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  1. Article ; Online: Romanian Neurosurgery Editor’s Page November 2010

    St.M. Iencean

    Romanian Neurosurgery, Vol XVII, Iss 4, Pp 381-

    2010  Volume 381

    Keywords Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Surgery ; RD1-811 ; DOAJ:Surgery
    Language English
    Publishing date 2010-11-01T00:00:00Z
    Publisher De Gruyter Open
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Intracranial hypertension: classification and patterns of evolution.

    Iencean, St M / Ciurea, A V

    Journal of medicine and life

    2010  Volume 1, Issue 2, Page(s) 101–107

    Abstract: Intracranial hypertension (ICH) was systematized in four categories according to its aetiology and pathogenic mechanisms: parenchymatous ICH with an intrinsic cerebral cause; vascular ICH, which has its actiology in disorders of cerebral blood ... ...

    Abstract Intracranial hypertension (ICH) was systematized in four categories according to its aetiology and pathogenic mechanisms: parenchymatous ICH with an intrinsic cerebral cause; vascular ICH, which has its actiology in disorders of cerebral blood circulation: ICH caused by disorders of cerebro-spinal fluid dynamics and idiopathic ICH. The increase of intracranial pressure is the first to happen and then intracranial hypertension develops from this initial effect becoming symptomatic: it then acquires its individuality, surpassing the initial disease. The intracranial hypertension syndrome corresponds to the stage at which the increased intracranial pressure can be compensated and the acute form of intracranial hypertension is equivalent to a decompensated ICH syndrome. The decompensation of intracranial hypertension is a condition of instability and appears when the normal intrinsic ratio of intracranial pressure time fluctuation is changed. The essential conditions for decompensation of intracranial hypertension are: the speed of intracranial pressure increase over normal values, the highest value of abnormal intracranial pressure and the duration of high ICP values. Medical objectives are preventing ICP from exceeding 20 mm Hg and maintaining a normal cerebral blood flow. The emergency therapy is the same for the acute form but each of the four forms of ICH has a specific therapy, according to the pathogenic mechanism and if possible to aetiology.
    MeSH term(s) Disease Progression ; Humans ; Intracranial Hypertension/classification ; Intracranial Hypertension/diagnosis ; Intracranial Hypertension/physiopathology ; Magnetic Resonance Imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2010-01-19
    Publishing country Romania
    Document type Journal Article ; Review
    ZDB-ID 2559353-5
    ISSN 1844-3117 ; 1844-3109 ; 1844-122X
    ISSN (online) 1844-3117 ; 1844-3109
    ISSN 1844-122X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Angiogenesis in the degeneration of the lumbar intervertebral disc.

    David, Gh / Ciurea, A V / Iencean, St M / Mohan, A

    Journal of medicine and life

    2010  Volume 3, Issue 2, Page(s) 154–161

    Abstract: The goal of the study is to show the histological and biochemical changes that indicate the angiogenesis of the intervertebral disc in lumbar intervertebral disc hernia and the existence of epidemiological correlations between these changes and the risk ... ...

    Abstract The goal of the study is to show the histological and biochemical changes that indicate the angiogenesis of the intervertebral disc in lumbar intervertebral disc hernia and the existence of epidemiological correlations between these changes and the risk factors of lumbar intervertebral disc hernia, as well as the patient's quality of life (QOL). We have studied 50 patients aged between 18 and 73 years old, who have undergone lumbar intervertebral disc hernia surgery, making fibroblast growth factor and vascular endothelial growth factor level measurements, as elements in the process of appreciating the disc angiogenesis. Also, pre-surgery and post-surgery QOL has been measured, as well as the intensity of the pain syndrome. We have identified factors capable of stimulating vascular endothelial growth (VEGF, FGF-2) for the examined disc material, but histological examination did not show angiogenesis. The process of angiogenesis at the degenerated intervertebral disc level affects the patient's quality of life both pre and postoperatively, and may be a predictive factor for the post-operative results. Patients can prevent the appearance of angiogenesis type degenerative processes of the intervertebral disc by avoiding angiogenesis correlated factors (weight control, physical effort, and smoking).
    MeSH term(s) Adolescent ; Adult ; Aged ; Cohort Studies ; Female ; Fibroblast Growth Factor 2/metabolism ; Humans ; Intervertebral Disc Degeneration/pathology ; Intervertebral Disc Degeneration/physiopathology ; Intervertebral Disc Degeneration/surgery ; Longitudinal Studies ; Low Back Pain/physiopathology ; Lumbar Vertebrae ; Male ; Middle Aged ; Neovascularization, Pathologic ; Quality of Life ; Vascular Endothelial Growth Factor A/metabolism ; Young Adult
    Chemical Substances VEGFA protein, human ; Vascular Endothelial Growth Factor A ; Fibroblast Growth Factor 2 (103107-01-3)
    Language English
    Publishing date 2010-10-22
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2559353-5
    ISSN 1844-3117 ; 1844-3109 ; 1844-122X
    ISSN (online) 1844-3117 ; 1844-3109
    ISSN 1844-122X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Management of unknown origin cerebral metastases

