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Article ; Online: Clinicopathological Features of Three Rare

Kosemehmetoglu, Kemal / Rekhi, Bharat / Erdem, Zeynep Betul / Yildiz, Adalet Elcin / Comunoglu, Nil

International journal of surgical pathology

2024 , Page(s) 10668969241228294

Abstract: Certain undifferentiated round cell sarcomas ... ...

Abstract	Certain undifferentiated round cell sarcomas displaying
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1336393-1
ISSN	1940-2465 ; 1066-8969
ISSN (online)	1940-2465
ISSN	1066-8969
DOI	10.1177/10668969241228294
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Article ; Online: Atypical medial femoral condylar fracture in Stuve-Wiedemann syndrome.

Ozkale Yavuz, Ozlem / Yildiz, Adalet Elcin / Aydingoz, Ustun

Clinical dysmorphology

2021 Volume 31, Issue 1, Page(s) 28–30

MeSH term(s)	Bone and Bones ; Exostoses, Multiple Hereditary ; Humans ; Osteochondrodysplasias
Language	English
Publishing date	2021-10-30
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1121482-x
ISSN	1473-5717 ; 0962-8827
ISSN (online)	1473-5717
ISSN	0962-8827
DOI	10.1097/MCD.0000000000000400
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Article ; Online: Case Report: Imaging-Guided Percutaneous Catheterization and Microwave Ablation of a Bone Hydatid Cyst with Soft-Tissue Component.

Akhan, Okan / Yildiz, Oguzhan / Unal, Emre / Yildiz, Adalet Elcin / Ciftci, Turkmen Turan / Akinci, Devrim

The American journal of tropical medicine and hygiene

2022

Abstract: Cystic echinococcosis (CE) of the bone is a rare disease compared with CE of the viscera, and the most involved bony structures are the spine and the pelvis. Both the diagnosis and the treatment of bone CE are challenging for several reasons. The ... ...

Abstract	Cystic echinococcosis (CE) of the bone is a rare disease compared with CE of the viscera, and the most involved bony structures are the spine and the pelvis. Both the diagnosis and the treatment of bone CE are challenging for several reasons. The combination of surgery and antimicrobial therapy is the most common approach, the results are far from adequate. Luckily, percutaneous treatment has appeared on the horizon for bone lesions as a more practical option with fewer drawbacks in light of current reports. This article deals with the successful result of ablation-assisted percutaneous treatment of a bone CE lesion and a soft tissue CE lesion treated by modified catheterization technique in a male patient with left hip pain that was unresponsive to previous surgery for CE.
Language	English
Publishing date	2022-07-25
Publishing country	United States
Document type	Case Reports
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.22-0066
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Article ; Online: MRI in the Diagnosis and Treatment Response Assessment of Chronic Nonbacterial Osteomyelitis in Children and Adolescents.

Aydıngöz, Üstün / Yıldız, Adalet Elçin

Current rheumatology reports

2022 Volume 24, Issue 2, Page(s) 27–39

Abstract: Purpose of review: To explain the central role of magnetic resonance imaging (MRI) in the diagnosis and follow-up of chronic nonbacterial osteomyelitis (CNO) in children and adolescents, centering on practical technical aspects and salient diagnostic ... ...

Abstract	Purpose of review: To explain the central role of magnetic resonance imaging (MRI) in the diagnosis and follow-up of chronic nonbacterial osteomyelitis (CNO) in children and adolescents, centering on practical technical aspects and salient diagnostic features. Recent findings: In the absence of conclusive clinical features and widely accepted laboratory tests, including validated disease biomarkers, MRI (whether targeted or covering the entire body) currently plays an indispensable role in the diagnosis and therapy response assessment of CNO. Whole-body MRI, which is the reference imaging standard for CNO, can be limited to a short tau inversion recovery (STIR) coronal image set covering the entire body and a STIR sagittal set covering the spine, an approximately 30-min examination with no need for intravenous contrast or diffusion-weighted imaging. The hallmark of CNO is periphyseal (metaphyseal and/or epi-/apophyseal) osteitis, identified as bright foci on STIR, with or without inflammation of the adjacent periosteum and surrounding soft tissue. Response to bisphosphonate treatment for CNO has some unique MRI findings that should not be mistaken for residual or relapsing disease. Diagnostic features and treatment response characteristics of MRI in pediatric CNO are discussed, also describing the techniques used, pitfalls encountered, and differential diagnostic possibilities considered during daily practice.
MeSH term(s)	Adolescent ; Child ; Chronic Disease ; Diphosphonates/therapeutic use ; Graft vs Host Disease/drug therapy ; Humans ; Magnetic Resonance Imaging/methods ; Osteomyelitis/diagnostic imaging ; Osteomyelitis/drug therapy ; Whole Body Imaging/methods
Chemical Substances	Diphosphonates
Language	English
Publishing date	2022-02-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057357-1
ISSN	1534-6307 ; 1523-3774
ISSN (online)	1534-6307
ISSN	1523-3774
DOI	10.1007/s11926-022-01053-x
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Zs.A 5531: Show issues

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Article ; Online: Subclinical enthesitis in enthesitis-related arthritis and sacroiliitis associated with familial Mediterranean fever.

