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  1. Article ; Online: Unilateral hemorrhagic macular infarction associated with marijuana, alcohol and antiepileptic drug intake.

    Aktaş, Serdar / Tetikoğlu, Mehmet / İnan, Sibel / Aktaş, Hatice / Özcura, Fatih

    Cutaneous and ocular toxicology

    2017  Volume 36, Issue 1, Page(s) 88–95

    Abstract: A 55-year-old male presented with a complaint of a painless and sudden loss of vision in the right eye. Fundus photography revealed loss of transparency and edema in the central macular region. Optical coherence tomography showed increased reflectivity ... ...

    Abstract A 55-year-old male presented with a complaint of a painless and sudden loss of vision in the right eye. Fundus photography revealed loss of transparency and edema in the central macular region. Optical coherence tomography showed increased reflectivity and diffused swelling in the inner retinal layers. Fluorescein angiography revealed a large area of capillary non-perfusion with a pronounced hypofluorescent area with distinct borders. To our knowledge, this is the first report of a hemorrhagic macular infarction associated with marijuana and pregabalin misuse.
    MeSH term(s) Anticonvulsants/adverse effects ; Cannabis/adverse effects ; Ethanol/adverse effects ; Humans ; Infarction/chemically induced ; Infarction/pathology ; Macula Lutea/blood supply ; Macula Lutea/drug effects ; Macula Lutea/pathology ; Male ; Middle Aged ; Pregabalin/adverse effects ; Prescription Drug Misuse/adverse effects ; Retinal Diseases/chemically induced ; Retinal Diseases/pathology ; Visual Acuity/drug effects
    Chemical Substances Anticonvulsants ; Ethanol (3K9958V90M) ; Pregabalin (55JG375S6M)
    Language English
    Publishing date 2017-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 605635-0
    ISSN 1556-9535 ; 1556-9527 ; 0731-3829
    ISSN (online) 1556-9535
    ISSN 1556-9527 ; 0731-3829
    DOI 10.3109/15569527.2016.1141420
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    Zs.A 1782: Show issues Location:
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  2. Article ; Online: Retrospective analysis of the effect of aflibercept loading dose on the retinal vessel diameters in patients with treatment-naive neovascular AMD

    Tetikoğlu, Mehmet / Kurt, Muhammed Mustafa / Sağdık, Hacı Murat / Aktaş, Serdar / Yıldırım, Medine Aslı / Özcura, Fatih

    Cutaneous and ocular toxicology

    2018  Volume 37, Issue 1, Page(s) 84–89

    Abstract: Background: To evaluate the effects of intravitreal aflibercept (IVA) on retinal vessel diameters in patients with neovascular age-related macular degeneration (AMD).: Design, setting, and participants: A retrospective study conducted at the Kutahya ... ...

    Abstract Background: To evaluate the effects of intravitreal aflibercept (IVA) on retinal vessel diameters in patients with neovascular age-related macular degeneration (AMD).
    Design, setting, and participants: A retrospective study conducted at the Kutahya Dumlupinar University Faculty of Medicine included 15 eyes of 15 patients with treatment naive neovascular AMD.
    Methods: All eyes received IVA injections once per month for 3 months; untreated contralateral eyes were used as controls. The central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), and artery-vein ratio (AVR) values were measured using a computer-based program before the first IVA injection and 30 days after the first, second, and third injections. The main outcome measurements were the central macular thickness (CMT), best-corrected visual acuity (BCVA), choroidal thickness, CRAE, CRVE, and AVR.
    Results: Significant vasoconstriction of the retinal arterioles was observed in all eyes treated with IVA when compared to baseline (p = 0.009). However, no significant differences were found for CRVE or AVR throughout the study period in treated eyes. In the control group, all parameters measured during each visit were similar to baseline measurements (p > 0.05). The mean BCVA significantly improved at the end of the loading dose of IVA, when compared to baseline (p = 0.006). After the IVA injections, the mean CMT and choroidal thickness were significantly reduced at all visits, compared to baseline (p < 0.001).
    Conclusions: The current study showed that IVA led to significant retinal arteriolar vasoconstriction and choroidal thinning, which may cause reduced retinal blood flow.
    MeSH term(s) Aged ; Aged, 80 and over ; Angiogenesis Inhibitors/administration & dosage ; Female ; Humans ; Intravitreal Injections ; Macular Degeneration/drug therapy ; Male ; Middle Aged ; Receptors, Vascular Endothelial Growth Factor/administration & dosage ; Recombinant Fusion Proteins/administration & dosage ; Retinal Vessels/drug effects ; Retinal Vessels/physiology ; Vasoconstriction/drug effects ; Visual Acuity/drug effects
    Chemical Substances Angiogenesis Inhibitors ; Recombinant Fusion Proteins ; aflibercept (15C2VL427D) ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1)
    Language English
    Publishing date 2018-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 605635-0
    ISSN 1556-9535 ; 1556-9527 ; 0731-3829
    ISSN (online) 1556-9535
    ISSN 1556-9527 ; 0731-3829
    DOI 10.1080/15569527.2017.1354217
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  3. Article ; Online: Comparison of the biometric formulas used for applanation A-scan ultrasound biometry.

