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  1. Article ; Online: Narrative review on nanoparticles based on current evidence: therapeutic agents for diabetic foot infection.

    Saleem, Mohd / Syed Khaja, Azharuddin Sajid / Moursi, Soha / Altamimi, Tahani Almofeed / Alharbi, Mohammed Salem / Usman, Kauser / Khan, Mohd Shahid / Alaskar, Alwaleed / Alam, Mohammad Jahoor

    Naunyn-Schmiedeberg's archives of pharmacology

    2024  

    Abstract: Diabetes's effects on wound healing present a major treatment challenge and increase the risk of amputation. When traditional therapies fail, new approaches must be investigated. With their submicron size and improved cellular internalisation, ... ...

    Abstract Diabetes's effects on wound healing present a major treatment challenge and increase the risk of amputation. When traditional therapies fail, new approaches must be investigated. With their submicron size and improved cellular internalisation, nanoparticles present a viable way to improve diabetic wound healing. They are attractive options because of their innate antibacterial qualities, biocompatibility, and biodegradability. Nanoparticles loaded with organic or inorganic compounds, or embedded in biomimetic matrices such as hydrogels, chitosan, and hyaluronic acid, exhibit excellent anti-inflammatory, antibacterial, and antioxidant properties. Drug delivery systems (DDSs)-more precisely, nanodrug delivery systems (NDDSs)-use the advantages of nanotechnology to get around some of the drawbacks of traditional DDSs. Recent developments show how expertly designed nanocarriers can carry a variety of chemicals, transforming the treatment of diabetic wounds. Biomaterials that deliver customised medications to the wound microenvironment demonstrate potential. Delivery techniques for nanomedicines become more potent than ever, overcoming conventional constraints. Therapeutics for diabetes-induced non-healing wounds are entering a revolutionary era thanks to precisely calibrated nanocarriers that effectively distribute chemicals. This review highlights the therapeutic potential of nanoparticles and outlines the multifunctional nanoparticles of the future that will be used for complete wound healing in diabetics. The investigation of novel nanodrug delivery systems has the potential to revolutionise diabetic wound therapy and provide hope for more efficient and focused therapeutic approaches.
    Language English
    Publishing date 2024-04-19
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-024-03094-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.5: Show issues Location:
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  2. Article: Community-Acquired Methicillin-Resistant

    Alsolami, Ahmed / ALGhasab, Naif Saad / Alharbi, Mohammed S M / Bashir, Abdelhafiz I / Saleem, Mohd / Syed Khaja, Azharuddin Sajid / Aldakheel, Dakheel F / Rakha, Ehab / Alshammari, Jabar Aziz / Taha, Taha E / Melibari, Ziyad / Alharbi, Yaseer H / Almutlag, Ali A / Said, Kamaleldin B

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 12

    Abstract: Methicillin- ... ...

    Abstract Methicillin-resistant
    Language English
    Publishing date 2023-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13122089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Molecular Characterization and Antibiogram of

    Saleem, Mohd / Syed Khaja, Azharuddin Sajid / Hossain, Ashfaque / Alenazi, Fahaad / Said, Kamaleldin B / Moursi, Soha Abdallah / Almalaq, Homoud Abdulmohsin / Mohamed, Hamza / Rakha, Ehab

    Healthcare (Basel, Switzerland)

    2022  Volume 10, Issue 11

    Abstract: A 2-year prospective study carried out on ventilator-associated pneumonia (VAP) patients in the intensive care unit at a tertiary care hospital, Hail, Kingdom of Saudi Arabia (KSA), revealed a high prevalence of extremely drug-resistant (XDR) ...

