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  1. Article: ["Nursing theory: notes on lectures"--a discussion with Prof. Hiroko Usui].

    Usui, T / Arai, F / Kaneko, M / Sugawarak, K

    Sogo kango. Comprehensive nursing, quarterly

    1980  Volume 15, Issue 3, Page(s) 44–64

    MeSH term(s) Education, Nursing ; Humans ; Japan ; Nursing
    Language Japanese
    Publishing date 1980
    Publishing country Japan
    Document type Journal Article
    ISSN 0038-0660
    ISSN 0038-0660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Modulation of mitochondrial activity by sugarcane (Saccharum officinarum L.) top extract and its bioactive polyphenols: a comprehensive transcriptomics analysis in C2C12 myotubes and HepG2 hepatocytes.

    Iwata, Kengo / Ferdousi, Farhana / Arai, Yoshinobu / Isoda, Hiroko

    Natural products and bioprospecting

    2024  Volume 14, Issue 1, Page(s) 2

    Abstract: Age-related mitochondrial dysfunction leads to defects in cellular energy metabolism and oxidative stress defense systems, which can contribute to tissue damage and disease development. Among the key regulators responsible for mitochondrial quality ... ...

    Abstract Age-related mitochondrial dysfunction leads to defects in cellular energy metabolism and oxidative stress defense systems, which can contribute to tissue damage and disease development. Among the key regulators responsible for mitochondrial quality control, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is an important target for mitochondrial dysfunction. We have previously reported that bioactive polyphenols extracted from sugarcane top (ST) ethanol extract (STEE) could activate neuronal energy metabolism and increase astrocyte PGC-1α transcript levels. However, their potential impact on the mitochondria activity in muscle and liver cells has not yet been investigated. To address this gap, our current study examined the effects of STEE and its polyphenols on cultured myotubes and hepatocytes in vitro. Rhodamine 123 assay revealed that the treatment with STEE and its polyphenols resulted in an increase in mitochondrial membrane potential in C2C12 myotubes. Furthermore, a comprehensive examination of gene expression patterns through transcriptome-wide microarray analysis indicated that STEE altered gene expressions related to mitochondrial functions, fatty acid metabolism, inflammatory cytokines, mitogen-activated protein kinase (MAPK) signaling, and cAMP signaling in both C2C12 myotubes and HepG2 hepatocytes. Additionally, protein-protein interaction analysis identified the PGC-1α interactive-transcription factors-targeted regulatory network of the genes regulated by STEE, and the quantitative polymerase chain reaction results confirmed that STEE and its polyphenols upregulated the transcript levels of PGC-1α in both C2C12 and HepG2 cells. These findings collectively suggest the potential beneficial effects of STEE on muscle and liver tissues and offer novel insights into the potential nutraceutical applications of this material.
    Language English
    Publishing date 2024-01-05
    Publishing country Germany
    Document type Journal Article
    ISSN 2192-2195
    ISSN 2192-2195
    DOI 10.1007/s13659-023-00423-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Interactions between Major Bioactive Polyphenols of Sugarcane Top: Effects on Human Neural Stem Cell Differentiation and Astrocytic Maturation.

    Iwata, Kengo / Ferdousi, Farhana / Arai, Yoshinobu / Isoda, Hiroko

    International journal of molecular sciences

    2022  Volume 23, Issue 23

    Abstract: Sugarcane ( ...

    Abstract Sugarcane (
    Language English
    Publishing date 2022-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232315120
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  4. Article ; Online: Caring for Things Helps Humans Grow

    Hiroko Kamide / Tatsuo Arai

    Sustainability, Vol 13, Iss 3969, p

    Effects of Courteous Interaction with Things on Pro-Environmental Behavior

    2021  Volume 3969

    Abstract: The purpose of this study was to clarify the influence of courteous interaction with familiar objects on pro-environmental behavior and well-being. We explored the process of interaction with everyday objects, such as pens and glasses in a preliminary ... ...

