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  1. Article: An interview with Aaron Ciechanover.

    Ciechanover, Aaron

    Trends in biochemical sciences

    2013  Volume 38, Issue 5, Page(s) 219–221

    MeSH term(s) History, 20th Century ; History, 21st Century ; Humans ; Israel ; Proteolysis ; Ubiquitin/history ; Ubiquitin/metabolism
    Chemical Substances Ubiquitin
    Language English
    Publishing date 2013-05
    Publishing country England
    Document type Autobiography ; Biography ; Historical Article ; Interview ; Portraits
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2013.02.007
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  2. Article ; Online: Interview with Aaron Ciechanover.

    Ciechanover, Aaron

    Biochemical and biophysical research communications

    2009  Volume 387, Issue 1, Page(s) 11–12

    MeSH term(s) Biochemistry ; Biophysics ; Editorial Policies ; Periodicals as Topic
    Language English
    Publishing date 2009-09-11
    Publishing country United States
    Document type Interview ; Portraits
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2009.06.093
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  3. Article ; Online: A conversation with Aaron Ciechanover. Interview by Ushma S. Neill.

    Ciechanover, Aaron

    The Journal of clinical investigation

    2013  Volume 123, Issue 10, Page(s) 4093–4094

    MeSH term(s) Biochemistry/history ; History, 20th Century ; History, 21st Century ; Israel ; Massachusetts ; Nobel Prize ; Proteolysis
    Language English
    Publishing date 2013-10-01
    Publishing country United States
    Document type Autobiography ; Biography ; Historical Article ; Interview ; Portrait
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI71859
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  4. Article ; Online: The 2008 Lindau Nobel Laureate Meeting: Aaron Ciechanover, Chemistry 2004.

    Ciechanover, Aaron

    Journal of visualized experiments : JoVE

    2009  , Issue 29

    Abstract: Aaron Ciechanover was born in Haifa, Israel in October 1947. He shared the Nobel Prize in Chemistry ... and life alltogether. The life and work of Aaron Ciechanover are deeply rooted and influenced ... When Ciechanover began his work on proteolysis, the field was outside the realm of scientific mainstream ...

    Abstract Aaron Ciechanover was born in Haifa, Israel in October 1947. He shared the Nobel Prize in Chemistry in 2004 with Avram Hershko and Irwin Rose for their discovery of ubiquitin-mediated protein degradation. When Ciechanover began his work on proteolysis, the field was outside the realm of scientific mainstream as many thought that the fundamental secrets relating to sequence specificity were relevant to the synthetic side, or code side. The notion that specific sequences could selectively guide a destructive process did not naturally occur to scientists including Ciechanover himself. The emergence of controversial evidence demonstrating a requirement for metabollic energy in intracellular protein degradation, refuted the idea that cellular proteolysis was an entirely exergonic process occuring in the lysosme and prompted Ciechanover, Hershko, and Rose to "launch an attack" on the system, in order to uncover true pathway. Later findings of Ciechanover and subsequent groups showed that not only was the process energy-dependent, but that 8% of the human genome is remarkabley one large ubiquitin system. Following the recapitulation and reflection of his work, Ciechanover shares insights into his principal and philosophical approach to science and life alltogether. The life and work of Aaron Ciechanover are deeply rooted and influenced by Judaism and Israel and it is therefore that with only brief intermission, Ciechanover spent his scientific career in Israel as he is--through his presence and work--able to contribute and shape presence and future of the State of Israel.
    MeSH term(s) Humans ; Israel ; Judaism ; Nobel Prize ; Peptide Hydrolases/genetics ; Peptide Hydrolases/metabolism ; Ubiquitin/genetics ; Ubiquitin/metabolism
    Chemical Substances Ubiquitin ; Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2009-07-01
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/1559
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  5. Article: Early work on the ubiquitin proteasome system, an interview with Aaron Ciechanover. Interview by CDD.

    Ciechanover, Aaron

    Cell death and differentiation

    2005  Volume 12, Issue 9, Page(s) 1167–1177

    MeSH term(s) Animals ; Biochemistry/history ; Cysteine Endopeptidases/physiology ; History, 20th Century ; Humans ; Israel ; Nobel Prize ; Proteins/chemistry ; Proteins/history ; Ubiquitin/physiology ; Ubiquitins/chemistry ; Ubiquitins/history ; United States
    Chemical Substances Proteins ; Ubiquitin ; Ubiquitins ; Cysteine Endopeptidases (EC 3.4.22.-)
    Language English
    Publishing date 2005-09
    Publishing country England
    Document type Historical Article ; Interview ; Portraits
    ZDB-ID 1225672-9
    ISSN 1350-9047
    ISSN 1350-9047
    DOI 10.1038/sj.cdd.4401691
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  6. Book: Can precision medicine be personal; Can personalized medicine be precise?

    Ciechanover, Aaron / Brusa, Margherita / Barilan, Y. Michael

    2022  

    Author's details Yechiel Michael Barilan was born and educated in Israel. He is an expert in Internal Medicine and js most recently a senior physician in the Covid-19 Dept. and Emergency Dept. Tel Aviv Medical Centre. He is a full professor in the Tel Aviv University School of Medicine, specializing in ethics and social history of medicine. He is also a member of national and international ethics committees and is an author of over a hundred peer reviewed academic publications. Margherita Brusa earned a PhD in bioethics from the University Complutense of Madrid, and a second PhD in paediatric healthcare planning from the University of Padua. She has served in ethics committees in Spain, USA, and Italy, and led the creation of the first ethics committee in the Palestinian Authority. The focus of her research is bioethics and children. Aaron Ciechanover is an Israeli physician and scientist working currently at the Faculty of Medicine of the Technion-Israel Institute of Technology in Haifa, Israel. He
    Size 352 p.
    Publisher Oxford University Press
    Document type Book
    Note PDA Manuell_14
    Format 137 x 214 x 20
    ISBN 9780198863465 ; 0198863462
    Database PDA

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  7. Book ; Online ; E-Book: Can precision medicine be personal, can personalized medicine be precise?

