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  1. AU=Weigelin Bettina
  2. AU="Arun Kumar S"
  3. AU="Dahlsjö, Cecilia A L"
  4. AU="Gavigan, Patrick"
  5. AU="Liu, Ye"
  6. AU="Changyang Xing"
  7. AU="Sarovich, Derek S"
  8. AU="Joseph P. Zackular"
  9. AU="Maes, Evelyn"
  10. AU="Haixiang Zhou"
  11. AU="Choi, Jinyong"
  12. AU="González-Mansilla, Ana"
  13. AU="Cho Kilwon"
  14. AU="Rachide Onadja, Palamanga Abdoul"
  15. AU="Bertacca, Sofia"
  16. AU="Bansal, Ayush"
  17. AU="Liao, Naikai"
  18. AU="Gomes, Lux Attiê Santos"
  19. AU="İdil Su Canıtez"
  20. AU="Baptiste Duceau"
  21. AU="Pedro Seoane-Zonjic"
  22. AU="Guthridge, Carla J"
  23. AU=Meena Netra P.
  24. AU="Boustany, Tara"

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Treffer 1 - 10 von insgesamt 35

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  1. Artikel ; Online: T cell-mediated additive cytotoxicity - death by multiple bullets.

    Weigelin, Bettina / Friedl, Peter

    Trends in cancer

    2022  Band 8, Heft 12, Seite(n) 980–987

    Abstract: Immune effector cells, including cytotoxic T cells (CTLs), induce apoptosis and eliminate target cells by direct cell-cell contacts. In vivo, CTLs fail to efficiently kill solid tumor cells by individual contacts but rely upon multihit interactions by ... ...

    Abstract Immune effector cells, including cytotoxic T cells (CTLs), induce apoptosis and eliminate target cells by direct cell-cell contacts. In vivo, CTLs fail to efficiently kill solid tumor cells by individual contacts but rely upon multihit interactions by many CTLs (swarming). Recent evidence has indicated that multihit interactions by CTLs induce a series of sublethal damage events in target cells, including perforin-mediated membrane damage, induction of reactive oxygen species (ROS), nuclear envelope rupture, and DNA damage. Individual damage can be repaired, but when induced in rapid sequence, sublethal damage can accumulate and induce target cell death. Here, we summarize the sublethal damage and additive cytotoxicity concepts for CTL-induced and other cell stresses and discuss the implications for improving immunotherapy and multitargeted anticancer therapies.
    Mesh-Begriff(e) Humans ; Immunity, Cellular ; T-Lymphocytes, Cytotoxic ; Perforin ; Apoptosis ; Cell Death/genetics
    Chemische Substanzen Perforin (126465-35-8)
    Sprache Englisch
    Erscheinungsdatum 2022-08-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2022.07.007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Recent advances in intravital microscopy for preclinical research.

    Giampetraglia, Martina / Weigelin, Bettina

    Current opinion in chemical biology

    2021  Band 63, Seite(n) 200–208

    Abstract: Intravital microscopy (IVM) has revolutionized our understanding of single-cell behavior in complex tissues by enabling real-time observation of molecular and cellular processes in their natural environment. In preclinical research, IVM has emerged as a ... ...

    Abstract Intravital microscopy (IVM) has revolutionized our understanding of single-cell behavior in complex tissues by enabling real-time observation of molecular and cellular processes in their natural environment. In preclinical research, IVM has emerged as a standard tool for mechanistic studies of therapy response and the rational design of new treatment strategies. Technological developments keep expanding the imaging depth and quality that can be achieved in living tissue, and the maturation of imaging modalities such as fluorescence and phosphorescence lifetime imaging facilitates co-registration of individual cell dynamics with metabolic tissue states. Correlation of IVM with mesoscopic and macroscopic imaging modalities further promotes the translation of mechanistic insights gained by IVM into clinically relevant information. This review highlights some of the recent advances in IVM that have made the transition from experimental optical techniques to practical applications in basic and preclinical research.
    Mesh-Begriff(e) Animals ; Brain ; Fluorescent Dyes/chemistry ; Humans ; Intravital Microscopy/methods ; Kinetics ; Microscopy, Fluorescence, Multiphoton ; Multimodal Imaging ; Optical Imaging ; Single-Cell Analysis/methods ; Tissue Distribution
    Chemische Substanzen Fluorescent Dyes
    Sprache Englisch
    Erscheinungsdatum 2021-07-15
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1439176-4
    ISSN 1879-0402 ; 1367-5931
    ISSN (online) 1879-0402
    ISSN 1367-5931
    DOI 10.1016/j.cbpa.2021.05.010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Editorial to the Special Issue Entitled "Imaging in Immunooncology".

