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  1. Book: Microwaves in organic and medicinal chemistry

    Kappe, Christian Oliver / Stadler, Alexander

    (Methods and principles in medicinal chemistry ; 25)

    2005  

    Author's details C. Oliver Kappe, Alexander Stadler
    Series title Methods and principles in medicinal chemistry ; 25
    Collection
    Keywords Organische Synthese ; Mikrowelle ; Kombinatorische Synthese
    Subject Mikrowellen ; Kombinatorische Chemie ; Kombinatorische Biologie ; Biokombinatorische Synthese ; Organische Chemie
    Language English
    Size XII, 409 S. : graph. Darst.
    Publisher Wiley-VCH
    Publishing place Weinheim
    Publishing country Germany
    Document type Book
    HBZ-ID HT014448415
    ISBN 978-3-527-31210-8 ; 3-527-31210-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 A 5823 order for loan Magazin

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  2. Article ; Online: Intravenous Thrombolysis for Stroke in a COVID-19 Positive Filipino Patient, a Case Report.

    Co, Christian Oliver C / Yu, Jeryl Ritzi T / Laxamana, Lina C / David-Ona, Deborah Ignacia A

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2020  Volume 77, Page(s) 234–236

    Abstract: The 2019 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which was first reported in Wuhan, China last December 2019, has been declared an emergency by the World Health Organization but eventually progressed to become a Pandemic. To date, ... ...

    Abstract The 2019 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which was first reported in Wuhan, China last December 2019, has been declared an emergency by the World Health Organization but eventually progressed to become a Pandemic. To date, Coronavirus Disease 2019 (COVID-19) has affected at least 100,000 individuals worldwide, reaching thousands of mortalities (Zhou et al., 2020; World Health Organization, 2020). In the Philippines, the number of COVID-19 confirmed positive cases is over 636 and is expected to rise (Department of Health, 2020). Respiratory infections alongside their comorbidities can induce acute myocardial infarction and acute ischemic stroke (Warren-Gash et al., 2018) [3]. These may further bring challenges in the management and administration of Intravenous (IV) Alteplase in eligible patients. Currently, there are no case reports in the administration IV Altepase in ischemic stroke patients who are COVID-19 positive. We present a case of a 62-year old female who was admitted due to cough, colds and shortness of breath of 2 weeks duration and was tested to be COVD-19 positive. She suffered from an ischemic stroke while in the Medical Intensive Care Unit and was given Intravenous thrombolysis.
    MeSH term(s) Administration, Intravenous ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Female ; Humans ; Middle Aged ; Pandemics ; Philippines ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Stroke/drug therapy ; Stroke/etiology ; Stroke/virology ; Thrombolytic Therapy/methods ; Tissue Plasminogen Activator/administration & dosage ; Tissue Plasminogen Activator/therapeutic use
    Chemical Substances Tissue Plasminogen Activator (EC 3.4.21.68)
    Keywords covid19
    Language English
    Publishing date 2020-05-11
    Publishing country Scotland
    Document type Case Reports
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2020.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Intravenous Thrombolysis for Stroke in a COVID-19 Positive Filipino Patient, a Case Report

    Co, Christian Oliver C. / Yu, Jeryl Ritzi T. / Laxamana, Lina C. / David-Ona, Deborah Ignacia A.

    Journal of Clinical Neuroscience

    2020  Volume 77, Page(s) 234–236

    Keywords Physiology (medical) ; Neurology ; Clinical Neurology ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1193674-5
    ISSN 0967-5868
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2020.05.006
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article: Intravenous Thrombolysis for Stroke in a COVID-19 Positive Filipino Patient, a Case Report

    Co, Christian Oliver C / Yu, Jeryl Ritzi T / Laxamana, Lina C / David-Ona, Deborah Ignacia A

    J Clin Neurosci

    Abstract: The 2019 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which was first reported in Wuhan, China last December 2019, has been declared an emergency by the World Health Organization but eventually progressed to become a Pandemic. To date, ... ...