Sener, Seher / Atalay, Erdal / Yildiz, Adalet Elcin / Kasap Cuceoglu, Muserref / Basaran, Ozge / Batu, Ezgi Deniz / Bilginer, Yelda / Ozen, Seza

Modern rheumatology

2023 Volume 34, Issue 3, Page(s) 607–613

Abstract: Objectives: In our study, we investigated the presence of subclinical enthesitis by ultrasonography (US) in asymptomatic patients with enthesitis-related arthritis (ERA) and sacroiliitis associated with familial Mediterranean fever (FMF).: Methods: A ...

Abstract	Objectives: In our study, we investigated the presence of subclinical enthesitis by ultrasonography (US) in asymptomatic patients with enthesitis-related arthritis (ERA) and sacroiliitis associated with familial Mediterranean fever (FMF). Methods: A total of 50 patients, including 35 patients with ERA and 15 with sacroiliitis associated with FMF, were included in the study. All patients were evaluated with US by a paediatric radiologist. Enthesis of seven tendons (common extensor and flexor tendons, quadriceps tendon, proximal and distal patellar tendon, Achilles tendon, and plantar fascia) was examined on both sides. Results: Subclinical enthesitis was detected in 10 ERA (28.5%) and three FMF (20%) patients. Enthesitis was radiologically diagnosed in 16 (2.3%) out of 700 evaluated entheseal sites. The most frequent sites of enthesitis were Achilles (37.5%) and quadriceps (31.3%) tendons. All patients were in clinical remission and had no active complaints, and acute phase reactants were within normal limits. Therefore, the patients were followed up without treatment change. However, disease flare-up was observed in three of these patients (23.1%) during the follow-up, and their treatments were intensified. Conclusions: Our results showed that the US can be particularly helpful in detecting subclinical enthesitis and predicting disease flare-ups.
MeSH term(s)	Child ; Humans ; Sacroiliitis/complications ; Sacroiliitis/diagnostic imaging ; Familial Mediterranean Fever/complications ; Familial Mediterranean Fever/diagnostic imaging ; Symptom Flare Up ; Enthesopathy/complications ; Enthesopathy/diagnostic imaging ; Arthritis, Juvenile/complications ; Achilles Tendon/diagnostic imaging
Language	English
Publishing date	2023-05-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2078157-X
ISSN	1439-7609 ; 1439-7595
ISSN (online)	1439-7609
ISSN	1439-7595
DOI	10.1093/mr/road053
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Article ; Online: Adamantinoma with a Prominent Spindle Cell Component Mimicking Intraosseous Synovial Sarcoma: Clinicopathological Features of Six Tumors.

Rekhi, Bharat / Yildiz, Adalet Elcin / Jennifer, Anne / Yukruk, Fisun Ardic / Gedikoglu, Gokhan / Banerjee, Devmalya / Shetty, Omshree / Kosemehmetoglu, Kemal

International journal of surgical pathology

2022 Volume 30, Issue 8, Page(s) 872–884

Abstract: Introduction. ...

Abstract	Introduction.
MeSH term(s)	Male ; Female ; Humans ; Sarcoma, Synovial/diagnosis ; Sarcoma, Synovial/genetics ; Sarcoma, Synovial/pathology ; Adamantinoma/diagnosis ; Adamantinoma/genetics ; Adamantinoma/pathology ; Biomarkers, Tumor/metabolism ; Proto-Oncogene Proteins/genetics ; Repressor Proteins/genetics ; Ameloblastoma ; Oncogene Proteins, Fusion/genetics
Chemical Substances	Biomarkers, Tumor ; Proto-Oncogene Proteins ; Repressor Proteins ; Oncogene Proteins, Fusion
Language	English
Publishing date	2022-08-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1336393-1
ISSN	1940-2465 ; 1066-8969
ISSN (online)	1940-2465
ISSN	1066-8969
DOI	10.1177/10668969221117977
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Article ; Online: A Child with Refractory and Relapsing Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Myopathy: Case-Based Review.