    Fruhwirth, Gilbert O / Weigelin, Bettina / Daldrup-Link, Heike E / Ponomarev, Vladimir

    Molecular imaging and biology

    2022  Band 24, Heft 2, Seite(n) 177–180

    Mesh-Begriff(e) Diagnostic Imaging
    Sprache Englisch
    Erscheinungsdatum 2022-03-11
    Erscheinungsland United States
    Dokumenttyp Editorial ; Introductory Journal Article
    ZDB-ID 2079160-4
    ISSN 1860-2002 ; 1536-1632
    ISSN (online) 1860-2002
    ISSN 1536-1632
    DOI 10.1007/s11307-022-01719-z
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    Verfügbar in ZB MED Köln/Königswinter

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  4. Artikel ; Online: Histological and functional characterization of 3D human skin models mimicking the inflammatory skin diseases psoriasis and atopic dermatitis.

    Scheurer, Jasmin / Sauer, Birgit / Focken, Jule / Giampetraglia, Martina / Jäger, Annika / Schürch, Christian M / Weigelin, Bettina / Schittek, Birgit

    Disease models & mechanisms

    2024  Band 17, Heft 1

    Abstract: Three-dimensional (3D) human skin equivalents have emerged as valuable tools in skin research, replacing animal experimentation and precluding the need for patient biopsies. In this study, we advanced 3D skin equivalents to model the inflammatory skin ... ...

    Abstract Three-dimensional (3D) human skin equivalents have emerged as valuable tools in skin research, replacing animal experimentation and precluding the need for patient biopsies. In this study, we advanced 3D skin equivalents to model the inflammatory skin diseases atopic dermatitis and psoriasis by cytokine stimulation, and were successful in integrating TH1 T cells into skin models to develop an immunocompetent 3D psoriasis model. We performed in-depth histological and functional characterization of 3D skin equivalents and validated them in terms of tissue architecture, pathological changes, expression of antimicrobial peptides and Staphylococcus aureus colonization using 3D reconstruction by multiphoton microscopy and phenotyping by highly multiplexed 'co-detection by indexing' (CODEX) microscopy. We show that our skin equivalents have a structural architecture with a well-developed dermis and epidermis, thus resembling human skin. In addition, the skin models of atopic dermatitis and psoriasis show several phenotypic features of inflammatory skin disease, including disturbed epidermal differentiation and alterations in the expression of epidermal barrier genes and antimicrobial peptides, and can be reliably used to test novel treatment strategies. Therefore, these 3D equivalents will be a valuable tool in experimental dermatological research.
    Mesh-Begriff(e) Animals ; Humans ; Dermatitis, Atopic ; Skin ; Psoriasis ; Epidermis ; Antimicrobial Peptides
    Chemische Substanzen Antimicrobial Peptides
    Sprache Englisch
    Erscheinungsdatum 2024-01-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.050541
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Mathematical Modelling Based on In Vivo Imaging Suggests CD137-Stimulated Cytotoxic T Lymphocytes Exert Superior Tumour Control Due to an Enhanced Antimitotic Effect on Tumour Cells.

    Beck, Richard J / Weigelin, Bettina / Beltman, Joost B

    Cancers

    2021  Band 13, Heft 11

    Abstract: Several immunotherapeutic strategies for the treatment of cancer are under development. Two prominent strategies are adoptive cell transfer (ACT) of CTLs and modulation of CTL function with immune checkpoint inhibitors or with costimulatory antibodies. ... ...

