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  1. Article: Efficacy Evaluation of Human Skin Treatment with Photodynamic Therapy in Actinic Keratoses Patients.

    Razzaghi, Zahra / Arjmand, Babak / Hamzeloo-Moghadam, Maryam / Rezaei Tavirani, Mostafa / Zamanian Azodi, Mona

    Journal of lasers in medical sciences

    2023  Volume 14, Page(s) e60

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-11-29
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2658681-2
    ISSN 2228-6721 ; 2008-9783
    ISSN (online) 2228-6721
    ISSN 2008-9783
    DOI 10.34172/jlms.2023.60
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Targeting colon cancer via antimicrobial RT2 peptide: a system biology study.

    Hosseinpour, Zahra / Zamanian Azodi, Mona / Jahani Sherafat, Somayeh / Rezaei Tavirani, Mostafa

    Gastroenterology and hepatology from bed to bench

    2023  Volume 16, Issue 4, Page(s) 415–420

    Abstract: Aim: This study aims to investigate the anticancer molecular mechanism of RT2 through protein-protein interaction (PPI) network analysis. For this aim, a bioinformatics evaluation of the proteome profile of colon cancer is carried out.: Background: ... ...

    Abstract Aim: This study aims to investigate the anticancer molecular mechanism of RT2 through protein-protein interaction (PPI) network analysis. For this aim, a bioinformatics evaluation of the proteome profile of colon cancer is carried out.
    Background: Antimicrobial peptides such as RT2 showed anticancer properties against various tumors. The molecular mechanism of the anticancer effect of RT2 is a challenging subject.
    Methods: By applying Cytoscape V.3.9.1 and integrated apps, the profile of the interaction network and related centrality is analyzed. An enrichment analysis of hub bottlenecks was also performed, and highlighted biological processes were visualized and determined.
    Results: Several 207 differentially expressed proteins were retrieved by PPI network analysis, and 10 hub bottlenecks were introduced. Among these differentially expressed proteins (DEPs), only AKT1 is from the queried DEPs. Key biological processes contributing to RT2 targeting mechanism include "Regulation of fibroblast proliferation", "Positive regulation of cyclin-dependent protein serine/threonine kinase activity", "positive regulation of miRNA transcription", and "fungiform papilla formation".
    Conclusion: In conclusion, central proteins Tp53, MYC, EGFR, AKT1, HDAC1, and SRC can be introduced as a targeted biomarker panel of bioactive peptide treatments. However, extensive research is required to establish this claim before clinical application.
    Language English
    Publishing date 2023-12-26
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2569124-7
    ISSN 2008-4234 ; 2008-2258
    ISSN (online) 2008-4234
    ISSN 2008-2258
    DOI 10.22037/ghfbb.v16i4.2695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Investigation into Chronic Low-Dose Ionizing Radiation Effect on Gene Expression Profile of Human HUVECs Cells.

    Ansari, Mojtaba / Rezaei-Tavirani, Mostafa / Hamzeloo-Moghadam, Maryam / Razzaghi, Mohhamadreza / Arjmand, Babak / Zamanian Azodi, Mona / Khodadoost, Mahmood / Okhovatian, Farshad

    Journal of lasers in medical sciences

    2022  Volume 13, Page(s) e35

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2022-08-27
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2658681-2
    ISSN 2228-6721 ; 2008-9783
    ISSN (online) 2228-6721
    ISSN 2008-9783
    DOI 10.34172/jlms.2022.35
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Hypofractionated Radiation Versus Conventional Fractionated Radiation: A Network Analysis.

    Arjmand, Babak / Rezaei-Tavirani, Mostafa / Hamzeloo-Moghadam, Maryam / Razzaghi, Zahra / Khodadoost, Mahmood / Okhovatian, Farshad / Zamanian-Azodi, Mona / Ansari, Mojtaba

    Journal of lasers in medical sciences

    2022  Volume 13, Page(s) e39

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2022-09-23
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2658681-2
    ISSN 2228-6721 ; 2008-9783
    ISSN (online) 2228-6721
    ISSN 2008-9783
    DOI 10.34172/jlms.2022.39
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Obsessive-Compulsive Disorder Interactome Profile Analysis: A Perspective From Molecular Mechanism.

