Result 1 - 10 of total 705
Research square
2023
Abstract: ... ...
| Abstract | Chlamydia |
|---|---|
| Language | English |
| Publishing date | 2023-09-27 |
| Publishing country | United States |
| Document type | Preprint |
| DOI | 10.21203/rs.3.rs-3376558/v1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Current opinion in genetics & development
2023 Volume 83, Page(s) 102133
Abstract: The noncoding genome imparts important regulatory control over gene expression. In particular, gene enhancers represent a critical layer of control that integrates developmental and differentiation signals outside the cell into transcriptional outputs ... ...
| Abstract | The noncoding genome imparts important regulatory control over gene expression. In particular, gene enhancers represent a critical layer of control that integrates developmental and differentiation signals outside the cell into transcriptional outputs inside the cell. Recently, there has been an explosion in genomic techniques to probe enhancer control, function, and regulation. How enhancers are regulated and integrate signals in stem cell development and differentiation is largely an open question. In this review, we focus on the role gene enhancers play in muscle stem cell specification, differentiation, and progression. We pay specific attention toward the identification of muscle-specific enhancers, the binding of transcription factors to these enhancers, and how enhancers communicate to their target genes via three-dimensional looping. |
|---|---|
| MeSH term(s) | Transcription Factors/genetics ; Cell Differentiation/genetics ; Muscle, Skeletal/metabolism ; Stem Cells/metabolism ; Enhancer Elements, Genetic |
| Chemical Substances | Transcription Factors |
| Language | English |
| Publishing date | 2023-11-09 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ZDB-ID | 1077312-5 |
| ISSN | 1879-0380 ; 0959-437X |
| ISSN (online) | 1879-0380 |
| ISSN | 0959-437X |
| DOI | 10.1016/j.gde.2023.102133 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 3240: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2022 Volume 135, Issue 19
Abstract: The obligate intracellular pathogen Chlamydia trachomatis manipulates the host actin cytoskeleton to assemble actin-rich structures that drive pathogen entry. The recent discovery of TmeA, which, like TarP, is an invasion-associated type III effector ... ...
| Abstract | The obligate intracellular pathogen Chlamydia trachomatis manipulates the host actin cytoskeleton to assemble actin-rich structures that drive pathogen entry. The recent discovery of TmeA, which, like TarP, is an invasion-associated type III effector implicated in actin remodeling, raised questions regarding the nature of their functional interaction. Quantitative live-cell imaging of actin remodeling at invasion sites revealed differences in recruitment and turnover kinetics associated with the TarP and TmeA pathways, with the former accounting for most of the robust actin dynamics at invasion sites. TarP-mediated recruitment of actin nucleators, i.e. formins and the Arp2/3 complex, was crucial for rapid actin kinetics, generating a collaborative positive feedback loop that enhanced their respective actin-nucleating activities within invasion sites. In contrast, the formin Fmn1 was not recruited to invasion sites and did not collaborate with Arp2/3 within the context of TmeA-associated actin recruitment. Although the TarP-Fmn1-Arp2/3 signaling axis is responsible for the majority of actin dynamics, its inhibition had similar effects as the deletion of TmeA on invasion efficiency, consistent with the proposed model that TarP and TmeA act on different stages of the same invasion pathway. |
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| MeSH term(s) | Actin-Related Protein 2-3 Complex/metabolism ; Actins/metabolism ; Bacterial Proteins/metabolism ; Chlamydia trachomatis/metabolism ; Formins |
| Chemical Substances | Actin-Related Protein 2-3 Complex ; Actins ; Bacterial Proteins ; Formins |
| Language | English |
| Publishing date | 2022-10-05 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2993-2 |
| ISSN | 1477-9137 ; 0021-9533 |
| ISSN (online) | 1477-9137 |
| ISSN | 0021-9533 |
| DOI | 10.1242/jcs.260185 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1200: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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ACS catalysis
2022 Volume 12, Issue 3, Page(s) 1758–1763
Abstract: Despite the wide use and popularity of metal hydride catalysis, methods utilizing zirconium hydride catalysts remain underexplored. Here, we report the development of a mild method for ... ...
