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Article: Spinal Solitary Plasmacytoma With Minimal Marrow Involvement Presenting With Epidural Spinal Cord Compression.

Al-Handola, Rami / Banerjee, Upasana / Navari, Yasaman / Ayad, Sarah / Marcus, Huda

2024 Volume 16, Issue 1, Page(s) e52460

Abstract: Solitary plasmacytoma (SPC) is a rare type of plasma cell dyscrasia characterized by the proliferation of neoplastic monoclonal plasma cells. It can involve bone or soft tissue without signs of systemic disease. The solitary bone plasmacytoma typically ... ...

Abstract	Solitary plasmacytoma (SPC) is a rare type of plasma cell dyscrasia characterized by the proliferation of neoplastic monoclonal plasma cells. It can involve bone or soft tissue without signs of systemic disease. The solitary bone plasmacytoma typically involves the axial skeleton, most commonly the vertebrae. This article presents a 58-year-old male with a history of Parkinson's disease, hypertension, and cervical spine degenerative joint disease. He arrived at the emergency department with severe thoracic and lumbar back pain, accompanied by numbness and weakness in both legs, which worsened with movement and deep breathing. Magnetic resonance imaging (MRI) findings revealed a sizable mass in the T11 vertebra, leading to thoracic spinal cord compression. Treatment included high-dose dexamethasone, and surgical intervention was undertaken. Subsequent pathology confirmed plasma cell dyscrasia. Radiotherapy and chemotherapy (lenalidomide and dexamethasone) were administered, resulting in no recurrence or new masses after two years. Solitary plasmacytoma is a rare disease with limited clinical trials due to the inability to accrue larger cohorts. Prompt diagnosis and staging of plasmacytomas, involving robust histopathological and radiographic methods, are needed to prevent further complications and possible progression to multiple myeloma. Radiation therapy is the primary treatment, with some studies showing the benefits of lenalidomide and dexamethasone. Further studies are needed to improve treatment options for these patients. This case report adds to the current literature the importance of a multidisciplinary approach to the treatment of SPC.
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52460
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Incidental Finding of Riedel's Lobe of the Liver and Intrahepatic Cholangiocarcinoma.

Al-Handola, Rami / Chinnappan, Justine / Bakeer, Mohammad / Ayad, Sarah

Cureus

2023 Volume 15, Issue 6, Page(s) e40683

Abstract: Riedel's lobe is a rare anatomical variant of the liver morphology with a downward tongue-like projection of the anterior edge of the right lobe. It is usually detected incidentally with abdominal imaging performed for other indications. We present a ... ...

Abstract	Riedel's lobe is a rare anatomical variant of the liver morphology with a downward tongue-like projection of the anterior edge of the right lobe. It is usually detected incidentally with abdominal imaging performed for other indications. We present a case where we found Riedel's lobe incidentally, with invasive adenocarcinoma arising from close proximity. A 64-year-old female came in with encephalopathy and was found to have a distended abdomen with tenderness. Imaging revealed a complex lobular mass in the right hepatic lobe with an elongated extension of the right lobe inferiorly consistent with Riedel's lobe. The differential considered was malignancy versus abscess. CT-guided biopsy revealed invasive adenocarcinoma consistent with intrahepatic cholangiocarcinoma, which was further supported by the presence of portocaval lymph nodes. Various studies have tried to establish an association between Riedel's lobe and the occurrence of cancer arising from the surrounding structures, primarily from liver or metastasis. This case report adds to the current literature when such an association is being studied.
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.40683
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Multiple Myeloma with CNS Involvement in the Form of Leptomeningeal Carcinomatosis Presenting as Vitamin B12 Deficiency.

Faheem, Beenish / Ayad, Sarah / Singh, Leena / Maroules, Michael

Journal of community hospital internal medicine perspectives

2022 Volume 12, Issue 1, Page(s) 59–63

Abstract: A 75-year-old male presented with lower back pain, bilateral lower extremity weakness, decreased sensation to vibration and proprioception in lower extremities, anemia, and vitamin B12 deficiency. The MRI of the lumbar spine revealed extensive ... ...

