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  1. Article ; Online: Report of the Medical Image De-Identification (MIDI) Task Group - Best Practices and Recommendations.

    Clunie, David A / Flanders, Adam / Taylor, Adam / Erickson, Brad / Bialecki, Brian / Brundage, David / Gutman, David / Prior, Fred / Seibert, J Anthony / Perry, John / Gichoya, Judy Wawira / Kirby, Justin / Andriole, Katherine / Geneslaw, Luke / Moore, Steve / Fitzgerald, T J / Tellis, Wyatt / Xiao, Ying / Farahani, Keyvan /
    Luo, James / Rosenthal, Alex / Kandarpa, Kris / Rosen, Rebecca / Goetz, Kerry / Babcock, Debra / Xu, Ben / Hsiao, John

    ArXiv

    2023  

    Language English
    Publishing date 2023-04-01
    Publishing country United States
    Document type Preprint
    ISSN 2331-8422
    ISSN (online) 2331-8422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reversing the stereoselectivity of intramolecular [2+2] photocycloaddition utilizing cucurbit[8]uril as a molecular flask.

    Qiu, Xujun / Seibert, Jasmin / Fuhr, Olaf / Biedermann, Frank / Bräse, Stefan

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 24, Page(s) 3267–3270

    Abstract: Macrocyclic hosts, such as cucurbit[8]uril (CB8), can significantly influence the outcomes of chemical reactions involving encapsulated reactive guests. In this study, we demonstrate that CB8 completely reverses the stereoselectivity of intramolecular [2+ ...

    Abstract Macrocyclic hosts, such as cucurbit[8]uril (CB8), can significantly influence the outcomes of chemical reactions involving encapsulated reactive guests. In this study, we demonstrate that CB8 completely reverses the stereoselectivity of intramolecular [2+2] photo-cycloaddition reactions. Notably, it was also found that CB8 can trigger the unreactive diene to be reactive.
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc05783f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Report of the Medical Image De-Identification (MIDI) Task Group -- Best Practices and Recommendations

    Clunie, David A. / Flanders, Adam / Taylor, Adam / Erickson, Brad / Bialecki, Brian / Brundage, David / Gutman, David / Prior, Fred / Seibert, J Anthony / Perry, John / Gichoya, Judy Wawira / Kirby, Justin / Andriole, Katherine / Geneslaw, Luke / Moore, Steve / Fitzgerald, TJ / Tellis, Wyatt / Xiao, Ying / Farahani, Keyvan

    2023  

    Abstract: This report addresses the technical aspects of de-identification of medical images of human subjects and biospecimens, such that re-identification risk of ethical, moral, and legal concern is sufficiently reduced to allow unrestricted public sharing for ... ...

    Abstract This report addresses the technical aspects of de-identification of medical images of human subjects and biospecimens, such that re-identification risk of ethical, moral, and legal concern is sufficiently reduced to allow unrestricted public sharing for any purpose, regardless of the jurisdiction of the source and distribution sites. All medical images, regardless of the mode of acquisition, are considered, though the primary emphasis is on those with accompanying data elements, especially those encoded in formats in which the data elements are embedded, particularly Digital Imaging and Communications in Medicine (DICOM). These images include image-like objects such as Segmentations, Parametric Maps, and Radiotherapy (RT) Dose objects. The scope also includes related non-image objects, such as RT Structure Sets, Plans and Dose Volume Histograms, Structured Reports, and Presentation States. Only de-identification of publicly released data is considered, and alternative approaches to privacy preservation, such as federated learning for artificial intelligence (AI) model development, are out of scope, as are issues of privacy leakage from AI model sharing. Only technical issues of public sharing are addressed.

    Comment: 131 pages
    Keywords Computer Science - Cryptography and Security ; Computer Science - Computer Vision and Pattern Recognition ; Electrical Engineering and Systems Science - Image and Video Processing
    Publishing date 2023-03-18
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Skeletal Editing-Nitrogen Deletion of Secondary Amines by Anomeric Amide Reagents.

