LIVIVO - Search results -

Search results

Result 1 - 10 of total 18

Search options

Article ; Online: Sensing the world and its dangers: An evolutionary perspective in neuroimmunology.

Kraus, Aurora / Buckley, Katherine M / Salinas, Irene

2021 Volume 10

Abstract: Detecting danger is key to the survival and success of all species. Animal nervous and immune systems cooperate to optimize danger detection. Preceding studies have highlighted the benefits of bringing neurons into the defense game, including regulation ... ...

Abstract	Detecting danger is key to the survival and success of all species. Animal nervous and immune systems cooperate to optimize danger detection. Preceding studies have highlighted the benefits of bringing neurons into the defense game, including regulation of immune responses, wound healing, pathogen control, and survival. Here, we summarize the body of knowledge in neuroimmune communication and assert that neuronal participation in the immune response is deeply beneficial in each step of combating infection, from inception to resolution. Despite the documented tight association between the immune and nervous systems in mammals or invertebrate model organisms, interdependence of these two systems is largely unexplored across metazoans. This review brings a phylogenetic perspective of the nervous and immune systems in the context of danger detection and advocates for the use of non-model organisms to diversify the field of neuroimmunology. We identify key taxa that are ripe for investigation due to the emergence of key evolutionary innovations in their immune and nervous systems. This novel perspective will help define the primordial principles that govern neuroimmune communication across taxa.
MeSH term(s)	Animals ; Biological Evolution ; Immune System/physiology ; Nervous System/immunology ; Neuroimmunomodulation ; Phylogeny
Language	English
Publishing date	2021-04-26
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.66706
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Sensing the world and its dangers

Aurora Kraus / Katherine M Buckley / Irene Salinas

eLife, Vol

An evolutionary perspective in neuroimmunology

2021 Volume 10

Abstract	Detecting danger is key to the survival and success of all species. Animal nervous and immune systems cooperate to optimize danger detection. Preceding studies have highlighted the benefits of bringing neurons into the defense game, including regulation of immune responses, wound healing, pathogen control, and survival. Here, we summarize the body of knowledge in neuroimmune communication and assert that neuronal participation in the immune response is deeply beneficial in each step of combating infection, from inception to resolution. Despite the documented tight association between the immune and nervous systems in mammals or invertebrate model organisms, interdependence of these two systems is largely unexplored across metazoans. This review brings a phylogenetic perspective of the nervous and immune systems in the context of danger detection and advocates for the use of non-model organisms to diversify the field of neuroimmunology. We identify key taxa that are ripe for investigation due to the emergence of key evolutionary innovations in their immune and nervous systems. This novel perspective will help define the primordial principles that govern neuroimmune communication across taxa.
Keywords	immunology ; nervous system ; neuroimmunology ; non-model organisms ; evolution ; metazoans ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Olfactory detection of viruses shapes brain immunity and behavior in zebrafish.

Kraus, Aurora / Garcia, Benjamin / Ma, Jie / Herrera, Kristian J / Zwaka, Hanna / Harpaz, Roy / Wong, Ryan Y / Engert, Florian / Salinas, Irene

bioRxiv : the preprint server for biology

2023

Abstract: Olfactory sensory neurons (OSNs) are constantly exposed to pathogens, including viruses. However, serious brain infection via the olfactory route rarely occurs. When OSNs detect a virus, they coordinate local antiviral immune responses to stop virus ... ...

Abstract	Olfactory sensory neurons (OSNs) are constantly exposed to pathogens, including viruses. However, serious brain infection via the olfactory route rarely occurs. When OSNs detect a virus, they coordinate local antiviral immune responses to stop virus progression to the brain. Despite effective immune control in the olfactory periphery, pathogen-triggered neuronal signals reach the CNS via the olfactory bulb (OB). We hypothesized that neuronal detection of a virus by OSNs initiates neuroimmune responses in the OB that prevent pathogen invasion. Using zebrafish (
Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.03.17.533129
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Intranasal delivery of SARS-CoV-2 spike protein is sufficient to cause olfactory damage, inflammation and olfactory dysfunction in zebrafish.

