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  1. Article ; Online: Renoprotective impact of allopurinol in elderly patients with hypertension

    Peyman Mottaghi

    Journal of Nephropathology, Vol 7, Iss 2, Pp 43-

    2018  Volume 44

    Keywords elderly ; hypertension ; uric acid ; glomerular filtration rate ; Pathology ; RB1-214 ; Internal medicine ; RC31-1245 ; Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2018-04-01T00:00:00Z
    Publisher Society of Diabetic Nephropathy Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Effectiveness of bosentan in the treatment of systemic sclerosis-related digital ulcers: Systematic review and meta-analysis.

    Hosseinbalam, Marziyeh / Nouri, Rasool / Farajzadegan, Ziba / Mottaghi, Peyman

    Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

    2023  Volume 28, Page(s) 3

    Abstract: Background: The aim of the present systematic review and meta-analysis was to evaluate the therapeutic efficacy of bosentan, a dual endothelin receptor antagonist, for systemic sclerosis (SSc) patients with digital ulcers (DUs).: Materials and methods! ...

    Abstract Background: The aim of the present systematic review and meta-analysis was to evaluate the therapeutic efficacy of bosentan, a dual endothelin receptor antagonist, for systemic sclerosis (SSc) patients with digital ulcers (DUs).
    Materials and methods: A systematic search of MEDLINE, Embase, Web of Science, and Scopus was done using appropriate keywords till September 2021. Weighted mean difference (WMD) as the effect of therapeutic efficacy of bosentan on continuous outcomes was an estimate. Furthermore, the pooled prevalence of diffuse SSc and limited SSc was computed. Fixed or random effects models when appropriate were used for data synthesis.
    Results: Totally, 469 patients, with a mean age ranging from 48.1 to 63.7 years, from 8 studies were included in the systematic review and meta-analysis. The pooled frequency of diffuse SSc and limited SSc was 56% (95% confidence interval [CI]: 39%, 73%) and 44% (95% CI: 27%, 61%). The pooled prevalence of new DUs following bosentan treatment was 21% (95% CI: 10%, 33%). The results of the meta-analysis showed a pooled mean decrease of WMD: -0.09 (95% CI: -0.020, 0.02,
    Conclusion: Bosentan possibly is an efficacious treatment option for SSc-related DUs. Although further large-scale randomized clinical trials are required to confirm the preliminary finding and underlying mechanisms of action.
    Language English
    Publishing date 2023-01-31
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2513029-8
    ISSN 1735-7136 ; 1735-1995
    ISSN (online) 1735-7136
    ISSN 1735-1995
    DOI 10.4103/jrms.jrms_386_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Antioxidant and Bone; Protect Your Future: A Brief Review.

    Mottaghi, Peyman / Nasri, Parto

    Iranian journal of public health

    2020  Volume 50, Issue 9, Page(s) 1783–1788

    Abstract: The global campaign of osteoporosis has been organized by the International Osteoporosis Foundation (IOF) and them introducing World Osteoporosis Day (WOD) in 1997. The day is celebrated on October ... ...

    Abstract The global campaign of osteoporosis has been organized by the International Osteoporosis Foundation (IOF) and them introducing World Osteoporosis Day (WOD) in 1997. The day is celebrated on October 20
    Language English
    Publishing date 2020-03-16
    Publishing country Iran
    Document type Journal Article ; Review
    ZDB-ID 2240935-X
    ISSN 2251-6093 ; 2251-6093
    ISSN (online) 2251-6093
    ISSN 2251-6093
    DOI 10.18502/ijph.v50i9.7049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Changes in bone biological markers after treatment of Iranian diabetic patients with pioglitazone: No relation to polymorphism of PPAR-γ (Pro12Ala).

    Mottaghi, Peyman

    Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

    2013  Volume 18, Issue 4, Page(s) 366–367

    Language English
    Publishing date 2013-10-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 2513029-8
    ISSN 1735-7136 ; 1735-1995
    ISSN (online) 1735-7136
    ISSN 1735-1995
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  5. Article ; Online: Changes in bone biological markers after treatment of Iranian diabetic patients with pioglitazone

    Peyman Mottaghi

    Journal of Research in Medical Sciences, Vol 18, Iss 4, Pp 366-

    No relation to polymorphism of PPAR-g (Pro12Ala)

    2013  Volume 367

    Keywords Medicine ; R
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Evaluation of Diagnostic Accuracy of Alpha-Fodrin Antibody in Iranian Patients with Sjogren's Disease.