    Abstract A 2-year prospective study carried out on ventilator-associated pneumonia (VAP) patients in the intensive care unit at a tertiary care hospital, Hail, Kingdom of Saudi Arabia (KSA), revealed a high prevalence of extremely drug-resistant (XDR)
    Language English
    Publishing date 2022-11-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare10112210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A Sequalae of Lineage Divergence in

    Said, Kamaleldin B / AlGhasab, Naif Saad / Alharbi, Mohammed S M / Alsolami, Ahmed / Bashir, Abdelhafiz I / Saleem, Mohd / Syed Khaja, Azharuddin Sajid / Aldakheel, Dakheel F / Rakha, Ehab / Alshamri, Jabar A / Al-Hazimi, Awdah / Alrodhaiman, Adel J / Taha, Taha E / Alanazi, Hamad H / Ha'il Com Research Unit Group

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 5

    Abstract: The rapidly changing epidemiology ... ...

    Abstract The rapidly changing epidemiology of
    Language English
    Publishing date 2023-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13050819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Glycation of Immunoglobulin-G from pentose sugar: A cause for structural perturbations.

    Alenazi, Fahaad / Saleem, Mohd / Syed Khaja, Azharuddin Sajid / Zafar, Mubashir / Alharbi, Mohammed Salem / Hagbani, Turki Al / Khan, Mohd Yasir / Ahmad, Saheem

    Current protein & peptide science

    2022  

    Abstract: Background: Glycation of immunoglobulin-G (IgG) molecule with monosaccharides may cause significant structural disability thus resulting in their loss of function. The accumulation of AGEs formed from glycation play an important role in the aliments ... ...

    Abstract Background: Glycation of immunoglobulin-G (IgG) molecule with monosaccharides may cause significant structural disability thus resulting in their loss of function. The accumulation of AGEs formed from glycation play an important role in the aliments associated with metabolic diseases. Therefore, excess of sugar in plasma, interferes with the functioning of IgG and may contribute to wide range of diabetes-associated complications. The long-term formation of these heterogeneous AGEs may accumulate and can affect plasma proteins, especially long-lived proteins. In this study, we analyze glycation of immunoglobulin-G (IgG) with 2'-deoxyribose (deoxyribose) instigated modification in IgG structure and AGEs formation.
    Methods: This study aims to glycate IgG from varying concentrations of a pentose sugar, 2'-deoxy-ribose (deoxyribose). Post glycation of IgG, both the native and its glycated analogue were characterized by various physicochemical methods and techniques. The glycated protein will be assessed for its stability and perturbations by UV-VIS., fluorescence and FT-IR spectroscopic techniques. Moreover, the early glycation product will be done by NBT assay and other biochemical parameters like HMF, carbonyl content and thioflavin-T assays were also performed to see the biochemical changes induced in the glycated IgG macromolecule.
    Results: Glycation of protein macromolecules generates stable early glycation products (Amadori products). Later on, these Amadori products involve in series of chemical reactions to form more stable advanced glycation end products (AGEs).Our experimental study results could validate the modification in IgG structure and AGEs formation.
    Conclusion: The formation of IgG-AGEs from glycation of IgG with deoxyribose could exert cellular toxicity and might initiates secondary complications of diabetes. Therefore, this study emphasized on glycation reaction of IgG from deoxyribose and which has not been reported yet.
    Language English
    Publishing date 2022-09-29
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2045662-1
    ISSN 1875-5550 ; 1389-2037
    ISSN (online) 1875-5550
    ISSN 1389-2037
    DOI 10.2174/1389203723666220929105859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5884: Show issues Location:
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  6. Article: Pathogen Burden Among ICU Patients in a Tertiary Care Hospital in Hail Saudi Arabia with Particular Reference to β-Lactamases Profile.

    Saleem, Mohd / Syed Khaja, Azharuddin Sajid / Hossain, Ashfaque / Alenazi, Fahaad / Said, Kamaleldin B / Moursi, Soha Abdallah / Almalaq, Homoud Abdulmohsin / Mohamed, Hamza / Rakha, Ehab / Alharbi, Mohammed Salem / Babiker, Salma Ahmed Ali / Usman, Kauser

    Infection and drug resistance

    2023  Volume 16, Page(s) 769–778

    Abstract: Purpose: Ventilator-associated pneumonia (VAP) is associated with a higher mortality risk for critical patients in the intensive care unit (ICU). Several strategies, including using β-lactam antibiotics, have been employed to prevent VAP in the ICU. ... ...

