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  1. Article ; Online: The SARS-CoV-2 main protease M

    Wenzel, Jan / Lampe, Josephine / Müller-Fielitz, Helge / Schuster, Raphael / Zille, Marietta / Müller, Kristin / Krohn, Markus / Körbelin, Jakob / Zhang, Linlin / Özorhan, Ümit / Neve, Vanessa / Wagner, Julian U G / Bojkova, Denisa / Shumliakivska, Mariana / Jiang, Yun / Fähnrich, Anke / Ott, Fabian / Sencio, Valentin / Robil, Cyril /
    Pfefferle, Susanne / Sauve, Florent / Coêlho, Caio Fernando Ferreira / Franz, Jonas / Spiecker, Frauke / Lembrich, Beate / Binder, Sonja / Feller, Nina / König, Peter / Busch, Hauke / Collin, Ludovic / Villaseñor, Roberto / Jöhren, Olaf / Altmeppen, Hermann C / Pasparakis, Manolis / Dimmeler, Stefanie / Cinatl, Jindrich / Püschel, Klaus / Zelic, Matija / Ofengeim, Dimitry / Stadelmann, Christine / Trottein, François / Nogueiras, Ruben / Hilgenfeld, Rolf / Glatzel, Markus / Prevot, Vincent / Schwaninger, Markus

    Nature neuroscience

    2021  Volume 24, Issue 11, Page(s) 1522–1533

    Abstract: ... We obtained evidence that brain endothelial cells are infected and that the main protease of SARS-CoV-2 (M ...

    Abstract Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and cause neurological symptoms. Here we describe structural changes in cerebral small vessels of patients with COVID-19 and elucidate potential mechanisms underlying the vascular pathology. In brains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals and animal models, we found an increased number of empty basement membrane tubes, so-called string vessels representing remnants of lost capillaries. We obtained evidence that brain endothelial cells are infected and that the main protease of SARS-CoV-2 (M
    MeSH term(s) Animals ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/pathology ; Brain/metabolism ; Brain/pathology ; Chlorocebus aethiops ; Coronavirus 3C Proteases/genetics ; Coronavirus 3C Proteases/metabolism ; Cricetinae ; Female ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Mesocricetus ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Microvessels/metabolism ; Microvessels/pathology ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; Vero Cells
    Chemical Substances Intracellular Signaling Peptides and Proteins ; NEMO protein, mouse ; Coronavirus 3C Proteases (EC 3.4.22.28)
    Language English
    Publishing date 2021-10-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-021-00926-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4891: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 67: Show issues

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  2. Book ; Online ; Conference proceedings: The Impact of the Roman Empire on Landscapes : Proceedings of the Fourteenth Workshop of the International Network Impact of Empire (Mainz, June 12-15, 2019)

    Horster, Marietta / Hächler, Nikolas

    2022  

    Keywords Classical history / classical civilisation ; Humanities
    Size 1 electronic resource (424 pages)
    Publisher Brill
    Document type Book ; Online ; Conference proceedings
    Note English ; Open Access
    HBZ-ID HT021289858
    ISBN 9789004411432 ; 9004411437
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Different dynamics of NLRP3 inflammasome-mediated IL‑1β production in GM-CSF- and M-CSF-differentiated human macrophages.

    Budai, Marietta Margit / Tőzsér, József / Benkő, Szilvia

    Journal of leukocyte biology

    2017  Volume 101, Issue 6, Page(s) 1335–1347

    Abstract: ... activation in LPS-stimulated, human, monocyte-derived GM- or M-macrophages, differentiated in the presence ... of GM-CSF or M-CSF, respectively. Our results show that IL-1β production by LPS-stimulated M-macrophages ... treatment enhances LPS-primed IL-1β secretion by GM-macrophages, but not by M-macrophages. These results ...