Kraus, Aurora / Huertas, Mar / Ellis, Laura / Boudinot, Pierre / Levraud, Jean-Pierre / Salinas, Irene

Brain, behavior, and immunity

2022 Volume 102, Page(s) 341–359

Abstract: Anosmia, loss of smell, is a prevalent symptom of SARS-CoV-2 infection. Anosmia may be explained by several mechanisms driven by infection of non-neuronal cells and damage in the nasal epithelium rather than direct infection of olfactory sensory neurons ( ...

Abstract	Anosmia, loss of smell, is a prevalent symptom of SARS-CoV-2 infection. Anosmia may be explained by several mechanisms driven by infection of non-neuronal cells and damage in the nasal epithelium rather than direct infection of olfactory sensory neurons (OSNs). Previously, we showed that viral proteins are sufficient to cause neuroimmune responses in the teleost olfactory organ (OO). We hypothesize that SARS-CoV-2 spike (S) protein is sufficient to cause olfactory damage and olfactory dysfunction. Using an adult zebrafish model, we report that intranasally delivered SARS-CoV-2 S RBD mostly binds to the non-sensory epithelium of the olfactory organ and causes severe olfactory histopathology characterized by loss of cilia, hemorrhages and edema. Electrophysiological recordings reveal impaired olfactory function to both food and bile odorants in animals treated intranasally with SARS-CoV-2 S RBD. However, no loss of behavioral preference for food was detected in SARS-CoV-2 S RBD treated fish. Single cell RNA-Seq of the adult zebrafish olfactory organ indicated widespread loss of olfactory receptor expression and inflammatory responses in sustentacular, endothelial, and myeloid cell clusters along with reduced numbers of T
MeSH term(s)	Animals ; Anosmia ; COVID-19 ; COVID-19 Vaccines ; Humans ; Inflammation/metabolism ; Olfactory Mucosa/metabolism ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/metabolism ; Zebrafish
Chemical Substances	COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-03-17
Publishing country	Netherlands
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2022.03.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2276: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 327: Show issues

Order via subito

Details ▾

Article ; Online: Compartmentalized ocular lymphatic system mediates eye-brain immunity.

Yin, Xiangyun / Zhang, Sophia / Lee, Ju Hyun / Dong, Huiping / Mourgkos, George / Terwilliger, Gordon / Kraus, Aurora / Geraldo, Luiz Henrique / Poulet, Mathilde / Fischer, Suzanne / Zhou, Ting / Mohammed, Farrah Shalima / Zhou, Jiangbing / Wang, Yongfu / Malloy, Seth / Rohner, Nicolas / Sharma, Lokesh / Salinas, Irene / Eichmann, Anne /

Thomas, Jean-Leon / Saltzman, W Mark / Huttner, Anita / Zeiss, Caroline / Ring, Aaron / Iwasaki, Akiko / Song, Eric

Nature

2024 Volume 628, Issue 8006, Page(s) 204–211

Abstract: The eye, an anatomical extension of the central nervous system (CNS), exhibits many molecular and cellular parallels to the brain. Emerging research demonstrates that changes in the brain are often reflected in the eye, particularly in the ... ...

Abstract	The eye, an anatomical extension of the central nervous system (CNS), exhibits many molecular and cellular parallels to the brain. Emerging research demonstrates that changes in the brain are often reflected in the eye, particularly in the retina
MeSH term(s)	Animals ; Female ; Humans ; Male ; Mice ; Rabbits ; Bacteria/immunology ; Brain/anatomy & histology ; Brain/immunology ; Dependovirus/immunology ; Eye/anatomy & histology ; Eye/immunology ; Glioblastoma/immunology ; Herpesvirus 2, Human/immunology ; Intravitreal Injections ; Lymphatic System/anatomy & histology ; Lymphatic System/immunology ; Lymphatic Vessels/anatomy & histology ; Lymphatic Vessels/immunology ; Macaca mulatta ; Meninges/immunology ; Optic Nerve/immunology ; Swine ; Zebrafish ; Vascular Endothelial Growth Factor C/immunology ; Vascular Endothelial Growth Factor C/metabolism ; Vascular Endothelial Growth Factor C/pharmacology
Chemical Substances	Vascular Endothelial Growth Factor C
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-024-07130-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: High-Resolution, 3D Imaging of the Zebrafish Gill-Associated Lymphoid Tissue (GIALT) Reveals a Novel Lymphoid Structure, the Amphibranchial Lymphoid Tissue.

