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  1. Article ; Online: Oral corticosteroids for acute preschool wheeze.

    Makrinioti, Heidi

    The Lancet. Respiratory medicine

    2024  

    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(24)00088-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7041: Show issues Location:
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  2. Article ; Online: Can We Test the Function of the Small Airways in Children Outside the Laboratory?

    Makrinioti, Heidi / Bush, Andrew

    Chest

    2023  Volume 165, Issue 2, Page(s) 241–242

    MeSH term(s) Child ; Humans ; Asthma/diagnosis
    Language English
    Publishing date 2023-12-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.10.004
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  3. Article ; Online: Editorial: Bridging the gap between immunology, virology, genetics, and epigenetics in bronchiolitis: The multiomics pathway to asthma development.

    Makrinioti, Heidi / Morita, Hideaki / Nastouli, Eleni / Jartti, Tuomas

    Frontiers in immunology

    2023  Volume 14, Page(s) 1154121

    MeSH term(s) Humans ; Multiomics ; Bronchiolitis ; Asthma/genetics ; Epigenesis, Genetic
    Language English
    Publishing date 2023-02-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1154121
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  4. Article: Severe asthma patients' and physicians' perspectives of disease burden: do they match?

    Makrinioti, Heidi / Tiotiu, Angelica / Gonzalez-Barcala, Francisco-Javier

    ERJ open research

    2023  Volume 9, Issue 3

    Abstract: A novel open-ended survey revealed contrasting viewpoints and priorities between patients with severe asthma and clinicians. These divergences must be considered when treating individual patients in multidisciplinary treatment teams. ...

    Abstract A novel open-ended survey revealed contrasting viewpoints and priorities between patients with severe asthma and clinicians. These divergences must be considered when treating individual patients in multidisciplinary treatment teams.
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Editorial
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00177-2023
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  5. Article ; Online: Infant Bronchiolitis Endotypes and the Risk of Developing Childhood Asthma: Lessons From Cohort Studies.

    Makrinioti, Heidi / Zhu, Zhaozhong / Saglani, Sejal / Camargo, Carlos A / Hasegawa, Kohei

    Archivos de bronconeumologia

    2024  Volume 60, Issue 4, Page(s) 215–225

    Abstract: Severe bronchiolitis (i.e., bronchiolitis requiring hospitalization) during infancy is a heterogeneous condition associated with a high risk of developing childhood asthma. Yet, the exact mechanisms underlying the bronchiolitis-asthma link remain ... ...

    Abstract Severe bronchiolitis (i.e., bronchiolitis requiring hospitalization) during infancy is a heterogeneous condition associated with a high risk of developing childhood asthma. Yet, the exact mechanisms underlying the bronchiolitis-asthma link remain uncertain. Birth cohort studies have reported this association at the population level, including only small groups of patients with a history of bronchiolitis, and have attempted to identify the underlying biological mechanisms. Although this evidence has provided valuable insights, there are still unanswered questions regarding severe bronchiolitis-asthma pathogenesis. Recently, a few bronchiolitis cohort studies have attempted to answer these questions by applying unbiased analytical approaches to biological data. These cohort studies have identified novel bronchiolitis subtypes (i.e., endotypes) at high risk for asthma development, representing essential and enlightening evidence. For example, one distinct severe respiratory syncytial virus (RSV) bronchiolitis endotype is characterized by the presence of Moraxella catarrhalis and Streptococcus pneumoniae, higher levels of type I/II IFN expression, and changes in carbohydrate metabolism in nasal airway samples, and is associated with a high risk for childhood asthma development. Although these findings hold significance for the design of future studies that focus on childhood asthma prevention, they require validation. However, this scoping review puts the above findings into clinical context and emphasizes the significance of future research in this area aiming to offer new bronchiolitis treatments and contribute to asthma prevention.
    MeSH term(s) Infant ; Humans ; Child ; Asthma/etiology ; Asthma/complications ; Bronchiolitis/etiology ; Bronchiolitis/complications ; Cohort Studies ; Respiratory Syncytial Virus Infections/complications ; Respiratory Syncytial Virus Infections/epidemiology
    Language Spanish
    Publishing date 2024-02-19
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2024.02.009
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  6. Article ; Online: Toward Precision Epidemiology in Bronchiolitis.

