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Article ; Online: Prognostic Significance of Two Dimensional AgNOR Evaluation in Local Advanced Rectal Cancer Treated with Chemoradiotherapy.

Gundog, Mete / Yildiz, Oguz G / Imamoglu, Nalan / Aslan, Dicle / Aytekin, Aynur / Soyuer, Isin / Soyuer, Serdar

Asian Pacific journal of cancer prevention : APJCP

2016 Volume 16, Issue 18, Page(s) 8155–8161

Abstract: The prognostic significance of AgNOR proteins in stage II-III rectal cancers treated with chemoradiotherapy was evaluated. Silver staining was applied to the 3μm sections of parafin blocked tissues from 30 rectal cancer patients who received 5-FU based ... ...

Abstract	The prognostic significance of AgNOR proteins in stage II-III rectal cancers treated with chemoradiotherapy was evaluated. Silver staining was applied to the 3μm sections of parafin blocked tissues from 30 rectal cancer patients who received 5-FU based chemoradiotherapy from May 2003 to June 2006. The microscopic displays of the cells were transferred into the computer via a video camera. AgNOR area (nucleolus organizer region area) and nucleus area values were determined as a nucleolus organizer regions area/total nucleus area (NORa/ TNa). The mean NORa/TNa value was found to be 9.02±3.68. The overall survival and disease free survival in the high NORa/TNa (>9.02) patients were 52.2 months and 39.4 months respectively, as compared to 100.7 months and 98.4 months in the low NORa/TNa (<9.02) cases. (p<0.001 and p<0.001 respectively). In addition, the prognosis in the high NORa/TNa patients was worse than low NORa/TNa patients (p<0.05). In terms of overall survival and disease-free survival, a statistically significant negative correlation was found with the value of NORa/TNa in the correlations tests. Cox regression analyses demostrated that overall survival and disease-free survival were associated with lymph node status (negative or positive) and the NORa/TNa value. We suggest that two-dimensional AgNOR evaluation may be a safe and usable parameter for prognosis and an indicator of cell proliferation instead of AgNOR dots.
MeSH term(s)	Adenocarcinoma/pathology ; Adenocarcinoma/therapy ; Adenocarcinoma/ultrastructure ; Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cell Nucleus/pathology ; Cell Nucleus/ultrastructure ; Chemoradiotherapy ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Invasiveness ; Neoplasm Staging ; Nucleolus Organizer Region/pathology ; Nucleolus Organizer Region/ultrastructure ; Prognosis ; Silver Staining ; Stomach Neoplasms/pathology ; Stomach Neoplasms/therapy ; Stomach Neoplasms/ultrastructure ; Survival Rate
Language	English
Publishing date	2016-01-07
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.7314/apjcp.2015.16.18.8155
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Article ; Online: Effect of an oral mucositis protocol on quality of life of patients with head and neck cancer treated with radiation therapy.

Kartin, Pinar Tekinsoy / Tasci, Sultan / Soyuer, Serdar / Elmali, Ferhan

Clinical journal of oncology nursing

2014 Volume 18, Issue 6, Page(s) E118–25

Abstract: This study was conducted to determine the effect of an oral mucositis prevention protocol on nutritional status and quality of life for patients undergoing radiation therapy for head and neck cancers. This randomized, controlled, experimental study ... ...

Abstract	This study was conducted to determine the effect of an oral mucositis prevention protocol on nutritional status and quality of life for patients undergoing radiation therapy for head and neck cancers. This randomized, controlled, experimental study placed 20 patients in an intervention group where they received an oral care protocol and a nutrition protocol. Thirty patients were placed in the control group. Data were collected through face-to-face interviews using an oral assessment guide, oral evaluation guidelines, an oral toxicity scale, a visual analog scale, a subjective global assessment index, and a quality-of-life scale. As time post-treatment progressed, the prevalence of malnutrition in the intervention group was lower than in the controls group, and the intervention group experienced significantly less pain related to oral mucositis. Similar deteriorations in quality of life were noted in each group.
MeSH term(s)	Head and Neck Neoplasms/radiotherapy ; Humans ; Quality of Life ; Radiotherapy/adverse effects ; Stomatitis/etiology ; Turkey
Language	English
Publishing date	2014-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2014665-6
ISSN	1538-067X ; 1092-1095
ISSN (online)	1538-067X
ISSN	1092-1095
DOI	10.1188/14.CJON.E118-E125
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Article: An institutional experience of quality assurance of a treatment planning system on photon beam.

