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Article ; Online: From inflammation to cancer: entering a new frontier in the management of Erdheim-Chester disease.

Nayak, Lakshmi

2020 Volume 22, Issue 7, Page(s) 905–906

MeSH term(s)	Erdheim-Chester Disease ; Humans ; Inflammation ; Medical Oncology ; Neoplasms
Language	English
Publishing date	2020-04-28
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2028601-6
ISSN	1523-5866 ; 1522-8517
ISSN (online)	1523-5866
ISSN	1522-8517
DOI	10.1093/neuonc/noaa110
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Zs.A 5307: Show issues

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Article ; Online: Bruton's tyrosine kinase (BTK) inhibitors for the treatment of primary central nervous system lymphoma (PCNSL): current progress and latest advances.

Schaff, Lauren / Nayak, Lakshmi / Grommes, Christian

Leukemia & lymphoma

2024 , Page(s) 1–13

Abstract: The incidence of primary central nervous system lymphoma (PCNSL) has steadily increased, particularly in elderly patients. Although highly responsive to first-line chemotherapy and radiotherapy, approximately 50% of patients relapse or become refractory ... ...

Abstract	The incidence of primary central nervous system lymphoma (PCNSL) has steadily increased, particularly in elderly patients. Although highly responsive to first-line chemotherapy and radiotherapy, approximately 50% of patients relapse or become refractory within 1 year. Prognosis following relapse is dismal and no standard salvage therapy exists. Bruton's tyrosine kinase (BTK), a key regulator of the B-cell receptor (BCR) pathway, has emerged as a promising therapeutic target. The first BTK inhibitor ibrutinib has been evaluated in the relapsed/refractory PCNSL setting, with overall response rates of 51.9%-89.0% and median progression-free survival of 4.6-4.8 months. However, ibrutinib inhibits several kinases in addition to BTK, leading to off-target effects. Second-generation BTK inhibitors have since been developed, which afford greater selectivity for BTK and fewer off-target effects. We review current practices in the diagnosis and evaluation of PCNSL, as well as clinical trials of BTK inhibitors in PCNSL and future developments in PCNSL treatment.
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2024.2333985
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Zs.A 2997: Show issues

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Article ; Online: Multifocal atypical teratoid/rhabdoid tumour in an infant-a rare case report.

Pai, Ashwin / Prasad, G Lakshmi / Vasudevan, Geetha / Nayak, Deepak M

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

2024 Volume 40, Issue 5, Page(s) 1591–1596

Abstract: Background: Atypical teratoid/rhabdoid tumours (AT/RT) are uncommon but aggressive, malignant tumours in the paediatric age group. Presentation of concomitant supratentorial and infratentorial lesions in an infant is extremely rare. We discuss an infant ...

Abstract	Background: Atypical teratoid/rhabdoid tumours (AT/RT) are uncommon but aggressive, malignant tumours in the paediatric age group. Presentation of concomitant supratentorial and infratentorial lesions in an infant is extremely rare. We discuss an infant diagnosed with such lesions. Systematic PubMed search was conducted using keywords 'atypical teratoid /rhabdoid tumor', 'paediatric' and 'multifocal'. Reports were included for patients younger than 18 years with two or more lesions. The search yielded additional five cases and were tabulated. Age, sex, location, treatment given and survival/outcome were noted. Case report: A 10-month-old child presented with complaints of drowsiness and intractable vomiting. Imaging showed multifocal supra- and infratentorial lesions with obstructive hydrocephalus. The child underwent ventriculoperitoneal shunt followed by surgical removal of the posterior fossa lesion. Histopathological features were consistent with AT/RT. Conclusions: Multifocal AT/RT are very rare. The impact of multifocality in the outcome is not known as very few reports are available. Newer targeted therapies may offer insight in improving outcomes in the future.
MeSH term(s)	Infant ; Child ; Humans ; Rhabdoid Tumor/diagnosis ; Teratoma/surgery ; Brain Neoplasms/pathology ; Central Nervous System Neoplasms ; Hydrocephalus
Language	English
Publishing date	2024-02-02
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	605988-0
ISSN	1433-0350 ; 0302-2803 ; 0256-7040
ISSN (online)	1433-0350
ISSN	0302-2803 ; 0256-7040
DOI	10.1007/s00381-023-06274-8
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Zs.A 2036: Show issues

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Article ; Online: Evidence-based management of primary and secondary CNS lymphoma.