| Abstract | Despite the wide use and popularity of metal hydride catalysis, methods utilizing zirconium hydride catalysts remain underexplored. Here, we report the development of a mild method for the |
|---|---|
| Language | English |
| Publishing date | 2022-01-18 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 2155-5435 |
| ISSN | 2155-5435 |
| DOI | 10.1021/acscatal.2c00079 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2024 Volume 25, Issue 3, Page(s) 255–256
| MeSH term(s) | Humans ; COVID-19 ; SARS-CoV-2 ; Wastewater ; Extracorporeal Membrane Oxygenation ; Minnesota/epidemiology ; Viral Load |
|---|---|
| Chemical Substances | Wastewater |
| Language | English |
| Publishing date | 2024-03-07 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 1440120-4 |
| ISSN | 1557-8674 ; 1096-2964 |
| ISSN (online) | 1557-8674 |
| ISSN | 1096-2964 |
| DOI | 10.1089/sur.2023.365 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 5617: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2022 Volume 48, Issue 12, Page(s) 1775–1777
| MeSH term(s) | Humans ; Aged ; Critical Care |
|---|---|
| Language | English |
| Publishing date | 2022-11-11 |
| Publishing country | United States |
| Document type | Editorial ; Comment |
| ZDB-ID | 80387-x |
| ISSN | 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701 |
| ISSN (online) | 1432-1238 |
| ISSN | 0340-0964 ; 0342-4642 ; 0935-1701 |
| DOI | 10.1007/s00134-022-06916-6 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1089: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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Alzheimer disease and associated disorders
2024 Volume 38, Issue 1, Page(s) 98–100
Abstract: The Mini-mental State Examination (MMSE) is a commonly used screening tool for cognitive impairment. Lenient scoring of spatial orientation errors (SOEs) on the MMSE is common and negatively affects its diagnostic utility. We examined the effect of ... ...
| Abstract | The Mini-mental State Examination (MMSE) is a commonly used screening tool for cognitive impairment. Lenient scoring of spatial orientation errors (SOEs) on the MMSE is common and negatively affects its diagnostic utility. We examined the effect of lenient SOE scoring on MMSE classification accuracy in a consecutive case series of 103 older adults (age 60 or above) clinically referred for neuropsychological evaluation. Lenient scoring of SOEs on the MMSE occurred in 53 (51.4%) patients and lowered the sensitivity by 7% to 18%, with variable gains in specificity (0% to 11%) to psychometrically operationalized cognitive impairment. Results are consistent with previous reports that lenient scoring is widespread and attenuates the sensitivity of the MMSE. Given the higher clinical priority of correctly detecting early cognitive decline over specificity, a warning against lenient scoring of SOEs (on the MMSE and other screening tools) during medical education and in clinical practice is warranted. |
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| MeSH term(s) | Humans ; Aged ; Middle Aged ; Orientation, Spatial ; Sensitivity and Specificity ; Empathy ; Cognitive Dysfunction/diagnosis ; Neuropsychological Tests |
| Language | English |
| Publishing date | 2024-01-29 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 1002700-2 |
| ISSN | 1546-4156 ; 0893-0341 |
| ISSN (online) | 1546-4156 |
| ISSN | 0893-0341 |
| DOI | 10.1097/WAD.0000000000000609 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 2569: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Proceedings. Biological sciences
2024 Volume 291, Issue 2018, Page(s) 20232522
Abstract: Pesticides have well-documented negative consequences to control crop pests, and natural predators are alternatives and can provide an ecosystem service as biological control agents. However, there remains considerable uncertainty regarding whether such ... ...