    F.M. Gramada / Anca Indrei / St.M. Iencean / I. Poeata / Gabriela Dumitrescu / L. Miron

    Romanian Neurosurgery, Vol XVIII, Iss 1, Pp 60-

    2011  Volume 67

    Abstract: ... were 102 males and 88females with a M:F ratio of 1.15:1. Themedian age of patients was 47.07 years ...

    Abstract Aim: The present study attempts todetermine the steps for obtaining theetiological diagnosis of brain metastaseswith unknown origin.Material and methods: A total of 190patients with brain metastases diagnosed inthe Department of Neurosurgery inEmergency Hospital ”N. Oblu” Iasibetween 2007-2010 were included in thisstudy. The clinical characteristics andpathological features were analyzed.Results: There were 102 males and 88females with a M:F ratio of 1.15:1. Themedian age of patients was 47.07 years(range 31-77 years). Females patients wereolder (mean age 57.21 years) than malespatients (49.15 years). 154 patients (81.05%)had single brain metastasis, and 36 patients(18.95%) had more than two. The lesionswere supratentorial in 142 patients(74.73%), infratentorial in 18 (9.47%), andboth infratentorial and supratentorial in 30patients (15.78%). Surgical treatmentinvolved complete resection in 47.9% ofcases, subtotal resection in 26.8%, andbiopsy alone in the remainder (25.3%).Brain metastases originating in lung cancerrepresented the most common type(47.39%), followed by those from breastcancer (19.79%), then those from skin(melanoma) (8.33%), genitourinarycarcinoma (6.30%), and gastrointestinalcarcinoma (2.62%). In 16.31% of cases, theprimary tumor remained unknown, despiteextensive investigation.Conclusion: The primary cancer leadingto brain metastases can be detected eitherby obtaining a sample of tumoral tissuethrough a neurosurgical operation on theintracerebral tumor (total ablation orstereotactic biopsy) with histopathologicalexamination, or by additional tests of thewhole body. Taken into consideration theresults of our own study, the managementof the patients with brain metastases shouldinclude a thoracic CT scan oranteroposterior and lateral chest X-ray,clinical breast examination andmammography, abdominal ultrasoundexploration, and skin, kidney and prostateexamination. With the most sophisticatedmethods of diagnosis in approximately 16%of cases the origin of metastasis remainsunknown. The identification of the primarysite by the neuropathologist afterstereotactic biopsy would clearly beadvantageous.
    Keywords brain metastases ; cerebral cancer treatment ; stereotactic biopsy ; tumoral type ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Surgery ; RD1-811 ; DOAJ:Surgery
    Subject code 616 ; 610
    Language English
    Publishing date 2011-03-01T00:00:00Z
    Publisher De Gruyter Open
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Stem cells & tissue engineering

    G. Onose / A. V. Ciurea / I. P. Florescu / Crina Sinescu / Fl. Purghel / Ruxandra Mihai / Ingrid Marinescu / A. Anghelescu / Monica Haras / F. Brehar / St. M. Iencean / Mihaela Unguru / Cristina Chendreanu

    Romanian Neurosurgery, Vol 14, Iss

    2007  Volume 1

    Abstract: This paper aims to be an introduction in stem cell therapies and tissue engineering, starting from the isolation and first description of stem cells in 1998, and emphasizing their huge importance and potential as they might lead to the long waited ... ...

    Abstract This paper aims to be an introduction in stem cell therapies and tissue engineering, starting from the isolation and first description of stem cells in 1998, and emphasizing their huge importance and potential as they might lead to the long waited healing of most, yet incurable diseases and conditions. Stem cells made a real landmark between traditional and nowadays revolutionary Regenerative Medicine, by encompassing also tissue engineering, i.e. building and replacing damaged organs or part of them. We will shortly present the achievement of scientists to grow replacement tissues for people with various conditions, including pancreatic cells for people with diabetes, neurons for people with Alzheimer's disease and spinal or brain injuries, bone marrow for cancer patients, skin for burn, trauma and aesthetic surgery, cardiac muscle cells for heart diseases, bone and cartilage for orthopedic or/and rheumatologic conditions, etc.
    Keywords stem cells ; tissue engineering ; regenerative medicine ; Neurology. Diseases of the nervous system ; RC346-429
    Subject code 571
    Language English
    Publishing date 2007-03-01T00:00:00Z
    Publisher London Academic Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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