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  1. Article: Editorial: Growth and Tissue Regeneration with focus on Proteoglycans.

    Pedersen, Mona Elisabeth / Rønning, Sissel Beate / Kolset, Svein Olav

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1139044

    Language English
    Publishing date 2023-03-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1139044
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  2. Article ; Online: Editorial

    Mona Elisabeth Pedersen / Sissel Beate Rønning / Svein Olav Kolset

    Frontiers in Cell and Developmental Biology, Vol

    Growth and Tissue Regeneration with focus on Proteoglycans

    2023  Volume 11

    Keywords proteoglycans ; tissue regeneration ; remodeling ; signaling ; shedding ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
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  3. Article ; Online: Systemic immune profile in Prader-Willi syndrome: elevated matrix metalloproteinase and myeloperoxidase and reduced macrophage inhibitory factor.

    Hope, Sigrun / Nærland, Terje / Olav Kolset, Svein / Ueland, Thor / Andreassen, Ole A / Nordstrøm, Marianne

    Orphanet journal of rare diseases

    2023  Volume 18, Issue 1, Page(s) 185

    Abstract: Background: Prader-Willi syndrome (PWS) is a rare genetic neurodevelopmental syndrome with highly increased risk of obesity and cardiovascular disease (CVD). Recent evidence suggests that inflammation is implicated in the pathogenesis. Here we ... ...

    Abstract Background: Prader-Willi syndrome (PWS) is a rare genetic neurodevelopmental syndrome with highly increased risk of obesity and cardiovascular disease (CVD). Recent evidence suggests that inflammation is implicated in the pathogenesis. Here we investigated CVD related immune markers to shed light on pathogenetic mechanisms.
    Methods: We performed a cross-sectional study with 22 participants with PWS and 22 healthy controls (HC), and compared levels of 21 inflammatory markers that reflect activity in different aspects of CVD related immune pathways and analyzed their association with clinical CVD risk factors.
    Results: Serum levels of matrix metalloproteinase 9 (MMP-9) was (median (range)) 121 (182) ng/ml in PWS versus 44 (51) ng/ml in HC, p = 1 × 10
    Conclusion: PWS had elevated levels of MMP-9 and MPO and of reduced levels of MIF, which were not secondary to comorbid CVD risk factors. This immune profile suggests enhanced monocyte/neutrophil activation, impaired macrophage inhibition with enhanced extracellular matrix remodeling. These findings warrant further studies targeting these immune pathways in PWS.
    MeSH term(s) Humans ; Peroxidase ; Prader-Willi Syndrome ; Matrix Metalloproteinase 9 ; Cross-Sectional Studies ; Macrophages ; Cardiovascular Diseases
    Chemical Substances Peroxidase (EC 1.11.1.7) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2225857-7
    ISSN 1750-1172 ; 1750-1172
    ISSN (online) 1750-1172
    ISSN 1750-1172
    DOI 10.1186/s13023-023-02730-5
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  4. Article ; Online: Medical disorders: Stop marginalizing rare syndromes.

    Kolset, Svein Olav

    Nature

    2016  Volume 536, Issue 7617, Page(s) 396

    MeSH term(s) Adult ; Biomedical Research/trends ; CHARGE Syndrome ; Female ; Humans ; Male ; Precision Medicine ; Rare Diseases/diagnosis ; Rare Diseases/genetics ; Rare Diseases/therapy ; Sex Characteristics ; Syndrome
    Language English
    Publishing date 2016--25
    Publishing country England
    Document type Letter
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/536396c
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  5. Article ; Online: Systemic immune profile in Prader-Willi syndrome

    Sigrun Hope / Terje Nærland / Svein Olav Kolset / Thor Ueland / Ole A. Andreassen / Marianne Nordstrøm

    Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-

    elevated matrix metalloproteinase and myeloperoxidase and reduced macrophage inhibitory factor

    2023  Volume 9

    Abstract: Abstract Background Prader-Willi syndrome (PWS) is a rare genetic neurodevelopmental syndrome with highly increased risk of obesity and cardiovascular disease (CVD). Recent evidence suggests that inflammation is implicated in the pathogenesis. Here we ... ...