Abstract	A 75-year-old male presented with lower back pain, bilateral lower extremity weakness, decreased sensation to vibration and proprioception in lower extremities, anemia, and vitamin B12 deficiency. The MRI of the lumbar spine revealed extensive leptomeningeal carcinomatosis. Subsequently, the patient was diagnosed with multiple myeloma (MM) and B12 deficiency with negative intrinsic factor antibodies. MM can present as extramedullary hematopoiesis (EM) to involve the central nervous system (CNS). CNS involvement is rare and develops in only around 1% of MM patients. It carries a poor prognosis with less than 6 months survival. MM is thought to be associated with both B12 deficiency and pernicious anemia. Some studies have even suggested B12 deficiency as a possible marker for worsening disease and a prognostic factor. In our patient's case, he had extensive CNS involvement at diagnosis of MM with very low B12 levels. The extent of his disease with extensive CNS involvement, which carries a poor prognosis, could possibly explain the very low levels of B12. This is the first reported case of a patient presenting with B12 deficiency found to have MM with leptomeningeal carcinomatosis at diagnosis. To the author's knowledge, there is no literature investigating association between B12 deficiency at the time of diagnosis of MM with CNS complications. Furthermore, there are no established guidelines on treatment for leptomeningeal myelomatosis. We present this case with the effort to learn more about this disease in terms of response and overall survival.
Language	English
Publishing date	2022-01-31
Publishing country	United States
Document type	Case Reports
ZDB-ID	2616884-4
ISSN	2000-9666
ISSN	2000-9666
DOI	10.55729/2000-9666.1011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Invasive Pneumococcal Disease in a Patient With COVID-19: A Case Report.

Ayad, Sarah / Alyacoub, Ramez / Gergis, Kirolos / Grossman, Daniel / Salamera, Julius

Cureus

2021 Volume 13, Issue 2, Page(s) e13559

Abstract: The spread of the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has resulted in a global health pandemic and caused profound morbidity and mortality worldwide. The virus is known to ... ...

Abstract	The spread of the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has resulted in a global health pandemic and caused profound morbidity and mortality worldwide. The virus is known to cause severe hypoxemic respiratory failure and has been associated with extrapulmonary manifestations and end-organ dysfunction in the setting of extensive inflammatory response. Recently, the association between COVID-19 and pneumococcal pneumonia co-infection or superinfections has gained increasing interest. In this report, we present the case of a 58-year-old man with a past medical history significant for pulmonary tuberculosis, diagnosed over two decades ago, who presented with pleuritic chest pain, myalgia, intermittent fevers, chills, and productive cough and was found to have invasive pneumococcal disease and COVID-19. To our knowledge, this is the first reported case of invasive pneumococcal infection in a patient with COVID-19.
Language	English
Publishing date	2021-02-25
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.13559
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Case Report of Brown Recluse Spider Bite.

Abdelazeem, Basel / Eurick-Bering, Kianna / Ayad, Sarah / Malik, Bilal / Kalynych, Zirka

Cureus

2021 Volume 13, Issue 7, Page(s) e16663

Abstract: Brown recluse spider is a spider of the ... ...

Abstract	Brown recluse spider is a spider of the genus
Language	English
Publishing date	2021-07-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.16663
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fat mass and obesity-associated (FTO) gene is essential for insulin secretion and β-cell function: In vitro studies using INS-1 cells and human pancreatic islets.

Taneera, Jalal / Khalique, Anila / Abdrabh, Sham / Mohammed, Abdul Khader / Bouzid, Amal / El-Huneidi, Waseem / Bustanji, Yasser / Sulaiman, Nabil / Albasha, Sarah / Saber-Ayad, Maha / Hamad, Mawieh

Life sciences

2024 Volume 339, Page(s) 122421

Abstract: Aims: In this study, we investigated the role of the FTO gene in pancreatic β-cell biology and its association with type 2 diabetes (T2D). To address this issue, human pancreatic islets and rat INS-1 (832/13) cells were used to perform gene silencing, ... ...