    Abstract The 2019 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which was first reported in Wuhan, China last December 2019, has been declared an emergency by the World Health Organization but eventually progressed to become a Pandemic. To date, Coronavirus Disease 2019 (COVID-19) has affected at least 100,000 individuals worldwide, reaching thousands of mortalities (Zhou et al., 2020; World Health Organization, 2020). In the Philippines, the number of COVID-19 confirmed positive cases is over 636 and is expected to rise (Department of Health, 2020). Respiratory infections alongside their comorbidities can induce acute myocardial infarction and acute ischemic stroke (Warren-Gash et al., 2018) [3]. These may further bring challenges in the management and administration of Intravenous (IV) Alteplase in eligible patients. Currently, there are no case reports in the administration IV Altepase in ischemic stroke patients who are COVID-19 positive. We present a case of a 62-year old female who was admitted due to cough, colds and shortness of breath of 2 weeks duration and was tested to be COVD-19 positive. She suffered from an ischemic stroke while in the Medical Intensive Care Unit and was given Intravenous thrombolysis.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32414622
    Database COVID19

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  5. Article ; Online: Continuous-Flow Synthesis of ZIF-8 Biocomposites with Tunable Particle Size.

    Carraro, Francesco / Williams, Jason D / Linares-Moreau, Mercedes / Parise, Chiara / Liang, Weibin / Amenitsch, Heinz / Doonan, Christian / Kappe, C Oliver / Falcaro, Paolo

    Angewandte Chemie (International ed. in English)

    2020  Volume 59, Issue 21, Page(s) 8123–8127

    Abstract: Zeolitic imidazolate framework (ZIF) biocomposites show the capacity to protect and deliver biotherapeutics. To date, the progress in this research area is based on laboratory batch methods. Now, the first continuous flow synthetic method is presented ... ...

    Abstract Zeolitic imidazolate framework (ZIF) biocomposites show the capacity to protect and deliver biotherapeutics. To date, the progress in this research area is based on laboratory batch methods. Now, the first continuous flow synthetic method is presented for the encapsulation of a model protein (bovine serum albumin, BSA) and a clinical therapeutic (α1-antitrypsin, AAT) in ZIF-8. The in situ kinetics of nucleation, growth, and crystallization of BSA@ZIF-8 were studied by small-angle X-ray scattering. By controlling the injection time of ethanol, the particle growth could be quenched by ethanol-induced crystallization from amorphous particles to ZIF-8 crystals. The particle size of the biocomposite was tuned in the 40-100 nm range by varying residence time prior to introduction of ethanol. As a proof-of-concept, this procedure was used for the encapsulation of AAT in ZIF-8. Upon release of the biotherapeutic from the composite, the trypsin inhibitor function of AAT was preserved.
    MeSH term(s) Animals ; Biocompatible Materials/chemistry ; Cattle ; Crystallization ; Drug Carriers/chemistry ; Drug Liberation ; Ethanol/chemistry ; Particle Size ; Serum Albumin, Bovine/chemistry ; Serum Albumin, Bovine/metabolism ; Zeolites/chemistry ; alpha 1-Antitrypsin/chemistry ; alpha 1-Antitrypsin/metabolism
    Chemical Substances Biocompatible Materials ; Drug Carriers ; alpha 1-Antitrypsin ; Zeolites (1318-02-1) ; Serum Albumin, Bovine (27432CM55Q) ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2020-03-17
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202000678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Cucumeropsis mannii

    Aja, Patrick M / Chiadikaobi, Chukwu D / Agu, Peter C / Ale, Boniface A / Ani, Onyedika G / Ekpono, Ezebuilo U / Ogwoni, Hilary A / Awoke, Joshua N / Ogbu, Patience N / Aja, Lucy / Nwite, Felix E / Ukachi, Oliver U / Orji, Obasi U / Nweke, Peter C / Egwu, Chinedu O / Ekpono, Ejike U / Ewa, Gift O / Igwenyi, Ikechuku O / Tusubira, Deusdedit /
    Offor, Christian E / Maduagwuna, Ekenechukwu K / Alum, Esther U / Uti, Daniel E / Njoku, Amobichukwu / Atoki, Victor A / Awuchi, Chinaza G

    Food science & nutrition

    2023  Volume 11, Issue 6, Page(s) 2642–2653

    Abstract: This study demonstrated the therapeutic potentials ... ...