    Abstract Abstract Background Prader-Willi syndrome (PWS) is a rare genetic neurodevelopmental syndrome with highly increased risk of obesity and cardiovascular disease (CVD). Recent evidence suggests that inflammation is implicated in the pathogenesis. Here we investigated CVD related immune markers to shed light on pathogenetic mechanisms. Methods We performed a cross-sectional study with 22 participants with PWS and 22 healthy controls (HC), and compared levels of 21 inflammatory markers that reflect activity in different aspects of CVD related immune pathways and analyzed their association with clinical CVD risk factors. Results Serum levels of matrix metalloproteinase 9 (MMP-9) was (median (range)) 121 (182) ng/ml in PWS versus 44 (51) ng/ml in HC, p = 1 × 10-9), myeloperoxidase (MPO) was 183 (696) ng/ml versus 65 (180) ng/ml, p = 1 × 10-5) and macrophage inhibitory factor (MIF) was 46 (150) ng/ml versus 121 (163) ng/ml (p = 1 × 10-3), after adjusting for age and sex. Also other markers tended to be elevated (OPG, sIL2RA, CHI3L1, VEGF) but not significantly after Bonferroni correction (p > 0.002). As expected PWS had higher body mass index, waist circumference, leptin, C-reactive protein, glycosylated hemoglobin (HbA1c), VAI and cholesterol, but MMP-9, MPO and MIF remained significantly different in PWS after adjustment for these clinical CVD risk factors. Conclusion PWS had elevated levels of MMP-9 and MPO and of reduced levels of MIF, which were not secondary to comorbid CVD risk factors. This immune profile suggests enhanced monocyte/neutrophil activation, impaired macrophage inhibition with enhanced extracellular matrix remodeling. These findings warrant further studies targeting these immune pathways in PWS.
    Keywords Prader-Willi Syndrome ; 15q11-q13 ; Obesity ; Inflammation ; Cardiovascular ; Extracellular matrix ; Medicine ; R
    Subject code 616 ; 610
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
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  6. Article: Characterization of wooden breast myopathy: a focus on syndecans and ECM remodeling.

    Pejšková, Lucie / Rønning, Sissel Beate / Kent, Matthew Peter / Solberg, Nina Therese / Høst, Vibeke / Thu-Hien, To / Wold, Jens Petter / Lunde, Marianne / Mosleth, Ellen / Pisconti, Addolorata / Kolset, Svein Olav / Carlson, Cathrine Rein / Pedersen, Mona Elisabeth

    Frontiers in physiology

    2023  Volume 14, Page(s) 1301804

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-12-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1301804
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  7. Article ; Online: Nutritional challenges in children and adolescents with Down syndrome.

    Nordstrøm, Marianne / Retterstøl, Kjetil / Hope, Sigrun / Kolset, Svein Olav

    The Lancet. Child & adolescent health

    2020  Volume 4, Issue 6, Page(s) 455–464

    Abstract: Several features and comorbidities in Down syndrome have nutritional implications and consequences. In infancy and early childhood, children with Down syndrome have a high risk of oral motor difficulties and pharyngeal dysphagia with aspiration, which ... ...

    Abstract Several features and comorbidities in Down syndrome have nutritional implications and consequences. In infancy and early childhood, children with Down syndrome have a high risk of oral motor difficulties and pharyngeal dysphagia with aspiration, which both require systematic attention. To improve nutritional status in children who are underweight and who have clinical signs of feeding problems, further evaluation of underlying causes is required. Clinical interventions should promote swallowing safety and development of feeding abilities. Even from 4-5 years of age, overweight in children with Down syndrome can be a concern. To prevent disease later in life, an urgent need exists for more research on nutritional aspects in the prevention and treatment of obesity in adolescents with Down syndrome. This Review did not find any data to support the use of dietary supplementation, except when deficiency is documented. Additionally, the literature reported the need for more research that uses larger study samples and control groups and that addresses important nutritional challenges in children and adolescents with Down syndrome.
    MeSH term(s) Adolescent ; Age Factors ; Child ; Child, Preschool ; Down Syndrome/diagnosis ; Down Syndrome/epidemiology ; Female ; Follow-Up Studies ; Humans ; Incidence ; Infant ; Male ; Nutritional Requirements ; Nutritional Status ; Obesity/epidemiology ; Overweight/epidemiology ; Risk Assessment ; Thinness/epidemiology
    Language English
    Publishing date 2020-05-22
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2352-4650
    ISSN (online) 2352-4650
    DOI 10.1016/S2352-4642(19)30400-6
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  8. Article ; Online: Production of food-grade microcarriers based on by-products from the food industry to facilitate the expansion of bovine skeletal muscle satellite cells for cultured meat production.

    Andreassen, R Christel / Rønning, Sissel Beate / Solberg, Nina Therese / Grønlien, Krister Gjestvang / Kristoffersen, Kenneth Aase / Høst, Vibeke / Kolset, Svein Olav / Pedersen, Mona Elisabeth

    Biomaterials

    2022  Volume 286, Page(s) 121602

    Abstract: A major challenge for successful cultured meat production is the requirement for large quantities of skeletal muscle satellite cells (MuSCs). Commercial microcarriers (MCs), such as Cytodex®1, enable extensive cell expansion by offering a large surface- ... ...