    Özcura, Fatih / Aktaş, Serdar / Sağdık, Hacı Murat / Tetikoğlu, Mehmet

    International ophthalmology

    2016  Volume 36, Issue 5, Page(s) 707–712

    Abstract: The purpose of the study was to compare the accuracy of various biometric formulas for predicting postoperative refraction determined using applanation A-scan ultrasound. This retrospective comparative study included 485 eyes that underwent uneventful ... ...

    Abstract The purpose of the study was to compare the accuracy of various biometric formulas for predicting postoperative refraction determined using applanation A-scan ultrasound. This retrospective comparative study included 485 eyes that underwent uneventful phacoemulsification with intraocular lens (IOL) implantation. Applanation A-scan ultrasound biometry and postoperative manifest refraction were obtained in all eyes. Biometric data were entered into each of the five IOL power calculation formulas: SRK-II, SRK/T, Holladay I, Hoffer Q, and Binkhorst II. All eyes were divided into three groups according to axial length: short (≤22.0 mm), average (22.0-25.0 mm), and long (≥25.0 mm) eyes. The postoperative spherical equivalent was calculated and compared with the predicted refractive error using each biometric formula. The results showed that all formulas had significantly lower mean absolute error (MAE) in comparison with Binkhorst II formula (P < 0.01). The lowest MAE was obtained with the SRK-II for average (0.49 ± 0.40 D) and short (0.67 ± 0.54 D) eyes and the SRK/T for long (0.61 ± 0.50 D) eyes. The highest postoperative hyperopic shift was seen with the SRK-II for average (46.8 %), short (28.1 %), and long (48.4 %) eyes. The highest postoperative myopic shift was seen with the Holladay I for average (66.4 %) and long (71.0 %) eyes and the SRK/T for short eyes (80.6 %). In conclusion, the SRK-II formula produced the lowest MAE in average and short eyes and the SRK/T formula produced the lowest MAE in long eyes. The SRK-II has the highest postoperative hyperopic shift in all eyes. The highest postoperative myopic shift is with the Holladay I for average and long eyes and SRK/T for short eyes.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biometry ; Female ; Humans ; Lens Implantation, Intraocular ; Male ; Middle Aged ; Optics and Photonics ; Phacoemulsification ; Postoperative Period ; Pseudophakia/physiopathology ; Refraction, Ocular/physiology ; Reproducibility of Results ; Retrospective Studies
    Language English
    Publishing date 2016-10
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-016-0195-6
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  4. Article ; Online: VEGF-A gene polymorphisms and responses to intravitreal ranibizumab treatment in patients with diabetic macular edema.

    Tetikoğlu, Mehmet / Yüksel, Zafer / Aktas, Serdar / Sağdik, Haci Murat / Özcura, Fatih

    International ophthalmology

    2017  Volume 38, Issue 6, Page(s) 2381–2388

    Abstract: Purpose: To investigate the association between VEGF gene polymorphisms and the responses to treatment with intravitreal ranibizumab (IVR) in patients with diabetic macular edema (DME).: Methods: This prospective study, conducted at the Kutahya ... ...