Dalum, Alf S / Kraus, Aurora / Khan, Shanawaz / Davydova, Erna / Rigaudeau, Dimitri / Bjørgen, Håvard / López-Porras, Adrián / Griffiths, Gareth / Wiegertjes, Geert F / Koppang, Erling O / Salinas, Irene / Boudinot, Pierre / Rességuier, Julien

Frontiers in immunology

2021 Volume 12, Page(s) 769901

Abstract: The zebrafish is extensively used as an animal model for human and fish diseases. However, our understanding of the structural organization of its immune system remains incomplete, especially the mucosa-associated lymphoid tissues (MALTs). Teleost MALTs ... ...

Abstract	The zebrafish is extensively used as an animal model for human and fish diseases. However, our understanding of the structural organization of its immune system remains incomplete, especially the mucosa-associated lymphoid tissues (MALTs). Teleost MALTs are commonly perceived as diffuse and scattered populations of immune cells throughout the mucosa. Yet, structured MALTs have been recently discovered in Atlantic salmon (
MeSH term(s)	Animals ; Fish Diseases/pathology ; Gills/anatomy & histology ; Gills/diagnostic imaging ; Gills/immunology ; Imaging, Three-Dimensional/methods ; Lymphoid Tissue/cytology ; Lymphoid Tissue/diagnostic imaging ; Viremia/pathology ; Zebrafish/anatomy & histology ; Zebrafish/immunology
Language	English
Publishing date	2021-11-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.769901
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Olfactory sensory neurons mediate ultrarapid antiviral immune responses in a TrkA-dependent manner.

Sepahi, Ali / Kraus, Aurora / Casadei, Elisa / Johnston, Christopher A / Galindo-Villegas, Jorge / Kelly, Cecelia / García-Moreno, Diana / Muñoz, Pilar / Mulero, Victoriano / Huertas, Mar / Salinas, Irene

Proceedings of the National Academy of Sciences of the United States of America

2019 Volume 116, Issue 25, Page(s) 12428–12436

Abstract: The nervous system regulates host immunity in complex ways. Vertebrate olfactory sensory neurons (OSNs) are located in direct contact with pathogens; however, OSNs' ability to detect danger and initiate immune responses is unclear. We report that nasal ... ...

Abstract	The nervous system regulates host immunity in complex ways. Vertebrate olfactory sensory neurons (OSNs) are located in direct contact with pathogens; however, OSNs' ability to detect danger and initiate immune responses is unclear. We report that nasal delivery of rhabdoviruses induces apoptosis in crypt OSNs via the interaction of the OSN TrkA receptor with the viral glycoprotein in teleost fish. This signal results in electrical activation of neurons and very rapid proinflammatory responses in the olfactory organ (OO), but dampened inflammation in the olfactory bulb (OB). CD8α
MeSH term(s)	Animals ; Apoptosis ; CD8-Positive T-Lymphocytes/immunology ; Caspase 3/metabolism ; Infectious hematopoietic necrosis virus/immunology ; Nasal Mucosa/immunology ; Nasal Mucosa/virology ; Olfactory Receptor Neurons/cytology ; Olfactory Receptor Neurons/physiology ; Olfactory Receptor Neurons/virology ; Oncorhynchus mykiss ; Receptor, trkA/metabolism
Chemical Substances	Receptor, trkA (EC 2.7.10.1) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2019-06-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1900083116
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A zebrafish model for COVID-19 recapitulates olfactory and cardiovascular pathophysiologies caused by SARS-CoV-2

Kraus, Aurora / Casadei, Elisa / Huertas, Mar / Ye, Chunyan / Bradfute, Steven / Boudinot, Pierre / Levraud, Jean-Pierre / Salinas, Irene

bioRxiv

Abstract: The COVID-19 pandemic has prompted the search for animal models that recapitulate the pathophysiology observed in humans infected with SARS-CoV-2 and allow rapid and high throughput testing of drugs and vaccines. Exposure of larvae to SARS-CoV-2 Spike (S) ...