    Abstract This study demonstrated the therapeutic potentials of
    Language English
    Publishing date 2023-02-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703010-6
    ISSN 2048-7177
    ISSN 2048-7177
    DOI 10.1002/fsn3.3271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Singlet-oxygen oxidation of 5-hydroxymethylfurfural in continuous flow.

    Heugebaert, Thomas S A / Stevens, Christian V / Kappe, C Oliver

    ChemSusChem

    2015  Volume 8, Issue 10, Page(s) 1648–1651

    Abstract: Singlet-oxygen oxidation of 5-hydroxymethylfurfural (5-HMF) was performed in continuous flow mode using rose Bengal as photosensitizer. The resulting butenolide (H(2) MF) was formed selectively in high yield. The procedure proved to be scalable and ... ...

    Abstract Singlet-oxygen oxidation of 5-hydroxymethylfurfural (5-HMF) was performed in continuous flow mode using rose Bengal as photosensitizer. The resulting butenolide (H(2) MF) was formed selectively in high yield. The procedure proved to be scalable and applicable to related bio-based furfurals. Furthermore, preliminary data show that H(2) MF can be readily isomerized thermally to 5-hydroxy-4-keto-pentenoic acid oligomers.
    MeSH term(s) 4-Butyrolactone/analogs & derivatives ; 4-Butyrolactone/chemistry ; Furaldehyde/analogs & derivatives ; Furaldehyde/chemistry ; Light ; Oxidation-Reduction ; Photosensitizing Agents/chemistry ; Rose Bengal/chemistry ; Singlet Oxygen/chemistry
    Chemical Substances Photosensitizing Agents ; Singlet Oxygen (17778-80-2) ; Rose Bengal (1ZPG1ELY14) ; 5-hydroxymethylfurfural (70ETD81LF0) ; butenolide (8KXK25H388) ; Furaldehyde (DJ1HGI319P) ; 4-Butyrolactone (OL659KIY4X)
    Language English
    Publishing date 2015-05-22
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1864-564X
    ISSN (online) 1864-564X
    DOI 10.1002/cssc.201403182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Dabigatran Reversal With Idarucizumab Preceding Thrombolysis in an Octogenarian Patient with Chronic Kidney Disease and Acute Stroke: A Case Report.

    Laxamana, Lina C / Co, Christian Oliver C / Yu, Jeryl Ritzi T / Mojica, Christianne V / Iboleon-Dy, Maria Adelaida M / Domingo, Alyssa Mae C / Ilano, Karen Czarina S / Macrohon-Valdez, Ma Cristina Z

    Clinical therapeutics

    2020  Volume 42, Issue 9, Page(s) 1840–1845

    Abstract: Background and purpose: Reversing the effect of dabigatran among patients with atrial fibrillation is important to normalize coagulation profile among patients who develop serious hemorrhage from any source. However, such intervention always has the ... ...

