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  1. Article ; Online: Choroidal Thickness Influences Near-Infrared Reflectance Intensity in Eyes With Geographic Atrophy Due To Age-Related Macular Degeneration.

    Dolz-Marco, Rosa / Gal-Or, Orly / Freund, K Bailey

    Investigative ophthalmology & visual science

    2016  Volume 57, Issue 14, Page(s) 6440–6446

    Abstract: ... NIR) scanning laser ophthalmoscopy in eyes with geographic atrophy (GA) secondary to non-neovascular ... fundus photography, fundus autofluorescence, NIR, and structural spectral-domain ... performed to model the relationship between mean NIR gray scale value and retinal and choroidal thickness ...

    Abstract Purpose: To evaluate the effects of retinal and choroidal thickness on near-infrared reflectance (NIR) scanning laser ophthalmoscopy in eyes with geographic atrophy (GA) secondary to non-neovascular age-related macular degeneration (AMD).
    Methods: This was a cross-sectional review of the clinical records and multimodal imaging data of eyes diagnosed with GA secondary to non-neovascular AMD. Imaging modalities included color fundus photography, fundus autofluorescence, NIR, and structural spectral-domain optical coherence tomography (SD-OCT). On SD-OCT images, the foveal retina thickness and the subfoveal choroidal thickness were measured by two independent readers. Near-infrared reflectance intensity within areas of GA was subjectively graded as hyperreflective, isoreflective, or hyporeflective and objectively estimated by using ImageJ to calculate the mean gray scale value within each GA area. A linear regression analysis was performed to model the relationship between mean NIR gray scale value and retinal and choroidal thickness.
    Results: One hundred four eyes of 104 patients with a mean age of 81.3 years (SD: ±8.3) were included. The area of GA was hyperreflective on NIR in 88 eyes (85%), isoreflective in 13 eyes (12%), and hyporeflective in 3 eyes (3%). The mean foveal retinal thickness was 101.5 μm (SD: ±54) showing no significant relationship with mean NIR (P = 0.464); and the mean subfoveal choroidal thickness was 172.6 μm (SD: ±114.7) showing a statistically significant relationship with mean NIR intensity in the linear regression analysis (r = 0.590; r2 = 0.348; P < 0.00001).
    Conclusions: Variations in choroidal thickness appear to influence NIR intensity in areas of GA and have the potential to affect image interpretation. The recognition of this relationship may provide useful information regarding choroidal thickness.
    MeSH term(s) Aged ; Aged, 80 and over ; Choroid/pathology ; Cross-Sectional Studies ; Female ; Fluorescein Angiography/methods ; Fundus Oculi ; Geographic Atrophy/diagnosis ; Geographic Atrophy/etiology ; Humans ; Macular Degeneration/complications ; Macular Degeneration/diagnosis ; Male ; Middle Aged ; Multimodal Imaging/methods ; Ophthalmoscopy ; Retina/pathology ; Severity of Illness Index ; Tomography, Optical Coherence/methods ; Visual Acuity
    Language English
    Publishing date 2016-11-01
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.16-20265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Intralesional cryosurgery for the treatment of severe stoma hypergranulation following percutaneous endoscopic gastrostomy.

    Gal-or, Nir / Gil, Tamir / Metanes, Issa / Nashshibi, Munir / Bryzgalin, Leonid / Amir, Aharon / Har-Shai, Yaron

    The Israel Medical Association journal : IMAJ

    2015  Volume 17, Issue 4, Page(s) 251–252

    MeSH term(s) Child ; Cryosurgery/methods ; Ectodermal Dysplasia/surgery ; Facies ; Failure to Thrive/surgery ; Gastrostomy/adverse effects ; Gastrostomy/methods ; Granulation Tissue/pathology ; Granulation Tissue/surgery ; Heart Defects, Congenital/surgery ; Humans ; Injections, Intralesional ; Male ; Postoperative Complications/pathology ; Postoperative Complications/surgery ; Treatment Outcome
    Language English
    Publishing date 2015-04
    Publishing country Israel
    Document type Case Reports ; Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Intralesional cryosurgery for the treatment of basal cell carcinoma of the lower extremities in elderly subjects: a feasibility study.