Abstract	The COVID-19 pandemic has prompted the search for animal models that recapitulate the pathophysiology observed in humans infected with SARS-CoV-2 and allow rapid and high throughput testing of drugs and vaccines. Exposure of larvae to SARS-CoV-2 Spike (S) receptor binding domain (RBD) recombinant protein was sufficient to elevate larval heart rate and treatment with captopril, an ACE inhibitor, reverted this effect. Intranasal administration of SARS-CoV-2 S RBD in adult zebrafish recombinant protein caused severe olfactory and mild renal histopathology. Zebrafish intranasally treated with SARS-CoV-2 S RBD became hyposmic within minutes and completely anosmic by 1 day to a broad-spectrum of odorants including bile acids and food. Single cell RNA-Seq of the adult zebrafish olfactory organ indicated widespread loss of expression of olfactory receptors as well as inflammatory responses in sustentacular, endothelial, and myeloid cell clusters. Exposure of wildtype zebrafish larvae to SARS-CoV-2 in water did not support active viral replication but caused a sustained inhibition of ace2 expression, triggered type 1 cytokine responses and inhibited type 2 cytokine responses. Combined, our results establish adult and larval zebrafish as useful models to investigate pathophysiological effects of SARS-CoV-2 and perform pre-clinical drug testing and validation in an inexpensive, high throughput vertebrate model.
Keywords	covid19
Publisher	BioRxiv; WHO
Document type	Article ; Online
DOI	10.1101/2020.11.06.368191
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: A zebrafish model for COVID-19 recapitulates olfactory and cardiovascular pathophysiologies caused by SARS-CoV-2

Kraus, Aurora / Casadei, Elisa / Huertas, Mar / Ye, Chunyan / Bradfute, Steven B / Boudinot, Pierre / Levraud, Jean-Pierre / Salinas, Irene

bioRxiv

Abstract	The COVID-19 pandemic has prompted the search for animal models that recapitulate the pathophysiology observed in humans infected with SARS-CoV-2 and allow rapid and high throughput testing of drugs and vaccines. Exposure of larvae to SARS-CoV-2 Spike (S) receptor binding domain (RBD) recombinant protein was sufficient to elevate larval heart rate and treatment with captopril, an ACE inhibitor, reverted this effect. Intranasal administration of SARS-CoV-2 S RBD in adult zebrafish recombinant protein caused severe olfactory and mild renal histopathology. Zebrafish intranasally treated with SARS-CoV-2 S RBD became hyposmic within minutes and completely anosmic by 1 day to a broad-spectrum of odorants including bile acids and food. Single cell RNA-Seq of the adult zebrafish olfactory organ indicated widespread loss of expression of olfactory receptors as well as inflammatory responses in sustentacular, endothelial, and myeloid cell clusters. Exposure of wildtype zebrafish larvae to SARS-CoV-2 in water did not support active viral replication but caused a sustained inhibition of ace2 expression, triggered type 1 cytokine responses and inhibited type 2 cytokine responses. Combined, our results establish adult and larval zebrafish as useful models to investigate pathophysiological effects of SARS-CoV-2 and perform pre-clinical drug testing and validation in an inexpensive, high throughput vertebrate model.
Keywords	covid19
Language	English
Publishing date	2020-11-08
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2020.11.06.368191
Database	COVID19

Full text online

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion.

Meena, Jitendra K / Cerutti, Aurora / Beichler, Christine / Morita, Yohei / Bruhn, Christopher / Kumar, Mukesh / Kraus, Johann M / Speicher, Michael R / Wang, Zhao-Qi / Kestler, Hans A / Fagagna, Fabrizio d'Adda di / Günes, Cagatay / Rudolph, Karl Lenhard

The EMBO journal

2017 Volume 36, Issue 19, Page(s) 2922–2924

Language	English
Publishing date	2017-09-26
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.15252/embj.201797470
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1808: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 100: Show issues

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Kategorien

Inter-library loan at ZB MED

Full text online

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito