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Article ; Online: Life Sciences undergraduate students' preferences on online learning.

Lee, Zheng-Wei

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

2023 Volume 51, Issue 4, Page(s) 446–450

Abstract: Online learning is implemented in response to emergency remote teaching during global pandemic. We conducted a survey on Life Sciences undergraduate students on their preferences on mode of lesson delivery, mode of learning and learning activities. ... ...

Abstract	Online learning is implemented in response to emergency remote teaching during global pandemic. We conducted a survey on Life Sciences undergraduate students on their preferences on mode of lesson delivery, mode of learning and learning activities. Students across different study years responded in a similar order ranking blended learning delivery as highly favorable. The survey gathered insightful understandings on Life Sciences undergraduates' learning preferences on online learning which inform future purposeful learning design taking student's preferences into consideration.
MeSH term(s)	Humans ; Education, Distance ; Students ; Learning ; Biological Science Disciplines ; Pandemics
Language	English
Publishing date	2023-05-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2039717-3
ISSN	1539-3429 ; 1470-8175
ISSN (online)	1539-3429
ISSN	1470-8175
DOI	10.1002/bmb.21738
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Article ; Online: Online conferencing platform provides opportunity for reciprocal teaching.

Lee, Zheng-Wei / Yeong, Foong May

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

2020 Volume 48, Issue 5, Page(s) 471–472

Abstract: The use of online platform to conduct teaching and learning activities has becoming a new norm for teachers and students during this COVID-19 outbreak. In this commentary, we share our experiences of using online conferencing platform to promote active ... ...

Abstract	The use of online platform to conduct teaching and learning activities has becoming a new norm for teachers and students during this COVID-19 outbreak. In this commentary, we share our experiences of using online conferencing platform to promote active and interactive learning among students. We also suggest approaches that teachers can use to design their teaching and learning activities by employing reciprocal teaching as a way to engage students online instead of using the platform for didactic teaching by the teacher. The proposed strategy is applicable and transferable to other domains.
MeSH term(s)	COVID-19/epidemiology ; Education, Distance ; Educational Measurement ; Humans ; Pandemics ; Problem-Based Learning ; SARS-CoV-2 ; Simulation Training
Keywords	covid19
Language	English
Publishing date	2020-08-01
Publishing country	United States
Document type	Journal Article
ISSN	1539-3429
ISSN (online)	1539-3429
DOI	10.1002/bmb.21405
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Article: Online conferencing platform provides opportunity for reciprocal teaching

Lee, Zheng-Wei / Yeong, Foong May

Abstract	The use of online platform to conduct teaching and learning activities has becoming a new norm for teachers and students during this COVID-19 outbreak. In this commentary, we share our experiences of using online conferencing platform to promote active and interactive learning among students. We also suggest approaches that teachers can use to design their teaching and learning activities by employing reciprocal teaching as a way to engage students online instead of using the platform for didactic teaching by the teacher. The proposed strategy is applicable and transferable to other domains.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #690730
Database	COVID19

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Article: Anatomical and functional remodeling of left ventricle in patients with primary aldosteronism and concomitant albuminuria.

Kao, Ting-Wei / Wu, Xue-Ming / Liao, Che-Wei / Tsai, Cheng-Hsuan / Chen, Zheng-Wei / Chang, Yi-Yao / Lee, Bo-Ching / Chiu, Yu-Wei / Lai, Tai-Shuan / Wu, Vin-Cent / Lin, Yen-Hung / Hung, Chi-Sheng

Therapeutic advances in chronic disease

2023 Volume 14, Page(s) 20406223221143253

Abstract: Background: Primary aldosteronism (PA) is the leading cause of secondary hypertension globally and is associated with adverse cardiovascular outcomes. However, the cardiac impact of concomitant albuminuria remains unknown.: Objective: To compare ... ...