    Abstract Purpose: Ventilator-associated pneumonia (VAP) is associated with a higher mortality risk for critical patients in the intensive care unit (ICU). Several strategies, including using β-lactam antibiotics, have been employed to prevent VAP in the ICU. However, the lack of a gold-standard method for VAP diagnosis and a rise in antibiotic-resistant microorganisms have posed challenges in managing VAP. The present study is designed to identify, characterize, and perform antimicrobial susceptibility of the microorganisms from different clinical types of infections in ICU patients with emphasis on VAP patients to understand the frequency of the latter, among others.
    Patients and methods: A 1-year prospective study was carried out on patients in the ICU unit at a tertiary care hospital, Hail, Saudi Arabia.
    Results: A total of 591 clinically suspected hospital-acquired infections (HAI) were investigated, and a total of 163 bacterial isolates were obtained from different clinical specimens with a high proportion of bacteria found associated with VAP (70, 43%), followed by CAUTI (39, 24%), CLABSI (25, 15%), and SSI (14, 8.6%).
    Conclusion: Proper use of antibiotics, continuous monitoring of drug sensitivity patterns, and taking all precautionary measures to prevent beta-lactamase-producing organisms in clinical settings are crucial and significant factors in fending off life-threatening infections for a better outcome.
    Language English
    Publishing date 2023-02-05
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S394777
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  7. Article: Assessment of Knowledge and Attitude Toward Pelvic Inflammatory Disease Among Women in Saudi Arabia.

    Syed Khaja, Azharuddin Sajid / Zafar, Mubashir / Alshammari, Abdulrahman Musaad A / Alharbi, Saqer / Alghaithi, Abdulkarim Muflih S / Alshahri, Badr / Saleem, Mohd / Parveen, Nuzhat / Mohammed, Ghorashy

    Cureus

    2023  Volume 15, Issue 9, Page(s) e45013

    Abstract: Purpose Pelvic inflammatory disease (PID) is a serious infection of the female reproductive system that can lead to long-term complications such as infertility, chronic pelvic pain, and ectopic pregnancy. PID is also associated with an increased risk of ... ...

    Abstract Purpose Pelvic inflammatory disease (PID) is a serious infection of the female reproductive system that can lead to long-term complications such as infertility, chronic pelvic pain, and ectopic pregnancy. PID is also associated with an increased risk of HIV infection and other sexually transmitted infections (STIs). Early diagnosis and treatment of PID is crucial to prevent complications. Despite the severe consequences of PID, many women are unaware of the risks associated with this condition. This lack of awareness can lead to delayed diagnosis and treatment, increasing the risk of complications. This study explores women's knowledge and attitudes regarding PID. Methods A cross-sectional survey was conducted using a bilingual, community-based questionnaire, circulated using different social media platforms. A total of 239 participants were selected through convenient non-probability sampling from the public in the Kingdom of Saudi Arabia. The collected data was analyzed using SPSS Statistics version 26 (IBM Corp. Released 2019. IBM SPSS Statistics for Windows, Version 26.0. Armonk, NY: IBM Corp.). The chi-square test was applied to determine the differences between knowledge and attitude levels with participants' socio-demographic characteristics. A p-value <0.005 was considered statistically significant. Results Appropriate PID knowledge level was found only in 32% of the respondents and was significantly associated with the respondents' family history of the PID (p=0.025). A positive attitude toward PID/STI was also observed only in 36% of the study participants, which was significantly associated with the respondents' age (p˂0.001), marital status (p˂0.001), occupation (p˂ 0.001), past medical/surgical history (p=0.006), and family history of the PID (p˂0.009). Conclusion The present study reported average levels of appropriate knowledge and attitudes toward PID among female respondents, which could be further improved by increasing PID/STI awareness programs.
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.45013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Antiglycation potential of plant based TiO