| Abstract | Pesticides have well-documented negative consequences to control crop pests, and natural predators are alternatives and can provide an ecosystem service as biological control agents. However, there remains considerable uncertainty regarding whether such biological control can be a widely applicable solution, especially given ongoing climatic variation and climate change. Here, we performed a meta-analysis focused on field studies with natural predators to explore broadly whether and how predators might control pests and in turn increase yield. We also contrasted across studies pest suppression by a single and multiple predators and how climate influence biological control. Predators reduced pest populations by 73% on average, and increased crop yield by 25% on average. Surprisingly, the impact of predators did not depend on whether there were many or a single predator species. Precipitation seasonality was a key climatic influence on biological control: as seasonality increased, the impact of predators on pest populations increased. Taken together, the positive contribution of predators in controlling pests and increasing yield, and the consistency of such responses in the face of precipitation variability, suggest that biocontrol has the potential to be an important part of pest management and increasing food supplies as the planet precipitation patterns become increasingly variable. |
|---|---|
| MeSH term(s) | Ecosystem ; Climate Change ; Pesticides ; Uncertainty |
| Chemical Substances | Pesticides |
| Language | English |
| Publishing date | 2024-03-06 |
| Publishing country | England |
| Document type | Meta-Analysis ; Journal Article |
| ZDB-ID | 209242-6 |
| ISSN | 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193 |
| ISSN (online) | 1471-2954 |
| ISSN | 0080-4649 ; 0962-8452 ; 0950-1193 |
| DOI | 10.1098/rspb.2023.2522 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1364: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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2024 Volume 257, Page(s) 111126
Abstract: Background: The understanding of the molecular genetic contributions to smoking is largely limited to the additive effects of individual single nucleotide polymorphisms (SNPs), but the underlying genetic risk is likely to also include dominance, ... ...
| Abstract | Background: The understanding of the molecular genetic contributions to smoking is largely limited to the additive effects of individual single nucleotide polymorphisms (SNPs), but the underlying genetic risk is likely to also include dominance, epistatic, and gene-environment interactions. Methods: To begin to address this complexity, we attempted to identify genetic interactions between rs16969968, the most replicated SNP associated with smoking quantity, and all SNPs and genes across the genome. Results: Using the UK Biobank European subsample, we found one SNP, rs1892967, and two genes, PCNA and TMEM230, that showed a significant genome-wide interaction with rs16969968 for log10 CPD and raw CPD, respectively, in a sample of 116 442 individuals who self-reported currently or previously smoking. We extended these analyses to individuals of South Asian descent and meta-analyzed the combined sample of 117 212 individuals of European and South Asian ancestry. We replicated the gene findings in a meta-analysis of five Finnish samples (N=40 140): FinHealth, FINRISK, Finnish Twin Cohort, GeneRISK, and Health-2000-2011. Conclusions: To our knowledge, this represents the first reliable epistatic association between single nucleotide polymorphisms for smoking behaviors and provides a novel direction for possible future functional studies related to this interaction. Furthermore, this work demonstrates the feasibility of these analyses by pooling multiple datasets across various ancestries, which may be applied to other top SNPs for smoking and/or other phenotypes. |
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| MeSH term(s) | Humans ; Chromosomes, Human, Pair 20 ; Membrane Proteins/genetics ; Parkinson Disease ; Smoking/genetics ; Tobacco Products ; Polymorphism, Single Nucleotide/genetics ; Genome-Wide Association Study ; Genetic Predisposition to Disease |
| Chemical Substances | Membrane Proteins |
| Language | English |
| Publishing date | 2024-02-15 |
| Publishing country | Ireland |
| Document type | Meta-Analysis ; Journal Article |
| ZDB-ID | 519918-9 |
| ISSN | 1879-0046 ; 0376-8716 |
| ISSN (online) | 1879-0046 |
| ISSN | 0376-8716 |
| DOI | 10.1016/j.drugalcdep.2024.111126 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1310: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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POCUS journal
2023 Volume 8, Issue 1, Page(s) 71–80
Abstract: ... ...
| Abstract | Background |
|---|---|
| Language | English |
| Publishing date | 2023-04-26 |
| Publishing country | Canada |
| Document type | Journal Article |
| ISSN | 2369-8543 |
| ISSN (online) | 2369-8543 |
| DOI | 10.24908/pocus.v8i1.15683 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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