    Abstract The purpose of this study was to clarify the influence of courteous interaction with familiar objects on pro-environmental behavior and well-being. We explored the process of interaction with everyday objects, such as pens and glasses in a preliminary study ( N = 64), and to reveal two aspects that define these interactions, namely active care for objects and awareness of learning from the interaction ( N = 687; Study 1). The more people cared for and learned through their interactions with a particular object, the more they perceived a connectedness to it ( N = 195; Study 2). Furthermore, caring for and learning with familiar objects promoted various environmentally conscious behaviors and contributed to individual well-being (Study 3; N = 600). In this way, we discussed the relationship between interaction with everyday objects, the aspects of these interactions, and the influence of these interactions on an individual’s perspective toward the wider environment.
    Keywords pro-environmental behavior ; care ; learn ; courteous interaction ; familiar objects ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 004
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Interactions between Major Bioactive Polyphenols of Sugarcane Top

    Kengo Iwata / Farhana Ferdousi / Yoshinobu Arai / Hiroko Isoda

    International Journal of Molecular Sciences, Vol 23, Iss 15120, p

    Effects on Human Neural Stem Cell Differentiation and Astrocytic Maturation

    2022  Volume 15120

    Abstract: Sugarcane ( Saccharum officinarum L.) is a tropical plant grown for sugar production. We recently showed that sugarcane top (ST) ameliorates cognitive decline in a mouse model of accelerated aging via promoting neuronal differentiation and neuronal ... ...

    Abstract Sugarcane ( Saccharum officinarum L.) is a tropical plant grown for sugar production. We recently showed that sugarcane top (ST) ameliorates cognitive decline in a mouse model of accelerated aging via promoting neuronal differentiation and neuronal energy metabolism and extending the length of the astrocytic process in vitro. Since the crude extract consists of multicomponent mixtures, it is crucial to identify bioactive compounds of interest and the affected molecular targets. In the present study, we investigated the bioactivities of major polyphenols of ST, namely 3- O -caffeoylquinic acid (3CQA), 5- O -caffeoylquinic acid (5CQA), 3- O -feruloylquinic acid (3FQA), and Isoorientin (ISO), in human fetal neural stem cells (hNSCs)- an in vitro model system for studying neural development. We found that multiple polyphenols of ST contributed synergistically to stimulate neuronal differentiation of hNSCs and induce mitochondrial activity in immature astrocytes. Mono-CQAs (3CQA and 5CQA) regulated the expression of cyclins related to G1 cell cycle arrest, whereas ISO regulated basic helix-loop-helix transcription factors related to cell fate determination. Additionally, mono-CQAs activated p38 and ISO inactivated GSK3β. In hNSC-derived immature astrocytes, the compounds upregulated mRNA expression of PGC-1α, a master regulator of astrocytic mitochondrial biogenesis. Altogether, our findings suggest that synergistic interactions between major polyphenols of ST contribute to its potential for neuronal differentiation and astrocytic maturation.
    Keywords sugarcane top ; neural stem cells ; caffeoylquinic acid ; isoorientin ; G1 cell cycle arrest ; bHLH transcription factor ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 571
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Sedanolide Activates KEAP1-NRF2 Pathway and Ameliorates Hydrogen Peroxide-Induced Apoptotic Cell Death.

    Tabei, Yosuke / Abe, Hiroko / Suzuki, Shingo / Takeda, Nobuaki / Arai, Jun-Ichiro / Nakajima, Yoshihiro

    International journal of molecular sciences

    2023  Volume 24, Issue 22

    Abstract: Sedanolide is a bioactive compound with anti-inflammatory and antitumor activities. Although it has been recently suggested that sedanolide activates the nuclear factor E2-related factor 2 (NRF2) pathway, there is little research on its effects on ... ...

    Abstract Sedanolide is a bioactive compound with anti-inflammatory and antitumor activities. Although it has been recently suggested that sedanolide activates the nuclear factor E2-related factor 2 (NRF2) pathway, there is little research on its effects on cellular resistance to oxidative stress. The objective of the present study was to investigate the function of sedanolide in suppressing hydrogen peroxide (H
    MeSH term(s) Humans ; Hydrogen Peroxide/pharmacology ; Hydrogen Peroxide/metabolism ; NF-E2-Related Factor 2/metabolism ; Kelch-Like ECH-Associated Protein 1/metabolism ; Signal Transduction ; Oxidative Stress ; Apoptosis ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Reactive Oxygen Species/metabolism
    Chemical Substances Hydrogen Peroxide (BBX060AN9V) ; NF-E2-Related Factor 2 ; Kelch-Like ECH-Associated Protein 1 ; neocnidilide (6415-59-4) ; Antioxidants ; Reactive Oxygen Species ; KEAP1 protein, human
    Language English
    Publishing date 2023-11-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242216532
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  7. Article: Association between reasons for employment and burnout tendencies among rehabilitation technology professionals.

    Furuya, Tomoki / Ogawa, Susumu / Yamazaki, Hiroko / Matsumoto, Daiki / Motomiya, Mitsunobu / Tamura, Yuma / Arai, Keisuke

    Journal of physical therapy science

    2023  Volume 35, Issue 10, Page(s) 696–702

    Abstract: Purpose] The deterioration in the psychological states of healthcare workers may impact the quality and quantity of medical care provided to patients, leading to unfavorable treatment outcomes. Thus, we aimed to investigate the relationship between ... ...