    Abstract Background and purpose: Reversing the effect of dabigatran among patients with atrial fibrillation is important to normalize coagulation profile among patients who develop serious hemorrhage from any source. However, such intervention always has the potential to cause a prothrombotic state. Among patients suspected of ischemic stroke, Idarucizumab, may be administered preceding thrombolysis. This is a considerable option when given during the critical phase of revascularization.
    Methods: We report the case of an 84-year old, male, banker, known hypertensive with chronic renal disease. He has non valvular atrial fibrillation receiving Dabigatran at 75 mg twice daily and presented with symptoms of right-sided weakness, right hemisensory loss, facial asymmetry, and slurring of speech equating to National Institute of Health Stroke Scale (NIHSS) of 5. After coming into the hospital for a suspected stroke, 3 hours and 25 minutes after symptoms, complete reversal of Dabigatran with Idarucizumab was administered and intravenous thrombolysis was initiated 271 minutes post ictus. There was immediate improvement of the right upper extremity weakness and dysarthria 30 minutes post infusion. At 13 days post ictus, the patient was discharged with minimal right central facial palsy and right arm drift (NIHSS 2). Brain CT scan post revascularization did not reveal any hemorrhage and anticoagulant Apixaban 2.5 mg twice daily was started and maintained thereafter. Brain Magnetic Resonance Angiogram (MRA) showed complete recanalization of the left proximal MCA after 52 days.
    Conclusion: Our case showed the effectiveness and safety of giving Idarucizumab followed by thrombolysis in Dabigatran-treated atrial fibrillation with ischemic stroke. Based on this case, the procedure can be performed in an elderly population with chronic kidney disease when administered close to the limit of threshold for thrombolysis.
    MeSH term(s) Administration, Intravenous ; Aged, 80 and over ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antithrombins/administration & dosage ; Antithrombins/adverse effects ; Atrial Fibrillation/drug therapy ; Dabigatran/adverse effects ; Dabigatran/therapeutic use ; Humans ; Hypertension/drug therapy ; Male ; Renal Insufficiency, Chronic/drug therapy ; Stroke/drug therapy ; Thrombolytic Therapy/adverse effects ; Thrombolytic Therapy/methods
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antithrombins ; idarucizumab (97RWB5S1U6) ; Dabigatran (I0VM4M70GC)
    Language English
    Publishing date 2020-08-07
    Publishing country United States
    Document type Case Reports
    ZDB-ID 603113-4
    ISSN 1879-114X ; 0149-2918
    ISSN (online) 1879-114X
    ISSN 0149-2918
    DOI 10.1016/j.clinthera.2020.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1435: Show issues Location:
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    Zs.MO 404: Show issues

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  9. Article ; Online: Palladium-catalyzed direct arylation of heteroaromatic compounds: improved conditions utilizing controlled microwave heating.

    Baghbanzadeh, Mostafa / Pilger, Christian / Kappe, C Oliver

    The Journal of organic chemistry

    2011  Volume 76, Issue 19, Page(s) 8138–8142

    Abstract: A versatile and rapid microwave-assisted procedure for the palladium-catalyzed direct arylation of heterocycles by aryl bromides and heteroaryl bromides is described. This novel protocol features short coupling times (10-60 min) and low catalyst loadings ...

    Abstract A versatile and rapid microwave-assisted procedure for the palladium-catalyzed direct arylation of heterocycles by aryl bromides and heteroaryl bromides is described. This novel protocol features short coupling times (10-60 min) and low catalyst loadings (1 mol %) and allows the successful arylation of previously unreactive heterocyclic substrates.
    Language English
    Publishing date 2011-10-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/jo201516v
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4473: Show issues Location:
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  10. Article ; Online: Rapid nickel-catalyzed Suzuki-Miyaura cross-couplings of aryl carbamates and sulfamates utilizing microwave heating.

    Baghbanzadeh, Mostafa / Pilger, Christian / Kappe, C Oliver

    The Journal of organic chemistry

    2011  Volume 76, Issue 5, Page(s) 1507–1510

    Abstract: High-speed and scalable nickel-catalyzed cross-coupling of arylboronic acids with aryl carbamates and sulfamates is achieved by using sealed-vessel microwave processing. ...

    Abstract High-speed and scalable nickel-catalyzed cross-coupling of arylboronic acids with aryl carbamates and sulfamates is achieved by using sealed-vessel microwave processing.
    MeSH term(s) Aminobiphenyl Compounds/chemical synthesis ; Aminobiphenyl Compounds/chemistry ; Boronic Acids/chemistry ; Carbamates/chemistry ; Catalysis ; Microwaves ; Molecular Structure ; Nickel/chemistry ; Nitriles/chemical synthesis ; Nitriles/chemistry ; Organometallic Compounds/chemistry ; Stereoisomerism ; Sulfonic Acids/chemistry
    Chemical Substances Aminobiphenyl Compounds ; Boronic Acids ; Carbamates ; Nitriles ; Organometallic Compounds ; Sulfonic Acids ; Nickel (7OV03QG267) ; sulfamic acid (9NFU33906Q) ; benzonitrile (9V9APP5H5S)
    Language English
    Publishing date 2011-03-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/jo1024464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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