Khwaja, Jahanzaib / Nayak, Lakshmi / Cwynarski, Kate

Seminars in hematology

2023 Volume 60, Issue 5, Page(s) 313–321

Abstract: Central nervous system (CNS) lymphoma has traditionally had very poor outcomes however advances in management have resulted in dramatic improvements and long-term survival of patients. We describe the evidence for treatment strategies for these ... ...

Abstract	Central nervous system (CNS) lymphoma has traditionally had very poor outcomes however advances in management have resulted in dramatic improvements and long-term survival of patients. We describe the evidence for treatment strategies for these aggressive disorders. In primary CNS lymphoma there are randomized trial data to inform treatment decisions but these are lacking to guide management in secondary CNS lymphoma. Dynamic assessment of patient fitness and frailty is key throughout treatment, alongside delivery of CNS-bioavailable therapy and enrolment in clinical trials, at each stage of the disease. Intensive high-dose methotrexate-containing induction followed by consolidation with autologous stem cell transplantation with thiotepa-based conditioning is recommended for patients who are fit. Less intensive chemoimmunotherapy, novel agents (including Bruton tyrosine kinase inhibitors, cereblon targeting immunomodulatory agents, and checkpoint inhibitors in the context of clinical trials), and whole brain radiotherapy may be reserved for less fit patients or disease which is chemoresistant. Data regarding the efficacy of chimeric antigen receptor T-cells therapy is emerging, and concerns regarding greater toxicity have not been realized. Future areas of prospective studies include the identification of those at high risk of developing CNS lymphoma, management in elderly or frail patients as well as incorporating novel agents into regimens, particularly for those with chemoresistant disease.
MeSH term(s)	Humans ; Aged ; Hematopoietic Stem Cell Transplantation/methods ; Prospective Studies ; Combined Modality Therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Transplantation, Autologous ; Lymphoma/drug therapy ; Central Nervous System Neoplasms/drug therapy ; Central Nervous System Neoplasms/pathology
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	206923-4
ISSN	1532-8686 ; 0037-1963
ISSN (online)	1532-8686
ISSN	0037-1963
DOI	10.1053/j.seminhematol.2023.11.003
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Zs.A 328: Show issues

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Article ; Online: How I treat secondary CNS involvement by aggressive lymphomas.

Alderuccio, Juan Pablo / Nayak, Lakshmi / Cwynarski, Kate

Blood

2023 Volume 142, Issue 21, Page(s) 1771–1783

Abstract: Secondary central nervous system (CNS) lymphoma (SCNSL) is a rare but clinically challenging scenario with historically disappointing outcomes. SCNSL refers to lymphoma that has spread into the CNS concurrently with systemic disease or CNS relapse during ...

Abstract	Secondary central nervous system (CNS) lymphoma (SCNSL) is a rare but clinically challenging scenario with historically disappointing outcomes. SCNSL refers to lymphoma that has spread into the CNS concurrently with systemic disease or CNS relapse during or after frontline immunochemotherapy, presenting with or without systemic lymphoma. Diffuse large B-cell lymphoma (DLBCL) denotes the most common entity, but an increased incidence is observed in other histologies, such as Burkitt lymphoma and mantle-cell lymphoma. The incidence, timing in disease course, location, evidence supporting the use of CNS prophylaxis, and treatment pathways vary according to histology. No randomized data exist to delineate the best treatment approaches with current recommendations based on retrospective and single-arm studies. However, a regimen comprising immunochemotherapy, incorporating agents that cross the blood-brain barrier, followed by thiotepa-containing conditioning and autologous stem-cell transplant outlined in the international MARIETTA study demonstrated improvement in outcomes, representing a major accomplishment in the care of patients with DLBCL with SCNSL. Anti-CD19 chimeric antigen receptor T cell denotes a paradigm shift in the treatment of patients with systemic aggressive lymphomas, with emerging data also demonstrating efficacy without higher neurotoxicity in those with SCNSL. In this manuscript we discuss 5 clinical scenarios and review the evidence supporting our recommendations.
MeSH term(s)	Humans ; Adult ; Retrospective Studies ; Neoplasm Recurrence, Local/drug therapy ; Lymphoma, Large B-Cell, Diffuse/pathology ; Central Nervous System Neoplasms/drug therapy ; Thiotepa/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols
Chemical Substances	Thiotepa (905Z5W3GKH)
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2023020168
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Article ; Online: How I treat neurologic complications in patients with lymphoid cancer.