    Abstract A major challenge for successful cultured meat production is the requirement for large quantities of skeletal muscle satellite cells (MuSCs). Commercial microcarriers (MCs), such as Cytodex®1, enable extensive cell expansion by offering a large surface-to-volume ratio. However, the cell-dissociation step post cell expansion makes the cell expansion less efficient. A solution is using food-grade MCs made of sustainable raw materials that do not require a dissociation step and can be included in the final meat product. This study aimed to produce food-grade MCs from food industry by-products (i.e., turkey collagen and eggshell membrane) and testing their ability to expand bovine MuSCs in spinner flask systems for eight days. The MCs' physical properties were characterized, followed by analyzing the cell adhesion, growth, and metabolic activity. All MCs had an interconnected porous structure. Hybrid MCs composed of eggshell membrane and collagen increased the mechanical hardness and stabilized the buoyancy compared to pure collagen MCs. The MuSCs successively attached and covered the entire surface of all MCs while expressing high cell proliferation, metabolic activity, and low cell cytotoxicity. Cytodex®1 MCs were included in the study. Relative gene expression of skeletal muscle markers showed reduced PAX7 and increased MYF5, which together with augmented proliferation marker MKI67 indicated activated and proliferating MuSCs on all MCs. Furthermore, the expression pattern of cell adhesion receptors (ITGb5 and SDC4) and focal adhesion marker VCL varied between the distinct MCs, indicating different specific cell receptor interactions with the various biomaterials. Altogether, our results demonstrate that these biomaterials are promising prospects to produce custom-fabricated food-grade MCs intended to expand MuSCs.
    MeSH term(s) Animals ; Biocompatible Materials/chemistry ; Cattle ; Cell Differentiation/physiology ; Cells, Cultured ; Food Industry ; Meat ; Muscle, Skeletal ; Porosity ; Satellite Cells, Skeletal Muscle/metabolism
    Chemical Substances Biocompatible Materials
    Language English
    Publishing date 2022-05-27
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603079-8
    ISSN 1878-5905 ; 0142-9612
    ISSN (online) 1878-5905
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2022.121602
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  9. Article ; Online: The right to a health-promoting diet for people with intellectual disabilities.

    Hope, Sigrun / Nordstrøm, Marianne / Retterstøl, Kjetil / Iversen, Per Ole / Kolset, Svein Olav

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2018  Volume 138, Issue 2

    Title translation Retten til et helsefremmende kosthold for personer med utviklingshemning.
    MeSH term(s) Health Promotion ; Healthy Diet ; Humans ; Intellectual Disability ; Nutrition Policy
    Language Norwegian
    Publishing date 2018-01-22
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    DOI 10.4045/tidsskr.17.0985
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  10. Article ; Online: Inflammatory markers calprotectin, NETs, syndecan-1 and neopterin in COVID-19 convalescent blood donors.

    Hetland, Geir / Fagerhol, Magne Kristoffer / Dimova-Svetoslavova, Veselka Petrova / Mirlashari, Mohammad Reza / Nguyen, Nhan Trung / Lind, Andreas / Kolset, Svein Olav / Søraas, Arne Vasli Lund / Nissen-Meyer, Lise Sofie Haug

    Scandinavian journal of clinical and laboratory investigation

    2022  Volume 82, Issue 6, Page(s) 481–485

    Abstract: Persisting inflammation has been discovered in lungs and other parenchymatous organs of some COVID-19 convalescents. Calprotectin, neutrophil extracellular traps (NETs), syndecan-1 and neopterin are general key inflammatory markers, and systemically ... ...

    Abstract Persisting inflammation has been discovered in lungs and other parenchymatous organs of some COVID-19 convalescents. Calprotectin, neutrophil extracellular traps (NETs), syndecan-1 and neopterin are general key inflammatory markers, and systemically enhanced levels of them may remain after the COVID-19 infection. These inflammatory markers were therefore measured in serum samples of 129 COVID-19 convalescent and 27 healthy blood donors or employees at Oslo Blood bank, Norway. Also antibodies against SARS-CoV-2 nucleocapsid antigen were measured, and timing of sampling and severity of infection noted. Whereas neopterin and NETs values remained low and those for syndecan-1 were not raised to statistically significant level, concentrations for calprotectin, as measured by a novel mixed monoclonal assay, were significantly increased in the convalescents. Antibodies against SARS-CoV-2 nucleocapsid antigen were elevated, but did not correlate with levels of inflammatory markers. Difference between the groups in only one biomarker makes evaluation of ongoing or residual inflammation in the convalescents difficult. If there is a low-grade inflammation, it would in that case involve neutrophils.
    MeSH term(s) Biomarkers ; Blood Donors ; COVID-19/diagnosis ; Extracellular Traps ; Humans ; Inflammation/diagnosis ; Leukocyte L1 Antigen Complex ; Neopterin ; SARS-CoV-2 ; Syndecan-1
    Chemical Substances Biomarkers ; Leukocyte L1 Antigen Complex ; Syndecan-1 ; Neopterin (670-65-5)
    Language English
    Publishing date 2022-09-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 3150-1
    ISSN 1502-7686 ; 0036-5513
    ISSN (online) 1502-7686
    ISSN 0036-5513
    DOI 10.1080/00365513.2022.2123387
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