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Article ; Online: Introduction to the Special Issue: COVID-19 and Its Impact on Racial/Ethnic Groups.

Price, Gregory N

2020 Volume 3, Issue 4, Page(s) 221–222

Language	English
Publishing date	2020-11-23
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2932821-4
ISSN	2520-842X ; 2520-8411
ISSN (online)	2520-842X
ISSN	2520-8411
DOI	10.1007/s41996-020-00074-x
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Article ; Online: Cardiovascular health assessment in routine cancer follow-up in community settings: survivor risk awareness and perspectives.

Weaver, Kathryn E / Dressler, Emily V / Smith, Sydney / Nightingale, Chandylen L / Klepin, Heidi D / Lee, Simon Craddock / Wells, Brian J / Hundley, W Gregory / DeMari, Joseph A / Price, Sarah N / Foraker, Randi E

BMC cancer

2024 Volume 24, Issue 1, Page(s) 158

Abstract: Background: Guidelines recommend cardiovascular risk assessment and counseling for cancer survivors. For effective implementation, it is critical to understand survivor cardiovascular health (CVH) profiles and perspectives in community settings. We ... ...

Abstract	Background: Guidelines recommend cardiovascular risk assessment and counseling for cancer survivors. For effective implementation, it is critical to understand survivor cardiovascular health (CVH) profiles and perspectives in community settings. We aimed to (1) Assess survivor CVH profiles, (2) compare self-reported and EHR-based categorization of CVH factors, and (3) describe perceptions regarding addressing CVH during oncology encounters. Methods: This cross-sectional analysis utilized data from an ongoing NCI Community Oncology Research Program trial of an EHR heart health tool for cancer survivors (WF-1804CD). Survivors presenting for routine care after potentially curative treatment recruited from 8 oncology practices completed a pre-visit survey, including American Heart Association Simple 7 CVH factors (classified as ideal, intermediate, or poor). Medical record abstraction ascertained CVD risk factors and cancer characteristics. Likert-type questions assessed desired discussion during oncology care. Results: Of 502 enrolled survivors (95.6% female; mean time since diagnosis = 4.2 years), most had breast cancer (79.7%). Many survivors had common cardiovascular comorbidities, including high cholesterol (48.3%), hypertension or high BP (47.8%) obesity (33.1%), and diabetes (20.5%); 30.5% of survivors received high cardiotoxicity potential cancer treatment. Less than half had ideal/non-missing levels for physical activity (48.0%), BMI (18.9%), cholesterol (17.9%), blood pressure (14.1%), healthy diet (11.0%), and glucose/ HbA1c (6.0%). While > 50% of survivors had concordant EHR-self-report categorization for smoking, BMI, and blood pressure; cholesterol, glucose, and A1C were unknown by survivors and/or missing in the EHR for most. Most survivors agreed oncology providers should talk about heart health (78.9%). Conclusions: Tools to promote CVH discussion can fill gaps in CVH knowledge and are likely to be well-received by survivors in community settings. Trial registration: NCT03935282, Registered 10/01/2020.
MeSH term(s)	Female ; Humans ; Male ; Blood Pressure ; Breast Neoplasms ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cholesterol ; Cross-Sectional Studies ; Follow-Up Studies ; Glucose ; Health Status ; Risk Assessment ; Risk Factors ; Survivors ; United States ; Clinical Trials as Topic
Chemical Substances	Cholesterol (97C5T2UQ7J) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-024-11912-8
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Article ; Online: Characterization of Fragile X Mental Retardation Protein expression in human nociceptors and their axonal projections to the spinal dorsal horn.

Mitchell, Molly E / Cook, Lauren C / Shiers, Stephanie / Tavares-Ferreira, Diana / Akopian, Armen N / Dussor, Gregory / Price, Theodore J

The Journal of comparative neurology

2023 Volume 531, Issue 7, Page(s) 814–835

Abstract: Fragile X Mental Retardation Protein (FMRP) regulates activity-dependent RNA localization and local translation to modulate synaptic plasticity throughout the central nervous system. Mutations in the FMR1 gene that hinder or ablate FMRP function cause ... ...

