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  1. Article ; Online: Flowing Beyond Conventions: Rethinking Coronary Slow Flow in the Diagnosis of Microvascular Dysfunction.

    Korjian, Serge / Gibson, C Michael

    JACC. Cardiovascular interventions

    2024  Volume 17, Issue 7, Page(s) 930–932

    MeSH term(s) Humans ; Treatment Outcome ; Coronary Circulation ; Coronary Vessels/diagnostic imaging ; Microcirculation ; Fractional Flow Reserve, Myocardial ; Vascular Resistance ; Coronary Angiography
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2024.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6669: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Thrombin as target for prevention of recurrent events after acute coronary syndromes.

    Bahit, M Cecilia / Gibson, C Michael

    Thrombosis research

    2024  Volume 235, Page(s) 116–121

    Abstract: The mechanism underlying thrombus formation in acute coronary syndrome (ACS) involves both platelets and thrombin. While both pathways are targeted in acute care, platelet inhibition has been predominantly administered in the chronic phase, yet thrombin ... ...

    Abstract The mechanism underlying thrombus formation in acute coronary syndrome (ACS) involves both platelets and thrombin. While both pathways are targeted in acute care, platelet inhibition has been predominantly administered in the chronic phase, yet thrombin plays a key role in platelet activation and fibrin formation. Among ACS patients, there is also a persistent chronic increase in thrombin generation, which is associated with a higher rate of adverse events. In the setting of post-ACS care with rivaroxaban or vorapaxar, targeting thrombin has been associated with decreased thrombin generation and reduced cardiovascular events, but has been associated with increased bleeding risk. We explored the evidence supporting thrombin generation in the pathophysiology of recurrent events post-ACS and the role of thrombin as a viable therapeutic target. One specific target is factor XI inhibition, which is involved in thrombin generation, but may also allow for the preservation of normal hemostasis.
    MeSH term(s) Humans ; Acute Coronary Syndrome/drug therapy ; Acute Coronary Syndrome/complications ; Thrombin/physiology ; Platelet Aggregation Inhibitors/therapeutic use ; Rivaroxaban/pharmacology ; Rivaroxaban/therapeutic use ; Hemorrhage/drug therapy
    Chemical Substances Thrombin (EC 3.4.21.5) ; Platelet Aggregation Inhibitors ; Rivaroxaban (9NDF7JZ4M3)
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2024.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 863: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Book: Optimizing anti-platelet therapy for patients with at-risk acute coronary syndrome

    Gibson, Charles Michael

    the era of triple anti-platelet therapy

    (European heart journal : Supplements ; 12D)

    2010  

    Author's details ed. by C. Michael Gibson
    Series title European heart journal : Supplements ; 12D
    European heart journal
    European heart journal ; Supplements
    Collection European heart journal
    European heart journal ; Supplements
    Language English
    Size D35 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016554679
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1563 -Suppl.12D- not available for loan Zeitschriften-Lesesaal

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  4. Article ; Online: MINOCA: Myocardial infarction no obstructive coronary artery disease.

    Bakhshi, Hooman / Gibson, C Michael

    American heart journal plus : cardiology research and practice

    2023  Volume 33, Page(s) 100312

    Abstract: Myocardial infarction without obstructive coronary artery disease (MINOCA) is defined as myocardial infarction with mild or no obstructive coronary artery disease (CAD) on angiogram. MINOCA has a number of heterogeneous causes, including coronary ... ...

    Abstract Myocardial infarction without obstructive coronary artery disease (MINOCA) is defined as myocardial infarction with mild or no obstructive coronary artery disease (CAD) on angiogram. MINOCA has a number of heterogeneous causes, including coronary disruption, coronary vasospasm, coronary embolism, spontaneous coronary artery dissection (SCAD), and coronary microvascular dysfunction (CMD). Even though MINOCA might have a better prognosis than MI with obstructive CAD, it is not benign. A stepwise diagnostic approach is crucial to identifying the underlying cause of MINOCA or conditions mimicking it. A cause-specific treatment approach is the key to managing MINOCA.
    Language English
    Publishing date 2023-07-29
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2666-6022
    ISSN (online) 2666-6022
    DOI 10.1016/j.ahjo.2023.100312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: An Ailment with Which I Will Contend: A Narrative Review of 5000 Years of Esophagogastric Cancers and Their Treatments, with Special Emphasis on Recent Advances in Immunotherapeutics.

    Hilton, C Beau / Lander, Steven / Gibson, Michael K

    Cancers

    2024  Volume 16, Issue 3

    Abstract: Esophagogastric cancers are among the most common and deadly cancers worldwide. This review traces their chronology from 3000 BCE to the present. The first several thousand years were devoted to palliation, before advances in operative technique and ... ...

    Abstract Esophagogastric cancers are among the most common and deadly cancers worldwide. This review traces their chronology from 3000 BCE to the present. The first several thousand years were devoted to palliation, before advances in operative technique and technology led to the first curative surgery in 1913. Systemic therapies were introduced in 1910, and radiotherapy shortly thereafter. Operative technique improved massively over the 20th century, with operative mortality rates reducing from over 50% in 1933 to less than 5% by 1981. In addition to important roles in palliation, endoscopy became a key nonsurgical curative option for patients with limited-stage disease by the 1990s. The first nonrandomized studies on combination therapies (chemotherapy ± radiation ± surgery) were reported in the early 1980s, with survival benefit only for subsets of patients. Randomized trials over the next decades had similar overall results, with increasing nuance. Disparate conclusions led to regional variation in global practice. Starting with the first FDA approval in 2017, multiple immunotherapies now encompass more indications and earlier lines of therapy. As standards of care incorporate these effective yet expensive therapies, care must be given to disparities and methods for increasing access.
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16030618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A cross-sectional study of outcomes for patients undergoing mechanical thrombectomy for pulmonary embolism during 2018-2022: Insights from the PINC AI Healthcare Database.

