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  1. Book ; Online ; E-Book: The science of glaucoma management

    Gillmann, Kevin / Mansouri, Kaweh

    from translational research to next-generation clinical practice

    2023  

    Author's details edited by Kevin Gillmann, Kaweh Mansouri
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xxiii, 458 Seiten)
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030022987
    ISBN 978-0-323-88443-3 ; 9780323884426 ; 0-323-88443-1 ; 0323884423
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Optical coherence tomography angiography and glaucoma: searching for the missing link.

    Mansouri, Kaweh

    Expert review of medical devices

    2016  Volume 13, Issue 10, Page(s) 879–880

    MeSH term(s) Angiography/methods ; Eye/blood supply ; Glaucoma/diagnosis ; Humans ; Models, Biological ; Tomography, Optical Coherence/methods
    Language English
    Publishing date 2016-10
    Publishing country England
    Document type Editorial
    ZDB-ID 2250857-0
    ISSN 1745-2422 ; 1743-4440
    ISSN (online) 1745-2422
    ISSN 1743-4440
    DOI 10.1080/17434440.2016.1230014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The World Glaucoma Association During the COVID-19 Pandemic.

    Lerner, Simon F / Lin, Shan / Mansouri, Kaweh

    Journal of glaucoma

    2020  Volume 29, Issue 7, Page(s) 505–506

    Keywords covid19
    Language English
    Publishing date 2020-12-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 913494-3
    ISSN 1536-481X ; 1057-0829
    ISSN (online) 1536-481X
    ISSN 1057-0829
    DOI 10.1097/IJG.0000000000001564
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  4. Article ; Online: Glaucoma in the Age of E-Learning.

    Lerner, S Fabian / Mansouri, Kaweh / Lin, Shan C

    Journal of glaucoma

    2019  Volume 28, Issue 5, Page(s) 367

    Language English
    Publishing date 2019-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 913494-3
    ISSN 1536-481X ; 1057-0829
    ISSN (online) 1536-481X
    ISSN 1057-0829
    DOI 10.1097/IJG.0000000000001261
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  5. Article: Minimally Invasive Surgery, Implantable Sensors, and Personalized Therapies.

    Gillmann, Kevin / Mansouri, Kaweh

    Journal of ophthalmic & vision research

    2020  Volume 15, Issue 4, Page(s) 531–546

    Abstract: Glaucoma management has changed dramatically over the last decades, through clinical advances and technological revolutions. This review discusses the latest innovations and challenges faced in the field around three major axes: minimally-invasive ... ...

    Abstract Glaucoma management has changed dramatically over the last decades, through clinical advances and technological revolutions. This review discusses the latest innovations and challenges faced in the field around three major axes: minimally-invasive glaucoma surgery (MIGS), implantable sensors and injectable therapeutics. Indeed, the vast number of recently developed MIGS techniques has not only provided clinicians with a wide range of therapeutic options, but they have also enabled them to adjust their therapies more finely which may have contributed a more patient-centric decision-making process. Yet, despite considerable advances in the field, the wide heterogeneity in clinical trial designs blurs the surgical outcomes, specificities and indications. Thus, more high-quality data are required to make the choice of a specific MIGS procedure more than an educated guess. Beyond the scope of MIGS, the potential of IOP telemetry for self-assessment of IOP-control through implantable sensors is developing into a real option for clinicians and an empowering opportunity for patients. Indeed, providing patients with direct feedback enables them to take control and have a clearer representation of their care, in turn leading to a better control of the disease. However, there are potential issues with self-monitoring of IOP, such as increased anxiety levels induced by measured IOP fluctuations and peaks, leading to patients self-treating during IOP spikes and additional office visits. Furthermore, the advent of implantable therapeutics may soon provide yet another step towards personalized glaucoma treatment, by offering not only an efficient alternative to current treatments, but also a therapeutic option that may better adapt to patients' lifestyle. After several decades of relative stagnation through the last century, glaucoma has now entered what many view as a golden age for the specialty. Like every revolution, this one brings its fair share of uncertainty, clinical questioning and uneasy periods of adaptation to ever-changing expectations. Yet, while it is impossible to guess what the landscape of glaucoma surgery will be like in ten or fifteen years, data suggest a bright outlook both for patients and clinicians.
    Language English
    Publishing date 2020-10-25
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ISSN 2008-2010
    ISSN 2008-2010
    DOI 10.18502/jovr.v15i4.7792
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Minimally Invasive Glaucoma Surgery: Where Is the Evidence?