    Abstract Purpose: To investigate the association between VEGF gene polymorphisms and the responses to treatment with intravitreal ranibizumab (IVR) in patients with diabetic macular edema (DME).
    Methods: This prospective study, conducted at the Kutahya Dumlupinar University Faculty of Medicine, included 95 patients with DME that were treated with IVR and 32 patients without DME despite proliferative diabetic retinopathy (PDR). The participants were divided into three groups: DME with non-proliferative diabetic retinopathy, DME with PDR, and PDR without DME; patients with DME who were treated with IVR were further divided into two groups based on their response to the treatment. Each patient was genotyped for five single nucleotide variations (SNVs) in VEGF-A: rs2010963, rs2146323, rs10434, rs833069, and rs6921438.
    Result: There was a statistically significant difference in allelic distribution of VEGF-A rs833069 polymorphism in relation to the severity of diabetic retinopathy (DRP) (p = 0.031). The allelic distribution of VEGF-A rs2146323 polymorphism tended to be associated with the severity of DRP (p = 0.069). There were no statistically significant differences in the allelic distribution of the studied five SNVs in DME patients regarding the patients' responses to IVR therapy.
    Conclusions: There is no association between the studied VEGF-A SNVs and the responses to IVR therapy in DME. However, the VEGF-A rs833069 gene polymorphism has a clear association with the severity of diabetic retinopathy.
    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Diabetic Retinopathy/diagnostic imaging ; Diabetic Retinopathy/drug therapy ; Diabetic Retinopathy/genetics ; Female ; Genotyping Techniques ; Humans ; Intravitreal Injections ; Macular Edema/diagnostic imaging ; Macular Edema/drug therapy ; Macular Edema/genetics ; Male ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Single Nucleotide ; Prospective Studies ; Ranibizumab/therapeutic use ; Tomography, Optical Coherence ; Vascular Endothelial Growth Factor A/genetics ; Visual Acuity
    Chemical Substances Angiogenesis Inhibitors ; VEGFA protein, human ; Vascular Endothelial Growth Factor A ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2017-10-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-017-0738-5
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  5. Article ; Online: Mean Platelet Volume is Associated with Diabetic Macular Edema in Patients with Type-2 Diabetes Mellitus.

    Tetikoğlu, Mehmet / Aktas, Serdar / Sagdık, Hacı Murat / Tasdemir Yigitoglu, Sıla / Özcura, Fatih

    Seminars in ophthalmology

    2017  Volume 32, Issue 5, Page(s) 651–654

    Abstract: Aim: To evaluate the effect of the platelet indices on the stage of diabetic retinopathy (DR) and diabetic macular edema (DME).: Methods: In this retrospective study, the mean platelet valume (MPV), Plateletcrit (PCT), platelet (PLT), and platelet ... ...

    Abstract Aim: To evaluate the effect of the platelet indices on the stage of diabetic retinopathy (DR) and diabetic macular edema (DME).
    Methods: In this retrospective study, the mean platelet valume (MPV), Plateletcrit (PCT), platelet (PLT), and platelet distribution width (PDW) of 199 diabetic patients and 76 healthy subjects were enrolled. The participants were divided into four groups. The first group was healthy control; the second group consisted of diabetic patients without DR; the third group was nonproliferative DR (NPDR); and the fourth group was proliferative DR (PDR).
    Results: Significant differences were found only in MPV and PCT values between patients with diabetes and healthy participants (8.6±0.96 fL vs 8.32±0.9 fL, P=0.011, 0.216± 0.58 vs 0.202±0.52, P=0.038). Comparing the groups, a statistically significant difference in MPV values was found between groups 4 and 1 (8.91±.7 fL vs 8.32±0.9 fL P=0.001) and between groups 4 and 3 (8.91±.7 fL vs 8.42±0.9 fL P=0.014). The MPV values of patients with DME were significantly higher than those of diabetic patients without DME (8.87±0.80 fL vs 8.45±0.97 fL).
    Conclusion: High MPV values may be an important risk factor for the development of PDR and DME in patients with diabetic retinopathy.
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article
    ZDB-ID 632820-9
    ISSN 1744-5205 ; 0882-0538
    ISSN (online) 1744-5205
    ISSN 0882-0538
    DOI 10.3109/08820538.2016.1157612
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  6. Article ; Online: Central corneal thickness and corneal curvature in patients with rheumatoid arthritis.