    Zamanian-Azodi, Mona / Rezaei-Tavirani, Mostafa / Rezaei Tavirani, Majid

    Basic and clinical neuroscience

    2021  Volume 12, Issue 2, Page(s) 187–198

    Abstract: Introduction: Obsessive-Compulsive Disorder (OCD) is one of the complex neuropsychiatric conditions. This disorder disables individuals in many different aspects of their personal and social life. Interactome analysis may provide a better understanding ... ...

    Abstract Introduction: Obsessive-Compulsive Disorder (OCD) is one of the complex neuropsychiatric conditions. This disorder disables individuals in many different aspects of their personal and social life. Interactome analysis may provide a better understanding of this disorder's molecular origin and its underlying mechanisms.
    Methods: In this study, the OCD-associated genes were extracted from the literature. The criterion for gene selection was to choose genes with at least one significant report. Furthermore, by applying Cytoscape and its plugins, protein-protein interaction network, and gene ontology of the 31 candidate genes related to OCD from genetic association studies is examined. The cross-validation method was used for network centrality assessment.
    Results: A scale-free network, including 1940 nodes and 3269 edges for 31 genes, was constructed. According to the network centrality evaluation,
    Conclusion: Among 31 initial genes, 7 were introduced as crucial elements for onset and development in OCD and can be suggested for further investigations. Furthermore, the complex molecular origin of OCD requires high-throughput screening for diagnosis and treatment goals. The findings are a possible valuable source to establish molecular-based diagnostic tools for OCD.
    Language English
    Publishing date 2021-03-01
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2652444-2
    ISSN 2228-7442 ; 2008-126X
    ISSN (online) 2228-7442
    ISSN 2008-126X
    DOI 10.32598/bcn.12.2.941.7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Evaluating Serum Proteome in Women with Obsessive-Compulsive Disorder/Bipolar Disorder Compared to Pure Obsessive- Compulsive Disorder Subjects and Healthy Controls.

    Tahery, Noorollah / Rezaei Tavirani, Mostafa / Zamanian Azodi, Mona / Hamdieh, Mostafa / Rostami Nejad, Mohammad / Mahmoodi, Nahid

    Iranian journal of child neurology

    2023  Volume 17, Issue 3, Page(s) 133–142

    Abstract: Objectives: The present study aimed to evaluate the serum proteome of women with obsessive-compulsive disorder (OCD)/bipolar disorder (BP) compared to pure OCD subjects and healthy controls.: Materials & methods: Serum proteome of women with OCD/BP, ... ...

    Abstract Objectives: The present study aimed to evaluate the serum proteome of women with obsessive-compulsive disorder (OCD)/bipolar disorder (BP) compared to pure OCD subjects and healthy controls.
    Materials & methods: Serum proteome of women with OCD/BP, pure OCD individuals, and healthy controls were subjected to 2DE-based proteomics accompanied with MALDI-TOF-TOF mass spectrometry. Further evaluation of the identified protein spots with the significance of p<0.05 and fold≥1.5 was done by applying protein interaction mapping via Cytoscape v. 5.3.1 and its plugins.
    Results: The results indicate that vitamin D binding protein (GC) and haptoglobin spots (HP) significantly changed expression in OCD and OCD/BP with different expression patterns. These identified spots may contribute to OCD/BP and act as differentially recognized biomarkers comparing pure OCD and OCD/BP.
    Conclusion: The Findings imply that these proteins in the serum of the patients could be potential distinguishable biomarkers in clinical usage after related validation experiments. Therefore, this study provides a preliminary evaluation to understand OCD/BP proteome behavior better.
    Language English
    Publishing date 2023-07-01
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2542305-8
    ISSN 2008-0700 ; 1735-4668
    ISSN (online) 2008-0700
    ISSN 1735-4668
    DOI 10.22037/ijcn.v17i1.34795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Assessment of the Response of Human Umbilical Vein Endothelial Cells to Photodynamic Therapy: Highlighting the Role of Il-17 Signaling Pathway.

