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  1. Article ; Online: N-Difluoromethylation of imidazoles and benzimidazoles using the Ruppert-Prakash reagent under neutral conditions.

    Prakash, G K Surya / Krishnamoorthy, Sankarganesh / Ganesh, Somesh K / Kulkarni, Aditya / Haiges, Ralf / Olah, George A

    Organic letters

    2014  Volume 16, Issue 1, Page(s) 54–57

    Abstract: ... the Ruppert-Prakash reagent) under neutral conditions. Difluoromethylated products were obtained in good ...

    Abstract Direct N-difluoromethylation of imidazoles and benzimidazoles has been achieved using TMS-CF3 (the Ruppert-Prakash reagent) under neutral conditions. Difluoromethylated products were obtained in good-to-excellent yields. Inexpensive, commercially available starting materials, neutral conditions, and shorter reaction times are advantages of this methodology. Reactions are accessible through conventional as well as microwave irradiation conditions.
    Language English
    Publishing date 2014-01-03
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/ol403007j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: N-Difluoromethylation of Imidazoles and Benzimidazoles Using the Ruppert–Prakash Reagent under Neutral Conditions

    Prakash, G. K. Surya / Krishnamoorthy Sankarganesh / Ganesh Somesh K / Kulkarni Aditya / Haiges Ralf / Olah George A

    Organic letters. 2014 Jan. 03, v. 16, no. 1

    2014  

    Abstract: ... the Ruppert–Prakash reagent) under neutral conditions. Difluoromethylated products were obtained in good ...

    Abstract Direct N-difluoromethylation of imidazoles and benzimidazoles has been achieved using TMS-CF₃ (the Ruppert–Prakash reagent) under neutral conditions. Difluoromethylated products were obtained in good-to-excellent yields. Inexpensive, commercially available starting materials, neutral conditions, and shorter reaction times are advantages of this methodology. Reactions are accessible through conventional as well as microwave irradiation conditions.
    Keywords benzimidazoles ; chemical reactions ; chemical structure ; imidazoles ; microwave radiation
    Language English
    Dates of publication 2014-0103
    Size p. 54-57.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021%2Fol403007j
    Database NAL-Catalogue (AGRICOLA)

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  3. Book ; Online: Integrating Clinical and Translational Research Networks-Building Team Medicine - Series 2

    Salgia, Ravi / Kulkarni, Prakash

    2023  

    Keywords Medicine ; Oncology ; drug resistance ; drug tolerance ; eco-evolutionary ; intermittent therapy ; adaptive therapy ; continuous therapy ; Team Medicine ; intrinsically disordered proteins ; complex case discussions ; decision support ; oncology pathways ; personalized medicine ; subspecialty expertise ; colorectal cancer survivor ; emergency utilization ; SARS-CoV-2 ; care satisfaction ; pandemic ; cisplatin ; non-small cell lung cancer ; group behavior ; IDPs ; phenotype switching ; mathematical modeling ; oncolytic virotherapy ; T-VEC ; immune checkpoint inhibitors ; immunotherapy ; targeted therapy ; combinational therapy ; melanoma ; cutaneous cancers ; clinical trials ; neuroendocrine tumors ; self-assessment ; NET VITALS ; implementation science ; tobacco control ; smoking cessation ; cancer prevention ; lung cancer screening ; low dose Ct scans ; LDCT ; cancer disparities ; minority health ; pathways to success ; renal cell carcinoma ; gut microbiome ; translational research ; EGFR ; genetic/nongenetic ; epigenetics ; oligometastatic ; prostate cancer ; metastasis-directed therapy ; imaging ; PSMA PET ; advanced soft tissue sarcoma ; sarcoma treatment ; Midwest Sarcoma Trials Partnership ; multidisciplinary tumor board ; collaboration ; endometrial cancer ; PARP inhibition ; pathologic complete response ; Olaparib ; BRIP1 mutation ; ATM mutation ; RAD51C mutation ; POLE mutation ; TMB high ; brain metastases ; delivery of health care ; leptomeningeal metastases ; tumor board ; integrative oncology ; clinical care network ; implementation ; integration ; community clinical network ; phase 1 ; genomic-driven ; team medicine ; precision medicine ; cancer systems biology ; clinical network systems biology ; artificial intelligence ; City of Hope ; oncology ; community practice ; n/a
    Language English
    Size 1 electronic resource (230 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English
    HBZ-ID HT030381372
    ISBN 9783036584737 ; 3036584730
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online: Physics of Protein Folding, Misfolding, and Intrinsic Disorder: A Themed Issue in Honour of Professor Vladimir Uversky on the Occasion of His 60th Birthday