Nayak, Lakshmi / Batchelor, Tracy T

Blood

2021 Volume 139, Issue 10, Page(s) 1469–1478

Abstract: Neurologic complications of lymphoid cancer can be challenging to recognize and treat. The nervous system can be affected directly by hematogenous or local spread of lymphoma. Indirect neurologic effects of lymphoma include paraneoplastic syndromes and ... ...

Abstract	Neurologic complications of lymphoid cancer can be challenging to recognize and treat. The nervous system can be affected directly by hematogenous or local spread of lymphoma. Indirect neurologic effects of lymphoma include paraneoplastic syndromes and vascular complications. Lymphoma treatments can also cause neurologic complications. Early identification and treatment are crucial to stabilize or reverse neurologic deficits, prevent further nervous system injury, and optimize overall oncologic therapy. This article provides an overview of the different neurologic complications of lymphoma and its treatments, in addition to presenting case studies that emphasize commonly encountered clinical scenarios.
MeSH term(s)	Humans ; Lymphoma/complications ; Lymphoma/therapy ; Neoplasms/complications ; Nervous System Diseases/etiology ; Nervous System Diseases/therapy ; Paraneoplastic Syndromes/etiology
Language	English
Publishing date	2021-09-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2019003690
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Article ; Online: The Milan system for reporting salivary gland cytopathology - Assessment of utility and the risk of malignancy.

Prakash, Annu E / Sukumaran, Renu / Nayak, Nileena / Lakshmi, K / Mathews, Anitha / Kattoor, Jayasree

Indian journal of cancer

2023

Abstract: Background: Cytological diagnosis of salivary gland lesions furnishes several challenges to pathologists and clinicians owing to their diverse morphology and varying reporting terminology. The Milan system for reporting salivary gland cytopathology was ... ...

Abstract	Background: Cytological diagnosis of salivary gland lesions furnishes several challenges to pathologists and clinicians owing to their diverse morphology and varying reporting terminology. The Milan system for reporting salivary gland cytopathology was proposed to overcome these defects. The aim of this study was to grade histopathologically diagnosed cases of salivary gland pathology using Milan system and to correlate Milan system with histopathological diagnosis. The study aims to assess the utility of the Milan system and the risk of malignancy in each category. Materials and methods: This is a retrospective study of 4 years duration. All the cases of salivary gland pathology with fine-needle aspiration cytology findings from January 2015 to December 2018 were retrieved and classified according to the Milan system. Histopathology follow-up of these cases were reviewed from the archives, and risk of malignancy was calculated. Sensitivity, specificity, positive predictive value, and negative predictive value were calculated using histopathological diagnosis as the gold standard. Results: Cytology slides of 151 cases were reviewed, and the Milan system was applied. Histopathology follow-up was obtained in 94 cases (attrition rate = 37.74%). The percentage of cases in each category were as follows: nondiagnostic = 9.27%, nonneoplastic = 4.64%, atypia of undetermined significance = 3.97%, benign neoplasm = 23.84%, neoplasm of uncertain malignant potential = 8.61%, suspicious for malignancy = 11.92%, and malignant = 37.75%. Sensitivity, specificity, positive predictive value, and negative predictive value of the Milan system were 94.20%, 96.00%, 98.48%, and 85.71%, respectively. Conclusion: The Milan system has high sensitivity and specificity in comparison with histopathology. This system proves helpful to the pathologist as well as the clinician in achieving uniformity of reporting terminology by classifying salivary gland lesions into subcategories with prognostic relevance.
Language	English
Publishing date	2023-12-29
Publishing country	India
Document type	Journal Article
ZDB-ID	410194-7
ISSN	1998-4774 ; 0019-509X
ISSN (online)	1998-4774
ISSN	0019-509X
DOI	10.4103/ijc.IJC_158_21
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Article ; Online: Experimental investigation of modified indirect solar dryer with integrated thermal storage material for drying of dhekia (Diplazium esculentum) fern.

