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Article ; Online: Intraoperative mixed-reality spinal neuronavigation system: a novel navigation technique for spinal intradural pathologies.

Caliskan, Kadri Emre / Yavas, Gorkem / Cagli, Mehmet Sedat

2023 Volume 56, Issue 1, Page(s) E2

Abstract: Objective: The objective of this study was to assess the intraoperative accuracy and feasibility of 3D-printed marker-based mixed-reality neurosurgical navigation for spinal intradural pathologies.: Methods: The authors produced 3D segmentations of ... ...

Abstract	Objective: The objective of this study was to assess the intraoperative accuracy and feasibility of 3D-printed marker-based mixed-reality neurosurgical navigation for spinal intradural pathologies. Methods: The authors produced 3D segmentations of spinal intradural tumors with neighboring structures by using combined CT and MRI, and preoperative registration of pathology and markers was successfully performed. A patient-specific, surgeon-facilitated application for mobile devices was built, and a mixed-reality light detection and ranging (LIDAR) camera on a mobile device was employed for cost-effective, high-accuracy spinal neuronavigation. Results: Mobile device LIDAR cameras can successfully overlay images of virtual tumor segmentations according to the position of a 3D-printed marker. The surgeon can visualize and manipulate 3D segmentations of the pathology intraoperatively in 3D. Conclusions: A 3D-printed marker-based mixed-reality spinal neuronavigation technique was performed in spinal intradural pathology procedures and has potential to be clinically feasible and easy to use for surgeons, as well as being time saving, cost-effective, and highly precise for spinal surgical procedures.
MeSH term(s)	Humans ; Neuronavigation/methods ; Augmented Reality ; Neurosurgical Procedures/methods ; Magnetic Resonance Imaging ; Spinal Neoplasms ; Spinal Cord Neoplasms/diagnostic imaging ; Spinal Cord Neoplasms/surgery ; Surgery, Computer-Assisted/methods ; Imaging, Three-Dimensional/methods
Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2026589-X
ISSN	1092-0684 ; 1092-0684
ISSN (online)	1092-0684
ISSN	1092-0684
DOI	10.3171/2023.10.FOCUS23624
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Article ; Online: Three-dimensional-printed marker-based augmented reality neuronavigation: a new neuronavigation technique.

Yavas, Gorkem / Caliskan, Kadri Emre / Cagli, Mehmet Sedat

Neurosurgical focus

2021 Volume 51, Issue 2, Page(s) E20

Abstract: Objective: The aim of this study was to assess the precision and feasibility of 3D-printed marker-based augmented reality (AR) neurosurgical navigation and its use intraoperatively compared with optical tracking neuronavigation systems (OTNSs).: ... ...

Abstract	Objective: The aim of this study was to assess the precision and feasibility of 3D-printed marker-based augmented reality (AR) neurosurgical navigation and its use intraoperatively compared with optical tracking neuronavigation systems (OTNSs). Methods: Three-dimensional-printed markers for CT and MRI and intraoperative use were applied with mobile devices using an AR light detection and ranging (LIDAR) camera. The 3D segmentations of intracranial tumors were created with CT and MR images, and preoperative registration of the marker and pathology was performed. A patient-specific, surgeon-facilitated mobile application was developed, and a mobile device camera was used for neuronavigation with high accuracy, ease, and cost-effectiveness. After accuracy values were preliminarily assessed, this technique was used intraoperatively in 8 patients. Results: The mobile device LIDAR camera was found to successfully overlay images of virtual tumor segmentations according to the position of a 3D-printed marker. The targeting error that was measured ranged from 0.5 to 3.5 mm (mean 1.70 ± 1.02 mm, median 1.58 mm). The mean preoperative preparation time was 35.7 ± 5.56 minutes, which is longer than that for routine OTNSs, but the amount of time required for preoperative registration and the placement of the intraoperative marker was very brief compared with other neurosurgical navigation systems (mean 1.02 ± 0.3 minutes). Conclusions: The 3D-printed marker-based AR neuronavigation system was a clinically feasible, highly precise, low-cost, and easy-to-use navigation technique. Three-dimensional segmentation of intracranial tumors was targeted on the brain and was clearly visualized from the skin incision to the end of surgery.
MeSH term(s)	Augmented Reality ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/surgery ; Humans ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Neuronavigation ; Surgery, Computer-Assisted
Language	English
Publishing date	2021-07-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2026589-X
ISSN	1092-0684 ; 1092-0684
ISSN (online)	1092-0684
ISSN	1092-0684
DOI	10.3171/2021.5.FOCUS21206
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Article ; Online: Bilateral Laryngocele Causing Epiglottic Deformity and Upper Airway Obstruction.