Ozgüven, Yıldıray / Yaray, Kadir / Alkaya, Fadime / Yücel, Birsen / Soyuer, Serdar

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

2013 Volume 19, Issue 3, Page(s) 195–205

Abstract: Aim: The purpose of the present study is to show the application of the IAEA TRS-430 QA procedures of Eclipse™v7.5 TPS for photon energies. In addition, the trends of the deviations found in the conducted tests were determined.: Background: In the ... ...

Abstract	Aim: The purpose of the present study is to show the application of the IAEA TRS-430 QA procedures of Eclipse™v7.5 TPS for photon energies. In addition, the trends of the deviations found in the conducted tests were determined. Background: In the past, the lack of complete TPS QA procedures led to some serious accidents. So, QA in the radiotherapy treatment planning process is essential for determination of accuracy in the radiotherapy process and avoidance of treatment errors. Materials and methods: The calculations of TPS and measurements of irradiations of the treatment device were compared in the study. As a result, the local dose deviation values (δ 1: central beam axis, δ 2: penumbra and build up region, δ 3: inside field, δ 4: outside beam edges, δ 50-90: beam fringe, RW50: radiological width) and their confidence limit values (including systematic and random errors) were obtained. Results: The confidence limit values of δ 4 were detected to increase with expanding field size. The values of δ 1 and δ 3 of hard wedge were larger than open fields. The values of δ 2 and δ 50-90 of the inhomogeneity effect test were larger, especially than other tests of this study. The average deviation was showed to increase with the rise of the wedge angle. The values of δ 3 and δ 4 of lung irradiation were outside tolerance. Conclusions: The QA of TPS was done and it was found that there were no reservations in its use in patient treatment. The trend of the deviations is shown.
Language	English
Publishing date	2013-12-08
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2188087-6
ISSN	1507-1367
ISSN	1507-1367
DOI	10.1016/j.rpor.2013.10.008
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Article ; Online: Which urine marker test provides more diagnostic value in conjunction with standard cytology- ImmunoCyt/uCyt+ or Cytokeratin 20 expression.

Soyuer, Isin / Sofikerim, Mustafa / Tokat, Fatma / Soyuer, Serdar / Ozturk, Figen

Diagnostic pathology

2009 Volume 4, Page(s) 20

Abstract: Background: Because of the poor sensitivity of urinary cytological findings for the diagnosis of especially low grade urinary bladder carcinoma, new molecular diagnostic methods have been proposed. We decided to verify the ImmunoCyt/uCyt+ (UCyt+) test ... ...

Abstract	Background: Because of the poor sensitivity of urinary cytological findings for the diagnosis of especially low grade urinary bladder carcinoma, new molecular diagnostic methods have been proposed. We decided to verify the ImmunoCyt/uCyt+ (UCyt+) test and cytology combination and cytokeratin 20 (CK20) and cytology combination in urine as possible diagnostic and monitoring tool for bladder cancer. Methods: Evaluation of CK20 expression and UCyt+ was performed in urine of 90 patients of which 54 with bladder cancer with primary/recurrent diagnosis (low grade urothelial carcinoma (LGUC) = 23/8 patients, high grade urothelial carcinoma (HGUC) = 18/5 patients), and 36 patients as control; except of neoplastic bladder disease patients. For the evaluation of the three tests, CK20 and UCyt+ tests were combined with urine cytology and compared with each other. Results: The overall sensitivity detected for each tumor marker was as follows: for urine cytology was 75.9% and UCyt+ was 83.3%, for CK20 70.4%, while the specificity was 66.7% for urine cytology and 86.1% for UCyt+ and 83.3% for CK20. The sensitivity of cytology and UCyt+ combination was higher (88.9%) than the sensitivity cytology and CK20 combination (77.8%). The simultaneous use of the three markers, sensitivity was reaching 92.5%. Conclusion: The UCyt+ test and CK20 expression are valid tools for the performance of adjunctive analyses with conventional cytologic examination.
Language	English
Publishing date	2009-06-26
Publishing country	England
Document type	Journal Article
ISSN	1746-1596
ISSN (online)	1746-1596
DOI	10.1186/1746-1596-4-20
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Article ; Online: An institutional experience