    Gillmann, Kevin / Mansouri, Kaweh

    Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)

    2020  Volume 9, Issue 3, Page(s) 203–214

    Abstract: Purpose: The last decade has witnessed an unprecedented growth in glaucoma treatment options through the introduction of minimally invasive glaucoma surgeries (MIGS). The aim of the present review is to provide an understanding of the currently ... ...

    Abstract Purpose: The last decade has witnessed an unprecedented growth in glaucoma treatment options through the introduction of minimally invasive glaucoma surgeries (MIGS). The aim of the present review is to provide an understanding of the currently available MIGS and to examine what data are currently available to guide treatment choice.
    Design: Meta-analysis and systematic review of randomized and non-randomized control trials.
    Methods: Out of 2567 articles identified, a total of 77 articles were retained for analysis, including 28 comparative studies and 12 randomized control trials. Overall, 7570 eyes were included. When data permitted, the weighted mean difference in intraocular pressure reduction was calculated for comparison purposes.
    Results: Weighted mean intraocular pressure reductions from all analyzed studies were: 15.3% (iStent), 29.1% (iStent inject), 36.2% (ab interno canaloplasty), 34.4% (Hydrus), 36.5% (gonioscopically-assisted transluminal trabeculotomy), 24.0% (trabectome), 25.1% (Kahook dual blade), 30.2% (Cypass), 38.8% (XEN), and 50.0% (Preserflo).
    Conclusions: One of the advantages of the heterogenous range of available MIGS options is the chance to tailor therapy in an individualized manner. However, high-quality data are required to make this choice more than an educated guess. Overall, this review confirms the efficiency of assessed MIGS compared with standalone phacoemulsification, but it highlights that only few studies compare different MIGS techniques and even fewer assess MIGS against criterion standard treatments. Current evidence, while non-negligible, is mostly limited to heterogenous nonrandomized studies and uncontrolled retrospective comparisons, with few quality randomized control trials. We suggest that future research should be comparative and include relevant comparators, standardized to report key outcome features, long-term to assess sustainability and late complications, and ideally randomized.
    MeSH term(s) Filtering Surgery/methods ; Glaucoma/physiopathology ; Glaucoma/surgery ; Humans ; Intraocular Pressure/physiology ; Minimally Invasive Surgical Procedures/methods
    Language English
    Publishing date 2020-08-27
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2756329-7
    ISSN 2162-0989 ; 2162-0989
    ISSN (online) 2162-0989
    ISSN 2162-0989
    DOI 10.1097/APO.0000000000000294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Intereye Symmetry of 24-Hour Intraocular Pressure-related Patterns in Untreated Glaucoma Patients Using a Contact Lens Sensor.

    Mansouri, Kaweh / Gillmann, Kevin

    Journal of glaucoma

    2020  Volume 29, Issue 8, Page(s) 666–670

    Abstract: Purpose: Scarce data are available on the symmetry of 24-hour intraocular pressure (IOP) variations between fellow eyes of glaucoma patients, and such evidence could have profound consequences on the interpretation of monocular therapeutic trials. The ... ...

    Abstract Purpose: Scarce data are available on the symmetry of 24-hour intraocular pressure (IOP) variations between fellow eyes of glaucoma patients, and such evidence could have profound consequences on the interpretation of monocular therapeutic trials. The objective is to evaluate the intereye correlation of continuously measured circadian IOP-related patterns in untreated glaucoma patients.
    Methods: In this single-center prospective study, a total of 29 untreated patients with open-angle glaucoma underwent bilateral ambulatory 24-hour monitoring of IOP-related patterns using a contact lens sensor (CLS; SENSIMED Triggerfish). IOP was measured before and after CLS monitoring using Goldmann applanation tonometry. Intereye agreement of 24-hour patterns was calculated using Spearman correlation (r) of raw data and after cosinor rhythmometry modeling.
    Results: Complete bilateral CLS data could be obtained in 20 patients (mean age: 55.5±15.7 y; 51.7% women). On average, intereye correlation was r=0.76±0.19 (range: 0.16 to 0.95) and r=0.77±0.15 (range: 0.49 to 0.91), after excluding 8 patients with lower quality recordings. Cosine rhythmometry modeling showed mean acrophases occurring at 4:21±2:20 AM in left eyes and 3:39±1:50 AM in right eyes (r=0.48; P=0.034). Mean acrophase amplitude was 110.9±51.9 for left eyes and 107.8±46.2 for right eyes (r=0.79; P<0.001). No serious adverse events related to CLS monitoring were recorded. Transient conjunctival hyperemia (13 patients) and blurred vision (11 patients) were the most frequent adverse events.
    Conclusions: In this group of untreated glaucoma patients, there was good intereye agreement for circadian IOP-related patterns using the CLS. These results show a higher degree of intereye symmetry, in terms of IOP peak timings and amplitudes, than previously reported with standard tonometry.
    MeSH term(s) Adult ; Aged ; Biosensing Techniques/instrumentation ; Circadian Rhythm/physiology ; Contact Lenses ; Female ; Glaucoma, Open-Angle/physiopathology ; Humans ; Intraocular Pressure/physiology ; Male ; Middle Aged ; Monitoring, Ambulatory ; Prospective Studies ; Tonometry, Ocular ; Young Adult
    Language English
    Publishing date 2020-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 913494-3
    ISSN 1536-481X ; 1057-0829
    ISSN (online) 1536-481X
    ISSN 1057-0829
    DOI 10.1097/IJG.0000000000001563
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  8. Article ; Online: The Road Ahead to Continuous 24-Hour Intraocular Pressure Monitoring in Glaucoma