Abstract	Fragile X Mental Retardation Protein (FMRP) regulates activity-dependent RNA localization and local translation to modulate synaptic plasticity throughout the central nervous system. Mutations in the FMR1 gene that hinder or ablate FMRP function cause Fragile X Syndrome (FXS), a disorder associated with sensory processing dysfunction. FXS premutations are associated with increased FMRP expression and neurological impairments including sex dimorphic presentations of chronic pain. In mice, FMRP ablation causes dysregulated dorsal root ganglion (DRG) neuron excitability and synaptic vesicle exocytosis, spinal circuit activity, and decreased translation-dependent nociceptive sensitization. Activity-dependent, local translation is a key mechanism for enhancing primary nociceptor excitability that promotes pain in animals and humans. These works indicate that FMRP likely regulates nociception and pain at the level of the primary nociceptor or spinal cord. Therefore, we sought to better understand FMRP expression in the human DRG and spinal cord using immunostaining in organ donor tissues. We find that FMRP is highly expressed in DRG and spinal neuron subsets with substantia gelatinosa exhibiting the most abundant immunoreactivity in spinal synaptic fields. Here, it is expressed in nociceptor axons. FMRP puncta colocalized with Nav1.7 and TRPV1 receptor signals suggesting a pool of axoplasmic FMRP localizes to plasma membrane-associated loci in these branches. Interestingly, FMRP puncta exhibited notable colocalization with calcitonin gene-related peptide (CGRP) immunoreactivity selectively in female spinal cord. Our results support a regulatory role for FMRP in human nociceptor axons of the dorsal horn and implicate it in the sex dimorphic actions of CGRP signaling in nociceptive sensitization and chronic pain.
MeSH term(s)	Humans ; Animals ; Mice ; Female ; Fragile X Mental Retardation Protein/genetics ; Fragile X Mental Retardation Protein/metabolism ; Nociceptors/metabolism ; Chronic Pain ; Calcitonin Gene-Related Peptide/metabolism ; Axons/metabolism ; Fragile X Syndrome/genetics ; Spinal Cord Dorsal Horn/metabolism
Chemical Substances	Fragile X Mental Retardation Protein (139135-51-6) ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z) ; FMR1 protein, human ; Fmr1 protein, mouse
Language	English
Publishing date	2023-02-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3086-7
ISSN	1096-9861 ; 0021-9967 ; 0092-7317
ISSN (online)	1096-9861
ISSN	0021-9967 ; 0092-7317
DOI	10.1002/cne.25463
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Article ; Online: The allometry of metabolism and stature: worker fatigue and height in the Tanzanian labor market.

Price, Gregory N

Economics and human biology

2013 Volume 11, Issue 4, Page(s) 515–521

Abstract: If the positive wage-height correlation is at least partially biological in origin, one plausible pathway is the effect of stature on energy expenditure in individuals. If metabolism scales proportionately with stature, then relative to short individuals, ...

Abstract	If the positive wage-height correlation is at least partially biological in origin, one plausible pathway is the effect of stature on energy expenditure in individuals. If metabolism scales proportionately with stature, then relative to short individuals, taller individuals can produce more energy for a given work task. This also suggests that end-of-the-workday fatigue, or lack of energy, varies inversely with stature. We test this hypothesis with data from the 2004 Tanzanian Household Worker Survey in which workers report the extent of their fatigue at the end-of-the-workday. Ordinal latent variable parameter estimates reveal that relative to short workers, taller workers are less likely to report being tired at the end-of-the-workday. This suggests that the positive wage-height relationship also has a biological foundation whereby the energy requirements and metabolic costs associated with work effort/tasks are inversely related to stature.
MeSH term(s)	Adult ; Body Height/physiology ; Demography ; Energy Metabolism/physiology ; Fatigue/physiopathology ; Female ; Humans ; Interviews as Topic ; Male ; Salaries and Fringe Benefits/statistics & numerical data ; Tanzania
Language	English
Publishing date	2013-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2099749-8
ISSN	1873-6130 ; 1570-677X
ISSN (online)	1873-6130
ISSN	1570-677X
DOI	10.1016/j.ehb.2013.07.003
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Article: Race, social capital, and health disparities

Price, Gregory N / Moore, Kyle

The empirical economics letters : a monthly international journal of economics Vol. 16, No. 11 , p. 1103-1113

2017 Volume 16, Issue 11, Page(s) 1103–1113

Author's details	Gregory N. Price, Kyle Moore
Keywords	Race ; Social capital ; Health disparities
Language	English
Publishing place	Rajshahi
Document type	Article
ZDB-ID	2560109X
ISSN	1681-8997
Database	ECONomics Information System

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Article ; Online: Prolactin signaling modulates stress-induced behavioral responses in a preclinical mouse model of migraine.

Mason, Bianca N / Kallianpur, Rohini / Price, Theodore J / Akopian, Armen N / Dussor, Gregory O

Headache

2021 Volume 62, Issue 1, Page(s) 11–25

Abstract: ... Plasma prolactin levels were assessed in naïve and stressed CD-1 mice (n = 3-5/group) and transgenic mice ... with conditional deletion of the Prlr in Nav1.8-positive sensory neurons (Prlr conditional knock-out [CKO]; n = 3 ... CD-1 mice were treated with the prolactin release inhibitor bromocriptine (2 mg/kg; n = 7-12/group ...