Abstract	Aims: In this study, we investigated the role of the FTO gene in pancreatic β-cell biology and its association with type 2 diabetes (T2D). To address this issue, human pancreatic islets and rat INS-1 (832/13) cells were used to perform gene silencing, overexpression, and functional analysis of FTO expression; levels of FTO were also measured in serum samples obtained from diabetic and obese individuals. Results: The findings revealed that FTO expression was reduced in islets from hyperglycemic/diabetic donors compared to normal donors. This reduction correlated with decreased INS and GLUT1 expression and increased PDX1, GCK, and SNAP25 expression. Silencing of Fto in INS-1 cells impaired insulin release and mitochondrial ATP production and increased apoptosis in pro-apoptotic cytokine-treated cells. However, glucose uptake and reactive oxygen species production rates remained unaffected. Downregulation of key β-cell genes was observed following Fto-silencing, while Glut2 and Gck were unaffected. RNA-seq analysis identified several dysregulated genes involved in metal ion binding, calcium ion binding, and protein serine/threonine kinase activity. Furthermore, our findings showed that Pdx1 or Mafa-silencing did not influence FTO protein expression. Overexpression of FTO in human islets promoted insulin secretion and upregulated INS, PDX1, MAFA, and GLUT1 expression. Serum FTO levels did not significantly differ between individuals with diabetes or obesity and their healthy counterparts. Conclusion: These findings suggest that FTO plays a crucial role in β-cell survival, metabolism, and function and point to a potential therapeutic utility of FTO in T2D patients.
MeSH term(s)	Humans ; Rats ; Animals ; Insulin Secretion/genetics ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Glucose Transporter Type 1/metabolism ; Islets of Langerhans/metabolism ; Insulin-Secreting Cells/metabolism ; Insulin/metabolism ; Obesity/genetics ; Obesity/metabolism ; Glucose/metabolism ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/metabolism
Chemical Substances	Glucose Transporter Type 1 ; Insulin ; Glucose (IY9XDZ35W2) ; FTO protein, human (EC 1.14.11.33) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33)
Language	English
Publishing date	2024-01-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2024.122421
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Hepatosplenic Abscess From

Ejikeme, Chidinma / Nwachukwu, Onyeka / Ayad, Sarah / Rath, Payal / Ejikeme, Ifunanya / Salamera, Julius

Journal of investigative medicine high impact case reports

2021 Volume 9, Page(s) 23247096211033046

Abstract: ... ...

Abstract	Invasive
MeSH term(s)	Bacteremia ; Diabetes Mellitus/epidemiology ; Female ; Humans ; Klebsiella Infections/complications ; Klebsiella Infections/drug therapy ; Klebsiella pneumoniae ; Liver Abscess, Pyogenic/epidemiology ; Middle Aged
Language	English
Publishing date	2021-07-20
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2710326-2
ISSN	2324-7096 ; 2324-7096
ISSN (online)	2324-7096
ISSN	2324-7096
DOI	10.1177/23247096211033046
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Azithromycin-Induced Bradycardia.

Abdelazeem, Basel / Hollander, Rachel M / Ayad, Sarah / Gergis, Kirolos / Gismalla, Mohamed E

Cureus

2021 Volume 13, Issue 8, Page(s) e16995

Abstract: Azithromycin is a broad-spectrum antibiotic of the macrolide class and has multiple effects on the cardiovascular system, including prolonged corrected QT (QTc) interval. However, there is limited literature on the association between azithromycin and ... ...