Abstract	Background: Primary aldosteronism (PA) is the leading cause of secondary hypertension globally and is associated with adverse cardiovascular outcomes. However, the cardiac impact of concomitant albuminuria remains unknown. Objective: To compare anatomical and functional remodeling of left ventricle (LV) in PA patients with or without albuminuria. Design: Prospective cohort study. Methods: The cohort was separated into two arms according to the presence or absence of albuminuria (>30 mg/g of morning spot urine). Propensity score matching with age, sex, systolic blood pressure, and diabetes mellitus was performed. Multivariate analysis was conducted with adjustments for age, sex, body mass index, systolic blood pressure, duration of hypertension, smoking, diabetes mellitus, number of antihypertensive agents, and aldosterone level. A local-linear model with bandwidth of 2.07 was used to study correlations. Results: A total of 519 individuals with PA were enrolled in the study, of whom 152 had albuminuria. After matching, the albuminuria group had a higher creatinine level, at baseline. With regard to LV remodeling, albuminuria was independently associated with a significantly higher interventricular septum (1.22 > 1.17 cm, Conclusion: The presence of concomitant albuminuria in patients with PA was associated with pronounced LV hypertrophy and compromised LV diastolic function. These alterations were reversible after treatment for PA. Plain language summary: Cardiac Impact of Primary Aldosteronism and Albuminuria
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2554816-5
ISSN	2040-6231 ; 2040-6223
ISSN (online)	2040-6231
ISSN	2040-6223
DOI	10.1177/20406223221143253
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Article ; Online: Synergistic effects of ozone/peroxymonosulfate for isothiazolinone biocides degradation: Kinetics, synergistic performance and influencing factors.

Yang, Zheng-Wei / Wang, Wen-Long / Lee, Min-Yong / Wu, Qian-Yuan / Guan, Yun-Tao

Environmental pollution (Barking, Essex : 1987)

2021 Volume 294, Page(s) 118626

Abstract: Synergistic effects of ozone ( ... ...

Abstract	Synergistic effects of ozone (O
MeSH term(s)	Disinfectants ; Kinetics ; Oxidation-Reduction ; Ozone ; Peroxides ; Water Pollutants, Chemical/analysis ; Water Purification
Chemical Substances	Disinfectants ; Peroxides ; Water Pollutants, Chemical ; peroxymonosulfate (22047-43-4) ; Ozone (66H7ZZK23N)
Language	English
Publishing date	2021-12-02
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2021.118626
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Zs.A 2599: Show issues

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Article: Synergistic effects of ozone/peroxymonosulfate for isothiazolinone biocides degradation: Kinetics, synergistic performance and influencing factors

Yang, Zheng-Wei / Wang, Wen-Long / Lee, Min-Yong / Wu, Qian-Yuan / Guan, Yun-Tao

Environmental pollution. 2022 Feb. 01, v. 294

2022

Abstract: Synergistic effects of ozone (O₃) and peroxymonosulfate (PMS, HSO₅⁻) for isothiazolinone biocides degradation was studied. The synergistic ozonation process (O₃/PMS) increased the efficiency of methyl-isothiazolinone (MIT) and chloro-methyl- ... ...