    Har-Shai, Yaron / Sommer, Adir / Gil, Tamir / Krausz, Judit / Gal-Or, Nir / Mettanes, Issa / Lavi, Idit / Eyal, Nir / Brizgalin, Leonid / Taran, Amir / Har-Shai, Lior / Elmalach, Irit

    International journal of dermatology

    2016  Volume 55, Issue 3, Page(s) 342–350

    Abstract: ... eight patients aged >60 years in whom a total of 10 nodular or superficial BCCs of the lower limbs were ... destruction of the tumor. There was no evidence of wound infection or tumor recurrence over a follow-up period ...

    Abstract Background: Incidences of basal cell carcinoma (BCC) on the lower extremities in elderly patients are rising. Surgical approaches to the treatment of BCC are subject to possible difficulties in healing, failure of skin grafts, and wound infection. This study assessed the efficacy of intralesional cryosurgery in the treatment of BCC of the lower limbs in elderly patients.
    Methods: This study included eight patients aged >60 years in whom a total of 10 nodular or superficial BCCs of the lower limbs were confirmed by biopsy. The patients' medical histories revealed comorbidities including hypertension, diabetes, hypercholesterolemia, venous insufficiency, and deep vein thrombosis of the legs, congestive heart failure, chronic renal failure, and ischemic heart disease. Using liquid nitrogen, an intralesional cryosurgery needle (CryoShape) was inserted into the tumor to facilitate its complete freezing. Treatment success was confirmed by biopsy taken approximately 3 months after complete healing of the cryo-wound.
    Results: The average size of the lesions treated was 2.49 cm(2) (16.4 × 15.2 mm). Mean recovery time was 79.9 days. Biopsies were obtained at a mean of 85.3 days after the wound had healed. All 10 biopsies verified the complete destruction of the tumor. There was no evidence of wound infection or tumor recurrence over a follow-up period of 28 months.
    Conclusions: This study demonstrates that a single intralesional cryosurgery session can completely eradicate BCC on the lower extremities in elderly patients. This technique is associated with relatively minor complications, is well tolerated, and represents a safe and effective therapeutic modality for BCC of the lower limbs.
    MeSH term(s) Aged ; Aged, 80 and over ; Biopsy ; Carcinoma, Basal Cell/pathology ; Carcinoma, Basal Cell/surgery ; Cryosurgery/adverse effects ; Cryosurgery/methods ; Feasibility Studies ; Female ; Humans ; Lower Extremity ; Male ; Pain/etiology ; Prospective Studies ; Skin/pathology ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2016-03
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.13168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Triage performance in adolescent patients with SARS-CoV-2 infection in Israel.

    Levy, Nitai / Friedman, Nir / Kaplan, Or / Padeh, Gabi / Krupik, Danna / Buchshtav, Nachshon / Gamsu, Shirly / Weiser, Giora / Cohen, Naama Kuchinski / Schnapp, Zeev / Cohen, Noy / Koppel, Jordanna H / Porat, Danit / Gal, Moran / Gleyzer, Alexandra / Capua, Tali / Chistyakov, Irena / Shavit, Itai

    The American journal of emergency medicine

    2022  Volume 59, Page(s) 70–73

    Abstract: Objective: The aim of this study was to assess the performance of the Pediatric Canadian Triage and Acuity Scale (PaedCTAS) in adolescent patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.: Methods: A time-series ... ...

    Abstract Objective: The aim of this study was to assess the performance of the Pediatric Canadian Triage and Acuity Scale (PaedCTAS) in adolescent patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
    Methods: A time-series study was conducted in the Emergency Departments (EDs) of 17 public hospitals during the Delta (B.1.617.2) variant spread in Israel. Data were collected prospectively from June 11, 2021 to August 15, 2021. Multivariate regression analyses were performed to identify independent variables associated with hospital admission and with admission to an Intensive Care Unit (ICU).
    Results: During the study period, 305 SARS-CoV-2 patients ages 12-18 years presenting to the ED were included, and 267 (87.5%) were unvaccinated. Sixty-seven (22.0%) and 12 (3.9%) patients were admitted to pediatric wards and ICUs, respectively. PaedCTAS level 1-2 and the presence of chronic disease increased the odds of hospital admission (adjusted odds ratio (aOR) 5.74, 95% CI, 2.30-14.35, p < 0.0001), and (aOR 2.9, 95% CI, 1.48-5.67, p < 0.02), respectively. PaedCTAS level 1-2 and respiratory symptoms on presentation to ED increased the odds of ICU admission (aOR 27.79; 95% CI, 3.85-176.91, p < 0.001), and (aOR 26.10; 95% CI, 4.47-172.63, p < 0.0001), respectively. PaedCTAS level 3-5 was found in 217/226 (96%) of the patients who were discharged home from the ED.
    Conclusions: The findings suggest that PaedCTAS level 1-2 was the strongest factor associated with hospital and ICU admission. Almost all the patients who were discharged home had PaedCTAS level 3-5. Study findings suggest good performance of the PaedCTAS in this cohort.
    MeSH term(s) Adolescent ; COVID-19/epidemiology ; COVID-19/therapy ; Canada ; Child ; Humans ; Intensive Care Units ; Israel/epidemiology ; Retrospective Studies ; SARS-CoV-2 ; Triage
    Language English
    Publishing date 2022-07-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2022.06.061
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  5. Article ; Online: Pediatric Hospitalizations After School Reopening During the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Alpha (B.1.1.7) Variant Spread: A Multicenter Cross-sectional Study in Israel.

    Friedman, Nir / Levy, Nitai / Kaplan, Or / Padeh, Gabi / Krupik, Danna / Jacob, Ron / Gamsu, Shirly / Weiser, Giora / Cohen, Naama Kuchinski / Schnapp, Zeev / Cohen, Noy / Feldman, Oren / Porat, Danit / Gal, Moran / Gleyzer, Alexandra / Capua, Tali / Klein, Adi / Sharkansky, Livnat / Shilo, Smadar /
    Grotto, Itamar / Kozer, Eran / Shavit, Itai

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 75, Issue 1, Page(s) e300–e302

    Abstract: This multicenter, cross-sectional study provides evidence on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated emergency department visits and hospitalizations in pediatric wards and intensive care units after school reopening ... ...

    Abstract This multicenter, cross-sectional study provides evidence on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated emergency department visits and hospitalizations in pediatric wards and intensive care units after school reopening during the SARS-CoV-2 Alpha (B.1.1.7) variant spread in Israel. Study findings suggest that school reopening was not followed by an increase in SARS-CoV-2-related pediatric morbidity.
    MeSH term(s) COVID-19/epidemiology ; Child ; Cross-Sectional Studies ; Hospitalization ; Humans ; Israel/epidemiology ; SARS-CoV-2/genetics ; Schools
    Language English
    Publishing date 2022-01-28
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac065
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  6. Article: [TURNOVER CAPSULAR FLAPS FOR THE TREATMENT OF IMPENDING EXTRUSION OF SILICONE PROSTHESIS IN RECONSTRUCTED BREASTS].

    Eyal, Nir / Mattanes, Issa / Or, Nir Gal / BrizgaLin, Lionid / Amir, Aharon / Gil, Tamir / Bitterman, Arie / Hanna-Zaknun, Rene / Har-Shai, Yaron

    Harefuah

    2015  Volume 154, Issue 9, Page(s) 591–3, 607

    Abstract: Pressure necrosis which might be followed by skin necrosis and implant extrusion is a dreaded complication of breast reconstructive surgery. Over the years, several techniques have been introduced to address this challenging problem. We offer a novel ... ...

    Abstract Pressure necrosis which might be followed by skin necrosis and implant extrusion is a dreaded complication of breast reconstructive surgery. Over the years, several techniques have been introduced to address this challenging problem. We offer a novel surgical technique to confront this perplexing complication. By using the capsule of the implant as a turnover flap, the soft tissue coverage is enhanced thereby decreasing the pressure between the breast prosthesis and the over-laying skin. The technique is simply reproduced, requires no new incisions, and avoids further morbidity to the involved breast reconstructed patient.
    MeSH term(s) Breast Implantation/adverse effects ; Breast Implantation/methods ; Breast Implants/adverse effects ; Female ; Humans ; Mammaplasty/methods ; Middle Aged ; Necrosis ; Silicone Gels ; Surgical Flaps
    Chemical Substances Silicone Gels
    Language Hebrew
    Publishing date 2015-09
    Publishing country Israel
    Document type Case Reports ; English Abstract ; Journal Article ; Review
    ZDB-ID 953872-0
    ISSN 0017-7768
    ISSN 0017-7768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Frequent misdiagnosis of adult polyglucosan body disease.

    Hellmann, Mark A / Kakhlon, Or / Landau, Ezekiel H / Sadeh, Menachem / Giladi, Nir / Schlesinger, Ilana / Kidron, Daphne / Abramsky, Oded / Reches, Avinoam / Argov, Zohar / Rabey, Jose M / Chapman, Joab / Rosenmann, Hanna / Gal, Aya / Moshe Gomori, J / Meiner, Vardiella / Lossos, Alexander

    Journal of neurology

    2015  Volume 262, Issue 10, Page(s) 2346–2351

    Abstract: ... with bladder dysfunction (47 %), gait problems (33 %) or both. Diagnosis of APBD was delayed by 6.8 (±4.8 ... years. Consistent signs at diagnosis were spasticity in the legs (93 %), decreased or absent ankle ... not respond to medical treatment or prostatectomy. These findings suggest that despite limited ...

    Abstract Adult polyglucosan body disease (APBD) is a rare glycogenosis manifesting progressive spastic paraparesis, sensorimotor polyneuropathy and neurogenic bladder. Misdiagnosis of APBD may lead to unnecessary investigations and to potentially harmful therapeutic interventions. To examine the frequency of misdiagnosis of APBD, we retrospectively reviewed the clinical data of 30 patients diagnosed between 1991 and 2013. Diagnosis was based on the combination of typical clinical and imaging findings, reduced glycogen branching enzyme activity, and the presence of p.Y326S GBE1 mutation. Initial symptoms started in the 5th-6th decade with bladder dysfunction (47 %), gait problems (33 %) or both. Diagnosis of APBD was delayed by 6.8 (±4.8) years. Consistent signs at diagnosis were spasticity in the legs (93 %), decreased or absent ankle reflexes (100 %), bilateral extensor plantar response (100 %) and distal sensory deficit (80 %). Nerve conduction study showed invariable sensorimotor polyneuropathy, and MRI demonstrated cervical spinal cord atrophy (100 %) and leukoencephalopathy (97 %). All 30 patients were initially misdiagnosed. Common misdiagnoses included cerebral small vessel disease (27 %), multiple sclerosis (17 %), amyotrophic lateral sclerosis (17 %) and peripheral neuropathies (20 %). Consequently, 27 % received inappropriate therapy. In addition, lower urinary tract symptoms in 60 % of men were attributed solely to prostatic disorders but did not respond to medical treatment or prostatectomy. These findings suggest that despite limited clinical variability, APBD is invariably misdiagnosed and patients are often mistreated. Physicians' unfamiliarity with the typical clinical and imaging features of APBD appears as the main reason for misdiagnosis.
    MeSH term(s) Adult ; Aged ; Delayed Diagnosis ; Diagnostic Errors ; Female ; Glycogen Storage Disease/diagnosis ; Glycogen Storage Disease/therapy ; Humans ; Male ; Middle Aged ; Nervous System Diseases/diagnosis ; Nervous System Diseases/therapy ; Retrospective Studies
    Language English
    Publishing date 2015-10
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-015-7859-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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