    Makrinioti, Heidi / Camargo, Carlos A / Jartti, Tuomas / Hasegawa, Kohei

    Chest

    2022  Volume 162, Issue 4, Page(s) 744–746

    MeSH term(s) Bronchiolitis/epidemiology ; Bronchiolitis, Viral ; Humans ; Infant
    Language English
    Publishing date 2022-06-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2022.06.003
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    Zs.MO 349: Show issues

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  7. Article: Can vitamin D

    Bokobza, Idan / El Hadi, Nour / Bush, Andrew / Makrinioti, Heidi

    Breathe (Sheffield, England)

    2022  Volume 17, Issue 3, Page(s) 210071

    Abstract: Vitamin D deficiency in children needs to be treated irrespective of asthma benefits. The VDKA trial showed that vitamin D supplementation in school-age asthmatic children with vitamin D insufficiency did not improve asthma control. ...

    Abstract Vitamin D deficiency in children needs to be treated irrespective of asthma benefits. The VDKA trial showed that vitamin D supplementation in school-age asthmatic children with vitamin D insufficiency did not improve asthma control.
    Language English
    Publishing date 2022-01-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0071-2021
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  8. Article ; Online: Severe bronchiolitis profiling as the first step towards prevention of asthma.

    Orzołek, Izabela / Ambrożej, Dominika / Makrinioti, Heidi / Zhu, Zhaozhong / Jartti, Tuomas / Feleszko, Wojciech

    Allergologia et immunopathologia

    2023  Volume 51, Issue 3, Page(s) 99–107

    Abstract: Bronchiolitis is the most common respiratory infection leading to hospitalization and constitutes a significant healthcare burden. The two main viral agents causing bronchiolitis, respiratory syncytial virus (RSV) and rhinovirus (RV), have distinct ... ...

    Abstract Bronchiolitis is the most common respiratory infection leading to hospitalization and constitutes a significant healthcare burden. The two main viral agents causing bronchiolitis, respiratory syncytial virus (RSV) and rhinovirus (RV), have distinct cytopathic, immune response, and clinical characteristics. Different approaches have been suggested for subtyping bronchiolitis based on viral etiology, atopic status, transcriptome profiles in blood, airway metabolome, lipidomic data, and airway microbiota. The highest risk of asthma at school age has been in a subgroup of bronchiolitis characterized by older age, high prevalence of RV infection, previous breathing problems, and/or eczema. Regarding solely viral etiology, RV-bronchiolitis in infancy has been linked to a nearly three times higher risk of developing asthma than RSV-bronchiolitis. Although treatment with betamimetics and systemic corticosteroids has been found ineffective in bronchiolitis overall, it can be beneficial for infants with severe RV bronchiolitis. Thus, there is a need to develop a more individualized therapeutic approach for bronchiolitis and follow-up strategies for infants at higher risk of asthma in the future perspective.
    MeSH term(s) Infant ; Humans ; Bronchiolitis/epidemiology ; Respiratory Syncytial Virus Infections/epidemiology ; Asthma/epidemiology ; Asthma/prevention & control ; Asthma/etiology ; Respiratory Syncytial Virus, Human ; Hospitalization ; Respiratory Sounds/etiology ; Bronchiolitis, Viral
    Language English
    Publishing date 2023-05-01
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 193144-1
    ISSN 1578-1267 ; 0301-0546
    ISSN (online) 1578-1267
    ISSN 0301-0546
    DOI 10.15586/aei.v51i3.788
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  9. Article: European Respiratory Society International Congress 2018: insights from the paediatric assembly.

    Nenna, Raffaella / Makrinioti, Heidi

    Journal of thoracic disease

    2018  Volume 10, Issue Suppl 25, Page(s) S3001–S3004

    Language English
    Publishing date 2018-09-24
    Publishing country China
    Document type Editorial
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.08.57
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  10. Article ; Online: Can low-dose dexamethasone be used instead of prednisolone in acute asthma attacks?

    Wallace, Susan / Chan, Nigel Ij / Makrinioti, Heidi / Phillips, Bob

    Archives of disease in childhood

    2021  

    Language English
    Publishing date 2021-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2020-320239
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