Abstract	Synergistic effects of ozone (O₃) and peroxymonosulfate (PMS, HSO₅⁻) for isothiazolinone biocides degradation was studied. The synergistic ozonation process (O₃/PMS) increased the efficiency of methyl-isothiazolinone (MIT) and chloro-methyl-isothiazolinone (CMIT) degradation to 91.0% and 81.8%, respectively, within 90 s at pH 7.0. This is 30.6% and 62.5% higher than the corresponding ozonation efficiency, respectively. Total radical formation value (Rcₜ,R) for the O₃/PMS process was 24.6 times that of ozonation alone. Calculated second-order rate constants for the reactions between isothiazolinone biocides and ▪ (kSO₄₋,MIT and kSO₄₋,CMIT) were 8.15 × 10⁹ and 4.49 × 10⁹ M⁻¹ s⁻¹, respectively. Relative contributions of O₃, hydroxyl radical (OH) and ▪ oxidation to MIT and CMIT removal were estimated, which were 15%, 45%, and 40% for O₃, OH and ▪ oxidation to MIT, and 1%, 67%, and 32% for O₃, OH and ▪ oxidation to CMIT at pH 7.0, respectively. Factors influencing the O₃/PMS process, namely the solution pH, chloride ions (Cl⁻), and bicarbonate (HCO₃⁻), were evaluated. Increasing the solution pH markedly accelerated O₃ decay and OH and ▪ formation, thus weakening the relative contribution of O₃ oxidation while enhancing that of OH and ▪. Cl⁻ had a negligible effect on MIT and CMIT degradation. Under the dual effect of bicarbonate (HCO₃⁻) as inhibitor and promoter, low concentrations (1–2 mM) of bicarbonate weakly promoted MIT and CMIT degradation, while high concentrations (10–20 mM) induced strong inhibition. Lastly, oxidation performance of O₃ and O₃/PMS processes for MIT and CMIT degradation in different water matrices was compared.
Keywords	bicarbonates ; biocides ; chlorides ; hydroxyl radicals ; oxidation ; ozonation ; ozone ; pH ; pollution
Language	English
Dates of publication	2022-0201
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2021.118626
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Reversal of arterial stiffness in medically and surgically treated unilateral primary aldosteronism.

Chen, Zheng-Wei / Liao, Che-Wei / Pan, Chien-Ting / Tsai, Cheng-Hsuan / Chang, Yi-Yao / Chang, Chin-Chen / Lee, Bo-Ching / Chiu, Yu-Wei / Huang, Wei-Chieh / Lai, Tai-Shuan / Lu, Ching-Chu / Chueh, Jeff S / Wu, Vin-Cent / Hung, Chi-Sheng / Lin, Yen-Hung

Journal of hypertension

2023 Volume 42, Issue 3, Page(s) 538–545

Abstract: Objective: Hyperaldosteronism has adverse effects on cardiovascular structure and function. Laparoscopic adrenalectomy is the gold standard for patients with unilateral primary aldosteronism. For unilateral primary aldosteronism patients unable or ... ...

Abstract	Objective: Hyperaldosteronism has adverse effects on cardiovascular structure and function. Laparoscopic adrenalectomy is the gold standard for patients with unilateral primary aldosteronism. For unilateral primary aldosteronism patients unable or unwilling to undergo surgery, the effects of mineralocorticoid receptor antagonists (MRAs) on the reversibility of arterial stiffness and other clinical data remain unclear. We aimed to compare the reversibility of arterial stiffness using pulse wave velocity (PWV) and other clinical parameters between surgically and medically treated unilateral primary aldosteronism patients. Methods: We prospectively enrolled 306 unilateral primary aldosteronism patients, of whom 247 received adrenalectomy and 59 received medical treatment with MRAs. Detailed medical history, basic biochemistry and PWV data were collected in both groups before treatment and 1 year after treatment. After propensity score matching (PSM) for age, sex, SBP and DBPs, 149 patients receiving adrenalectomy and 54 patients receiving MRAs were included for further analysis. Results: After PSM, the patients receiving adrenalectomy had a greater reduction in blood pressure, increase in serum potassium, and change in PWV (ΔPWV, -53 ± 113 vs. -10 ± 140 cm/s, P = 0.028) than those receiving MRAs 1 year after treatment. Multivariable regression analysis further identified that surgery (compared with MRA treatment), baseline PWV, baseline DBP, the change in DBP and the use of diuretics were independently correlated with ΔPWV. Conclusion: Adrenalectomy is superior to MRA treatment with regards to vascular remodeling when treating unilateral primary aldosteronism patients.
MeSH term(s)	Humans ; Vascular Stiffness ; Pulse Wave Analysis ; Hyperaldosteronism ; Adrenalectomy ; Blood Pressure ; Mineralocorticoid Receptor Antagonists/therapeutic use
Chemical Substances	Mineralocorticoid Receptor Antagonists
Language	English
Publishing date	2023-12-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0000000000003631
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Zs.A 1885: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Aldosteronism is associated with more severe cerebral small vessel disease in hypertensive intracerebral hemorrhage.