Kara, İrfan / Kökoğlu, Kerem / Çağlı, Sedat / Yüce, İmdat

Turkish archives of otorhinolaryngology

2019 Volume 57, Issue 2, Page(s) 99–101

Abstract: Laryngocele is the cystic dilatation of laryngeal ventricle. Most cases are asymptomatic and incidentally diagnosed in radiologic examinations. Although the etiology is unclear, obstruction, laryngeal pressure, congenital defects are possible risk ... ...

Abstract	Laryngocele is the cystic dilatation of laryngeal ventricle. Most cases are asymptomatic and incidentally diagnosed in radiologic examinations. Although the etiology is unclear, obstruction, laryngeal pressure, congenital defects are possible risk factors. Computed tomography is the best method for diagnosis. Endoscopic, external or combined approaches have been described in the surgical treatment. Laryngocele should be kept in mind in patients with acute upper airway obstruction. Such patients may require tracheostomy. Some patients with laryngocele can also have laryngeal cancer, in which case direct laryngoscopy must be performed. This report presents a case with respiratory distress associated with bilateral laryngocele, and his management in the light of the literature.
Language	English
Publishing date	2019-03-14
Publishing country	Turkey
Document type	Case Reports
ISSN	2667-7474
ISSN (online)	2667-7474
DOI	10.5152/tao.2019.3949
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Article ; Online: The role of CT angiography and endovascular treatment in acute-massive head and neck bleeding.

Ökçesiz, İzzet / Dönmez, Halil / Vural, Alperen / Karabıyık, Özgür / Yüce, İmdat / Çağlı, Sedat

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2021 Volume 279, Issue 2, Page(s) 875–882

Abstract: Purpose: To report the results of the endovascular treatment of acute-massive head and neck bleeding in a single center and underline the value of computerized tomography-angiography and endovascular treatment of this desperate patient group.: Methods! ...

Abstract	Purpose: To report the results of the endovascular treatment of acute-massive head and neck bleeding in a single center and underline the value of computerized tomography-angiography and endovascular treatment of this desperate patient group. Methods: Forty-eight patients who suffered from acute-massive head and neck bleeding and in whom conservative treatment options had failed were included in the study. To localize the site of the bleeding, computerized tomography-angiography was obtained above the supra-aortic level. Depending on the type and site of bleeding, an urgent angiographic evaluation and appropriate endovascular treatment procedure were performed in the same session immediately. Complete control of all active bleeding was determined as "technical success" at the end of the procedure. Results: The majority of the endovascular treatment indications were tumoral mass bleedings in this study. Eight patients, all of which had head and neck tumors as the cause of the bleeding underwent repeated interventional procedures due to acute re-bleeding. All patients left the angiography unit with technical success and dramatic clinical improvement. Two patients had procedure-related severe complications, such as contrast-induced nephropathy and acute cerebrovascular accident. One patient died due to massive re-bleeding during the follow-up period. Conclusion: Computerized tomography-angiography is a successful imaging method to reveal the location and cause of bleeding. Endovascular treatment of acute-massive head and neck bleeding is an effective and life-saver treatment option that can be used successfully with relatively low-risk potential.
MeSH term(s)	Computed Tomography Angiography ; Embolization, Therapeutic ; Endovascular Procedures ; Head/diagnostic imaging ; Hemorrhage/diagnostic imaging ; Hemorrhage/etiology ; Hemorrhage/therapy ; Humans ; Neck/diagnostic imaging ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-05-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-021-06813-6
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Article ; Online: Root Canal File Stick Into the Epiglottis