    Abstract IL-1β is a "master" cytokine regulating a wide variety of physiologic and immunologic processes. The most frequently studied models for NLRP3 inflammasome-mediated IL-1β production are the macrophages; however, depending on their microenvironment, they can develop into functionally different cells. Several protocols have been developed to model the diversity of these cells in vitro. Here, we report for the first time, to our knowledge, a comparative study about the dynamics and molecular mechanisms of NLRP3 inflammasome priming and activation in LPS-stimulated, human, monocyte-derived GM- or M-macrophages, differentiated in the presence of GM-CSF or M-CSF, respectively. Our results show that IL-1β production by LPS-stimulated M-macrophages is a rapid and short event that requires ATP supplementation and is attenuated, in part, by the presence of IL-10, which reduces Akt signaling. However, IL-1β production by GM-macrophages develops gradually, and these cells produce IL-1β, even in the absence of ATP supplementation, because of the constitutively active caspase-1 enzyme. We show that the membrane-bound ectonucleotidases have an important regulatory role on the IL-1β secretion in GM-macrophages. Furthermore, we provide evidence that adenosine treatment enhances LPS-primed IL-1β secretion by GM-macrophages, but not by M-macrophages. These results show that, because of the different activation status and expression levels of the NLRP3 inflammasome components, as well as the signaling activity of the pathways, the two subtypes of macrophages respond very differently to the same stimuli. For this reason, the molecular composition of the microenvironment that shapes macrophage development should be considered when research or therapeutic methods are planned to control IL-1β production.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Cell Differentiation/immunology ; Cells, Cultured ; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Humans ; Inflammasomes/immunology ; Inflammasomes/metabolism ; Interleukin-1beta/metabolism ; Lipopolysaccharides/pharmacology ; Macrophage Colony-Stimulating Factor/metabolism ; Macrophages/cytology ; Macrophages/immunology ; Macrophages/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Signal Transduction
    Chemical Substances Inflammasomes ; Interleukin-1beta ; Lipopolysaccharides ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human ; Macrophage Colony-Stimulating Factor (81627-83-0) ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1) ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2017-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1189/jlb.3A0716-300RR
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 603: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Acute toxicity assessment of N,N-diethyl-m-toluamide (DEET) on the oxygen flux of the dinoflagellate Gymnodinium instriatum.

    Martinez, Eloy / Vélez, Sylvia M / Mayo, Marietta / Sastre, Miguel P

    Ecotoxicology (London, England)

    2011  Volume 25, Issue 1, Page(s) 248–252

    Abstract: Despite the ubiquitous occurrence of N,N-diethyl-m-toluamide (DEET) in aquatic systems, assessments ...

    Abstract Despite the ubiquitous occurrence of N,N-diethyl-m-toluamide (DEET) in aquatic systems, assessments evaluating the toxicity of DEET on phytoplankton species are summed to a single study on a unicellular green alga. In particular, the toxicological effects of DEET in dinoflagellates are unknown. In this study, we employed the mixotrophic dinoflagellate Gymnodinium instriatum as a study system to evaluate acute effects of DEET on the oxygen flux of laboratory cultures. This study reports an inhibitory reaction model of DEET described by the equation y = 4.99x(0.54), where y represents the percent inhibition of oxygen flux and x represents DEET concentration in mg L(−1) (r(2) = 0.98). Based on this model, the effective concentration of DEET needed to reduce O2 flux by 50% (EC50) for this species was found to be at 72.9 mg L(−1). The reported EC50 is more than five times lower than the EC50 reported previously for the unicellular green algae Chlorella protothecoides. This study raises the question of the potential toxicological effects of DEET in dinoflagellates, in particular those populations inhabiting systems characterized by low water circulation such as enclosed bays and lagoons.
    MeSH term(s) DEET/toxicity ; Dinoflagellida/drug effects ; Dinoflagellida/metabolism ; Dose-Response Relationship, Drug ; Insect Repellents/toxicity ; Oxygen/metabolism ; Sensitivity and Specificity ; Toxicity Tests, Acute/methods ; Water Pollutants, Chemical/toxicity
    Chemical Substances Insect Repellents ; Water Pollutants, Chemical ; DEET (134-62-3) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2011-09-16
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 34042-x
    ISSN 1573-3017 ; 0963-9292
    ISSN (online) 1573-3017
    ISSN 0963-9292
    DOI 10.1007/s10646-015-1564-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7663: Show issues

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  5. Book ; Online: Les ruines résonnent encore de leurs pas. La circulation dans les monuments grecs (VIIe s. - 31 a.C.)