Kadir YARAY / Yıldıray ÖZGÜVEN / Fadime ALKAYA / Birsen YÜCEL / Serdar SOYUER

Turkish Journal of Oncology, Vol 28, Iss 4, Pp 154-

quality assurance of a treatment planning system on electron beam

2013 Volume 162

Abstract: OBJECTIVES This study aims to application of the IAEA TRS-430 QA pro- cedures of EclipseTM v7.5 TPS for electron energies. In addi- tion, the trends of the deviations found in the conducted tests have been determined. METHODS The calculations of TPS and ... ...

Abstract	OBJECTIVES This study aims to application of the IAEA TRS-430 QA pro- cedures of EclipseTM v7.5 TPS for electron energies. In addi- tion, the trends of the deviations found in the conducted tests have been determined. METHODS The calculations of TPS and measurements irradiations of the treatment device have been compared. As a result, the local dose deviation values and their confidence limit values have been obtained. RESULTS All confidence limit values were detected that it was increased depending on expanding depth. But each confidence limit val- ues were found to show different change depending on ex- panding field size. Results of CT based inhomogeneity cor- rections and complex surface shapes tests were found outside tolerances, especially δ3. CONCLUSION The QA of our clinic’s TPS has been done and it has been found that there aren’t drawbacks in its use in treatment. Only the errors found in our study for the parameters used in treat- ment planning has to be considered.
Keywords	Confidence limit; electron beam; treatment planning sys- tem; quality assurance. ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R
Language	Turkish
Publishing date	2013-12-01T00:00:00Z
Document type	Article ; Online
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Article ; Online: Prognostic significance of CD9 expression in locally advanced gastric cancer treated with surgery and adjuvant chemoradiotherapy.

Soyuer, Serdar / Soyuer, Isin / Unal, Dilek / Ucar, Kadir / Yildiz, Oguz Galip / Orhan, Okan

Pathology, research and practice

2010 Volume 206, Issue 9, Page(s) 607–610

Abstract: The tetraspanin transmembrane protein CD9 plays an important role in inhibiting cell motility in numerous neoplastic cell lines, including lung, gastric, pancreatic, and bladder carcinomas. The prognostic importance of CD9 in the survival of gastric ... ...

Abstract	The tetraspanin transmembrane protein CD9 plays an important role in inhibiting cell motility in numerous neoplastic cell lines, including lung, gastric, pancreatic, and bladder carcinomas. The prognostic importance of CD9 in the survival of gastric carcinoma patients has not been examined to date, and in the present study, we attempted to define its prognostic value. The study included 49 (35 men and 14 women) patients with locally advanced (stages II-IV) gastric cancer. The median age was 55 years (range, 22-73 years). Surgery was the initial treatment for all patients, followed by adjuvant chemoradiotherapy. Tissue sections were evaluated immunohistochemically with a monoclonal anti-CD9 antibody. Of the 49 patients with gastric adenocarcinoma, 11 (22.4%) were CD9-positive, and 38 (77.6%) were CD9-negative. A significant prognostic value in disease-free survival and overall survival was observed in T classification and CD9 positivity. In conclusion, CD9 expression in gastric cancer appears to be associated with poor prognosis.
MeSH term(s)	Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Adenocarcinoma/therapy ; Adult ; Aged ; Antigens, CD/biosynthesis ; Biomarkers, Tumor/analysis ; Chemotherapy, Adjuvant ; Digestive System Surgical Procedures ; Disease-Free Survival ; Female ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Membrane Glycoproteins/biosynthesis ; Middle Aged ; Neoplasm Staging ; Prognosis ; Proportional Hazards Models ; Radiotherapy ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Stomach Neoplasms/therapy ; Tetraspanin-29 ; Young Adult
Chemical Substances	Antigens, CD ; Biomarkers, Tumor ; CD9 protein, human ; Membrane Glycoproteins ; Tetraspanin-29
Language	English
Publishing date	2010-09-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2010.04.004
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Article ; Online: Which urine marker test provides more diagnostic value in conjunction with standard cytology- ImmunoCyt/uCyt+ or Cytokeratin 20 expression

