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  1. Article ; Online: Pott's Puffy Tumour: A Rare Complication of Sinusitis.

    Maenhout, Marine / Gudelj, Maxime / Gilbert, Allison

    European journal of case reports in internal medicine

    2024  Volume 11, Issue 4, Page(s) 4287

    Abstract: Introduction: Pott's puffy tumour is a rare entity defined by the presence of a subperiosteal abscess of the frontal bone associated with frontal osteomyelitis. Several predisposing conditions can lead to this entity, such as frontal sinusitis.: Case ... ...

    Abstract Introduction: Pott's puffy tumour is a rare entity defined by the presence of a subperiosteal abscess of the frontal bone associated with frontal osteomyelitis. Several predisposing conditions can lead to this entity, such as frontal sinusitis.
    Case description: We report the case of a 15-year-old patient who presented to the emergency department for headache, fever and forehead swelling. Computed tomography revealed severe pansinusitis complicated by a subperiosteal abscess associated with frontal osteomyelitis, leading to the diagnosis of Pott's puffy tumour. The management combined intravenous antibiotics and surgical drainage of both the sinusitis and subperiosteal abscess.
    Discussion: Pott's puffy tumour represents a rare but serious complication of frontal sinusitis. Clinicians should be aware of this potential complication as the diagnosis can be challenging at an early stage but may influence the subsequent prognosis.
    Learning points: Pott's puffy tumour is a rare but severe complication of frontal sinusitis.The main symptoms are fever, headache, rhinorrhoea, and forehead swelling.Early diagnosis and treatment can prevent neurological sequelae and associated mortality.
    Language English
    Publishing date 2024-03-11
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2024_004287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Injury of the Deep Branch of the Ulnar Nerve: A Sonographic Diagnosis.

    Félicie, Lorthioir / Didier, Clermont / Maxime, Gudelj

    Journal of the Belgian Society of Radiology

    2023  Volume 107, Issue 1, Page(s) 34

    Abstract: Teaching Point: ...

    Abstract Teaching Point:
    Language English
    Publishing date 2023-04-28
    Publishing country England
    Document type Case Reports
    ZDB-ID 2834839-4
    ISSN 2514-8281
    ISSN 2514-8281
    DOI 10.5334/jbsr.3103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Hip Pain in a Child Caused by Coxal Bone Infection.

    Wendling, Matthieu / Gudelj, Maxime

    Journal of the Belgian Society of Radiology

    2021  Volume 105, Issue 1, Page(s) 47

    Abstract: ... Teaching ... ...

    Abstract Teaching Point
    Language English
    Publishing date 2021-09-17
    Publishing country England
    Document type Case Reports
    ZDB-ID 2834839-4
    ISSN 2514-8281
    ISSN 2514-8281
    DOI 10.5334/jbsr.2491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Intraperitoneal Bladder Rupture Revealed by the Sentinel Clot Sign.

    Gudelj, Maxime / Giroul, Frederic / Dorthu, Laurent

    Journal of the Belgian Society of Radiology

    2018  Volume 102, Issue 1, Page(s) 33

    Language English
    Publishing date 2018-03-21
    Publishing country England
    Document type Case Reports
    ISSN 2514-8281
    ISSN 2514-8281
    DOI 10.5334/jbsr.1517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intraperitoneal Bladder Rupture Revealed by the Sentinel Clot Sign

    Maxime Gudelj / Frederic Giroul / Laurent Dorthu

    Journal of the Belgian Society of Radiology, Vol 102, Iss

    2018  Volume 1

    Keywords Bladder injury ; Clot sign ; Abdominal trauma ; CT ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2018-03-01T00:00:00Z
    Publisher Ubiquity Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Endovascular Treatment of Intracranial Aneurysms: Initial Experience in a Low-Volume Center.

    Gudelj, Maxime / Bruyère, Pierre-Julien / Tebache, Malek / Collignon, Laurent / Lubicz, Boris

    Journal of the Belgian Society of Radiology

    2020  Volume 104, Issue 1, Page(s) 19

    Abstract: Objective: Endovascular treatment (EVT) is the first-line treatment for ruptured and unruptured intracranial aneurysms (IA). EVT may be performed by interventional neuroradiologist (INR) with different levels of experience. This study aimed at ... ...

