LIVIVO - Search results -

Search results

Result 1 - 10 of total 19

Search options

Article ; Online: Methods of In Ovo and Ex Ovo Ostrich Embryo Culture with Observations on the Development and Maturation of the Chorioallantoic Membrane.

Makanya, Andrew N / Jimoh, Sikiru A / Maina, John N

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

2023 Volume 29, Issue 4, Page(s) 1523–1530

Abstract: Culture of shell-free and windowed eggs for drug testing and other experiments has been perfected for smaller eggs such as those of chickens, where the developing blood vessels of the chorioallantoic membrane (CAM) become accessible for manipulative ... ...

Abstract	Culture of shell-free and windowed eggs for drug testing and other experiments has been perfected for smaller eggs such as those of chickens, where the developing blood vessels of the chorioallantoic membrane (CAM) become accessible for manipulative studies. However, due to the thickness and hardness of the ostrich egg shell, such techniques are not applicable. Using a tork craft mini rotary and a drill bit, we established windowed egg, in-shell-membrane windowed egg, and in-shell-membrane shell-free methods in the ostrich egg, depending on whether the shell membranes were retained or not. Concomitant study of the developing CAM revealed that at embryonic day 16 (E16), the three layers of the CAM were clearly delineated and at E25, the chorionic capillaries had fused with the epithelium while the CAM at E37 had reached maturity and the chorion and the allantois were both 3-4 times thicker and villous cavity (VC) and capillary-covering cells were well delineated. Both intussusceptive and sprouting angiogenesis were found to be the predominant modes of vascular growth in the ostrich CAM. Development and maturation of the ostrich CAM are similar to those of the well-studied chicken egg, albeit its incubation time being twice in duration.
MeSH term(s)	Animals ; Chorioallantoic Membrane/blood supply ; Struthioniformes ; Chickens ; Allantois/blood supply ; Chorion/blood supply
Language	English
Publishing date	2023-08-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1385710-1
ISSN	1435-8115 ; 1431-9276
ISSN (online)	1435-8115
ISSN	1431-9276
DOI	10.1093/micmic/ozad060
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Membrane mediated development of the vertebrate blood-gas-barrier.

Makanya, Andrew N

Birth defects research. Part C, Embryo today : reviews

2016 Volume 108, Issue 1, Page(s) 85–97

Abstract: During embryonic lung development, establishment of the gas-exchanging units is guided by epithelial tubes lined by columnar cells. Ultimately, a thin blood-gas barrier (BGB) is established and forms the interface for efficient gas exchange. This thin ... ...

Abstract	During embryonic lung development, establishment of the gas-exchanging units is guided by epithelial tubes lined by columnar cells. Ultimately, a thin blood-gas barrier (BGB) is established and forms the interface for efficient gas exchange. This thin BGB is achieved through processes, which entail lowering of tight junctions, stretching, and thinning in mammals. In birds the processes are termed peremerecytosis, if they involve cell squeezing and constriction, or secarecytosis, if they entail cutting cells to size. In peremerecytosis, cells constrict at a point below the protruding apical part, resulting in fusion of the opposing membranes and discharge of the aposome, or the cell may be squeezed by the more endowed cognate neighbors. Secarecytosis may entail formation of double membranes below the aposome, subsequent unzipping and discharge of the aposome, or vesicles form below the aposome, fuse in a bilateral manner, and release the aposome. These processes occur within limited developmental windows, and are mediated through cell membranes that appear to be of intracellular in origin. In addition, basement membranes (BM) play pivotal roles in differentiation of the epithelial and endothelial layers of the BGB. Laminins found in the BM are particularly important in the signaling pathways that result in formation of squamous pneumocytes and pulmonary capillaries, the two major components of the BGB. Some information exists on the contribution by BM to BGB formation, but little is known regarding the molecules that drive peremerecytosis, or even the origins and composition of the double and vesicular membranes involved in secarecytosis.
MeSH term(s)	Animals ; Blood Gas Analysis ; Blood-Air Barrier/embryology ; Blood-Air Barrier/physiology ; Capillaries/metabolism ; Cell Differentiation/physiology ; Epithelial Cells/metabolism ; Epithelial Cells/physiology ; Humans ; Lung/embryology ; Lung/metabolism ; Membranes/physiology ; Signal Transduction
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2104792-3
ISSN	1542-9768 ; 1542-0752 ; 1542-9733 ; 1542-975X
ISSN (online)	1542-9768
ISSN	1542-0752 ; 1542-9733 ; 1542-975X
DOI	10.1002/bdrc.21120
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 749: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Slight volume changes in the duck lung do not imply a fundamental change in the structure of the parenchyma.