Soyuer Serdar / Tokat Fatma / Sofikerim Mustafa / Soyuer Isin / Ozturk Figen

Diagnostic Pathology, Vol 4, Iss 1, p

2009 Volume 20

Abstract: Abstract Background Because of the poor sensitivity of urinary cytological findings for the diagnosis of especially low grade urinary bladder carcinoma, new molecular diagnostic methods have been proposed. We decided to verify the ImmunoCyt/uCyt+ (UCyt+™) ...

Abstract	Abstract Background Because of the poor sensitivity of urinary cytological findings for the diagnosis of especially low grade urinary bladder carcinoma, new molecular diagnostic methods have been proposed. We decided to verify the ImmunoCyt/uCyt+ (UCyt+™) test and cytology combination and cytokeratin 20 (CK20) and cytology combination in urine as possible diagnostic and monitoring tool for bladder cancer. Methods Evaluation of CK20 expression and UCyt+™ was performed in urine of 90 patients of which 54 with bladder cancer with primary/recurrent diagnosis (low grade urothelial carcinoma (LGUC) = 23/8 patients, high grade urothelial carcinoma (HGUC) = 18/5 patients), and 36 patients as control; except of neoplastic bladder disease patients. For the evaluation of the three tests, CK20 and UCyt+™ tests were combined with urine cytology and compared with each other. Results The overall sensitivity detected for each tumor marker was as follows: for urine cytology was 75.9% and UCyt+™ was 83.3%, for CK20 70.4%, while the specificity was 66.7% for urine cytology and 86.1% for UCyt+™ and 83.3% for CK20. The sensitivity of cytology and UCyt+™ combination was higher (88.9%) than the sensitivity cytology and CK20 combination (77.8%). The simultaneous use of the three markers, sensitivity was reaching 92.5%. Conclusion The UCyt+™ test and CK20 expression are valid tools for the performance of adjunctive analyses with conventional cytologic examination.
Keywords	Pathology ; RB1-214 ; Medicine ; R ; DOAJ:Pathology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	2009-06-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
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Article ; Online: Contribution of involved-field radiotherapy to survival in patients with relapsed or refractory Hodgkin lymphoma undergoing autologous stem cell transplantation.

Eroglu, Celalettin / Kaynar, Leylagül / Orhan, Okan / Keklik, Muzaffer / Sahin, Cem / Yildiz, Oğuz G / Mentes, Selahattin / Kurnaz, Fatih / Aslan, Dicle / Sivgin, Serdar / Soyuer, Serdar / Eser, Bülent / Cetin, Mustafa / Unal, Ali

American journal of clinical oncology

2015 Volume 38, Issue 1, Page(s) 68–73

Abstract: Objectives: To assess the outcomes of overall survival and posttransplantation survival in patients with Hodgkin lymphoma (HL) undergoing autologous stem cell transplantation (ASCT) because of the development of relapse or resistance after chemotherapy ( ...