    Kaweh Mansouri

    Journal of Ophthalmic & Vision Research, Vol 9, Iss 2, Pp 260-

    2014  Volume 268

    Abstract: Intraocular pressure (IOP) is the only treatable risk factor for glaucoma. Yet, current glaucoma management usually relies on single IOP measurements during clinic hours despite the fact that IOP is a dynamic parameter with individual rhythms. Single IOP ...

    Abstract Intraocular pressure (IOP) is the only treatable risk factor for glaucoma. Yet, current glaucoma management usually relies on single IOP measurements during clinic hours despite the fact that IOP is a dynamic parameter with individual rhythms. Single IOP measurements underpin all major clinical guidelines on treatment of glaucoma. Other potentially informative parameters, such as IOP fluctuations and peak IOP, have been neglected, and effects of IOP-lowering interventions on such measures are largely unknown. The search for continuous 24-hour IOP monitoring started over 50 years ago, but only recent technological advances have provided clinician-researchers with devices for continuous IOP monitoring. Herein, we discuss innovative approaches with permanent and temporary devices for 24-hour IOP monitoring, such as a contact lens sensor. Despite being in their infancy, these devices may soon enable clinicians to use 24-hour IOP data to improve glaucoma management and reduce the glaucoma-related burden of disease.
    Keywords 24-hour; Intraocular Pressure; Glaucoma; Sensimed Triggerfish; Contact Lens Sensor ; Medicine ; R ; Ophthalmology ; RE1-994
    Publishing date 2014-01-01T00:00:00Z
    Publisher Ophthalmic Research Center
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: A Metric to Consider on the Global Accessibility of Glaucoma Surgery.

    Mansouri, Kaweh / Gillmann, Kevin / Bravetti, Giorgio Enrico

    JAMA ophthalmology

    2019  Volume 137, Issue 9, Page(s) 1090–1091

    Language English
    Publishing date 2019-08-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2019.2337
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  10. Article ; Online: Intraocular Pressure Monitoring Using an Intraocular Sensor Before and After Glaucoma Surgery.

    Saxby, Edward / Mansouri, Kaweh / Tatham, Andrew J

    Journal of glaucoma

    2021  Volume 30, Issue 10, Page(s) 941–946

    Abstract: Purpose: Intraocular pressure (IOP) is the only modifiable risk factor for glaucoma, with evidence from landmark randomized controlled trials demonstrating visual field preservation with IOP reduction. Over recent years, the use of remote sensors has ... ...

    Abstract Purpose: Intraocular pressure (IOP) is the only modifiable risk factor for glaucoma, with evidence from landmark randomized controlled trials demonstrating visual field preservation with IOP reduction. Over recent years, the use of remote sensors has formed an increasingly important component of the management of chronic diseases. During the coronavirus disease 2019 pandemic, the ability to remotely monitor IOP proved particularly useful when public stay at home orders have been in place.
    Patients and methods: This report describes the first case of glaucoma surgery in a patient who had previously received an EYEMATE-IO implant. The EYEMATE-IO is an implant for IOP monitoring placed in the ciliary sulcus during cataract surgery.
    Results: Remote IOP monitoring enabled the clinician to identify sustained high IOP readings and the need for glaucoma surgery. Postoperatively, response to treatment could be monitored to ensure sufficient long-term IOP control.
    Conclusion: The EYEMATE-IO implanted during cataract surgery in this patient provided valuable remote continuous IOP information that guided timely glaucoma surgical interventions for poorly controlled IOP.
    MeSH term(s) COVID-19 ; Cataract Extraction ; Glaucoma/surgery ; Humans ; Intraocular Pressure ; SARS-CoV-2
    Language English
    Publishing date 2021-08-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 913494-3
    ISSN 1536-481X ; 1057-0829
    ISSN (online) 1536-481X
    ISSN 1057-0829
    DOI 10.1097/IJG.0000000000001916
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