Sener, Seher / Batu, Ezgi Deniz / Sari, Seher / Kasap Cuceoglu, Muserref / Yildiz, Adalet Elcin / Talim, Beril / Aydingoz, Ustun / Ozen, Seza / Haliloglu, Goknur

Journal of neuromuscular diseases

2023 Volume 10, Issue 2, Page(s) 279–291

Abstract: Background/objective: Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) myopathy is rare in children. Here, we present a boy with relapsing refractory anti-HMGCR myopathy along with a systematic literature review.: Case report: 17- ... ...

Abstract	Background/objective: Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) myopathy is rare in children. Here, we present a boy with relapsing refractory anti-HMGCR myopathy along with a systematic literature review. Case report: 17-year-old boy with five years of muscle weakness, rash, high creatinine kinase (CK) levels, and muscle biopsy compatible with inflammatory myopathy was diagnosed with juvenile dermatomyositis. He was treated with corticosteroids, intravenous immunoglobulin (IVIG), and methotrexate. His muscle weakness improved with this treatment although never completely resolved. CK levels decreased from ∼15000 U/L to ∼3000 U/L. At the age of 15, muscle weakness relapsed after an upper respiratory tract infection; pulse corticosteroid treatment was administered. The re-evaluated muscle biopsy showed a necrotizing pattern and the HMGCR antibody was positive confirming anti-HMGCR myopathy when he was 16. The diagnostic delay was 50 months. Disease activity was monitored by Medical Research Council score, MRI and functional tests. Despite corticosteroids, methotrexate, IVIG, cyclosporine A, and rituximab therapies, muscle weakness improved only slightly during the first three months and remained stable afterwards.Results of the Literature Search:We identified 16 articles describing 50 children (76% female) with anti-HMGCR myopathy by reviewing the English literature up to March 1st, 2022. Proximal muscle weakness was the most common clinical symptom (70.8%). Corticosteroids (84.8%), IVIG (58.7%), and methotrexate (56.5%) were preferred in most cases. Complete remission was achieved in nine patients (28.1%). Conclusion: Diagnosis and management of children with anti-HMGCR myopathy are challenging. Complete remission is achieved in only one third of these patients. Imaging biomarkers may aid treatment.
MeSH term(s)	Male ; Humans ; Child ; Female ; Adolescent ; Oxidoreductases/therapeutic use ; Coenzyme A/therapeutic use ; Immunoglobulins, Intravenous/therapeutic use ; Methotrexate/therapeutic use ; Delayed Diagnosis ; Autoantibodies ; Muscular Diseases/pathology ; Muscle Weakness
Chemical Substances	Oxidoreductases (EC 1.-) ; Coenzyme A (SAA04E81UX) ; Immunoglobulins, Intravenous ; Methotrexate (YL5FZ2Y5U1) ; Autoantibodies
Language	English
Publishing date	2023-01-22
Publishing country	Netherlands
Document type	Systematic Review ; Case Reports ; Journal Article
ISSN	2214-3602
ISSN (online)	2214-3602
DOI	10.3233/JND-221557
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Article ; Online: Two siblings with Majeed syndrome and neutropenia.

Kasap Cuceoglu, Muserref / Batu, Ezgi Deniz / Yildiz, Adalet Elcin / Kaya Akca, Ummusen / Atalay, Erdal / Sener, Seher / Balik, Zeynep / Basaran, Ozge / Bilginer, Yelda / Ozen, Seza

Archives of rheumatology

2022 Volume 37, Issue 4, Page(s) 638–640

Language	English
Publishing date	2022-09-20
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	3012972-2
ISSN	2618-6500 ; 2148-5046
ISSN (online)	2618-6500
ISSN	2148-5046
DOI	10.46497/ArchRheumatol.2022.9437
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Article ; Online: Glenoid Track Assessment at Imaging in Anterior Shoulder Instability: Rationale and Step-by-Step Guide.

Aydıngöz, Üstün / Yıldız, Adalet Elçin / Huri, Gazi

Radiographics : a review publication of the Radiological Society of North America, Inc

2023 Volume 43, Issue 8, Page(s) e230030

Abstract: Anterior shoulder dislocation is the most common form of joint instability in humans, usually resulting in soft-tissue injury to the glenohumeral capsuloligamentous and labral structures. Bipolar bone lesions in the form of fractures of the anterior ... ...

Abstract	Anterior shoulder dislocation is the most common form of joint instability in humans, usually resulting in soft-tissue injury to the glenohumeral capsuloligamentous and labral structures. Bipolar bone lesions in the form of fractures of the anterior glenoid rim and posterolateral humeral head are often associated with anterior shoulder dislocation and can be a cause or result of recurrent dislocations. Glenoid track assessment is an evolving concept that incorporates the pathomechanics of anterior shoulder instability into its management. Currently widely endorsed by orthopedic surgeons, this concept has ramifications for prognostication, treatment planning, and outcome assessment of anterior shoulder dislocation. The glenoid track is the contact zone between the humeral head and glenoid during shoulder motion from the neutral position to abduction and external rotation. Two key determinants of on-track or off-track status of a Hill-Sachs lesion (HSL) are the glenoid track width (GTW) and Hill-Sachs interval (HSI). If the GTW is less than the HSI, an HSL is off track. If the GTW is greater than the HSI, an HSL is on track. The authors focus on the rationale behind the glenoid track concept and explain stepwise assessment of the glenoid track at CT or MRI. Off-track to on-track conversion is a primary goal in stabilizing the shoulder with anterior instability. The key role that imaging plays in glenoid track assessment warrants radiologists' recognition of this concept along with its challenges and pitfalls and the production of relevant and actionable radiology reports for orthopedic surgeons-to the ultimate benefit of patients.
MeSH term(s)	Humans ; Shoulder Dislocation/diagnostic imaging ; Shoulder Dislocation/complications ; Shoulder Dislocation/pathology ; Shoulder Joint/diagnostic imaging ; Shoulder Joint/surgery ; Joint Instability/diagnostic imaging ; Shoulder/pathology ; Scapula ; Recurrence
Language	English
Publishing date	2023-07-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.230030
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Zs.A 1751: Show issues

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Article ; Online: Preferential involvement of the pelvis and hips along with active sacroiliitis in chronic nonbacterial osteomyelitis: MRI of 97 patients from a single tertiary referral center.

Aydıngöz, Üstün / Yıldız, Adalet Elçin / Ayaz, Ercan / Batu, Ezgi Deniz / Özen, Seza

European radiology

2024

Abstract: Objective: To present MRI distribution of active osteitis in a single tertiary referral center cohort of patients with chronic nonbacterial osteomyelitis (CNO).: Methods: Two musculoskeletal radiologists retrospectively reviewed MRI examinations of ... ...

Abstract	Objective: To present MRI distribution of active osteitis in a single tertiary referral center cohort of patients with chronic nonbacterial osteomyelitis (CNO). Methods: Two musculoskeletal radiologists retrospectively reviewed MRI examinations of all patients with a final clinical diagnosis of CNO over 15 years. Sites of active osteitis at any time during the course of disease were divided into seven groups: (A) mandible, sternum, clavicles, or scapulas; (B) upper extremities; (C) subchondral sacrum and ilium immediately subjacent to sacroiliac joints (active osteitis denoting "active sacroiliitis" here); (D) pelvis and proximal 1/3 of femurs (excluding group C); (E) bones surrounding knees including distal 2/3 of femurs and 1/2 of proximal tibias and fibulas; (F) distal legs (including distal 1/2 of tibias and fibulas), ankles, or feet; (G) spine (excluding group C). Temporal changes of lesions in response to treatment (or other treatment-related changes such as pamidronate lines) were not within the scope of the study. Results: Among 97 CNO patients (53 males [55%], 44 females; age at onset, mean ± SD, 8.5 ± 3.2 years; age at diagnosis, 10.3 ± 3.3 years), whole-body (WB) MRI was performed in 92%, mostly following an initial targeted MRI (94%). A total of 557 (346 targeted and 211 WB) MRIs were analyzed. Biopsy was obtained in 39 patients (40%), all consistent with CNO or featuring supporting findings. The most common locations for active osteitis were groups D (78%; 95% CI 69‒85%) and C (72%; 95% CI 62‒80%). Conclusion: Pelvis and hips were preferentially involved in this cohort of CNO patients along with a marked presence of active sacroiliitis. Clinical relevance statement: When suggestive findings of CNO are identified elsewhere in the body, the next targeted site of MRI should be the pelvis (entirely including sacroiliac joints) and hips, if whole-body MRI is not available or feasible. Key points: • Heavy reliance on MRI for diagnosis of CNO underscores the importance of suggestive distribution patterns. • Pelvis and hips are the most common (78%) sites of CNO involvement along with active sacroiliitis (72%). • Pelvis including sacroiliac joints and hips should be targeted on MRI when CNO is suspected.
Language	English
Publishing date	2024-01-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-023-10558-7
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