Abstract	Azithromycin is a broad-spectrum antibiotic of the macrolide class and has multiple effects on the cardiovascular system, including prolonged corrected QT (QTc) interval. However, there is limited literature on the association between azithromycin and bradyarrhythmias. Monitoring the patient via telemetry can detect bradycardia. The diagnosis of azithromycin-induced bradycardia is usually made by the exclusion of other causes of bradycardia. We report a case of a 44-year-old female with past medical history of obstructive sleep apnea who presented to our hospital due to polysubstance drug overdose with possible aspiration pneumonia. The patient received azithromycin and subsequently developed symptomatic bradycardia two days post-onset of antibiotic treatment. This case raises awareness amongst physicians about the possibility of azithromycin-induced bradycardia and explains the different mechanisms that can cause it.
Language	English
Publishing date	2021-08-08
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.16995
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: COVID-19 and arterial thrombosis: Report of 2 cases.

Singh, Balraj / Kaur, Parminder / Patel, Prem / Nabati, Camellia / Ayad, Sarah / Shamoon, Fayez / Maroules, Michael

Radiology case reports

2021 Volume 16, Issue 7, Page(s) 1603–1607

Abstract: The SARS-CoV-2 infection has been predominately associated with lung disease. However, emerging evidence has associated the COVID-19 infection with a hypercoagulable state. This hypercoagulable state can occur despite the use of anticoagulants and ... ...

Abstract	The SARS-CoV-2 infection has been predominately associated with lung disease. However, emerging evidence has associated the COVID-19 infection with a hypercoagulable state. This hypercoagulable state can occur despite the use of anticoagulants and antiplatelets. In fact, it may even be the presenting symptom of COVID-19 in some patients. Thromboembolism associated with COVID-19 carries a worse prognosis and should be identified as early as possible. Therefore, we report 2 patients with arterial thrombosis in the form of limb ischemia in the setting of COVID-19.
Language	English
Publishing date	2021-04-29
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2021.04.033
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Novel Case of Hypoparathyroidism Secondary to SARS-CoV-2 Infection.

Elkattawy, Sherif / Alyacoub, Ramez / Ayad, Sarah / Pandya, Manthan / Eckman, Ari

Cureus

2020 Volume 12, Issue 8, Page(s) e10097

Abstract: Hypoparathyroidism is usually caused by postsurgical or autoimmune damage to the parathyroid gland. We present the case of a 46-year-old Hispanic male with no significant past medical history who was admitted to the hospital with hypoxic respiratory ... ...

Abstract	Hypoparathyroidism is usually caused by postsurgical or autoimmune damage to the parathyroid gland. We present the case of a 46-year-old Hispanic male with no significant past medical history who was admitted to the hospital with hypoxic respiratory failure due to coronavirus disease 2019 (COVID-19) infection and had a prolonged hospital course. He was incidentally found to have hyperphosphatemia and low parathyroid hormone (PTH) levels. During the second month of hospitalization, his phosphorus levels rose to 6.9 mg/dL (normal range: 2.4-4.7 mg/dl). His PTH levels were found to be at 8 pg/mL. Vitamin D levels obtained were also low (7 ng/dL), phosphorus was at 5.8 mg/dL with albumin of 2.9 g/dL, and calcium level was normal at 9.2 mg/dl. Parathyroid hormone-related peptide (PTHrP) level was low at 10. Malignancy and genetic causes were ruled out. The patient was started on 50,000 units of ergocalciferol once a week. He was also started on calcium acetate 1,334 mg three times a day for hyperphosphatemia. Phosphorus levels remained elevated, and sevelamer was added on discharge after he was weaned off oxygen and cleared by physical therapy. No explanation for persistent hyperphosphatemia and hypoparathyroidism was found. To date, there have been some reports linking severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to widespread tissue injury; however, there have been no reports so far on the effect of the parathyroid gland. Further studies are necessary to elaborate and to confirm the causative relationship between SARS-CoV-2 and hyperphosphatemia.
Keywords	covid19
Language	English
Publishing date	2020-08-28
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.10097
Database	MEDical Literature Analysis and Retrieval System OnLINE

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