    Alenazi, Fahaad / Saleem, Mohd / Syed Khaja, Azharuddin Sajid / Zafar, Mubashir / Alharbi, Mohammed Salem / Al Hagbani, Turki / Khan, Mohd Yasir / Ahmad, Waseem / Ahmad, Saheem

    Cell biochemistry and function

    2022  Volume 40, Issue 7, Page(s) 784–796

    Abstract: Biosynthetic procedure is one of the best alternatives, inexpensive and ecologically sound for the synthesis of titanium dioxide ( ... ...

    Abstract Biosynthetic procedure is one of the best alternatives, inexpensive and ecologically sound for the synthesis of titanium dioxide (TiO
    MeSH term(s) Glycation End Products, Advanced/metabolism ; Nanoparticles ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Ribose/chemistry ; Ribose/metabolism ; Serum Albumin, Bovine/chemistry ; Serum Albumin, Bovine/metabolism ; Titanium
    Chemical Substances Glycation End Products, Advanced ; Plant Extracts ; titanium dioxide (15FIX9V2JP) ; Serum Albumin, Bovine (27432CM55Q) ; Ribose (681HV46001) ; Titanium (D1JT611TNE)
    Language English
    Publishing date 2022-09-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 283643-9
    ISSN 1099-0844 ; 0263-6484
    ISSN (online) 1099-0844
    ISSN 0263-6484
    DOI 10.1002/cbf.3744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1994: Show issues Location:
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  9. Article: GLUL

    Muthu, Magesh / Kumar, Ranjeet / Syed Khaja, Azharuddin Sajid / Gilthorpe, Jonathan D / Persson, Jenny L / Nordström, Anders

    Cancers

    2019  Volume 11, Issue 12

    Abstract: Glutamate-ammonia ligase (GLUL) is important for acid-base homeostasis, ammonia detoxification, cell signaling, and proliferation. Here, we reported ... ...

    Abstract Glutamate-ammonia ligase (GLUL) is important for acid-base homeostasis, ammonia detoxification, cell signaling, and proliferation. Here, we reported that
    Language English
    Publishing date 2019-12-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers11121945
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  10. Article: Catheter-Associated Urinary Tract Infection in Intensive Care Unit Patients at a Tertiary Care Hospital, Hail, Kingdom of Saudi Arabia.

    Saleem, Mohd / Syed Khaja, Azharuddin Sajid / Hossain, Ashfaque / Alenazi, Fahaad / Said, Kamaleldin B / Moursi, Soha Abdallah / Almalaq, Homoud Abdulmohsin / Mohamed, Hamza / Rakha, Ehab / Mishra, Sunit Kumar

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 7

    Abstract: Catheter-associated urinary tract infections (CAUTIs) are some of the most common hospital-acquired infections (HAIs). Prolonged hospitalization, invasive devices such as catheters, and irrational use of antimicrobial agents are believed to be the major ... ...

    Abstract Catheter-associated urinary tract infections (CAUTIs) are some of the most common hospital-acquired infections (HAIs). Prolonged hospitalization, invasive devices such as catheters, and irrational use of antimicrobial agents are believed to be the major causes of high rates of HAIs. Infections such as pyelonephritis, urethritis, cystitis, and prostatitis are the main concerns in catheterized ICU patients. In these cases, Gram-negative bacteria are the most common bacteria. The present study was undertaken to determine the frequency, antibiograms, disease pattern, and risk factors involved in providing an advocacy recommendation to prevent CAUTI. A total of 1078 patients were admitted to the hospital ICU, out of which healthcare-associated infection was reported in 316 patients. CAUTI was reported only in 70 patients.
    Language English
    Publishing date 2022-07-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12071695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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