ; Online: Reductive cell death: the other side of the coin.

    Zhang, Ruoxi / Kang, Rui / Tang, Daolin

    Cancer gene therapy

    2023  Volume 30, Issue 7, Page(s) 929–931

    MeSH term(s) Humans ; Cell Death
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 1212513-1
    ISSN 1476-5500 ; 0929-1903
    ISSN (online) 1476-5500
    ISSN 0929-1903
    DOI 10.1038/s41417-023-00612-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4125: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Correction: The KRAS-G12C inhibitor: activity and resistance.

    Liu, Jiao / Kang, Rui / Tang, Daolin

    Cancer gene therapy

    2023  Volume 30, Issue 12, Page(s) 1715

    Language English
    Publishing date 2023-11-15
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1212513-1
    ISSN 1476-5500 ; 0929-1903
    ISSN (online) 1476-5500
    ISSN 0929-1903
    DOI 10.1038/s41417-023-00692-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4125: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Impact of the Unstirred Water Layer on the Permeation of Small-Molecule Drugs.

    Kang, Christopher / Shoji, Alyson / Chipot, Christophe / Sun, Rui

    Journal of chemical information and modeling

    2024  Volume 64, Issue 3, Page(s) 933–943

    Abstract: Over the last two decades, numerous molecular dynamics (MD) simulation-based investigations have attempted to predict the membrane permeability to small-molecule drugs as indicators of their bioavailability, a majority of which utilize the inhomogeneous ... ...

    Abstract Over the last two decades, numerous molecular dynamics (MD) simulation-based investigations have attempted to predict the membrane permeability to small-molecule drugs as indicators of their bioavailability, a majority of which utilize the inhomogeneous solubility diffusion (ISD) model. However, MD-based membrane permeability is routinely 3-4 orders of magnitude larger than the values measured with the intestinal perfusion technique. There have been contentious discussions on the sources of the large discrepancies, and the two indisputable, potentially dominant ones are the fixed protonation state of the permeant and the neglect of the unstirred water layer (UWL). Employing six small-molecule drugs of different biopharmaceutical classification system classes, the current MD study relies on the ISD model but introduces the (de)protonation of the permeant by characterizing the permeation free energy of both neutral and charged states. In addition, the role of the UWL as a potential resistance against permeation is explored. The new MD protocol closely mimics the nature of small-molecule permeation and yields estimates that agree well with in vivo intestinal permeability.
    MeSH term(s) Water ; Intestinal Absorption ; Permeability ; Diffusion ; Cell Membrane Permeability
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 190019-5
    ISSN 1549-960X ; 0095-2338
    ISSN (online) 1549-960X
    ISSN 0095-2338
    DOI 10.1021/acs.jcim.3c01629
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    Zs.A 1230: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: Atomistic Insight into the Lipid Nanodomains of Synaptic Vesicles.

    Kang, Christopher / Fujioka, Kazuumi / Sun, Rui

    The journal of physical chemistry. B

    2024  Volume 128, Issue 11, Page(s) 2707–2716

    Abstract: Membrane curvature, once regarded as a passive consequence of membrane composition and cellular architecture, has been shown to actively modulate various properties of the cellular membrane. These changes could also lead to segregation of the ... ...

    Abstract Membrane curvature, once regarded as a passive consequence of membrane composition and cellular architecture, has been shown to actively modulate various properties of the cellular membrane. These changes could also lead to segregation of the constituents of the membrane, generating nanodomains with precise biological properties. Proteins often linked with neurodegeneration (e.g., tau, alpha-synuclein) exhibit an unintuitive affinity for synaptic vesicles in neurons, which are reported to lack distinct, ordered nanodomains based on their composition. In this study, all-atom molecular dynamics simulations are used to study a full-scale synaptic vesicle of realistic Gaussian curvature and its effect on the membrane dynamics and lipid nanodomain organization. Compelling indicators of nanodomain formation, from the perspective of composition, surface areas per lipid, order parameter, and domain lifetime, are identified in the vesicle membrane, which are absent in a flat bilayer of the same lipid composition. Therefore, our study supports the idea that curvature may induce phase separation in an otherwise fluid, disordered membrane.
    MeSH term(s) Synaptic Vesicles ; Cell Membrane ; Molecular Dynamics Simulation ; Lipids ; Lipid Bilayers
    Chemical Substances Lipids ; Lipid Bilayers
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.3c07982
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