Makanya, Andrew N / Kavoi, Boniface M / Kihurani, David O

Anatomia, histologia, embryologia

2020 Volume 50, Issue 1, Page(s) 169–174

Abstract: Slight changes in lung volume have previously been reported in ducks. We studied the functional structure of the lung of the domestic duck using classical anatomical techniques as well as ultrasound monitoring to unravel the causes of such changes. Later ...

Abstract	Slight changes in lung volume have previously been reported in ducks. We studied the functional structure of the lung of the domestic duck using classical anatomical techniques as well as ultrasound monitoring to unravel the causes of such changes. Later dorsal and medioventral secondary bronchi were superficially positioned and covered with a thin transparent and collapsible membrane, internally lined with a cuboidal to squamous epithelium. The lung parenchyma was rigid, with atria well supported by septa containing smooth muscles, interparabronchial septa reinforced by collagen fibres, and blood capillaries supported by epithelial plates. On ultrasound monitoring, an outward and inward movement of the lung surface during inspiration and expiration, respectively, was evident at the region where the airways were covered by the thin membranes. The movements plausibly facilitated air movement in the lung just like the air sacs. We conclude that volume changes in the duck lung occur due to a slight morphological adaptation rather than a change in the archetypical design of the avian lung parenchyma.
MeSH term(s)	Air Sacs/anatomy & histology ; Animals ; Bronchi/anatomy & histology ; Ducks/anatomy & histology ; Lung/anatomy & histology ; Parenchymal Tissue/anatomy & histology
Language	English
Publishing date	2020-09-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	537922-2
ISSN	1439-0264 ; 0340-2096 ; 0044-4294
ISSN (online)	1439-0264
ISSN	0340-2096 ; 0044-4294
DOI	10.1111/ahe.12615
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 1221: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Slight volume changes in the duck lung do not imply a fundamental change in the structure of the parenchyma

Makanya, Andrew N / Kavoi, Boniface M / Kihurani, David O

Anatomia, histologia, embryologia. 2021 Jan., v. 50, no. 1

2021

Abstract	Slight changes in lung volume have previously been reported in ducks. We studied the functional structure of the lung of the domestic duck using classical anatomical techniques as well as ultrasound monitoring to unravel the causes of such changes. Later dorsal and medioventral secondary bronchi were superficially positioned and covered with a thin transparent and collapsible membrane, internally lined with a cuboidal to squamous epithelium. The lung parenchyma was rigid, with atria well supported by septa containing smooth muscles, interparabronchial septa reinforced by collagen fibres, and blood capillaries supported by epithelial plates. On ultrasound monitoring, an outward and inward movement of the lung surface during inspiration and expiration, respectively, was evident at the region where the airways were covered by the thin membranes. The movements plausibly facilitated air movement in the lung just like the air sacs. We conclude that volume changes in the duck lung occur due to a slight morphological adaptation rather than a change in the archetypical design of the avian lung parenchyma.
Keywords	air ; air flow ; blood ; collagen ; ducks ; epithelium ; parenchyma (animal tissue) ; ultrasonics
Language	English
Dates of publication	2021-01
Size	p. 169-174.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-light ; JOURNAL ARTICLE
ZDB-ID	537922-2
ISSN	1439-0264 ; 0340-2096 ; 0044-4294
ISSN (online)	1439-0264
ISSN	0340-2096 ; 0044-4294
DOI	10.1111/ahe.12615
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 960 c: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Book: The vertebrate blood-gas barrier in health and disease

Makanya, Andrew N

structure, development, and remodeling

2015

Author's details	Andrew N. Makanya, editor
MeSH term(s)	Blood-Air Barrier/physiology ; Respiratory Physiological Phenomena ; Pulmonary Gas Exchange/physiology ; Pulmonary Circulation/physiology ; Capillaries/physiology ; Vertebrates/physiology
Language	English
Size	xiv, 243 pages :, illustrations
Document type	Book
ISBN	9783319183916 ; 9783319183923 ; 3319183915 ; 3319183923
Database	Catalogue of the US National Library of Medicine (NLM)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Casting materials and their application in research and teaching.

Haenssgen, Kati / Makanya, Andrew N / Djonov, Valentin

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

2014 Volume 20, Issue 2, Page(s) 493–513

Abstract: From a biological point of view, casting refers to filling of anatomical and/or pathological spaces with extraneous material that reproduces a three-dimensional replica of the space. Casting may be accompanied by additional procedures such as corrosion, ... ...

