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  1. Article ; Online: Introduction: Finding a way in daily clinical practice during COVID-19 pandemic.

    Twickler, Theodorus B / Regieli, Jakub J

    European journal of clinical investigation

    2020  Volume 50, Issue 7, Page(s) e13329

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/physiopathology ; Coronavirus Infections/therapy ; Europe/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 677: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: Introduction

    Twickler, Theodorus B. / Regieli, Jakub J.

    European Journal of Clinical Investigation

    Finding a way in daily clinical practice during COVID‐19 pandemic

    2020  Volume 50, Issue 7

    Keywords Clinical Biochemistry ; Biochemistry ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13329
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 677: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Misdiagnosis of Graves' hyperthyroidism due to therapeutic biotin intervention.

    De Roeck, Yentl / Philipse, Eva / Twickler, Theodorus B / Van Gaal, Luc

    Acta clinica Belgica

    2017  Volume 73, Issue 5, Page(s) 372–376

    Abstract: Background: Lately, high dose of biotin is often given orally to patients with a primary progressive multiple sclerosis (PPMS). However, the molecule biotin is also a principle compound in various analytic immunoassays.: Clinical case: An ... ...

    Abstract Background: Lately, high dose of biotin is often given orally to patients with a primary progressive multiple sclerosis (PPMS). However, the molecule biotin is also a principle compound in various analytic immunoassays.
    Clinical case: An asymptomatic 60-year-old woman with PPMS on high dose of biotin therapy (3 × 100 mg/d) displayed abnormal thyroid function tests (TSH 0.02 mU/l, fT4 > 103 pmol/l, and fT3 > 46 pmol/l). TSH was determined by a homogeneous sandwich chemiluminescent immunoassay and fT4 and fT3 were both determined by a homogeneous, sequential, chemiluminescent immunoassay. TSH receptor antibodies were found to be markedly elevated (>40 IU/l) using a electrochemiluminescence immunoassay, suggestive for Graves' hyperthyroidism. Due to inconsistency between clinical presentation and laboratory results, thyroid function tests have been repeated with two other immunoassays. A direct, labeled antibody, competitive immunoassay to determine TSH and a luminescent immunometric immunoassay to determine fT4 and fT3 showed a subclinical hyperthyroidism (TSH < 0.02 mU/l, fT4 15.9 pmol/l, and fT3 4.7 pmol/l). Normal thyroid function tests (TSH 1.66 mU/l, fT4 15.3 pmol/l, and fT3 4.7 pmol/l) were obtained by a chemiluminescent microparticle immunoassay. All abnormal levels of TSH, fT4, fT3, and TSH-R-Ab were observed in immunoassays using biotin as a reagent.
    Conclusion: Abnormal thyroid function tests in this euthyroid patient were found to be false due to significant interference of supraphysiological levels of plasma biotin. Laboratory tests applying immunoassays using a biotin-containing reagent should be interpreted with caution in patients on biotin substitution.
    MeSH term(s) Biotin/blood ; Biotin/chemistry ; Biotin/therapeutic use ; Diagnostic Errors ; Female ; Graves Disease/diagnosis ; Humans ; Immunoassay ; Middle Aged ; Multiple Sclerosis, Chronic Progressive/drug therapy ; Thyroid Function Tests
    Chemical Substances Biotin (6SO6U10H04)
    Language English
    Publishing date 2017-11-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 390201-8
    ISSN 2295-3337 ; 0001-5512 ; 1784-3286
    ISSN (online) 2295-3337
    ISSN 0001-5512 ; 1784-3286
    DOI 10.1080/17843286.2017.1396676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.283: Show issues Location:
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  5. Article: Patients with the metabolic syndrome and a disturbed cortisol balance display more microalbuminuria.

    Janssen, Sarah F / Twickler, Theodorus B / Jublanc, Christel / Cramer, Maarten J / Bruckert, Eric

    Diabetes & vascular disease research

    2008  Volume 5, Issue 1, Page(s) 54–58

    Abstract: The objective of this study was to investigate whether patients with the metabolic syndrome (MetS) and an imbalance in cortisol metabolism express increased urinary albumin excretion compared to those patients with metabolic syndrome alone. Seventy-four ... ...

    Abstract The objective of this study was to investigate whether patients with the metabolic syndrome (MetS) and an imbalance in cortisol metabolism express increased urinary albumin excretion compared to those patients with metabolic syndrome alone. Seventy-four patients with MetS were evaluated using a low-dose dexamethasone suppression test (LDDST) to identify disturbed cortisol balance (cortisol levels > 50 nmol/L after LDDST). The level of albumin in the urine was also evaluated. Disturbed cortisol balance was found in 8% of all evaluated patients with MetS. Microalbuminuria was present significantly more often (p<0.01) in those patients with MetS and an imbalance in cortisol metabolism compared with patients suffering MetS alone (urine albumin: 210 mg/L vs. 26 mg/L, respectively, p<0.01). A substantial percentage of patients with MetS had inappropriate cortisol homeostasis. Of importance, excretion of urinary albumin was increased in these patients. This observation may indicate that this subgroup within the MetS population has a higher cardiovascular risk and possible increased endothelial dysfunction, with a subsequent need for stricter control to prevent cardiovascular morbidity and mortality.
    MeSH term(s) Adrenocortical Hyperfunction/complications ; Albuminuria/etiology ; Biomarkers/metabolism ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Female ; Humans ; Hydrocortisone/metabolism ; Male ; Metabolic Syndrome/complications ; Metabolic Syndrome/physiopathology ; Middle Aged
    Chemical Substances Biomarkers ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2008-03
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2250793-0
    ISSN 1479-1641
    ISSN 1479-1641
    DOI 10.3132/dvdr.2008.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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