Kerem Kökoğlu / Tuğrul Arslan / İmdat Yüce / Sedat Çağlı

Erciyes Medical Journal, Vol 41, Iss 2, Pp 209-

A Dangerous Complication of an Endodontic Procedure

2019 Volume 211

Abstract: Root canal treatment is one of the most frequently performed operations in dentistry. Some complications regarding the instruments used during operation include breakage of root canal file, inhalation, or ingestion. There are some reports in the ... ...

Abstract	Root canal treatment is one of the most frequently performed operations in dentistry. Some complications regarding the instruments used during operation include breakage of root canal file, inhalation, or ingestion. There are some reports in the literature on ingestion of dental instruments, and these could be life threatening because of the possibility of airway obstruction or tubular organ perforation. In this paper, an interesting case of root canal file stick into the epiglottis and its management are presented.
Keywords	foreign body ingestion ; root canal file ; Medicine (General) ; R5-920
Language	English
Publishing date	2019-05-01T00:00:00Z
Publisher	KARE Publishing
Document type	Article ; Online
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Article ; Online: The role of CD133 expression of cancer stem cells on radiotherapy response in early stage glottic cancers.

Gülmez, Emrah / Yüce, Imdat / Gündoğ, Mete / Canöz, Özlem / Kökoğlu, Kerem / Vural, Alperen / Çağlı, Sedat

2020 Volume 277, Issue 11, Page(s) 3121–3126

Abstract: Purpose: To investigate the relationship between CD133 positivity and radiotherapy (RT) response in early stage glottic laryngeal cancers.: Methods: Thirty seven patients with early-stage glottic laryngeal carcinoma who were treated with primary RT ... ...

Abstract	Purpose: To investigate the relationship between CD133 positivity and radiotherapy (RT) response in early stage glottic laryngeal cancers. Methods: Thirty seven patients with early-stage glottic laryngeal carcinoma who were treated with primary RT were evaluated. Patients with regular follow-up of at least 3 years were included in the study. Patients who had previously received chemotherapy for laryngeal surgery or underwent surgery were excluded. The patients were divided into two groups as recurrent and non-recurrent. These two groups were compared in terms of CD133 expression by immunohistochemical method. Results: There were 37 patients in the study. Ten patients had recurrence and seven (70%) had CD133 positive and three had CD133 negative. Of 27 patients who had no recurrence, 16 (59%) had CD133 positive and 11 (41%) had CD133 negative. 7 (70%) of ten patients with recurrence were found to be positive for CD133; There was no statistically significant difference between recurrent and non-recurrent patient groups in terms of CD133 positivity (p > 0.05). There was no correlation between the final CD133 score and recurrence status as well (p > 0.05). Conclusion: There was no relationship between radiotherapy response and CD133 staining in early-stage glottic laryngeal cancers. It is the largest study about CD133 and RT sensitivity in early stage glottic carcinomas.
MeSH term(s)	Carcinoma, Squamous Cell/pathology ; Glottis/pathology ; Humans ; Laryngeal Neoplasms/pathology ; Laryngeal Neoplasms/radiotherapy ; Laryngectomy ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Neoplastic Stem Cells ; Retrospective Studies
Language	English
Publishing date	2020-06-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-020-06106-4
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Article ; Online: Clinical Outcomes of Posterior C1 and C2 Screw-Rod Fixation for Atlantoaxial Instability.

Işik, Hasan Serdar / Sandal, Evren / Çağli, Sedat

Turkish neurosurgery

2017

Abstract: Aim: In this study, we aimed at sharing our experiences and contributing to the literature by making a retrospective analysis of the patients we operated with screw-rod system for atlantoaxial instability in our clinic.: Material and methods: Archive ...