Abstract	Objective: The aim of this study was to determine if prolactin signaling modulates stress-induced behavioral responses in a preclinical migraine model. Background: Migraine is one of the most complex and prevalent disorders. The involvement of sex-selective hormones in migraine pathology is highly likely as migraine is more common in women and its frequency correlates with reproductive stages. Prolactin has been shown to be a worsening factor for migraine. Normally prolactin levels are low; however levels can surge during stress. Dopamine receptor agonists, which suppress pituitary prolactin release, are an effective migraine treatment in a subset of patients. Previously, we showed that administration of prolactin onto the dura mater induces female-specific behavioral responses, suggesting that prolactin may play a sex-specific role in migraine. Methods: The effects of prolactin signaling were assessed using a preclinical migraine model we published recently in which behavioral sensitization is induced by repeated stress. Plasma prolactin levels were assessed in naïve and stressed CD-1 mice (n = 3-5/group) and transgenic mice with conditional deletion of the Prlr in Nav1.8-positive sensory neurons (Prlr conditional knock-out [CKO]; n = 3/group). To assess the contribution of prolactin release during stress, naïve or stressed male and female CD-1 mice were treated with the prolactin release inhibitor bromocriptine (2 mg/kg; n = 7-12/group) or vehicle for 5 days (8-12/group) and tested for facial hypersensitivity following stress. Additionally, the contribution of ovarian hormones in regulating the prolactin-induced responses was assessed in ovariectomized female CD-1 mice (n = 6-10/group). Furthermore, the contribution of Prlr activation on Nav1.8-positive sensory neurons was assessed. Naïve or stressed male and female Prlr CKO mice and their control littermates were tested for facial hypersensitivity (n = 8-9/group). Immunohistochemistry was used to confirm loss of Prlr in Nav1.8-positive neurons in Prlr CKO mice. The total sample size is n = 245; the full analysis sample size is n = 221. Results: Stress significantly increased prolactin levels in vehicle-treated female mice (39.70 ± 2.77; p < 0.0001). Bromocriptine significantly reduced serum prolactin levels in stressed female mice compared to vehicle-treated mice (-44.85 ± 3.1; p < 0.0001). Additionally, no difference was detected between female stressed mice that received bromocriptine compared to naïve mice treated with bromocriptine (-0.70 ± 2.9; p = 0.995). Stress also significantly increased serum prolactin levels in male mice, although to a much smaller extent than in females (0.61 ± 0.08; p < 0.001). Bromocriptine significantly reduced serum prolactin levels in stressed males compared to those treated with vehicle (-0.49 ± 0.08; p = 0.002). Furthermore, bromocriptine attenuated stress-induced behavioral responses in female mice compared to those treated with vehicle (maximum effect observed on day 4 post stress [0.21 ± 0.08; p = 0.03]). Bromocriptine did not attenuate stress-induced behavior in males at any timepoint compared to those treated with vehicle. Moreover, loss of ovarian hormones did not affect the ability of bromocriptine to attenuate stress responses compared to vehicle-treated ovariectomy mice that were stressed (maximum effect observed on day 4 post stress [0.29 ± 0.078; p = 0.013]). Similar to CD-1 mice, stress increased serum prolactin levels in both Prlr CKO female mice (27.74 ± 9.96; p = 0.047) and control littermates (28.68 ± 9.9; p = 0.041) compared to their naïve counterparts. There was no significant increase in serum prolactin levels detected in male Prlr CKO mice or control littermates. Finally, conditional deletion of Prlr from Nav1.8-positive sensory neurons led to a female-specific attenuation of stress-induced behavioral responses (maximum effect observed on day 7 post stress [0.32 ± 0.08; p = 0.007]) compared to control littermates. Conclusion: These data demonstrate that prolactin plays a female-specific role in stress-induced behavioral responses in this preclinical migraine model through activation of Prlr on sensory neurons. They also support a role for prolactin in migraine mechanisms in females and suggest that modulation of prolactin signaling may be an effective therapeutic strategy in some cases.
MeSH term(s)	Animals ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Bromocriptine/administration & dosage ; Bromocriptine/pharmacology ; Disease Models, Animal ; Facial Pain/chemically induced ; Facial Pain/metabolism ; Facial Pain/physiopathology ; Female ; Hormone Antagonists/administration & dosage ; Hormone Antagonists/pharmacology ; Hyperalgesia/chemically induced ; Hyperalgesia/metabolism ; Hyperalgesia/physiopathology ; Male ; Mice ; Mice, Knockout ; Migraine Disorders/metabolism ; Migraine Disorders/physiopathology ; Ovariectomy ; Prolactin/antagonists & inhibitors ; Prolactin/drug effects ; Prolactin/metabolism ; Receptors, Prolactin/genetics ; Sex Characteristics ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Stress, Psychological/metabolism ; Stress, Psychological/physiopathology
Chemical Substances	Hormone Antagonists ; Receptors, Prolactin ; Bromocriptine (3A64E3G5ZO) ; Prolactin (9002-62-4)
Language	English
Publishing date	2021-12-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	410130-3
ISSN	1526-4610 ; 0017-8748
ISSN (online)	1526-4610
ISSN	0017-8748
DOI	10.1111/head.14248
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Article ; Online: Cardiac Cachexia in Left Ventricular Assist Device Recipients and the Implications of Weight Gain Early After Implantation.