    Abstract [Purpose] The deterioration in the psychological states of healthcare workers may impact the quality and quantity of medical care provided to patients, leading to unfavorable treatment outcomes. Thus, we aimed to investigate the relationship between reasons for employment and the mental health status of rehabilitation technology professionals in Japan. A cross-sectional survey was conducted using a questionnaire to gather relevant data. [Participants and Methods] Data from 112 rehabilitation technology professionals, including physical and occupational therapists as well as speech-language pathologists, were analyzed. Questionnaires were utilized to collect data on participant characteristics, reasons for employment, virtual competence, self-esteem, burnout levels, self-compassion responses, subjective health assessments, and feelings of isolation. [Results] Multiple regression analysis indicated that the regression coefficients of the Lubben Social Network Scale-6, the World Health Organization-five well-being index, the virtual ability scale, the self-esteem scale, and the reasons for employment scale scores were -0.168, -0.191, -0.273, -0.197, and -0.329, respectively. Additionally, structural equation modeling was used to verify the goodness-of-fit indices. The burnout scale scores exhibited a satisfactory fit with the Lubben Social Network Scale-6, the World Health Organization-five well-being index, the virtual ability scale, the self-esteem scale, and the reasons for employment, as indicated by all goodness-of-fit indices. [Conclusion] This study revealed a significant association between the reason for employment and burnout tendency, which was found to be the strongest. Therefore, it is important to know the reason for employment to ascertain burnout tendencies. Conversely, as associations were also found for several adjustment variables, it is necessary to consider not only the reasons for employment but also other factors when assessing burnout tendencies.
    Language English
    Publishing date 2023-10-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2038898-6
    ISSN 0915-5287
    ISSN 0915-5287
    DOI 10.1589/jpts.35.696
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  8. Article ; Online: Effect of biotin supplementation in infant formula: A multi-center study in Japan.

    Takahashi, Naoto / Shoji, Hiromichi / Arai, Hiroko / Tanaka, Kyoko / Kakiuchi, Satsuki / Yoda, Hitoshi / Shimizu, Toshiaki

    Pediatrics international : official journal of the Japan Pediatric Society

    2023  Volume 65, Issue 1, Page(s) e15359

    Abstract: Background: This non-randomized intervention study aimed to evaluate the effect of supplementing infant formula with biotin on biotin metabolism and on development.: Methods: We enrolled healthy Japanese infants (n = 84) and assigned them to groups ... ...

    Abstract Background: This non-randomized intervention study aimed to evaluate the effect of supplementing infant formula with biotin on biotin metabolism and on development.
    Methods: We enrolled healthy Japanese infants (n = 84) and assigned them to groups offered Formula A (total biotin, 0.5 μg/100 kcal) or Formula B (total biotin, 2.4 μg/100 kcal) until they were 6 months of age, and completed an additional follow up to age 36 months. Urinary biotin concentrations were measured at 1 and 6 months, and were compared among breast-fed, Formula A-fed, and Formula B-fed infants at each age. In a follow-up subgroup analysis, we compared scores on the Ages and Stages Questionnaire, version 3 (ASQ-3), from 9 to 36 months among infants continuously fed Formula A, Formula B, or breastmilk.
    Results: No adverse events occurred during the intervention period. At 1 month, urinary biotin concentrations were highest in Formula B-fed infants and lowest in Formula A-fed infants. At 6 months, Formula B-fed infants retained higher biotin levels than Formula A-fed and breast-fed infants. Both differences were statistically significant (P < 0.05). The breast-fed, Formula A-fed, and Formula B-fed groups had similar ASQ scores at 9-36 months.
    Conclusions: Biotin supplementation of infant formula contributed to improving biotin status in formula-fed infants. The results support the official approval of the use of biotin in infant formula by the government of Japan in 2014.
    MeSH term(s) Infant ; Female ; Humans ; Child, Preschool ; Infant Formula ; Biotin ; Japan ; Breast Feeding ; Dietary Supplements
    Chemical Substances Biotin (6SO6U10H04)
    Language English
    Publishing date 2023-01-01
    Publishing country Australia
    Document type Clinical Trial ; Multicenter Study ; Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15359
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  9. Article ; Online: Evaluation of Cognitive and Physical Function Among Older Adults by Their Physical Activity: A Cross-Sectional Kasama Study, Japan.