Abstract	Objectives: To assess the outcomes of overall survival and posttransplantation survival in patients with Hodgkin lymphoma (HL) undergoing autologous stem cell transplantation (ASCT) because of the development of relapse or resistance after chemotherapy (CT) or CT plus radiotherapy (combined modality treatment, CMT). Methods: Forty-five patients undergoing ASCT because of the development of relapse or resistance after CT or CMT for HL were enrolled in the study. Radiotherapy was given as involved-field radiotherapy. Patients were treated with CT alone (n=25) or CMT (n=20). These 2 groups were further divided into 2 subgroups: the patients with early-stage (I to II) and advanced-stage (III to IV) HL. Results: Median patients age was 29 years (range, 16 to 60 y) and the median follow-up was 60 months (range, 12 to 172 mo). In the patients with advanced-stage HL, there was no statistically significant difference in overall survival between irradiated and nonirradiated patients (n=18, irradiated n=4 and nonirradiated n=14). However, in the patients with early-stage disease, there was a significant difference in 5- and 10-year overall survival between the irradiated and nonirradiated groups (81% vs. 48% and 66% vs. 24%, respectively, P=0.045; n=26, irradiated n=16 and nonirradiated n=10). In the univariate analysis, irradiated group and involvement of 1 to 2 nodal regions were found to be significant for overall survival, whereas irradiated group, early stage, and involvement of 1 to 2 nodal regions were found to be significant for posttransplantation survival. However, only irradiated group was found to be significant for posttransplantation survival in multivariate analysis (P<0.05). Conclusions: Addition of involved-field radiotherapy to CT in patients undergoing ASCT after relapse or recurrence failed to provide survival benefit in patients with advanced HL, while a survival benefit was observed in patients with early-stage HL. Radiotherapy should be considered as part of CMT in the patients with early-stage HL, which should not be neglected.
MeSH term(s)	Adolescent ; Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bleomycin/therapeutic use ; Carboplatin/therapeutic use ; Carmustine/therapeutic use ; Chemoradiotherapy/methods ; Cisplatin/therapeutic use ; Cohort Studies ; Cytarabine/therapeutic use ; Dacarbazine/therapeutic use ; Dexamethasone/therapeutic use ; Doxorubicin/therapeutic use ; Etoposide/therapeutic use ; Female ; Hodgkin Disease/pathology ; Hodgkin Disease/therapy ; Humans ; Ifosfamide/therapeutic use ; Male ; Mediastinal Neoplasms/pathology ; Mediastinal Neoplasms/therapy ; Melphalan/therapeutic use ; Methylprednisolone/therapeutic use ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/therapy ; Neoplasm Staging ; Retrospective Studies ; Stem Cell Transplantation/methods ; Transplantation, Autologous ; Treatment Outcome ; Vinblastine/therapeutic use ; Young Adult
Chemical Substances	Cytarabine (04079A1RDZ) ; Bleomycin (11056-06-7) ; Vinblastine (5V9KLZ54CY) ; Etoposide (6PLQ3CP4P3) ; Dacarbazine (7GR28W0FJI) ; Dexamethasone (7S5I7G3JQL) ; Doxorubicin (80168379AG) ; Carboplatin (BG3F62OND5) ; Cisplatin (Q20Q21Q62J) ; Melphalan (Q41OR9510P) ; Carmustine (U68WG3173Y) ; Ifosfamide (UM20QQM95Y) ; Methylprednisolone (X4W7ZR7023)
Language	English
Publishing date	2015-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	604536-4
ISSN	1537-453X ; 0277-3732
ISSN (online)	1537-453X
ISSN	0277-3732
DOI	10.1097/COC.0b013e3182880b9f
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Article: Fine needle aspiration cytology of adenoid cystic carcinoma of the breast.