    Abstract Objective: Endovascular treatment (EVT) is the first-line treatment for ruptured and unruptured intracranial aneurysms (IA). EVT may be performed by interventional neuroradiologist (INR) with different levels of experience. This study aimed at evaluating clinical and anatomic results of IA embolisations performed by a INR with a short experience.
    Materials and methods: Within a 26-month period, 35 IA embolisations were managed by a young INR, 26 of these IA being ruptured. Different EVT techniques were used: coiling alone, stent-assisted coiling and remodeling techniques. Initial angiographic results, clinical outcomes and mid-term anatomic results were evaluated.
    Results: Out of 35 procedures, there were seven per-procedural complications leading to one ischemic stroke and one death. Immediate post-procedural complete occlusion was obtained in 91% of procedures (32/35). Good clinical results (modified Rankin Scale Score of 0 or 1) were obtained in 79% of patients (26/33). In a mean follow-up time of 9.5 months, stable occlusion was shown in 88% of IA (21/24).
    Conclusion: This study suggests that IA embolisation may be performed by a recently trained INR with good clinical and anatomical outcomes.
    Language English
    Publishing date 2020-05-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2834839-4
    ISSN 2514-8281
    ISSN 2514-8281
    DOI 10.5334/jbsr.1918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Endovascular Treatment of Intracranial Aneurysms

    Maxime Gudelj / Pierre-Julien Bruyère / Malek Tebache / Laurent Collignon / Boris Lubicz

    Journal of the Belgian Society of Radiology, Vol 104, Iss

    Initial Experience in a Low-Volume Center

    2020  Volume 1

    Abstract: Objective: Endovascular treatment (EVT) is the first-line treatment for ruptured and unruptured intracranial aneurysms (IA). EVT may be performed by interventional neuroradiologist (INR) with different levels of experience. This study aimed at evaluating ...

    Abstract Objective: Endovascular treatment (EVT) is the first-line treatment for ruptured and unruptured intracranial aneurysms (IA). EVT may be performed by interventional neuroradiologist (INR) with different levels of experience. This study aimed at evaluating clinical and anatomic results of IA embolisations performed by a INR with a short experience. Materials and Methods: Within a 26-month period, 35 IA embolisations were managed by a young INR, 26 of these IA being ruptured. Different EVT techniques were used: coiling alone, stent-assisted coiling and remodeling techniques. Initial angiographic results, clinical outcomes and mid-term anatomic results were evaluated. Results: Out of 35 procedures, there were seven per-procedural complications leading to one ischemic stroke and one death. Immediate post-procedural complete occlusion was obtained in 91% of procedures (32/35). Good clinical results (modified Rankin Scale Score of 0 or 1) were obtained in 79% of patients (26/33). In a mean follow-up time of 9.5 months, stable occlusion was shown in 88% of IA (21/24). Conclusion: This study suggests that IA embolisation may be performed by a recently trained INR with good clinical and anatomical outcomes.
    Keywords intracranial aneurysms ; endovascular therapy ; education ; follow-up ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Subject code 616
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Ubiquity Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Predicting microbial growth dynamics in response to nutrient availability.

    Nev, Olga A / Lindsay, Richard J / Jepson, Alys / Butt, Lisa / Beardmore, Robert E / Gudelj, Ivana

    PLoS computational biology

    2021  Volume 17, Issue 3, Page(s) e1008817

    Abstract: ... baker's yeast, and common coliform bacteria, and uncover the following patterns. We observed that the maximal ... maximal nutrient uptake rate and initial nutrient concentration. Incorporating these two functions ...

    Abstract Developing mathematical models to accurately predict microbial growth dynamics remains a key challenge in ecology, evolution, biotechnology, and public health. To reproduce and grow, microbes need to take up essential nutrients from the environment, and mathematical models classically assume that the nutrient uptake rate is a saturating function of the nutrient concentration. In nature, microbes experience different levels of nutrient availability at all environmental scales, yet parameters shaping the nutrient uptake function are commonly estimated for a single initial nutrient concentration. This hampers the models from accurately capturing microbial dynamics when the environmental conditions change. To address this problem, we conduct growth experiments for a range of micro-organisms, including human fungal pathogens, baker's yeast, and common coliform bacteria, and uncover the following patterns. We observed that the maximal nutrient uptake rate and biomass yield were both decreasing functions of initial nutrient concentration. While a functional form for the relationship between biomass yield and initial nutrient concentration has been previously derived from first metabolic principles, here we also derive the form of the relationship between maximal nutrient uptake rate and initial nutrient concentration. Incorporating these two functions into a model of microbial growth allows for variable growth parameters and enables us to substantially improve predictions for microbial dynamics in a range of initial nutrient concentrations, compared to keeping growth parameters fixed.
    MeSH term(s) Biotechnology ; Candida/cytology ; Candida/growth & development ; Candida/physiology ; Cell Proliferation/physiology ; Computational Biology ; Ecology ; Enterobacteriaceae/cytology ; Enterobacteriaceae/growth & development ; Enterobacteriaceae/physiology ; Models, Biological ; Saccharomyces cerevisiae/cytology ; Saccharomyces cerevisiae/growth & development ; Saccharomyces cerevisiae/physiology
    Language English
    Publishing date 2021-03-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1008817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The unconstrained evolution of fast and efficient antibiotic-resistant bacterial genomes.