Vest, Amanda R / Price, Lori Lyn / Chanda, Anindita / Sweigart, Benjamin A / Chery, Joronia / Lawrence, Matthew / Parsly, Lauren / Gulati, Gaurav / Kiernan, Michael S / Upshaw, Jenica N / Kawabori, Masashi / Couper, Gregory S / Saltzman, Edward

Journal of the American Heart Association

2023 Volume 12, Issue 13, Page(s) e029086

Abstract: Background Severe cardiac cachexia or malnutrition are commonly considered relative contraindications to left ventricular assist device (LVAD) implantation, but post-LVAD prognosis for patients with cachexia is uncertain. Methods and Results Intermacs ( ... ...

Abstract	Background Severe cardiac cachexia or malnutrition are commonly considered relative contraindications to left ventricular assist device (LVAD) implantation, but post-LVAD prognosis for patients with cachexia is uncertain. Methods and Results Intermacs (Interagency Registry for Mechanically Assisted Circulatory Support) 2006 to 2017 was queried for the preimplantation variable cachexia/malnutrition. Cox proportional hazards modeling examined the relationship between cachexia and LVAD outcomes. Of 20 332 primary LVAD recipients with available data, 516 (2.54%) were reported to have baseline cachexia and had higher risk baseline characteristics. Cachexia was associated with higher mortality during LVAD support (unadjusted hazard ratio [HR], 1.36 [95% CI, 1.18-1.56];
MeSH term(s)	Humans ; Heart-Assist Devices/adverse effects ; Heart Failure ; Cachexia/etiology ; Malnutrition ; Registries ; Treatment Outcome ; Retrospective Studies
Language	English
Publishing date	2023-06-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.122.029086
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Article: The allometry of metabolism and stature

Price, Gregory N

Economics and human biology Vol. 11, No. 4 , p. 515-521

worker fatigue and height in the Tanzanian labor market

2013 Volume 11, Issue 4, Page(s) 515–521

Author's details	Gregory N. Price
Language	English
Publisher	Elsevier Science
Publishing place	Amsterdam [u.a.]
Document type	Article
ZDB-ID	2114400X ; 2099749-8
ISSN	1873-6130 ; 1570-677X
ISSN (online)	1873-6130
ISSN	1570-677X
Database	ECONomics Information System

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Article ; Online: Does affirmative action in Chinese college admissions lead to mismatch? Educational quality and the relative returns to a baccalaureate degree for minorities in China.

Ding, Sai / Myers, Samuel L / Price, Gregory N

International journal of anthropology and ethnology

2017 Volume 1

Abstract: This paper provides a unique illustration of the benefits of affirmative action in higher educaiton. It focuses on China in the early ... ...

Abstract	This paper provides a unique illustration of the benefits of affirmative action in higher educaiton. It focuses on China in the early 21
Language	English
Publishing date	2017-12-08
Publishing country	China
Document type	Journal Article
ZDB-ID	2918110-0
ISSN	2366-1003 ; 2366-1003
ISSN (online)	2366-1003
ISSN	2366-1003
DOI	10.1186/s41257-017-0006-7
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Article ; Online: Climate change and cross-state Islamist terrorism in Nigeria

Price, Gregory N / Elu, Juliet U

Peace economics, peace science and public policy Vol. 23, No. 3 , p. 1-12

2017 Volume 23, Issue 3, Page(s) 1–12

Author's details	Gregory N. Price, Juliet U. Elu
Keywords	climate change ; islamist terrorism ; Nigeria ; Sub-Saharan Africa
Language	English
Size	Online-Ressource
Publisher	De Gruyter
Publishing place	Berlin
Document type	Article ; Online
ZDB-ID	2133452-3
ISSN	1554-8597
DOI	10.1515/peps-2016-0047
Database	ECONomics Information System

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