Lee, Bo-Ching / Tsai, Hsin-Hsi / Chen, Zheng-Wei / Chang, Chin-Chen / Huang, Jia-Zheng / Chang, Yi-Yao / Tsai, Cheng-Hsuan / Chou, Chia-Hung / Liao, Che-Wei / Pan, Chien-Ting / Wu, Vin-Cent / Hung, Chi-Sheng / Tsai, Li-Kai / Lin, Yen-Hung

Hypertension research : official journal of the Japanese Society of Hypertension

2023 Volume 47, Issue 3, Page(s) 608–617

Abstract: Primary aldosteronism is associated with various types of cardiovascular and cerebrovascular damage independently of hypertension. Although chronic hypertension and related cerebral arteriosclerosis are the main risk factors for intracerebral hemorrhage, ...

Abstract	Primary aldosteronism is associated with various types of cardiovascular and cerebrovascular damage independently of hypertension. Although chronic hypertension and related cerebral arteriosclerosis are the main risk factors for intracerebral hemorrhage, the effects of aldosteronism remain poorly understood. We enrolled 90 survivors of hypertensive intracerebral hemorrhage, 21 of them with aldosteronism and 69 with essential hypertension as controls in this study. Clinical parameters and neuroimaging markers of cerebral small vessel disease were recorded, and its correlations with aldosteronism were investigated. Our results showed that the aldosteronism group (55.2 ± 9.7 years, male 47.6%) had similar hypertension severity but exhibited a higher cerebral microbleed count (interquartile range) (8.5 [2.0‒25.8] vs 3 [1.0‒6.0], P = 0.005) and higher severity of dilated perivascular space in the basal ganglia (severe perivascular space [number >20], 52.4% vs. 24.6%, P = 0.029; large perivascular space [>3 mm], 52.4% vs. 20.3%, P = 0.010), compared to those with essential hypertension (53.8 ± 11.7 years, male 73.9%). In multivariate models, aldosteronism remained an independent predictor of a higher (>10) microbleed count (odds ratio = 8.60, P = 0.004), severe perivascular space (odds ratio = 4.00, P = 0.038); the aldosterone-to-renin ratio was associated with dilated perivascular space (P = 0.043) and large perivascular space (P = 0.008). In conclusions, survivors of intracerebral hemorrhage with aldosteronism showed a tendency towards more severe hypertensive arteriopathy than the essential hypertension counterparts independently of blood pressure; aldosteronism may contribute to dilated perivascular space around the deep perforating arteries. Aldosteronism is associated with more severe cerebral small vessel disease in hypertensive intracerebral hemorrhage.
MeSH term(s)	Male ; Humans ; Intracranial Hemorrhage, Hypertensive/diagnostic imaging ; Intracranial Hemorrhage, Hypertensive/etiology ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/diagnostic imaging ; Hypertension/complications ; Essential Hypertension ; Hyperaldosteronism/complications ; Cerebral Small Vessel Diseases/complications ; Cerebral Small Vessel Diseases/diagnostic imaging ; Magnetic Resonance Imaging
Language	English
Publishing date	2023-11-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1175297-x
ISSN	1348-4214 ; 0916-9636
ISSN (online)	1348-4214
ISSN	0916-9636
DOI	10.1038/s41440-023-01458-w
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Zs.A 3898: Show issues

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Article: Role of H2S Donors in Cancer Biology.