    Gandhi, Ripal T / Gibson, C Michael / Jaber, Wissam A

    Health science reports

    2024  Volume 7, Issue 4, Page(s) e2031

    Abstract: Background and aims: Mechanical thrombectomy (MT) treatments for pulmonary embolism (PE) have yet to be compared directly. We aimed to determine if patient outcomes varied following treatment of PE with different MT devices.: Methods: All PE ... ...

    Abstract Background and aims: Mechanical thrombectomy (MT) treatments for pulmonary embolism (PE) have yet to be compared directly. We aimed to determine if patient outcomes varied following treatment of PE with different MT devices.
    Methods: All PE encounters with an index treatment of MT between January 2018 and March 2022 were analyzed for in-hospital mortality, discharge to home, and 30-day readmission outcomes in the PINC AI™ Healthcare Database. MT devices used in each encounter were extracted from hospital charge description free-text fields using keyword text and fuzzy matching. Unadjusted and adjusted logistic regression was used to model outcomes by device.
    Results: A total of 5893 encounters were identified using MT as the sole index PE treatment and 1812 using MT with another treatment. Of these, 41% had insufficient information to identify the devices used (unspecified MT), 33% used the FlowTriever System (large-bore volume-controlled aspiration MT), 23% the Indigo System (continuous aspiration MT), and 3% some other MT. Large-bore volume-controlled aspiration MT was used with other treatments 13% of the time compared with 23% and 39% for unspecified MT and continuous aspiration MT, respectively. Adjusted logistic regression modeling revealed the odds of in-hospital mortality were significantly higher for patients treated with unspecified MT ([OR] = 1.42, 95% confidence interval [CI]: [1.10-1.83],
    Conclusion: PE outcomes and treatment patterns differ significantly based on the type of MT utilized. Clinical studies directly comparing MT treatments are needed to further understand optimal treatment of PE.
    Language English
    Publishing date 2024-04-21
    Publishing country United States
    Document type Journal Article
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.2031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Conference proceedings: Antiplatelet treatment for ACS

    Gibson, Charles Michael

    weighing long-term outcomes vs. short-term risk ; [Live Symposium Entitled "Antiplatelet Therapy for ACS: Weighing Long-Term Outcomes Versus Short-Term Risk" on October 22, 2007]

    (Journal of interventional cardiology ; 21, Suppl. 1)

    2008  

    Event/congress Live Symposium Entitled Antiplatelet Therapy for ACS: Weighing Long Term Outcomes Versus Short Term Risk (2007)
    Author's details guest ed. C. Michael Gibson
    Series title Journal of interventional cardiology ; 21, Suppl. 1
    Collection
    Language English
    Size S24 S. : Ill., graph. Darst.
    Publisher Wiley
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT015784069
    Database Catalogue ZB MED Medicine, Health

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    Zs A 2719 -21,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  8. Article ; Online: Myocardial Infarction During SARS-CoV-2 Infection: Another Piece in the Long-COVID Puzzle.

    Nguyen, Thach / Zuin, Marco / Ngo, Khiem / Gibson, C Michael

    The American journal of cardiology

    2024  Volume 215, Page(s) 92–93

    MeSH term(s) Humans ; Post-Acute COVID-19 Syndrome ; COVID-19 ; SARS-CoV-2 ; Myocardial Infarction/epidemiology
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2024.01.013
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    Ui IV Zs.73: Show issues Location:
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  9. Article ; Online: Innovation in Event Adjudication-Human vs Machine.

    Mahaffey, Kenneth W / Gibson, C Michael / Lopes, Renato D

    JAMA cardiology

    2023  Volume 9, Issue 2, Page(s) 101–102

    Language English
    Publishing date 2023-11-11
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2023.4900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Digital technologies and the democratization of clinical research: Social media, wearables, and artificial intelligence.

    Korjian, Serge / Gibson, C Michael

    Contemporary clinical trials

    2022  Volume 117, Page(s) 106767

    Abstract: With unprecedented access to the internet and media devices, a cultural shift in healthcare practice and research is already underway. Social media has transformed the way we communicate and has found applications in healthcare research from data sharing ...

    Abstract With unprecedented access to the internet and media devices, a cultural shift in healthcare practice and research is already underway. Social media has transformed the way we communicate and has found applications in healthcare research from data sharing to study recruitment. Wearables and personal health monitoring platforms have become increasingly widespread in the past decade allowing for novel studies with remote clinical monitoring and data collection. Furthermore, artificial intelligence has evolved with the advent of machine learning to exponentially improve prediction algorithms and become a powerful tool for clinical decision making and research. These technologies offer unprecedented opportunities to advance clinical research, while empowering patients to be active participants. As these digital tools evolve, our understanding of their advantages and pitfalls will help us optimize their use while ensuring ethical practices and most importantly, patient safety.
    MeSH term(s) Artificial Intelligence ; Digital Technology ; Humans ; Machine Learning ; Social Media ; Wearable Electronic Devices
    Language English
    Publishing date 2022-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2182176-8
    ISSN 1559-2030 ; 1551-7144
    ISSN (online) 1559-2030
    ISSN 1551-7144
    DOI 10.1016/j.cct.2022.106767
    Database MEDical Literature Analysis and Retrieval System OnLINE

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