    Dromain, Marietta / Dubernet, Audrey

    (PrimaLun@ ; 6)

    2021  

    Series title PrimaLun@ ; 6
    Keywords Archaeology ; History of architecture ; accessibility ; way ; traffic ; stroll ; location ; epigraphy ; staircase ; loyal ; attendance ; greek ; Greece ; honour ; honorary ; itinerary ; monumentalization ; pilgrim ; door ; portico ; sanctuary ; show ; spectator ; theatre ; visibility
    Language 0|f
    Size 1 electronic resource (152 pages)
    Publisher Ausonius Éditions
    Publishing place Pessac
    Document type Book ; Online
    Note French ; English ; Open Access
    HBZ-ID HT021611963
    ISBN 9782356133779 ; 2356133771
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Book ; Thesis: Zusammenhänge der motorischen Leistungsfähigkeit, Körperzusammensetzung und Lebensumstände bei drei- bis sechsjährigen Kindern aus Freiburg

    Lechner, Marla

    2022  

    Author's details von Marla Marietta Ria Lechner
    Language German
    Size 128 Blätter, Illustrationen, 30 cm
    Publishing place Freiburg im Breisgau
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Albert-Ludwigs-Universität Freiburg im Breisgau, 2022
    HBZ-ID HT030008267
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 718 order for loan Magazin

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  7. Book ; Online: Affective Images

    Kesting, Marietta

    Post-apartheid Documentary Perspectives

    (SUNY Press Open Access)

    2017  

    Series title SUNY Press Open Access
    Keywords Social Science ; Ethnic Studies ; African Studies
    Language 0|e
    Size 1 electronic resource (292 pages)
    Publisher State University of New York Press
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021620316
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Book ; Online ; Thesis: Evaluation der Verträglichkeit und Wirksamkeit der nadellos, intradermal applizierten Vakzine Porcilis M Hyo ID ONCE gegen Mycoplasma hyopneumoniae unter Feldbedingungen

    Beffort, Lisa Marietta / Ritzmann, Mathias

    2015  

    Author's details Lisa Marietta Beffort
    Language German
    Size Online-Ressource
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Ludwig-Maximilians-Univ., Diss.--München, 2015
    Database Special collection on veterinary medicine and general parasitology

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  9. Book ; Online ; Thesis: Evaluation der Verträglichkeit und Wirksamkeit der nadellos, intradermal applizierten Vakzine Porcilis M Hyo ID ONCE gegen Mycoplasma hyopneumoniae unter Feldbedingungen

    Beffort, Lisa Marietta / Ritzmann, Mathias

    2015  

    Author's details Lisa Marietta Beffort
    Language German
    Size Online-Ressource
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Ludwig-Maximilians-Univ., Diss.--München, 2015
    Database Former special subject collection: coastal and deep sea fishing

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  10. Book: Testfall Münsterlingen

    König, Mario / Meier, Marietta / Tornay, Magaly

    Klinische Versuche in der Psychiatrie, 1940-1980

    2020  

    Author's details Historikerin an der Universität Zürich, hat zur Geschichte psycho­aktiver Stoffe seit LSD promoviert und forscht seither zu Substanzen, klinischen Versuchen und zum Wandel ethischer Normen
    Keywords Antidepressiva ; Medikamentenversuche ; Psychopharmaka ; Schweiz ; Tranquilizer ; Psychiatrie
    Language German
    Size 336 p.
    Edition 2
    Publisher Chronos Verlag
    Document type Book
    Note PDA Manuell_8
    Format 164 x 246 x 25
    ISBN 9783034015455 ; 3034015453
    Database PDA

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