    Zamanian Azodi, Mona / Arjmand, Babak / Hamzeloo-Moghadam, Maryam / Rezaei Tavirani, Mostafa / Razzaghi, Zahra / Ahmadzadeh, Alireza / Robati, Reza M / Rezaei Tavirani, Majid

    Journal of lasers in medical sciences

    2023  Volume 14, Page(s) e59

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-11-28
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2658681-2
    ISSN 2228-6721 ; 2008-9783
    ISSN (online) 2228-6721
    ISSN 2008-9783
    DOI 10.34172/jlms.2023.59
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Light at Night Exposure Effects on Differentiation and Cell Cycle in the Rat Liver With Autonomic Nervous System Denervation.

    Heidari, Mohammad Hossein / Zamanian Azodi, Mona / Zali, Mohammad Reza / Akbari, Zahra

    Journal of lasers in medical sciences

    2019  Volume 10, Issue Suppl 1, Page(s) S43–S48

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2019-12-01
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2658681-2
    ISSN 2228-6721 ; 2008-9783
    ISSN (online) 2228-6721
    ISSN 2008-9783
    DOI 10.15171/jlms.2019.S8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Bioinformatics Investigation and Contribution of Other Chromosomes Besides Chromosome 21 in the Risk of Down Syndrome Development.

    Zamanian Azodi, Mona / Rezaei Tavirani, Mostafa / Rezaei Tavirani, Majid / Rostami Nejad, Mohammad

    Basic and clinical neuroscience

    2021  Volume 12, Issue 1, Page(s) 79–88

    Abstract: Introduction: Down syndrome as a genetic disorder is a popular research topic in molecular studies. One way to study Down syndrome is via bioinformatics.: Methods: In this study, a gene expression profile from a microarray study was selected for more ...

    Abstract Introduction: Down syndrome as a genetic disorder is a popular research topic in molecular studies. One way to study Down syndrome is via bioinformatics.
    Methods: In this study, a gene expression profile from a microarray study was selected for more investigation.
    Results: The study of Down syndrome patients shows specific genes with differential expression and network centrality properties. These genes are introduced as RHOA, FGF2, FYN, and CD44, and their level of expression is high in these patients.
    Conclusion: This study suggests that besides chromosomes 21, there are additional contributing chromosomes to the risk of Down syndrome development. Besides, these genes could be used for clinical studies after more analysis.
    Language English
    Publishing date 2021-01-01
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2652444-2
    ISSN 2228-7442 ; 2008-126X
    ISSN (online) 2228-7442
    ISSN 2008-126X
    DOI 10.32598/bcn.12.1.941.6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Gallbladder cancer integrated bioinformatics analysis of protein profile data.

    Zali, Mohammad Reza / Zamanian Azodi, Mona / Razzaghi, Zahra / Heydari, Mohammad Hossain

    Gastroenterology and hepatology from bed to bench

    2020  Volume 12, Issue Suppl1, Page(s) S66–S73

    Abstract: Aim: Identifying the critical genes that differentiate gall bladder cancer from a normal gall bladder and the related biological terms was the aim of this study.: Background: The molecular mechanism underlying gall bladder cancer (GBC) trigger and ... ...

    Abstract Aim: Identifying the critical genes that differentiate gall bladder cancer from a normal gall bladder and the related biological terms was the aim of this study.
    Background: The molecular mechanism underlying gall bladder cancer (GBC) trigger and development still requires investigations. Potential therapeutic biomarkers can be identified through protein-protein interaction network prediction of proteome as a complementary study.
    Methods: Here, a literature review of proteomics studies of gall bladder cancer from 2010 to 2019 was undertaken to screen differentially expressed proteins in this cancer. A network of 27 differentially expressed proteins (DEPs) via Cytoscape 3.7.1 and its plug-ins was constructed and analyzed.
    Results: Ten proteins were introduced as hub-bottlenecks among which four were from DEPs. The gene ontology analysis also indicated that positive regulation of multi-organism process and regulation of response to biotic stimulus are the most disrupted biological processes of GBC considering their relationships with the DEPs.
    Conclusion: ACTG, ALB, GGH, and DYNC1H1, and relative biological terms were introduced as drug targets and possible diagnostic biomarkers.
    Language English
    Publishing date 2020-02-17
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2569124-7
    ISSN 2008-4234 ; 2008-2258
    ISSN (online) 2008-4234
    ISSN 2008-2258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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