    Özcura, Fatih / Aktaş, Serdar / Özkan, Yasemin / Tetikoğlu, Mehmet / Sağdik, Hacı Murat

    International ophthalmology

    2017  Volume 37, Issue 1, Page(s) 159–163

    Abstract: The aims of this study were to determine the central corneal thickness (CCT) and corneal curvature (CC) in patients with rheumatoid arthritis (RA), and to evaluate the correlations between the CCT, CC, RA activity, and RA duration. Fifty-four RA patients ...

    Abstract The aims of this study were to determine the central corneal thickness (CCT) and corneal curvature (CC) in patients with rheumatoid arthritis (RA), and to evaluate the correlations between the CCT, CC, RA activity, and RA duration. Fifty-four RA patients (104 eyes; 35 with dry eye, 69 without dry eye) and 21 age- and gender-matched control patients (42 eyes) were enrolled in the study. The CCT and CC were measured by ultrasonic pachymeter and autorefractor-keratometer, respectively. RA activity was assessed using the disease activity score (DAS) 28. The independent samples' t test and Pearson correlation analysis were used in the statistical analyses. Mean CCTs were found to be 535.88 ± 38.24, 530.46 ± 32.88, 538.64 ± 40.64, and 543.40 ± 40.66 μm in all RA eyes, RA with dry eyes, RA without dry eyes, and control eyes, respectively. Mean keratometry (K) readings were found to be 43.84 ± 1.76, 43.73 ± 1.23, 43.90 ± 1.98, and 43.60 ± 1.48 D in all RA eyes, RA with dry eyes, RA without dry eyes, and control eyes, respectively. There were no significant differences in CCT values (p values, 0.293, 0.134, and 0.550, respectively) and K readings (p values, 0.435, 0.681, and 0.402, respectively) between the RA and control eyes. These findings led us to the conclusion that the CCT and K readings were not significantly associated with DAS (p values, 0.678 and 0.812, respectively) and RA duration (p values, 0.108 and 0.080, respectively). Our results show that CCTs and CCs were not significantly different between the RA eyes and control eyes. CCTs and CCs were also not associated with RA activity and RA duration.
    MeSH term(s) Adult ; Aged ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/pathology ; Case-Control Studies ; Cornea/pathology ; Dry Eye Syndromes/etiology ; Dry Eye Syndromes/pathology ; Female ; Humans ; Intraocular Pressure ; Male ; Middle Aged ; Severity of Illness Index ; Tonometry, Ocular
    Language English
    Publishing date 2017-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-016-0243-2
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    Zs.A 1479: Show issues Location:
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  7. Article: Effect of Corneal Incision Enlargement on Surgically Induced Astigmatism in Biaxial Microincision Cataract Surgery.

    Tetikoğlu, Mehmet / Yeter, Celal / Helvacıoğlu, Fırat / Aktaş, Serdar / Sağdık, Hacı Murat / Özcura, Fatih

    Turkish journal of ophthalmology

    2016  Volume 46, Issue 3, Page(s) 99–103

    Abstract: Objectives: To evaluate surgically induced astigmatism (SIA) in biaxial microincision cataract surgery with enlargement of one corneal incision during intraocular lens implantation (IOL).: Materials and methods: Data from 683 eyes with cataract that ... ...

    Abstract Objectives: To evaluate surgically induced astigmatism (SIA) in biaxial microincision cataract surgery with enlargement of one corneal incision during intraocular lens implantation (IOL).
    Materials and methods: Data from 683 eyes with cataract that underwent biaxial microincision cataract surgery and IOL were retrospectively analyzed. The operated eyes were divided into 4 groups defined by final corneal incision length after IOL implantation. There were 83 eyes with 1.6 mm corneal incisions (group 1) and 200 eyes in each of the 2, 2.4, and 2.8 mm corneal incision groups (groups 2, 3 and 4, respectively). SIA was assessed using preoperative and postoperative keratometric values at one month.
    Results: The mean magnitude of SIA was 0.83±0.4 D in group 1, 0.93±0.5 D in group 2, 1.03±0.6 D in group 3 and 1.04±0.7 D in group 4. The SIA showed statistically significant differences between the four groups (p=0.05). Pairwise group comparisons revealed significant differences between groups 1 and 3 and groups 1 and 4 (p=0.005).
    Conclusion: Biaxial microincision cataract surgery with an incision size of 1.6 mm resulted in the least SIA. Enlargement of the corneal incision beyond 2.0 mm during IOL implantation led to significant increases in SIA. We believe that with the development and dissemination of IOLs which can be inserted through small corneal incisions, biaxial microincision cataract surgery will be the best choice to prevent SIA and increase visual acuity.
    Language English
    Publishing date 2016-06
    Publishing country Turkey
    Document type Journal Article
    ISSN 2149-8695
    ISSN 2149-8695
    DOI 10.4274/tjo.52386
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  8. Article ; Online: Serum prolidase activity and oxidative stress in patients with pseudoexfoliation syndrome.