    Kulkarni, Prakash / Brocca, Stefania / Dunker, Keith / Longhi, Sonia

    2023  

    Keywords Research & information: general ; Biology, life sciences ; charge clustering ; polyelectrolytes ; average shape of conformational ensembles ; charged-residue patterning ; hydrodynamic radius ; solvent-accessible surface area ; proline content ; conformational compactness ; ellipsoid model ; intrinsically disordered proteins (IDPs) ; intrinsically disordered protein regions (IDRs) ; LC-MS/MS ; IUPred analysis ; Ostrinia nubilalis ; cold hardiness ; intrinsic disorder ; intrinsically disordered proteins ; intrinsic disordered regions ; disorder scale ; disorder propensity ; amino acids ; amino acid bias ; predictive performance ; disorder prediction ; SARS-CoV-2 ; COVID-19 ; IDP ; RNA ; NMR ; pH ; liquid-liquid phase separation ; protein solubility ; protein disorder ; mutations ; bioinformatics ; kinetics ; fluorescence ; site-directed mutagenesis ; protein-protein interactions ; SH2 domains ; Crkl ; Paxillin ; Calvin-Benson-Bassham cycle ; conditionally disordered protein ; history of modern science ; metabolism regulation ; moonlighting protein ; protein-protein interaction ; biomolecular condensates ; machine learning ; predictor ; physical interactions ; phase separation ; biomineralization ; calcium carbonate ; otoliths ; nucleation pathways ; nickel ; intrinsically disordered regions ; lung cancer ; nmr ; isothermal titration calorimetry ; circular dichroism ; light scattering ; Dss1 ; intrinsically disordered protein ; IDPs ; molecular dynamics ; sequence composition ; SAXS ; membrane-less organelles ; stress ; long foldable segments ; pyHCA ; soluble domains ; protein sequence ; conditional order ; hidden order ; dark proteomes ; intrinsically disordered domains ; coexistence line ; tumor suppressor p53 ; intramolecular interaction ; salt-dependent binding affinity ; counterion condensation theory ; DNA binding ; fluorescence anisotropy ; van't Hoff ; protein purification ; affinity chromatography ; Tau ; androgen receptor (AF1) ; isoform ; large-scale analysis ; protein structure ; AlphaFold ; canonical protein ; alpha-synuclein ; membrane ; synaptic vesicle ; synapsin ; Parkinson's ; Myc ; drug targets ; SLiM ; small-molecule inhibitors ; glutamate receptor ; discrete molecular dynamics ; single molecule fluorescence ; integrative structural biology ; unfolded ; unstructured ; flexible ; protein function ; polymer physics ; percolation ; entanglement ; topology ; polymer rheology ; D/E repeats ; K/R repeats ; molecular dynamics simulations ; hub proteins ; multivalency ; transcription factor ; linker length ; heterogeneity ; dimers ; duplexes ; coarse-grained simulation ; molecular mass ; LLPS stability ; FUS ; n/a
    Language English
    Size 1 electronic resource (486 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030649847
    ISBN 9783036591131 ; 3036591133
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Book ; Online: Integrating Clinical and Translational Research Networks-Building Team Medicine

    Salgia, Ravi / Kulkarni, Prakash

    2021  

    Keywords Medicine ; renal cell carcinoma ; team medicine ; translational research ; community practice ; clinical trials ; geriatric oncology ; older adults ; cancer clinical trials ; recruitment ; community ; team science ; bladder cancer ; urothelial carcinoma ; COVID-19 ; team-based medicine ; colorectal cancer ; precisian medicine ; academic and community oncology ; cancer center ; lung cancer ; lung cancer screening ; low-dose CT scans ; cancer prevention ; smoking cessation ; tobacco control ; national guidelines for screening and prevention ; pharmaceutical aids to smoking cessation ; non-small cell lung cancer ; driver mutations ; testing rates ; receptor tyrosine kinases ; actionable mutations ; next-generation sequencing ; fast-and-frugal trees ; personalized medicine ; minorities ; ethnicity ; race ; breast cancer ; research ; HER2-directed therapy ; community oncology ; academic cancer center ; precision medicine ; cancer genetics ; cancer genomics ; small cell lung cancer ; immunotherapy ; epithelial ovarian cancer ; frontline treatment ; surgical debulking ; adjuvant chemotherapy ; maintenance therapy ; PARP inhibitor ; genetics counseling ; clinical research ; n/a ; oropharyngeal cancer ; concurrent chemoradiation therapy ; human papillomavirus ; feeding tube dependency ; value-based care ; value-based cancer care ; oncology pathways ; Early Recovery After Surgery (ERAS) ; team-based care ; oncology medical home ; integrated cancer care ; supportive care pathways ; surgical pathways ; cancer care plans
    Size 1 electronic resource (250 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021044339
    ISBN 9783036503974 ; 3036503978
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Book ; Online: Intrinsically Disordered Proteins and Chronic Diseases

    Kulkarni, Prakash / Uversky, Vladimir N.