    Rostamian, Alireza / Baradaran, Azar / Mottaghi, Peyman / Salesi, Mansour / Karimifar, Mansour / Mansouri, Vahid

    Advanced biomedical research

    2022  Volume 11, Page(s) 64

    Abstract: Background: Sjogren's syndrome, as a chronic autoimmune disease, involves in lymphocytic infiltration in the exocrine glands. As the result of exocrine glands disruption, the clinical hallmark of this disease including dryness of mouth and eyes along ... ...

    Abstract Background: Sjogren's syndrome, as a chronic autoimmune disease, involves in lymphocytic infiltration in the exocrine glands. As the result of exocrine glands disruption, the clinical hallmark of this disease including dryness of mouth and eyes along with fatigue and joint pain occur. However, heterogeneity of clinical presentations among newly diagnosed adult patients with Sjogren's syndrome leads to difficulty in its diagnosis. One of the diagnostic criteria for Sjogren's syndrome is the presence of autoantibodies in patient serum. One of the novel biomarkers suggested for diagnosis of Sjogren is alpha-fodrin antibody. In this study, we aimed to evaluate the diagnostic power of anti-α-fodrin antibody among the Iranian population for the first time.
    Materials and methods: We recruited 82 individuals in this study. Alpha-fodrin were measured in case and control with Elisa kit as 16.71 (9.84) and 18.44 (11.54).
    Results: There was no any significant difference between two groups regarding alpha-fodrin level (
    Conclusions: Alpha-fodrin test did not have acceptable predictive power for predicting Sjogren's disease; however, it could be associated with disease progression.
    Language English
    Publishing date 2022-07-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 2672524-1
    ISSN 2277-9175
    ISSN 2277-9175
    DOI 10.4103/abr.abr_260_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Intravenous bisphosphonates for postmenopausal osteoporosis.

    Mottaghi, Peyman

    Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

    2011  Volume 15, Issue 3, Page(s) 175–184

    Abstract: Numerous clinical studies have shown bisphoshonates (BPs) to be useful and cost-effective options for the fractures prevention and postmenopausal bone loss. The use of oral bisphoshonates is an established option for managment of osteoporosis in ... ...

    Abstract Numerous clinical studies have shown bisphoshonates (BPs) to be useful and cost-effective options for the fractures prevention and postmenopausal bone loss. The use of oral bisphoshonates is an established option for managment of osteoporosis in postmenopausal women, but many of them complaint from gastrointestinal side effect or frequently dosed oral regimens. To improve upon the suboptimal therapeutic compliance in postmenopausal women, newer, longer-acting intravenous formulations of BPs has been approved for intermittent administration in postmenopausal women. These preparations would become an option for patients who can not tolerate oral BPs or it was ineffective in increasing their bone density.This article proposed to review effectiveness and tolerability of intravenous BPs in postmenopausal women with osteoporosis.
    Language English
    Publishing date 2011-01-18
    Publishing country India
    Document type Journal Article
    ZDB-ID 2513029-8
    ISSN 1735-7136 ; 1735-1995
    ISSN (online) 1735-7136
    ISSN 1735-1995
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    Zs.A 6810: Show issues Location:
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  8. Article ; Online: Teaching Medical Students

    Peyman Mottaghi / Arash Najimi

    مجله ایرانی آموزش در علوم پزشکی, Vol 18, Pp 1-

    Computer-Based Teaching versus Traditional Lecture

    2018  Volume 7

    Abstract: Introduction: Lecture and computer-based teaching are two important methods for the teaching of medical students. However, comparison of the effectiveness and efficacy of both of these methods shows substantial deficiencies. The aim of this study was to ... ...

    Abstract Introduction: Lecture and computer-based teaching are two important methods for the teaching of medical students. However, comparison of the effectiveness and efficacy of both of these methods shows substantial deficiencies. The aim of this study was to compare the effects of lecture and computer-based teaching methods on the learning of medical students taking introduction to clinical medicine (ICM) courses at Isfahan University of Medical Sciences. Methods: This study was a quasi-experimental research which was conducted in Isfahan University of Medical Sciences. Research population included students taking ICM courses in two consecutive semesters. The first group of students were assigned to the control group (n=67) and were taught rheumatology through in-class lecture method while the second group of students (the intervention group) received computer-based teaching. For evaluation and comparison of the effects of the intervention on learning, two multiple-choice question tests were administered at the end of the training course and 8 weeks after the intervention. Results: No significant difference was found between the mean scores of the two groups in the first test (p=0.77), but the difference in the second test was significant (p<0.001). The computer-based teaching group performed better in recalling of the learning materials. Conclusion: Although short-term results were similar in both groups, long-term learning and recalling were greater with computer-based teaching than with lecture.
    Keywords lecture ; computer based learning ; self-learning ; learning ; medical students ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 370
    Language Persian
    Publishing date 2018-04-01T00:00:00Z
    Publisher Isfahan University of Medical Sciences, Medical Education Development Center
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Evaluation of diagnostic accuracy of alpha-fodrin antibody in Iranian patients with Sjogren's disease

    Alireza Rostamian / Azar Baradaran / Peyman Mottaghi / Mansour Salesi / Mansour Karimifar / Vahid Mansouri

    Advanced Biomedical Research, Vol 11, Iss 1, Pp 64-

    2022  Volume 64

    Abstract: Background: Sjogren's syndrome, as a chronic autoimmune disease, involves in lymphocytic infiltration in the exocrine glands. As the result of exocrine glands disruption, the clinical hallmark of this disease including dryness of mouth and eyes along ... ...