Saikia, Deepanka / Nayak, Prakash Kumar / Krishnan, Kesavan Radha / Kondareddy, Rajesh / Lakshmi, Durga Venkata Naga

Environmental science and pollution research international

2023 Volume 31, Issue 12, Page(s) 18143–18156

Abstract: Food product drying is a crucial stage in the preservation of crops and agricultural by-products that are used as raw materials for numerous end applications. The novelty of the study is the application of a phase change material in a solar dryer to ... ...

Abstract	Food product drying is a crucial stage in the preservation of crops and agricultural by-products that are used as raw materials for numerous end applications. The novelty of the study is the application of a phase change material in a solar dryer to improve the effectiveness of drying and reducing the overall drying period for drying while retaining/improving the quality parameters of the dried dhekia (Diplazium esculentum). The modified indirect thermal storage integrated solar dryer made up of a single-pass solar collector is attached with the drying chamber of 16.5 kg capacity. A thermal energy storage system prepared with paraffin wax embedded inside the drying cabinet was used. The proposed solar dryer has a thermal efficiency that is 11 ± 0.2% greater than the conventionally constructed solar dryer and reduces drying time by 40 ± 2.1%. Drying kinetic analysis of dhekia was performed, and two new drying kinetic models were proposed to predict moisture ratio. From statistical analysis, it was found that the chi square value and root mean square error value fits well for the proposed models. The anti-oxidant, total phenolic content, and total flavonoid content values of samples dried in solar dryer exhibit better results compared to fresh, tray dried, and open sun-dried samples. The developed dryer shows better results in saving drying time and quality of the product. Due to its affordability and long-term solution for drying fresh farm goods, this dryer can be very helpful to small-scale farmers.
MeSH term(s)	Ferns ; Kinetics ; Desiccation/methods ; Sunlight ; Antioxidants ; Tracheophyta
Chemical Substances	Antioxidants
Language	English
Publishing date	2023-01-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-25310-3
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Article ; Online: Is it time to revisit R-CHOP for primary CNS lymphoma?

Nayak, Lakshmi / Batchelor, Tracy T

Blood

2019 Volume 134, Issue 3, Page(s) 221–222

MeSH term(s)	Blood-Brain Barrier ; Cyclophosphamide ; Humans ; Lymphoma ; Rituximab ; Tumor Necrosis Factor-alpha ; Vincristine
Chemical Substances	Tumor Necrosis Factor-alpha ; Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F) ; Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2019-07-18
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2019001383
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Article: Cell Junctions in Periodontal Health and Disease: An Insight.

Puzhankara, Lakshmi / Rajagopal, Anjale / Kedlaya, Madhurya N / Karmakar, Shaswata / Nayak, Namratha / Shanmugasundaram, Shashikiran

European journal of dentistry

2023

Abstract: Cells are the building blocks of all living organisms. The presence of cell junctions such as tight junctions, gap junctions, and anchoring junctions between cells play a role in cell-to-cell communication in periodontal health and disease. A literature ... ...

Abstract	Cells are the building blocks of all living organisms. The presence of cell junctions such as tight junctions, gap junctions, and anchoring junctions between cells play a role in cell-to-cell communication in periodontal health and disease. A literature search was done in Scopus, PubMed, and Web of Science to gather information about the effect of cell junctions on periodontal health and disease. The presence of tight junction in the oral cavity helps in cell-to-cell adhesiveness and assists in the barrier function. The gap junctions help in controlling growth and development and in the cell signaling process. The presence of desmosomes and hemidesmosomes as anchoring junctions aid in mechanical strength and tissue integrity. Periodontitis is a biofilm-induced disease leading to the destruction of the supporting structures of the tooth. The structures of the periodontium possess multiple cell junctions that play a significant role in periodontal health and disease as well as periodontal tissue healing. This review article provides an insight into the role of cell junctions in periodontal disease and health, and offers concepts for development of therapeutic strategies through manipulation of cell junctions.
Language	English
Publishing date	2023-12-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2491711-4
ISSN	1305-7464 ; 1305-7456
ISSN (online)	1305-7464
ISSN	1305-7456
DOI	10.1055/s-0043-1775726
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