Lee, Zheng-Wei / Deng, Lih-Wen

Handbook of experimental pharmacology

2015 Volume 230, Page(s) 243–265

Abstract: Hydrogen sulfide (H2S) donors including organosulfur compounds (OSC), inorganic sulfide salts, and synthetic compounds are useful tools in studies to elucidate the effects of H2S in cancer biology. Studies using such donors have shown the ability of H2S ... ...

Abstract	Hydrogen sulfide (H2S) donors including organosulfur compounds (OSC), inorganic sulfide salts, and synthetic compounds are useful tools in studies to elucidate the effects of H2S in cancer biology. Studies using such donors have shown the ability of H2S to suppress tumor growth both in vitro and in vivo, with some of them suggesting the selectivity of its cytotoxic effects to cancer cells. In addition to promoting cancer cell death, H2S donors were also found to inhibit cancer angiogenesis and metastasis. The underlying mechanisms for the anticancer activities of H2S involve (1) cell signaling pathways, such as MAPK and STAT; (2) cell cycle regulation; (3) microRNAs regulation; and (4) cancer metabolism and pH regulation. Altogether, compiling evidences have demonstrated the great potential of using H2S donors as anticancer agents. Nevertheless, the application and development of H2S for therapy are still facing challenges as identification of molecular targets of H2S awaits further investigation.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Cell Proliferation ; Cell Survival ; Humans ; Hydrogen Sulfide/metabolism ; Hydrogen Sulfide/pharmacology ; Neoplasms/blood supply ; Neoplasms/pathology ; Neovascularization, Pathologic/etiology
Chemical Substances	Antineoplastic Agents ; Hydrogen Sulfide (YY9FVM7NSN)
Language	English
Publishing date	2015
Publishing country	Germany
Document type	Journal Article ; Review
ISSN	0171-2004
ISSN	0171-2004
DOI	10.1007/978-3-319-18144-8_13
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Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
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Article: Cardiovascular and metabolic characters of

Chang, Yi-Yao / Lee, Bo-Ching / Chen, Zheng-Wei / Tsai, Cheng-Hsuan / Chang, Chin-Chen / Liao, Che-Wei / Pan, Chien-Ting / Peng, Kang-Yung / Chou, Chia-Hung / Lu, Ching-Chu / Wu, Vin-Cent / Hung, Chi-Sheng / Lin, Yen-Hung

Frontiers in endocrinology

2023 Volume 14, Page(s) 1061704

Abstract: Background: Primary aldosteronism (PA) is the leading cause of curable endocrine hypertension, which is associated with a higher risk of cardiovascular and metabolic insults compared to essential hypertension. Aldosterone-producing adenoma (APA) is a ... ...

Abstract	Background: Primary aldosteronism (PA) is the leading cause of curable endocrine hypertension, which is associated with a higher risk of cardiovascular and metabolic insults compared to essential hypertension. Aldosterone-producing adenoma (APA) is a major cause of PA, which can be treated with adrenalectomy. Somatic mutations are the main pathogenesis of aldosterone overproduction in APA, of which Evidence acquisition: PubMed literature research using keywords combination, including "aldosterone-producing adenoma," "somatic mutations," " Results: APA patients with Conclusion: KCNJ5
MeSH term(s)	Humans ; Female ; Aldosterone/metabolism ; Hyperaldosteronism/genetics ; Hyperaldosteronism/surgery ; Hyperaldosteronism/complications ; Hydrocortisone ; Metabolic Syndrome/genetics ; Metabolic Syndrome/complications ; Adrenocortical Adenoma/complications ; Adrenocortical Adenoma/genetics ; Adrenocortical Adenoma/surgery ; Mutation ; Hypertension/complications ; Adenoma/pathology ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/genetics
Chemical Substances	Aldosterone (4964P6T9RB) ; Hydrocortisone (WI4X0X7BPJ) ; KCNJ5 protein, human ; G Protein-Coupled Inwardly-Rectifying Potassium Channels
Language	English
Publishing date	2023-03-06
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1061704
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