    Barilan, Yechiel Michael / Brusa, Margherita / Ciechanover, Aaron J.

    2022  

    Abstract: The book provides a multidisciplinary and interdisciplinary discussion of the ethos and ethics of precision/personal medicine, involving scientists who have shaped the field, in dialogue with ethicists, social scientists and philosophers of science. ...

    Author's details edited by Yechiel Michael Barilan, Margherita Brusa, Aaron Ciechanover
    Abstract The book provides a multidisciplinary and interdisciplinary discussion of the ethos and ethics of precision/personal medicine, involving scientists who have shaped the field, in dialogue with ethicists, social scientists and philosophers of science.
    Keywords Medical ethics
    Subject code 174.2
    Language English
    Size 1 online resource (353 pages)
    Publisher Oxford University Press
    Publishing place Oxford, England ; New York, New York
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-19-189591-1 ; 0-19-260867-3 ; 0-19-260868-1 ; 9780198863465 ; 978-0-19-189591-3 ; 978-0-19-260867-3 ; 978-0-19-260868-0 ; 0198863462
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Tryptophanyl-Transfer RNA Synthetase Is Involved in a Negative Feedback Loop Mitigating Interferon-γ-Induced Gene Expression.

    Lazar, Ikrame / Livneh, Ido / Ciechanover, Aaron / Fabre, Bertrand

    Cells

    2024  Volume 13, Issue 2

    Abstract: Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes responsible for linking a transfer RNA (tRNA) with its cognate amino acid present in all the kingdoms of life. Besides their aminoacyl-tRNA synthetase activity, it was described that many of these ... ...

    Abstract Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes responsible for linking a transfer RNA (tRNA) with its cognate amino acid present in all the kingdoms of life. Besides their aminoacyl-tRNA synthetase activity, it was described that many of these enzymes can carry out non-canonical functions. They were shown to be involved in important biological processes such as metabolism, immunity, development, angiogenesis and tumorigenesis. In the present work, we provide evidence that tryptophanyl-tRNA synthetase might be involved in a negative feedback loop mitigating the expression of certain interferon-γ-induced genes. Mining the available TCGA and Gtex data, we found that
    MeSH term(s) Humans ; Tryptophan-tRNA Ligase/genetics ; Interferon-gamma/pharmacology ; Feedback ; Melanoma/genetics ; Skin Neoplasms ; Amino Acyl-tRNA Synthetases ; RNA, Transfer ; Gene Expression ; Apolipoprotein L1
    Chemical Substances Tryptophan-tRNA Ligase (EC 6.1.1.2) ; Interferon-gamma (82115-62-6) ; Amino Acyl-tRNA Synthetases (EC 6.1.1.-) ; RNA, Transfer (9014-25-9) ; APOL1 protein, human ; Apolipoprotein L1
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13020180
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  9. Book: The ubiquitin proteasome proteolytic system

    Ciechanover, Aaron J.

    from classical biochemistry to human diseases

    (Recent advances in human biology ; 9)

    2002  

    Title variant The ubiquitin-proteasome proteolytic system
    Author's details ed. Aaron J. Ciechanover
    Series title Recent advances in human biology ; 9
    Collection
    Keywords Ubiquitin / metabolism ; Cysteine Endopeptidases ; Multienzyme Complexes ; Ubiquitin ; Proteolytic enzymes
    Subject code 572.6
    Language English
    Size XX, 220 S. : Ill.
    Publisher World Scientific
    Publishing place River Edge, NJ u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographic references and index
    HBZ-ID HT014732827
    ISBN 9812381007 ; 9789812381002
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2006 A 4199 order for loan Magazin

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  10. Article ; Online: Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting.

    Ciechanover, Aaron

    Best practice & research. Clinical haematology

    2017  Volume 30, Issue 4, Page(s) 341–355

    Abstract: Between the 1950s and 1980s, scientists were focusing mostly on how the genetic code is transcribed to RNA and translated to proteins, but how proteins are degraded has remained a neglected research area. With the discovery of the lysosome by Christian ... ...

    Abstract Between the 1950s and 1980s, scientists were focusing mostly on how the genetic code is transcribed to RNA and translated to proteins, but how proteins are degraded has remained a neglected research area. With the discovery of the lysosome by Christian de Duve it was assumed that cellular proteins are degraded within this organelle. Yet, several independent lines of experimental evidence strongly suggested that intracellular proteolysis is largely non-lysosomal, but the mechanisms involved remained obscure. The discovery of the ubiquitin-proteasome system resolved the enigma. We now recognize that degradation of intracellular proteins is involved in regulation of a broad array of cellular processes, such as cell cycle and division, regulation of transcription factors, and assurance of the cellular quality control. Not surprisingly, aberrations in the system have been implicated in the pathogenesis of human disease, such as malignancies and neurodegenerative disorders, which led subsequently to an increasing effort to develop mechanism-based drugs.
    MeSH term(s) Animals ; Cell Cycle ; Humans ; Lysosomes/metabolism ; Lysosomes/pathology ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplasms/therapy ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Neurodegenerative Diseases/therapy ; Proteasome Endopeptidase Complex/metabolism ; Proteolysis ; Ubiquitin/metabolism
    Chemical Substances Ubiquitin ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2017-09-22
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2048027-1
    ISSN 1532-1924 ; 1521-6926
    ISSN (online) 1532-1924
    ISSN 1521-6926
    DOI 10.1016/j.beha.2017.09.001
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