    Abstract Background: Sjogren's syndrome, as a chronic autoimmune disease, involves in lymphocytic infiltration in the exocrine glands. As the result of exocrine glands disruption, the clinical hallmark of this disease including dryness of mouth and eyes along with fatigue and joint pain occur. However, heterogeneity of clinical presentations among newly diagnosed adult patients with Sjogren's syndrome leads to difficulty in its diagnosis. One of the diagnostic criteria for Sjogren's syndrome is the presence of autoantibodies in patient serum. One of the novel biomarkers suggested for diagnosis of Sjogren is alpha-fodrin antibody. In this study, we aimed to evaluate the diagnostic power of anti-α-fodrin antibody among the Iranian population for the first time. Materials and Methods: We recruited 82 individuals in this study. Alpha-fodrin were measured in case and control with Elisa kit as 16.71 (9.84) and 18.44 (11.54). Results: There was no any significant difference between two groups regarding alpha-fodrin level (P = 0.35). Then we applied the receiver operating characteristic (ROC) curve analysis to determine the predictive value of alpha-fodrin for diagnosing Sjogren's disease. The area under curve of the ROC curve was calculated as 0.5453. Also, there were significant association between age and alpha-fodrin antibody. Conclusions: Alpha-fodrin test did not have acceptable predictive power for predicting Sjogren's disease; however, it could be associated with disease progression.
    Keywords alpha-fodrin ; biomarkers ; diagnosis ; sjogren's syndrome ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The Mediating role of Pain Catastrophe, Depression and Anxiety in the Relationship between Psychological Flexibility and Pain Self-Efficacy in Patients with Musculoskeletal Pain

    Shila Kermani / Amrolah Ebrahimi / Reza Bagherian-Sararoudi / Awat Feizi / Peyman Mottaghi

    مجله دانشکده پزشکی اصفهان, Vol 40, Iss 690, Pp 789-

    2022  Volume 799

    Abstract: Background: Musculoskeletal pain is one of the most common pains in patients referred to medical centers which may have a psychological basis. The aim of this study was to develop a structural model to explain the mediating role of catastrophizing pain, ... ...

    Abstract Background: Musculoskeletal pain is one of the most common pains in patients referred to medical centers which may have a psychological basis. The aim of this study was to develop a structural model to explain the mediating role of catastrophizing pain, depression and anxiety between psychological flexibility and pain self-efficacy in patients with musculoskeletal pain.Methods: In a cross-sectional study, 200 patients with chronic musculoskeletal pain were selected by convenience sampling method from those referred to medical centers affiliated to Isfahan University of Medical Sciences in 2020-2021. Eligible participants filled out: Chronic Pain Acceptance Questionnaire (CPAQ), Cognitive Fusion Questionnaire (CFQ), Self-Experience Questionnaire (SEQ), Value-based Life Questionnaire (VLQ), Committed Action Questionnaire (CAQ-8), Pain Self-Efficacy Questionnaire (PSEQ) and the Mindful Attention Awareness Scale (MAAS), Pain Catastrophizing Scale (PCS), and Hospital Anxiety and Depression Scale (HADS). Then the data were analyzed using SPSS-24 and AMOS software and statistical methods of regression analysis and structural equations.Findings: The results showed that the direct effect coefficient of pain catastrophizing, anxiety, depression and psychological flexibility on pain self-efficacy is (0.357), (0.255), (0.127) and (0.849) respectively. The total relationship between psychological flexibility and pain self-efficacy is (0.346). To test the suitability of the models, NFI, TLI, CFI and IFI indices were used, which were within acceptable limits.Conclusion: The psychological flexibility variable predicts pain self-efficacy mediated by catastrophic pain, depression and anxiety (P < 0.01, r = 0.85) and it appears that predicting pain catastrophe, depression, anxiety and psychological resilience can increase pain self-efficacy. Ultimately, the improvement of these psychological factors may affect the process of better disease management.
    Keywords catastrophizing ; depression ; anxiety ; flexibility ; self-efficacy ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 150
    Language Persian
    Publishing date 2022-12-01T00:00:00Z
    Publisher Vesnu Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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