    Yoon, Jieun / Sasaki, Kazunori / Tateoka, Korin / Arai, Tetsuaki / Isoda, Hiroko / Okura, Tomohiro

    Journal of Alzheimer's disease : JAD

    2023  Volume 96, Issue 4, Page(s) 1801–1812

    Abstract: Background: The amyloid-β1-42 (Aβ42) level is a biomarker that is widely used to evaluate individual cognitive dysfunction early in neurodegenerative diseases, as well as differentiate between normal cognitive function, mild cognitive impairment, ... ...

    Abstract Background: The amyloid-β1-42 (Aβ42) level is a biomarker that is widely used to evaluate individual cognitive dysfunction early in neurodegenerative diseases, as well as differentiate between normal cognitive function, mild cognitive impairment, Alzheimer's disease, and vascular cognitive impairment.
    Objective: Our cross-sectional study evaluated the association between daily exercise and physical and cognitive function and Aβ42 levels among a subsample of 325 older adults from the Kasama Study.
    Methods: Participants (age: 74.5 [range 65-90] years) were classified into three exercise groups: the dual-task (DEG, n = 128), single-task (SEG, n = 122), and non-exercise (NEG, n = 75) groups. The main outcomes were the plasma Aβ42 levels and the scores of the five cognitive (5-COG) tests and five cognition-related physical function (5-PHYS) tests.
    Results: The Aβ42 levels and 5-COG and 5-PHYS scores were higher in the SEG and DEG than in the NEG. The Aβ42 levels were higher in the DEG than in the NEG (p = 0.008).
    Conclusions: Physical activities such as regular exercise may benefit older adults, improving their cognitive and physical function.
    MeSH term(s) Humans ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Japan ; Cognition ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/psychology ; Alzheimer Disease ; Exercise ; Amyloid beta-Peptides
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2023-11-24
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-230675
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  10. Article ; Online: Benefits of plerixafor for mobilization of peripheral blood stem cells prior to autologous transplantation: a dual-center retrospective cohort study.

    Nakamura, Naokazu / Jo, Tomoyasu / Arai, Yasuyuki / Matsumoto, Mayumi / Sakai, Tomomi / Tsunemine, Hiroko / Takaori-Kondo, Akifumi / Arima, Nobuyoshi

    Cytotherapy

    2023  Volume 25, Issue 7, Page(s) 773–781

    Abstract: Background aims: Before autologous stem cell transplantation (ASCT), hematopoietic stem cells must be stimulated to move from the bone marrow to the peripheral blood for harvesting. Plerixafor, a C-X-C chemokine receptor type 4 antagonist, is used to ... ...

    Abstract Background aims: Before autologous stem cell transplantation (ASCT), hematopoietic stem cells must be stimulated to move from the bone marrow to the peripheral blood for harvesting. Plerixafor, a C-X-C chemokine receptor type 4 antagonist, is used to increase stem cell harvests. However, the effects of plerixafor on post-ASCT outcomes remain unclear.
    Methods: In a dual-center retrospective cohort study of 43 Japanese patients who received ASCT, the authors compared transplantation outcomes in patients who underwent stem cell mobilization with granulocyte colony-stimulating factor with (n = 25) or without (n = 18) plerixafor.
    Results: The number of days to neutrophil and platelet engraftment was significantly shorter with plerixafor than without plerixafor, as assessed by univariate (neutrophil, P = 0.004, platelet, P = 0.002), subgroup, propensity score matching and inverse probability weighting analyses. Although the cumulative incidence of fever was comparable with or without plerixafor (P = 0.31), that of sepsis was significantly lower with plerixafor than without (P < 0.01). Thus, the present data indicate that plerixafor leads to earlier neutrophil and platelet engraftment and a reduction of infectious risk.
    Conclusions: The authors conclude that plerixafor may be safe to use and that it reduces the risk of infection in patients with a low CD34+ cell count the day before apheresis.
    MeSH term(s) Humans ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cell Mobilization ; Transplantation, Autologous ; Peripheral Blood Stem Cells ; Retrospective Studies ; Multiple Myeloma/therapy ; Heterocyclic Compounds/therapeutic use ; Heterocyclic Compounds/pharmacology ; Granulocyte Colony-Stimulating Factor/pharmacology
    Chemical Substances Heterocyclic Compounds ; Granulocyte Colony-Stimulating Factor (143011-72-7)
    Language English
    Publishing date 2023-03-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2039821-9
    ISSN 1477-2566 ; 1465-3249
    ISSN (online) 1477-2566
    ISSN 1465-3249
    DOI 10.1016/j.jcyt.2023.02.006
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