Abstract	Aim: In this study, we aimed at sharing our experiences and contributing to the literature by making a retrospective analysis of the patients we operated with screw-rod system for atlantoaxial instability in our clinic. Material and methods: Archive files of adult patients, who were operated for posterior C1-C2 stabilization with screw and rod in our clinic between January 2006 and January 2016, were analyzed. 28 patients, who had pre and post-operative images, follow-up forms and who were followed for at least one year, were analyzed. Preoperative clinical and radiological records, preoperative observations, postoperative complications, and clinical responses were evaluated. Results: The average age of 28 patients (F:13 M:19) was 44.7 (21-73). Fixation was performed with C1-C2 screw-rod system on the basis of the following diagnoses; type 2 odontoid fracture (16), basilar invagination (5), C1-C2 instability (5), and atlantoaxial subluxation secondary to rheumatoid arthritis (2). Lateral mass screws were inserted at C1 segment. C2 screws inserted were bilateral pedicle in 12 cases, bilateral pars in 4, bilateral laminar in 8 and one side pars, one side laminar in 4 cases. There was no screw malposition. Neither implant failure nor recurrent instability was observed during follow-up. Significant clinical improvement was reported according to the assessments done with JOA and VAS scores. Conclusion: C1-C2 screw fixation is regarded as a more successful and safe method than other fixation methods in surgical treatment of atlantoaxial instability considering complications, success in reduction, fusion and fixation strength. C2 laminar screw technique is as successful as the other alternatives in fixation and fusion.
Language	English
Publishing date	2017-06-14
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1203779-5
ISSN	2651-5032 ; 1019-5149
ISSN (online)	2651-5032
ISSN	1019-5149
DOI	10.5137/1019-5149.JTN.20525-17.1
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Article ; Online: Gluteus medius muscle metastasis of squamous cell carcinoma of larynx: a rare case.

Vural, Alperen / Avcı, Deniz / Çağlı, Sedat / Yüce, İmdat / Arlı, Turan

Brazilian journal of otorhinolaryngology

2017 Volume 86 Suppl 1, Page(s) 23–25

MeSH term(s)	Buttocks ; Head and Neck Neoplasms ; Humans ; Muscle, Skeletal ; Squamous Cell Carcinoma of Head and Neck
Language	English
Publishing date	2017-04-29
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	2428110-4
ISSN	1808-8686 ; 1808-8694
ISSN (online)	1808-8686
ISSN	1808-8694
DOI	10.1016/j.bjorl.2017.04.002
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Article ; Online: The effect of FoxP3 on tumour stage, treatment response, recurrence and survivalability in nasopharynx cancer patients.

Kara, İrfan / Çağlı, Sedat / Vural, Alperen / Yüce, İmdat / Gündoğ, Mete / Deniz, Kemal / Kökoğlu, Kerem

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

2019 Volume 44, Issue 3, Page(s) 349–355

Abstract: Objectives: To investigate the relationship between the cell percentage of T regulator (Treg) cells of patients' specimens and disease severity, survivability, recurrence and metastasis in patients who were diagnosed with nasopharyngeal carcinoma (NPC).! ...