    Tetikoğlu, Mehmet / Sağdik, Haci Murat / Aktas, Serdar / Uçar, Fatma / Özcura, Fatih

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2016  Volume 254, Issue 7, Page(s) 1339–1343

    Abstract: Purpose: We aimed to evaluate the serum prolidase activity (SPA), malondialdehyde (MDA), and catalase levels in patients with pseudoexfoliation (PEX) syndrome.: Method: Thirty-four patients with PEX syndrome and thirty-eight age- and gender-matched ... ...

    Abstract Purpose: We aimed to evaluate the serum prolidase activity (SPA), malondialdehyde (MDA), and catalase levels in patients with pseudoexfoliation (PEX) syndrome.
    Method: Thirty-four patients with PEX syndrome and thirty-eight age- and gender-matched healthy subjects were included in this prospective clinical study. Each participant underwent full ophthalmologic examination. The SPA, serum MDA, and catalase levels were measured and compared between the patients with PEX syndrome and healthy subjects.
    Results: The SPA was significantly lower in patients with PEX syndrome compared to healthy controls (14.1 ± 7.1 vs. 30.1 ± 4.3 ng/ml; p = 0.001). The mean serum MDA values the of PEX syndrome and control groups were comparable (28.7 ± 5.7 vs. 30.4 ± 5.3 nmol/ml, respectively; p = 0.185). The mean serum catalase level tended to be lower in the PEX group compared to healthy controls (0.12 ± 0.02 vs. 0.21 ± 0.05 k/ml, respectively; p = 0.077).
    Conclusion: Our findings suggest that the SPA was significantly lower in patients with PEX syndrome compared to healthy controls. Thus, prolidase may have a role in the pathogenesis of the PEX syndrome.
    MeSH term(s) Aged ; Biomarkers/blood ; Catalase/blood ; Dipeptidases/biosynthesis ; Enzyme-Linked Immunosorbent Assay ; Exfoliation Syndrome/enzymology ; Female ; Follow-Up Studies ; Humans ; Intraocular Pressure/physiology ; Male ; Malondialdehyde/blood ; Middle Aged ; Oxidative Stress ; Prospective Studies
    Chemical Substances Biomarkers ; Malondialdehyde (4Y8F71G49Q) ; Catalase (EC 1.11.1.6) ; Dipeptidases (EC 3.4.13.-) ; proline dipeptidase (EC 3.4.13.9)
    Language English
    Publishing date 2016-07
    Publishing country Germany
    Document type Clinical Study ; Journal Article
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-016-3338-6
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  9. Article: Analysis of the Retinal Nerve Fiber Layer in Retinitis Pigmentosa Using Optic Coherence Tomography.

    Yıldırım, Medine Aslı / Erden, Burak / Tetikoğlu, Mehmet / Kuru, Özlem / Elçioğlu, Mustafa

    Journal of ophthalmology

    2015  Volume 2015, Page(s) 157365

    Abstract: Aim. To evaluate the peripapillary retinal nerve fiber layer (RNFL) changes in retinitis pigmentosa (RP) patients using spectral domain optic coherence tomography (Sd-OCT). Methods. We retrospectively examined medical records of forty-four eyes of twenty- ...