    Zippel, Christoph / Seibert, Jasmin / Bräse, Stefan

    Angewandte Chemie (International ed. in English)

    2021  Volume 60, Issue 36, Page(s) 19522–19524

    Abstract: Late-stage modification is highly desirable for the diversification and modification of biologically active compounds. Peripheral editing (e.g., C-H activation) has been the predominant methodology, whereas skeletal editing is in its infancy. The single- ... ...

    Abstract Late-stage modification is highly desirable for the diversification and modification of biologically active compounds. Peripheral editing (e.g., C-H activation) has been the predominant methodology, whereas skeletal editing is in its infancy. The single-atom N-deletion using anomeric amide reagents constitutes a powerful tool to modify the underlying molecular skeletons of secondary amines. N-pivaloyloxy-N-alkoxyamide is easily prepared on a large scale and promotes C-C bond formation in good yields under the extrusion of N
    Language English
    Publishing date 2021-08-01
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202107490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intracranial aneurysms: review of current treatment options and outcomes.

    Seibert, Brad / Tummala, Ramachandra P / Chow, Ricky / Faridar, Alireza / Mousavi, Seyed A / Divani, Afshin A

    Frontiers in neurology

    2011  Volume 2, Page(s) 45

    Abstract: Intracranial aneurysms are present in roughly 5% of the population, yet most are often asymptomatic and never detected. Development of an aneurysm typically occurs during adulthood, while formation and growth are associated with risk factors such as age, ...

    Abstract Intracranial aneurysms are present in roughly 5% of the population, yet most are often asymptomatic and never detected. Development of an aneurysm typically occurs during adulthood, while formation and growth are associated with risk factors such as age, hypertension, pre-existing familial conditions, and smoking. Subarachnoid hemorrhage, the most common presentation due to aneurysm rupture, represents a serious medical condition often leading to severe neurological deficit or death. Recent technological advances in imaging modalities, along with increased understanding of natural history and prevalence of aneurysms, have increased detection of asymptomatic unruptured intracranial aneurysms (UIA). Studies reporting on the risk of rupture and outcomes have provided much insight, but the debate remains of how and when unruptured aneurysms should be managed. Treatment methods include two major intervention options: clipping of the aneurysm and endovascular methods such as coiling, stent-assisted coiling, and flow diversion stents. The studies reviewed here support the generalized notion that endovascular treatment of UIA provides a safe and effective alternative to surgical treatment. The risks associated with endovascular repair are lower and incur shorter hospital stays for appropriately selected patients. The endovascular treatment option should be considered based on factors such as aneurysm size, location, patient medical history, and operator experience.
    Keywords covid19
    Language English
    Publishing date 2011-07-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295 ; 1664-2295
    ISSN (online) 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2011.00045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Brief History of OLEDs-Emitter Development and Industry Milestones.

    Hong, Gloria / Gan, Xuemin / Leonhardt, Céline / Zhang, Zhen / Seibert, Jasmin / Busch, Jasmin M / Bräse, Stefan

    Advanced materials (Deerfield Beach, Fla.)

    2021  Volume 33, Issue 9, Page(s) e2005630

    Abstract: Organic light-emitting diodes (OLEDs) have come a long way ever since their first introduction in 1987 at Eastman Kodak. Today, OLEDs are especially valued in the display and lighting industry for their promising features. As one of the research fields ... ...