Abstract	Objectives: To investigate the relationship between the cell percentage of T regulator (Treg) cells of patients' specimens and disease severity, survivability, recurrence and metastasis in patients who were diagnosed with nasopharyngeal carcinoma (NPC). Design, setting and participants: Sixty patients who were diagnosed as NPC and treated by the same protocol were enrolled to the study. Patient files were reviewed retrospectively and their clinical and pathological results were recorded. Deparaffinized samples of nasopharyngeal carcinoma patients were stained immunohistochemically with anti-FoxP3 monoclonal antibody. All patients's Anti-FoxP3 stained slides were evaluated by the same pathologist. Stained Treg lymphocytes around the tumoral foci were investigated. Patients were divided into two groups according to the total anti-FoxP3-stained Treg cell counts of the specimens; that is, less than 20% of the total or more than 20% of the total. These groups were compared statistically. Main outcome measures: Intensity of FoxP3 which is related to negative tumor response was the main outcome measure. It was evaluated in terms of stage, survival, recurrence and metastasis. Results: The study group consisted of 42 male patients (70%) and 18 female patients (30%). The mean age was 47 ± 14.9. NPC subtypes among the patients were undifferentiated non-keratinized type in 54 patients (90%), differentiated non-keratinized type in 4 patients (6.66%) and keratinized type squamous cell carcinoma (SCC) in 2 patients (3.33%). When the two groups were compared in terms of pathological subtype, there was no significant variation between the two groups. There was also no significant variation between the two groups when compared on the basis of tumor stage (P = 0.36 for T phase, P = 0.122 for N phase), early stage, late phase (P = 0.15), survival rate (P = 0.69 for general survival), recurrence (P = 0.2 for local recurrence, P = 0.37 for regional recurrence) and distant metastasis (P = 0.3). Conclusion: There was no significant relationship between the concentration of these cells in the stained specimens and the disease stage, survival rate, recurrence and distant metastasis discovered.
MeSH term(s)	Adult ; Biomarkers, Tumor/metabolism ; Biopsy ; Female ; Follow-Up Studies ; Forkhead Transcription Factors/metabolism ; Humans ; Immunohistochemistry ; Incidence ; Male ; Middle Aged ; Nasopharyngeal Neoplasms/diagnosis ; Nasopharyngeal Neoplasms/epidemiology ; Nasopharyngeal Neoplasms/metabolism ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/metabolism ; Neoplasm Staging/methods ; Retrospective Studies ; Survival Rate/trends ; Turkey/epidemiology
Chemical Substances	Biomarkers, Tumor ; FOXP3 protein, human ; Forkhead Transcription Factors
Language	English
Publishing date	2019-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2205891-6
ISSN	1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
ISSN (online)	1749-4486
ISSN	1749-4478 ; 0307-7772 ; 1365-2273
DOI	10.1111/coa.13311
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Article ; Online: Surgery of Retrosternal Thyroid

Alperen Vural / Emrah Gülmez / Ömer Faruk Demir / Kerem Kökoğlu / Imdat Yüce / Sedat Çağlı

Erciyes Medical Journal, Vol 41, Iss 3, Pp 261-

Evaluation of 36 Cases

2019 Volume 264

Abstract: Objective: Retrosternal thyroid is the presence of thyroid tissue in the mediastinum either by enlarging of the cervical or by an ectopic mediastinal thyroid. Surgery for a retrosternal thyroid has technical differences than conventional cervical thyroid ...

Abstract	Objective: Retrosternal thyroid is the presence of thyroid tissue in the mediastinum either by enlarging of the cervical or by an ectopic mediastinal thyroid. Surgery for a retrosternal thyroid has technical differences than conventional cervical thyroid surgery and has a higher risk of complications. This paper aims to analyze the cases with retrosternal thyroid and to evaluate the outcomes of the surgery. Materials and Methods: Retrospective analysis in terms of age, sex, clinical course, thyroid hormone levels, parathormone (PTH) levels, diagnostic methods, and fine needle aspiration cytology (FNAC) results and complications of 36 cases that underwent surgery was performed. Results: In addition to routine evaluation for thyroid pathology, computerized tomography was used for each patient. Thirty-four surgeries were completed with a cervical incision, one with a sternotomy and one with a thoracotomy. Four patients (11.1%) experienced temporary postoperative hypocalcemia, and one patient had a transient vocal cord immobility. Neither permanent hypocalcemia nor vocal cord paralysis was present in any of the patients postoperatively. Conclusion: Planning surgery as early as possible is suggested to avoid compression symptoms and possible malignancy. Cervical approach is mostly enough for the majority of patients; however, in case of a need of an additional (transthoracic) approach, multidisciplinary planning with thoracic surgeons is proposed. The risk of complications in experienced centers is parallel to cervical thyroidectomy.
Keywords	mediastinal neoplasms ; thyroid ; surgery ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2019-09-01T00:00:00Z
Publisher	KARE Publishing
Document type	Article ; Online
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