Abstract	From a biological point of view, casting refers to filling of anatomical and/or pathological spaces with extraneous material that reproduces a three-dimensional replica of the space. Casting may be accompanied by additional procedures such as corrosion, in which the soft tissue is digested out, leaving a clean cast, or the material may be mixed with radiopaque substances to allow x-ray photography or micro computed topography (µCT) scanning. Alternatively, clearing of the surrounding soft tissue increases transparency and allows visualization of the casted cavities. Combination of casting with tissue fixation allows anatomical dissection and didactic surgical procedures on the tissue. Casting materials fall into three categories namely, aqueous substances (India ink, Prussian blue ink), pliable materials (gelatins, latex, and silicone rubber), or hard materials (methyl methacrylates, polyurethanes, polyesters, and epoxy resins). Casting has proved invaluable in both teaching and research and many phenomenal biological processes have been discovered through casting. The choice of a particular material depends inter alia on the targeted use and the intended subsequent investigative procedures, such as dissection, microscopy, or µCT. The casting material needs to be pliable where anatomical and surgical manipulations are intended, and capillary-passable for ultrastructural investigations.
Language	English
Publishing date	2014-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1385710-1
ISSN	1435-8115 ; 1431-9276
ISSN (online)	1435-8115
ISSN	1431-9276
DOI	10.1017/S1431927613014050
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Avian area vasculosa and CAM as rapid in vivo pro-angiogenic and antiangiogenic models.

Makanya, Andrew N / Styp-Rekowska, Beata / Dimova, Ivanka / Djonov, Valentin

Methods in molecular biology (Clifton, N.J.)

2015 Volume 1214, Page(s) 185–196

Abstract: Angiogenesis, the development of new blood vessels from preexisting ones, is driven by coordinated signaling pathways governed by specific molecules, hemodynamic forces, and endothelial and periendothelial cells. The processes involve adhesion, migration, ...

Abstract	Angiogenesis, the development of new blood vessels from preexisting ones, is driven by coordinated signaling pathways governed by specific molecules, hemodynamic forces, and endothelial and periendothelial cells. The processes involve adhesion, migration, and survival machinery within the target endothelial and periendothelial cells. Factors that interfere with any of these processes may therefore influence angiogenesis either positively (pro-angiogenesis) or negatively (antiangiogenesis). The avian area vasculosa (AV) and the avian chorioallantoic membrane (CAM) are two useful tools for studying both angiogenesis and antiangiogenesis since they are amenable to both intravascular and topical administration of target, agents, are relatively rapid assays, and can be adapted very easily to study angiogenesis-dependent processes, such as tumor growth. Both models provide a physiological setting that permits investigation of pro-angiogenic and antiangiogenic agent interactions in vivo.
MeSH term(s)	Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Animals ; Bone Marrow Cells/cytology ; Chick Embryo ; Chorioallantoic Membrane/blood supply ; Chorioallantoic Membrane/drug effects ; Dextrans/chemistry ; Fluorescein-5-isothiocyanate/analogs & derivatives ; Fluorescein-5-isothiocyanate/chemistry ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/drug effects ; Male ; Mice ; Models, Animal ; Neovascularization, Physiologic/drug effects ; Phthalazines/pharmacology ; Protease Inhibitors/pharmacology ; Pyridines/pharmacology ; Receptors, Notch/metabolism ; Signal Transduction/drug effects ; Tissue Culture Techniques ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Yolk Sac/blood supply ; Yolk Sac/cytology ; Yolk Sac/drug effects
Chemical Substances	Dextrans ; Phthalazines ; Protease Inhibitors ; Pyridines ; Receptors, Notch ; Vascular Endothelial Growth Factor A ; fluorescein isothiocyanate dextran ; vatalanib (5DX9U76296) ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; Fluorescein-5-isothiocyanate (I223NX31W9)
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-1462-3_11
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article: The structural design of the bat wing web and its possible role in gas exchange.

Makanya, Andrew N / Mortola, Jacopo P

Journal of anatomy

2007 Volume 211, Issue 6, Page(s) 687–697

Abstract: The structure of the skin in the epauletted fruit bat (Epomophorus wahlbergi) wing and body trunk was studied with a view to understanding possible adaptations for gas metabolism and thermoregulation. In addition, gas exchange measurements were performed ...