    Abstract Aim. To evaluate the peripapillary retinal nerve fiber layer (RNFL) changes in retinitis pigmentosa (RP) patients using spectral domain optic coherence tomography (Sd-OCT). Methods. We retrospectively examined medical records of forty-four eyes of twenty-two RP patients. The results were also compared with those of previously reported forty-four eyes of twenty-two normal subjects (controls). Records of average and four quadrants peripapillary RNFL thickness measurements using Sd-OCT were assessed. Results. In RP patients the mean RNFL thickness was 97.57 ± 3.21 μm. The RNFL in the superior, temporal, nasal, and inferior quadrants was 119.18 ± 4.47 μm, 84.68 ± 2.31 μm, 75.09 ± 3.34 μm, and 113.88 ± 4.25 μm, respectively. While the thinning of RNFL was predominantly observed in the inferior quadrant, the thickening was mostly noted in temporal quadrant. The differences between mean, superior, and nasal quadrant RNFL thicknesses were not statistically significant when compared with control group. The RP patients had thinner inferior quadrant and thicker temporal quadrant than control group (p < 0.05). Conclusion. Sd-OCT is highly sensitive and effective instrument to detect RNFL changes in RP patients. RNFL measurements can provide information about the progression of retinitis pigmentosa and may provide prognostic indices for future treatment modalities.
    Language English
    Publishing date 2015-08-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2546525-9
    ISSN 2090-0058 ; 2090-004X
    ISSN (online) 2090-0058
    ISSN 2090-004X
    DOI 10.1155/2015/157365
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  10. Article ; Online: Dynamic thiol/disulfide homeostasis in patients with age-related macular degeneration.

    Aktaş, Serdar / Sağdık, Hacı Murat / Tetikoğlu, Mehmet / Aktaş, Hatice / Özcura, Fatih / Uçar, Fatma / Alışık, Murat / Ergin, Merve

    Arquivos brasileiros de oftalmologia

    2017  Volume 80, Issue 4, Page(s) 234–237

    Abstract: Purpose:: We evaluated dynamic thiol/disulfide homeostasis (TDH), malondialdehyde (MDA) levels, and catalase (CAT) activity in patients with age-related macular degeneration (AMD). All analyzes were conducted on plasma samples.: Methods:: Thirty-two ... ...

    Abstract Purpose:: We evaluated dynamic thiol/disulfide homeostasis (TDH), malondialdehyde (MDA) levels, and catalase (CAT) activity in patients with age-related macular degeneration (AMD). All analyzes were conducted on plasma samples.
    Methods:: Thirty-two patients with AMD and 38 age-matched healthy controls were included. Native thiol, total thiol, and disulfide levels and TDH status were determined using a novel, automated assay. MDA levels and CAT activity were determined. Percentages were compared using the chi-squared test. The Student's t-test and Mann-Whitney U-test were used to compare quantitative variables.
    Results:: Native thiol levels were significantly lower (p=0.004) in patients with AMD (272.02 ± 52.41 µmol/l) than in healthy individuals (307.82 ± 47.18 µmol/l), whereas disulfide levels were significantly higher (p<0.001) in patients with AMD than in controls (21.64 ± 5.59 vs. 14.48 ± 5.37 µmol/L). Dynamic TDH was also significantly lower (p<0.001) in patients with AMD than in controls (13.41 ± 4.3 vs. 25.41 ± 14.52 µmol/l). No significant differences were evident in total thiol or MDA levels. Mean CAT activity was significantly higher (p=0.043) in patients with AMD compared with controls (0.035 vs. 0.018 k/ml).
    Conclusions:: The antioxidant/oxidant balance demonstrated by dynamic TDH is shifted to the oxidative side in patients with AMD.
    MeSH term(s) Age Factors ; Aged ; Aged, 80 and over ; Antioxidants ; Biomarkers/blood ; Case-Control Studies ; Catalase/metabolism ; Disulfides/blood ; Female ; Homeostasis ; Humans ; Macular Degeneration/blood ; Male ; Malondialdehyde/blood ; Oxidative Stress/physiology ; Sulfhydryl Compounds/blood
    Chemical Substances Antioxidants ; Biomarkers ; Disulfides ; Sulfhydryl Compounds ; Malondialdehyde (4Y8F71G49Q) ; Catalase (EC 1.11.1.6)
    Language English
    Publishing date 2017-07-13
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 603915-7
    ISSN 1678-2925 ; 0004-2749
    ISSN (online) 1678-2925
    ISSN 0004-2749
    DOI 10.5935/0004-2749.20170057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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