    Abstract Organic light-emitting diodes (OLEDs) have come a long way ever since their first introduction in 1987 at Eastman Kodak. Today, OLEDs are especially valued in the display and lighting industry for their promising features. As one of the research fields that equally inspires and drives development in academia and industry, OLED device technology has continuously evolved over more than 30 years. OLED devices have come forward based on three generations of emitter materials relying on fluorescence (first generation), phosphorescence (second generation), and thermally activated delayed fluorescence (third generation). Furthermore, research in academia and industry toward the fourth generation of OLEDs is in progress. Excerpts from the history of green, orange-red, and blue OLED emitter development on the side of academia and milestones achieved by key players in the industry are included in this report.
    Language English
    Publishing date 2021-01-18
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202005630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Intracranial Aneurysms

    AfshinADivani / BradSeibert / RamachandraTummala / SeyedAliMousavi

    Frontiers in Neurology, Vol

    Review of Current Treatment Options and outcomes

    2011  Volume 2

    Abstract: Intracranial aneurysms are present in roughly five percent of the population, yet most are often asymptomatic and never detected. Development of an aneurysm typically occurs during adulthood, while formation and growth are associated with risk factors ... ...

    Abstract Intracranial aneurysms are present in roughly five percent of the population, yet most are often asymptomatic and never detected. Development of an aneurysm typically occurs during adulthood, while formation and growth are associated with risk factors such as age, hypertension, pre-existing familial conditions, and smoking. Subarachnoid hemorrhage, the most common presentation due to aneurysm rupture, represents a serious medical condition often leading to severe neurological deficit or death. Recent technological advances in imaging modalities, along with increased understanding of natural history and prevalence of aneurysms, have increased detection of asymptomatic unruptured intracranial aneurysms. Studies reporting on the risk of rupture and outcomes have provided much insight, but the debate remains of how and when unruptured aneurysms should be managed. Treatment methods include two major intervention options: clipping of the aneurysm and endovascular methods such as coiling, stent-assisted coiling, and flow diversion stents. The studies reviewed here support the generalized notion that endovascular treatment of unruptured intracranial aneurysms provides a safe and effective alternative to surgical treatment. The risks associated with endovascular repair are lower and incur shorter hospital stays for appropriately selected patients. The endovascular treatment option should be considered based on factors such as aneurysm size, location, patient medical history, and operator experience.
    Keywords Stents ; Subarachnoid Hemorrhage ; Coiling ; Endovascular Surgery ; aneurysms ; clipping ; flow diversion ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2011-07-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Mild and severe SARS-CoV-2 infection induces respiratory and intestinal microbiome changes in the K18-hACE2 transgenic mouse model

    Seibert, Brittany A / Caceres, Joaquin / Cardenas-Garcia, Stivalis / Carnaccini, Silvia / Geiger, Ginger / Rajão, Daniela / Ottesen, Elizabeth A / Perez, Daniel R.

    bioRxiv

    Abstract: ... Simpson diversity index correlating with SARS-CoV-2 infection dosage and a difference of Bray-Curtis ...

    Abstract Transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths and declining economies around the world. K18-hACE2 mice develop disease resembling severe SARS-CoV-2 infection in a virus dose-dependent manner. The relationship between SARS-CoV-2 and the intestinal or respiratory microbiome is not fully understood. In this context, we characterized the cecal and lung microbiome of SARS-CoV-2 challenged K18-hACE2 transgenic mice in the presence or absence of treatment with the M<sup>pro</sup> inhibitor GC376. Cecum microbiome showed decreased Shannon and Inv Simpson diversity index correlating with SARS-CoV-2 infection dosage and a difference of Bray-Curtis dissimilarity distances among control and infected mice. Bacterial phyla such as Firmicutes, particularly Lachnospiraceae and Oscillospiraceae, were significantly less abundant while Verrucomicrobiota, particularly the family Akkermansiaceae, were increasingly more prevalent during peak infection in mice challenged with a high virus dose. In contrast to the cecal microbiome, the lung microbiome showed similar microbial diversity among the control, low and high challenge virus groups, independent of antiviral treatment. Bacterial phyla in the lungs such as Bacteroidota decreased while Firmicutes and Proteobacteria were significantly enriched in mice challenged with a high dose of SARS-CoV-2. In summary, we identified changes in the cecal and lung microbiome of K18-hACE2 mice with severe clinical signs of SARS-CoV-2 infection.
    Keywords covid19
    Language English
    Publishing date 2021-04-23
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2021.04.20.440722
    Database COVID19