    Abstract Several immunotherapeutic strategies for the treatment of cancer are under development. Two prominent strategies are adoptive cell transfer (ACT) of CTLs and modulation of CTL function with immune checkpoint inhibitors or with costimulatory antibodies. Despite some success with these approaches, there remains a lack of detailed and quantitative descriptions of the events following CTL transfer and the impact of immunomodulation. Here, we have applied ordinary differential equation models to two photon imaging data derived from a B16F10 murine melanoma. Models were parameterised with data from two different treatment conditions: either ACT-only, or ACT with intratumoural costimulation using a CD137 targeted antibody. Model dynamics and best fitting parameters were compared, in order to assess the mode of action of the CTLs and examine how the CD137 antibody influenced their activities. We found that the cytolytic activity of the transferred CTLs was minimal without CD137 costimulation, and that the CD137 targeted antibody did not enhance the per-capita killing ability of the transferred CTLs. Instead, the results of our modelling study suggest that an antiproliferative effect of CTLs exerted upon the tumour likely accounted for the majority of the reduction in tumour growth after CTL transfer. Moreover, we found that CD137 most likely improved tumour control via enhancement of this antiproliferative effect, as well as prolonging the period in which CTLs were inside the tumour, leading to a sustained duration of their antitumour effects following CD137 stimulation.
    Sprache Englisch
    Erscheinungsdatum 2021-05-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13112567
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: [

    Bowden, Gregory D / Stotz, Sophie / Dunkel, Gina / Haas, Sabrina / Kimmerle, Elena / Schaller, Martin / Weigelin, Bettina / Herfert, Kristina / Pichler, Bernd J / Maurer, Andreas

    Bioconjugate chemistry

    2024  Band 35, Heft 2, Seite(n) 254–264

    Abstract: Preclinical models of neurological diseases and gene therapy are essential for neurobiological research. However, the evaluation of such models lacks reliable reporter systems for use with noninvasive imaging methods. Here, we report the development of a ...

    Abstract Preclinical models of neurological diseases and gene therapy are essential for neurobiological research. However, the evaluation of such models lacks reliable reporter systems for use with noninvasive imaging methods. Here, we report the development of a reporter system based on the CLIP-tag enzyme and [
    Mesh-Begriff(e) Humans ; Mice ; Animals ; Genes, Reporter ; HEK293 Cells ; Radiopharmaceuticals/metabolism ; Positron-Emission Tomography/methods ; Brain/diagnostic imaging ; Brain/metabolism
    Chemische Substanzen Radiopharmaceuticals
    Sprache Englisch
    Erscheinungsdatum 2024-02-03
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.3c00551
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Neutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes.

    Focken, Jule / Scheurer, Jasmin / Jäger, Annika / Schürch, Christian M / Kämereit, Sofie / Riel, Simon / Schaller, Martin / Weigelin, Bettina / Schittek, Birgit

    Cell reports

    2023  Band 42, Heft 10, Seite(n) 113148

    Abstract: Staphylococcus aureus is the most common cause of bacterial skin infections in humans, including patients with atopic dermatitis (AD). Polymorphonuclear neutrophils (PMNs) are the first cells to infiltrate an infection site, where they usually provide an ...

    Abstract Staphylococcus aureus is the most common cause of bacterial skin infections in humans, including patients with atopic dermatitis (AD). Polymorphonuclear neutrophils (PMNs) are the first cells to infiltrate an infection site, where they usually provide an effective first line of defense, including neutrophil extracellular trap (NET) formation. Here, we show that infiltrating PMNs in inflamed human and mouse skin enhance S. aureus skin colonization and persistence. Mechanistically, we demonstrate that a crosstalk between keratinocytes and PMNs results in enhanced NET formation upon S. aureus infection, which in turn induces oxidative stress and expression of danger-associated molecular patterns such as high-mobility-group-protein B1 (HMGB1) in keratinocytes. In turn, HMGB1 enhances S. aureus skin colonization and persistence by promoting skin barrier dysfunctions by the downregulation of epidermal barrier genes. Using patient material, we show that patients with AD exhibit enhanced presence of PMNs, NETs, and HMGB1 in the skin, demonstrating the clinical relevance of our finding.
    Mesh-Begriff(e) Animals ; Mice ; Humans ; Extracellular Traps ; Staphylococcus aureus ; HMGB1 Protein/genetics ; Methicillin-Resistant Staphylococcus aureus ; Down-Regulation/genetics ; Skin/microbiology ; Dermatitis, Atopic/etiology ; Staphylococcal Infections/microbiology
    Chemische Substanzen HMGB1 Protein
    Sprache Englisch
    Erscheinungsdatum 2023-09-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.113148
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Cancer cells: Stemness shaped by curvature.

    Weigelin, Bettina / Friedl, Peter

    Nature materials

    2016  Band 15, Heft 8, Seite(n) 827–828

    Mesh-Begriff(e) Cell Differentiation ; Cell Shape ; Humans ; Neoplastic Stem Cells/pathology ; Phenotype ; Signal Transduction ; Stress, Mechanical
    Sprache Englisch
    Erscheinungsdatum 2016-07-20
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2088679-2
    ISSN 1476-4660 ; 1476-1122
    ISSN (online) 1476-4660
    ISSN 1476-1122
    DOI 10.1038/nmat4711
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  9. Artikel ; Online: Targeting Gα

    Köhler, David / Leiss, Veronika / Beichert, Lukas / Killinger, Simon / Grothe, Daniela / Kushwaha, Ragini / Schröter, Agnes / Roslan, Anna / Eggstein, Claudia / Focken, Jule / Granja, Tiago / Devanathan, Vasudharani / Schittek, Birgit / Lukowski, Robert / Weigelin, Bettina / Rosenberger, Peter / Nürnberg, Bernd / Beer-Hammer, Sandra

    Basic research in cardiology

    2024  

    Abstract: Neutrophils are not only involved in immune defense against infection but also contribute to the exacerbation of tissue damage after ischemia and reperfusion. We have previously shown that genetic ablation of regulatory ... ...

    Abstract Neutrophils are not only involved in immune defense against infection but also contribute to the exacerbation of tissue damage after ischemia and reperfusion. We have previously shown that genetic ablation of regulatory Gα
    Sprache Englisch
    Erscheinungsdatum 2024-05-30
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 189755-x
    ISSN 1435-1803 ; 0300-8428 ; 0175-9418
    ISSN (online) 1435-1803
    ISSN 0300-8428 ; 0175-9418
    DOI 10.1007/s00395-024-01057-x
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  10. Artikel ; Online: A Swiss Army knife for CTLs.

    Friedl, Peter / Weigelin, Bettina

    Immunity

    2014  Band 41, Heft 6, Seite(n) 873–875

    Abstract: Granzyme B released by leukocytes cleaves multiple intracellular substrates required for target cell lysis. In this issue of Immunity, Prakash et al. (2014) demonstrate that granzyme B cleaves basement membrane proteins and promotes cytotoxic T cell ... ...

    Abstract Granzyme B released by leukocytes cleaves multiple intracellular substrates required for target cell lysis. In this issue of Immunity, Prakash et al. (2014) demonstrate that granzyme B cleaves basement membrane proteins and promotes cytotoxic T cell diapedesis into inflamed tissue.
    Mesh-Begriff(e) Animals ; Ectromelia virus/immunology ; Ectromelia, Infectious/immunology ; Granzymes/metabolism ; Killer Cells, Natural/physiology ; T-Lymphocytes, Cytotoxic/physiology
    Chemische Substanzen Granzymes (EC 3.4.21.-)
    Sprache Englisch
    Erscheinungsdatum 2014-12-18
    Erscheinungsland United States
    Dokumenttyp Comment ; Journal Article
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2014.12.008
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