Soyuer, Isin / Soyuer, Serdar / Canoz, Ozlem / Er, Ozlem / Arýtap, Yücel

Cytopathology : official journal of the British Society for Clinical Cytology

2002 Volume 13, Issue 3, Page(s) 177–179

MeSH term(s)	Actins/analysis ; Aged ; Biomarkers, Tumor/analysis ; Biopsy, Needle ; Breast Neoplasms/chemistry ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Carcinoma, Adenoid Cystic/chemistry ; Carcinoma, Adenoid Cystic/pathology ; Carcinoma, Adenoid Cystic/surgery ; Female ; Humans ; Keratins/analysis ; Mastectomy, Modified Radical ; S100 Proteins/analysis
Chemical Substances	Actins ; Biomarkers, Tumor ; S100 Proteins ; Keratins (68238-35-7)
Language	English
Publishing date	2002-05-31
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	1034190-0
ISSN	1365-2303 ; 0956-5507 ; 1350-4037
ISSN (online)	1365-2303
ISSN	0956-5507 ; 1350-4037
DOI	10.1046/j.1365-2303.2002.t01-1-00381.x
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Article ; Online: Protective effects of caffeic acid phenethyl ester on radiation induced lung injury in rats.

Yildiz, Oguz Galip / Soyuer, Serdar / Saraymen, Recep / Eroglu, Celalettin

Clinical and investigative medicine. Medecine clinique et experimentale

2008 Volume 31, Issue 5, Page(s) E242–7

Abstract: Purpose: The prevention of radiation-induced pulmonary toxicity may help to improve radiation therapy in the cancer patient. The aim of this study was to investigate the pulmonary protective effects of caffeic acid phenethyl ester (CAPE), an antioxidant, ...

Abstract	Purpose: The prevention of radiation-induced pulmonary toxicity may help to improve radiation therapy in the cancer patient. The aim of this study was to investigate the pulmonary protective effects of caffeic acid phenethyl ester (CAPE), an antioxidant, on radiation-induced lung injury in rats. Methods: 30 Wistar albino rats were divided into three groups and treated with saline, Radiation (RT) and RT + CAPE respectively. All rats were treated with CAPE (50 ?mol/kg i.p.) or saline. The first dose of CAPE was injected 24 h before radiation and application continued daily, with radiation in second day and 2 days more after the radiation treatment. Radiation dose was 800 cGy for total body. At 72 hr after the last radiation application, under general anesthesia using ip ketamine, the lungs were removed immediately after decapitation. After sacrification, antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) activities and malondiadehyde (MDA) levels were evaluated in lung tissue. Results: The level of malondialdehyde (MDA) was higher in the RT group (233.4+/-1.5 nmol/g protein) than in both the control (131.8+/-0.92) and the RT + CAPE (151.4+/-1.8) groups (P < 0.001). However, CAT activity was decreased in the RT group (7.26+/-0.27 U mg protein) compared with control (8.49+/-0.51) and increased again in the RT + CAPE group (8.31+/-0.56; P < 0.001). In accord with CAT activity, SOD activity in the RT group (0.42+/-0.07 nmol MDA/g wet tissue) was different from the control (0.78+/-0.02) and RT + CAPE (0.86+/-0.06) groups (P < 0.001). Conclusion: CAPE application with radiation therapy attenuated radiation induced pulmonary injury in vivo, possibly by its antioxidant effect.
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Caffeic Acids/pharmacology ; Gamma Rays/adverse effects ; Lung/metabolism ; Lung Injury/metabolism ; Lung Injury/prevention & control ; Male ; Malondialdehyde/metabolism ; Phenylethyl Alcohol/analogs & derivatives ; Phenylethyl Alcohol/pharmacology ; Radiation Injuries, Experimental ; Rats ; Superoxide Dismutase/metabolism
Chemical Substances	Antioxidants ; Caffeic Acids ; Malondialdehyde (4Y8F71G49Q) ; Superoxide Dismutase (EC 1.15.1.1) ; caffeic acid phenethyl ester (G960R9S5SK) ; Phenylethyl Alcohol (ML9LGA7468)
Language	English
Publishing date	2008-10-01
Publishing country	Canada
Document type	Journal Article
ZDB-ID	434004-8
ISSN	1488-2353 ; 0147-958X
ISSN (online)	1488-2353
ISSN	0147-958X
DOI	10.25011/cim.v31i5.4870
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