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  9. Book: Pediatric radiology casebase

    James, Charles A / Braswell, Leah E / Glasier, Charles M / Greenberg, S. Bruce / Seibert, Joanna J

    2016  

    Author's details [edited by] Charles A. James, Leah E. Braswell, Charles M. Glasier, S. Bruce Greenberg, Joanna J. Seibert
    MeSH term(s) Diagnostic Imaging ; Child ; Diagnosis, Differential ; Infant
    Language English
    Size xxii, 402 pages :, illustrations
    Edition Second edition.
    Document type Book
    ISBN 9781604069075 ; 9781604069082 ; 1604069074 ; 1604069082
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article ; Online: Using Polygenic Hazard Scores to Predict Age at Onset of Alzheimer's Disease in Nordic Populations.

    Motazedi, Ehsan / Cheng, Weiqiu / Thomassen, Jesper Q / Frei, Oleksandr / Rongve, Arvid / Athanasiu, Lavinia / Bahrami, Shahram / Shadrin, Alexey / Ulstein, Ingun / Stordal, Eystein / Brækhus, Anne / Saltvedt, Ingvild / Sando, Sigrid B / O'Connell, Kevin S / Hindley, Guy / van der Meer, Dennis / Bergh, Sverre / Nordestgaard, Børge G / Tybjærg-Hansen, Anne /
    Bråthen, Geir / Pihlstrøm, Lasse / Djurovic, Srdjan / Frikke-Schmidt, Ruth / Fladby, Tormod / Aarsland, Dag / Selbæk, Geir / Seibert, Tyler M / Dale, Anders M / Fan, Chun C / Andreassen, Ole A

    Journal of Alzheimer's disease : JAD

    2022  Volume 88, Issue 4, Page(s) 1533–1544

    Abstract: Background: Polygenic hazard scores (PHS) estimate age-dependent genetic risk of late-onset Alzheimer's disease (AD), but there is limited information about the performance of PHS on real-world data where the population of interest differs from the ... ...

    Abstract Background: Polygenic hazard scores (PHS) estimate age-dependent genetic risk of late-onset Alzheimer's disease (AD), but there is limited information about the performance of PHS on real-world data where the population of interest differs from the model development population and part of the model genotypes are missing or need to be imputed.
    Objective: The aim of this study was to estimate age-dependent risk of late-onset AD using polygenic predictors in Nordic populations.
    Methods: We used Desikan PHS model, based on Cox proportional hazards assumption, to obtain age-dependent hazard scores for AD from individual genotypes in the Norwegian DemGene cohort (n = 2,772). We assessed the risk discrimination and calibration of Desikan model and extended it by adding new genotype markers (the Desikan Nordic model). Finally, we evaluated both Desikan and Desikan Nordic models in two independent Danish cohorts: The Copenhagen City Heart Study (CCHS) cohort (n = 7,643) and The Copenhagen General Population Study (CGPS) cohort (n = 10,886).
    Results: We showed a robust prediction efficiency of Desikan model in stratifying AD risk groups in Nordic populations, even when some of the model SNPs were missing or imputed. We attempted to improve Desikan PHS model by adding new SNPs to it, but we still achieved similar risk discrimination and calibration with the extended model.
    Conclusion: PHS modeling has the potential to guide the timing of treatment initiation based on individual risk profiles and can help enrich clinical trials with people at high risk to AD in Nordic populations.
    MeSH term(s) Age of Onset ; Alzheimer Disease/epidemiology ; Alzheimer Disease/genetics ; Genotype ; Humans ; Multifactorial Inheritance/genetics ; Polymorphism, Single Nucleotide/genetics
    Language English
    Publishing date 2022-06-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-220174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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