    2021  

    Keywords Research & information: general ; IDP ; fuzzy interactions ; protein complementation assays ; split-GFP reassembly ; kinetics ; membraneless organelles ; optical tweezer ; liquid-liquid phase separation ; protein diffusion ; depletion interaction ; entropic force ; low-complexity sequences ; intrinsically disordered proteins ; PAGE4 ; conformational plasticity ; order-disorder transition ; phosphorylation ; intrinsic disordered protein ; extremely fuzzy complex ; protein interaction ; binding mechanism ; tumor protein p53 ; mouse double minute 2 ; mouse double minute 4 ; Kinase-inducible domain interacting domain ; phosphomimetics ; nuclear magnetic resonance ; transient secondary structure ; COR15A ; Late embryogenesis abundant ; Trifluoroethanol ; Nuclear magnetic resonance ; intrinsically disordered regions ; functional segments ; disease-related proteins ; protein-protein interaction ; subcellular location ; glucocorticoid receptor ; intrinsically disordered ; transactivation activity ; gene regulation ; coactivators ; microtubule associated protein ; tau ; intrinsically disordered protein ; dynamic configuration ; free energy landscape ; microtubules ; electrostatics ; diffusion ; protein structure prediction ; molecular modelling ; molecular dynamics ; tau-microtubule association ; conformational ensemble ; replica exchange molecular dynamics ; drug design ; n/a
    Size 1 electronic resource (224 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021291634
    ISBN 9783036512631 ; 3036512632
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Book ; Online ; E-Book: Phenotypic switching

    Levine, Herbert / Jolly, Mohit Kumar / Kulkarni, Prakash / Nanjundiah, Vidyanand

    implications in biology and medicine

    2020  

    Author's details edited by Herbert Levine, Mohit Kumar Jolly, Prakash Kulkarni, Vidyanand Nanjundiah
    Keywords Phenotypic plasticity
    Subject code 576.53
    Language English
    Size 1 Online-Ressource (xlix, 721 Seiten), Illustrationen, Diagramme
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020535105
    ISBN 978-0-12-817997-0 ; 9780128179963 ; 0-12-817997-X ; 0128179961
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

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  8. Book ; Online: Intrinsically disordered proteins and chronic diseases

    Kulkarni, Prakash / Uverskij, Vladimir N.

    2021  

    Author's details Editors: Prakash Kulkarni and Vladimir N. Uverskij
    Language English
    Size 1 Online-Ressource (viii, 214 Seiten), Illustrationen
    Publisher MDPI
    Publishing place Bern
    Publishing country Switzerland
    Document type Book ; Online
    Note special issue, published in "Biomolecules" ; Open Access
    HBZ-ID HT021153181
    ISBN 978-3-0365-1263-1 ; 9783036512624 ; 3-0365-1263-2 ; 3036512624
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  9. Article ; Online: Comprehending phenotypic plasticity in cancer and evolution.

    Kulkarni, Prakash / Salgia, Ravi

    iScience

    2024  Volume 27, Issue 3, Page(s) 109308

    Abstract: Organisms as well as cancer cells are adept at adapting to changes in the environment in which they find themselves, by actively adjusting their phenotype. Phenotypic plasticity is a quantitative trait that confers a fitness advantage to the organism by ... ...

    Abstract Organisms as well as cancer cells are adept at adapting to changes in the environment in which they find themselves, by actively adjusting their phenotype. Phenotypic plasticity is a quantitative trait that confers a fitness advantage to the organism by tailoring its phenotype to environmental circumstances. While it is generally held that new traits arise solely from genetic factors, emerging evidence indicates that phenotypic plasticity also plays a critical role both in cancer and evolution. Thus, understanding the mechanisms that underlie phenotypic plasticity can not only provide new insights into organismal evolution and the origin of novelty but can also result in novel strategies and therapeutics to treat cancer.
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type News
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Boscombe Valley mystery: A lesson in the perils of dogmatism in science.

    Kulkarni, Prakash

    Journal of biosciences

    2021  Volume 46

    Abstract: The central dogma enunciated by Francis Crick and the postulate that sequence defines protein structure and function put forth by Christian Anfinsen (also referred to as the Thermodynamics Hypothesis) are some of the most fundamental tenets of molecular ... ...

    Abstract The central dogma enunciated by Francis Crick and the postulate that sequence defines protein structure and function put forth by Christian Anfinsen (also referred to as the Thermodynamics Hypothesis) are some of the most fundamental tenets of molecular biology that have had very profound influences and implications. They were formulated based on observations (evidence) that was obvious to the preceptors. However, as is well known, exception is the rule in biology and several works in the literature cite examples that appear to challenge these dogmas suggesting that being dogmatic can be perilous. In this perspective, using the
    MeSH term(s) Biological Evolution ; Gene Expression ; Genetics ; Intrinsically Disordered Proteins ; Learning ; Prions
    Chemical Substances Intrinsically Disordered Proteins ; Prions
    Language English
    Publishing date 2021-06-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 756157-x
    ISSN 0973-7138 ; 0250-5991
    ISSN (online) 0973-7138
    ISSN 0250-5991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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