    Reding-Roman, Carlos / Hewlett, Mark / Duxbury, Sarah / Gori, Fabio / Gudelj, Ivana / Beardmore, Robert

    Nature ecology & evolution

    2017  Volume 1, Issue 3, Page(s) 50

    Abstract: ... copy number, than can simultaneously maximize r and K. The optimal genome has fewer operons, and ...

    Abstract Evolutionary trajectories are constrained by trade-offs when mutations that benefit one life history trait incur fitness costs in other traits. As resistance to tetracycline antibiotics by increased efflux can be associated with an increase in length of the Escherichia coli chromosome of 10% or more, we sought costs of resistance associated with doxycycline. However, it was difficult to identify any because the growth rate (r), carrying capacity (K) and drug efflux rate of E. coli increased during evolutionary experiments where the species was exposed to doxycycline. Moreover, these improvements remained following drug withdrawal. We sought mechanisms for this seemingly unconstrained adaptation, particularly as these traits ought to trade-off according to rK selection theory. Using prokaryote and eukaryote microorganisms, including clinical pathogens, we show that r and K can trade-off, but need not, because of 'rK trade-ups'. r and K trade-off only in sufficiently carbon-rich environments where growth is inefficient. We then used E. coli ribosomal RNA (rRNA) knockouts to determine specific mutations, namely changes in rRNA operon (rrn) copy number, than can simultaneously maximize r and K. The optimal genome has fewer operons, and therefore fewer functional ribosomes, than the ancestral strain. It is, therefore, unsurprising for r-adaptation in the presence of a ribosome-inhibiting antibiotic, doxycycline, to also increase population size. We found two costs for this improvement: an elongated lag phase and the loss of stress protection genes.
    Language English
    Publishing date 2017-01-30
    Publishing country England
    Document type Journal Article
    ISSN 2397-334X
    ISSN (online) 2397-334X
    DOI 10.1038/s41559-016-0050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Predicting microbial growth dynamics in response to nutrient availability.

    Olga A Nev / Richard J Lindsay / Alys Jepson / Lisa Butt / Robert E Beardmore / Ivana Gudelj

    PLoS Computational Biology, Vol 17, Iss 3, p e

    2021  Volume 1008817

    Abstract: ... baker's yeast, and common coliform bacteria, and uncover the following patterns. We observed that the maximal ... maximal nutrient uptake rate and initial nutrient concentration. Incorporating these two functions ...

    Abstract Developing mathematical models to accurately predict microbial growth dynamics remains a key challenge in ecology, evolution, biotechnology, and public health. To reproduce and grow, microbes need to take up essential nutrients from the environment, and mathematical models classically assume that the nutrient uptake rate is a saturating function of the nutrient concentration. In nature, microbes experience different levels of nutrient availability at all environmental scales, yet parameters shaping the nutrient uptake function are commonly estimated for a single initial nutrient concentration. This hampers the models from accurately capturing microbial dynamics when the environmental conditions change. To address this problem, we conduct growth experiments for a range of micro-organisms, including human fungal pathogens, baker's yeast, and common coliform bacteria, and uncover the following patterns. We observed that the maximal nutrient uptake rate and biomass yield were both decreasing functions of initial nutrient concentration. While a functional form for the relationship between biomass yield and initial nutrient concentration has been previously derived from first metabolic principles, here we also derive the form of the relationship between maximal nutrient uptake rate and initial nutrient concentration. Incorporating these two functions into a model of microbial growth allows for variable growth parameters and enables us to substantially improve predictions for microbial dynamics in a range of initial nutrient concentrations, compared to keeping growth parameters fixed.
    Keywords Biology (General) ; QH301-705.5
    Subject code 551
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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