Abstract	The structure of the skin in the epauletted fruit bat (Epomophorus wahlbergi) wing and body trunk was studied with a view to understanding possible adaptations for gas metabolism and thermoregulation. In addition, gas exchange measurements were performed using a respirometer designed for the purpose. The body skin had an epidermis, a dermis with hair follicles and sweat glands and a fat-laden hypodermis. In contrast, the wing web skin was made up of a thin bilayered epidermis separated by a connective tissue core with collagen and elastic fibres and was devoid of hair follicles and sweat glands. The wings spanned 18-24 cm each, with about 753 cm2 of surface exposed to air. The body skin epidermis was thick (61 +/- 3 microm, SEM), the stratum corneum alone taking a third of it (21 +/- 3 microm). In contrast, the wing web skin epidermis was thinner at 9.8 +/- 0.7 microm, with a stratum corneum measuring 4.1 +/- 0.3 microm (41%). The wing capillaries in the wing web skin ran in the middle of the connective tissue core, with a resultant surface-capillary diffusion distance of 26.8 +/- 3.2 microm. The rate of oxygen consumption (VO2) of the wings alone and of the whole animal measured under light anaesthesia at ambient temperatures of 24 masculineC and 33 masculineC, averaged 6% and 10% of the total, respectively. Rate of carbon dioxide production had similar values. The membrane diffusing capacity for the wing web was estimated to be 0.019 ml O2 min(-1) mmHg(-1). We conclude that in Epomophorus wahlbergi, the wing web has structural modifications that permit a substantial contribution to the total gas exchange.
MeSH term(s)	Adaptation, Physiological ; Animals ; Capillaries/anatomy & histology ; Carbon Dioxide/metabolism ; Chiroptera/anatomy & histology ; Chiroptera/physiology ; Diffusion ; Gases ; Microscopy, Electron ; Oxygen/metabolism ; Respiratory Transport ; Skin Physiological Phenomena ; Skin Temperature ; Wings, Animal/anatomy & histology ; Wings, Animal/physiology
Chemical Substances	Gases ; Carbon Dioxide (142M471B3J) ; Oxygen (S88TT14065)
Language	English
Publishing date	2007-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2955-5
ISSN	1469-7580 ; 0021-8782
ISSN (online)	1469-7580
ISSN	0021-8782
DOI	10.1111/j.1469-7580.2007.00817.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ub I Zs.38: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Escape mechanisms after antiangiogenic treatment, or why are the tumors growing again?

Hlushchuk, Ruslan / Makanya, Andrew N / Djonov, Valentin

The International journal of developmental biology

2011 Volume 55, Issue 4-5, Page(s) 563–567

Abstract: Inhibitors of angiogenesis and radiation induce compensatory changes in the tumor vasculature both during and after cessation of treatment. In numerous preclinical studies, angiogenesis inhibitors were shown to be efficient in the treatment of many ... ...

Abstract	Inhibitors of angiogenesis and radiation induce compensatory changes in the tumor vasculature both during and after cessation of treatment. In numerous preclinical studies, angiogenesis inhibitors were shown to be efficient in the treatment of many pathological conditions, including solid cancers. In most clinical trials, however, this approach turned out to have no significant effect, especially if applied as monotherapy. Recovery of tumors after therapy is a major problem in the management of cancer patients. The mechanisms underlying tumor recovery (or therapy resistance) have not yet been explicitly elucidated. This review deals with the transient switch from sprouting to intussusceptive angiogenesis, which may be an adaptive response of tumor vasculature to cancer therapy that allows the vasculature to maintain its functional properties. Potential candidates for molecular targeting of this angioadaptive mechanism are yet to be elucidated in order to improve the currently poor efficacy of contemporary antiangiogenic therapies.
MeSH term(s)	Angiogenesis Inhibitors/therapeutic use ; Animals ; Fibroblast Growth Factor 2/physiology ; Humans ; Models, Biological ; Neoplasms/blood supply ; Neoplasms/drug therapy ; Neoplasms/pathology ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/etiology ; Neovascularization, Pathologic/pathology ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Vascular Endothelial Growth Factor A/physiology
Chemical Substances	Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A ; Fibroblast Growth Factor 2 (103107-01-3)
Language	English
Publishing date	2011
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	1036070-0
ISSN	1696-3547 ; 0214-6282
ISSN (online)	1696-3547
ISSN	0214-6282
DOI	10.1387/ijdb.103231rh
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3202: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: New insights into intussusceptive angiogenesis.

Djonov, Valentin / Makanya, Andrew N

EXS

2004 , Issue 94, Page(s) 17–33

MeSH term(s)	Animals ; Blood Vessels/physiology ; Blood Vessels/ultrastructure ; Capillaries/physiology ; Humans ; Intussusception/physiopathology ; Microcirculation/physiology ; Neovascularization, Pathologic/physiopathology ; Neovascularization, Physiologic/physiology
Language	English
Publishing date	2004-12-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	1023-294X
ISSN	1023-294X
DOI	10.1007/3-7643-7311-3_2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED