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Article ; Online: Development of an agar-based screening method for terbinafine, itraconazole, and amorolfine susceptibility testing of

Siopi, Maria / Efstathiou, Ioanna / Arendrup, Maiken C / Meletiadis, Joseph

2023 Volume 62, Issue 1, Page(s) e0130823

Abstract: Resistance in dermatophytes is an emerging global public health issue. We, therefore, developed an agar-based method for ... ...

Abstract	Resistance in dermatophytes is an emerging global public health issue. We, therefore, developed an agar-based method for screening
MeSH term(s)	Humans ; Terbinafine/pharmacology ; Itraconazole/pharmacology ; Trichophyton/genetics ; Antifungal Agents/pharmacology ; Agar ; Microbial Sensitivity Tests ; Squalene Monooxygenase/genetics ; Drug Resistance, Fungal/genetics ; Arthrodermataceae/genetics ; Morpholines
Chemical Substances	Terbinafine (G7RIW8S0XP) ; Itraconazole (304NUG5GF4) ; Antifungal Agents ; Agar (9002-18-0) ; amorolfine (AB0BHP2FH0) ; Squalene Monooxygenase (EC 1.14.14.17) ; Morpholines
Language	English
Publishing date	2023-12-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/jcm.01308-23
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Article ; Online: Corrigendum to "How to: EUCAST recommendations on the screening procedure E.Def 10.1 for the detection of azole resistance in Aspergillus fumigatus isolates using four-well azole-containing agar plates" [Clin Microbiol Infect 25 (2019) 681-687].

Guinea, J / Verweij, P E / Meletiadis, J / Mouton, J W / Barchiesi, F / Arendrup, M C

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2023 Volume 29, Issue 12, Page(s) 1618

Language	English
Publishing date	2023-09-12
Publishing country	England
Document type	Published Erratum
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2023.09.006
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 284: Show issues

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Article ; Online: Update on antifungal resistance in Aspergillus and Candida.

Arendrup, M C

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2014 Volume 20 Suppl 6, Page(s) 42–48

Abstract: Antifungal resistance in Candida and Aspergillus may be either intrinsic or acquired and may be encountered in the antifungal drug exposed but also the antifungal drug-naïve patient. Prior antifungal treatment confers a selection pressure and notoriously ...

Abstract	Antifungal resistance in Candida and Aspergillus may be either intrinsic or acquired and may be encountered in the antifungal drug exposed but also the antifungal drug-naïve patient. Prior antifungal treatment confers a selection pressure and notoriously raises the awareness of possible resistance in patients failing therapy, thus calling for susceptibility testing. On the contrary, antifungal resistance in the drug-naïve patient is less expected and therefore more challenging. This is particularly true when it concerns pathogens with acquired resistance which cannot be predicted from the species identification itself. This scenario is particularly relevant for A. fumigatus infections due to the increasing prevalence of azole-resistant isolates in the environment. For Candida, infections resistance is most common in the context of increasing prevalence of species with intrinsic resistance. Candida glabrata which has intrinsically reduced susceptibility to fluconazole is increasingly common particularly among the adult and elderly population on the Northern Hemisphere where it may be responsible for as many as 30% of the blood stream infections in population-based surveillance programmes. Candida parapsilosis is prevalent in the paediatric setting, at centres with increasing echinocandin use and at the southern or pacific parts of the world. In the following, the prevalence and drivers of intrinsic and acquired resistance in Aspergillus and Candida will be reviewed.
MeSH term(s)	Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Aspergillosis/diagnosis ; Aspergillosis/drug therapy ; Aspergillosis/microbiology ; Aspergillus/drug effects ; Candida/drug effects ; Candidiasis/diagnosis ; Candidiasis/drug therapy ; Candidiasis/microbiology ; Drug Resistance, Fungal ; Humans
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2014-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1111/1469-0691.12513
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 284: Show issues

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Article ; Online: EUCAST Ibrexafungerp MICs and Wild-Type Upper Limits for Contemporary Danish Yeast Isolates.

Jørgensen, Karin M / Astvad, Karen M T / Hare, Rasmus K / Arendrup, Maiken C

Journal of fungi (Basel, Switzerland)

2022 Volume 8, Issue 10

Abstract: Ibrexafungerp is a novel triterpenoid antifungal that inhibits glucan synthase and thus fungal cell wall synthesis. We examined the in vitro activity against contemporary clinical yeast, investigated inter-laboratory and intra-laboratory variability, ... ...

Abstract	Ibrexafungerp is a novel triterpenoid antifungal that inhibits glucan synthase and thus fungal cell wall synthesis. We examined the in vitro activity against contemporary clinical yeast, investigated inter-laboratory and intra-laboratory variability, suggested wild-type upper-limit values (WT-UL), and compared in vitro activity of ibrexafungerp to five licensed antifungals. Susceptibility to ibrexafungerp and comparators was investigated prospectively for 1965 isolates (11,790 MICs) and repetitively for three QC strains (1764 MICs) following the EUCAST E.Def 7.3.2 method. Elevated ibrexafungerp/echinocandin MICs prompted
Language	English
Publishing date	2022-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof8101106
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Article ; Online: Invasive fungal infections: past achievements and challenges ahead.

Arendrup, M C

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2009 Volume 15, Issue 7, Page(s) 599–601

MeSH term(s)	Antifungal Agents/therapeutic use ; Drug Resistance, Fungal ; Fungemia/drug therapy ; Fungemia/epidemiology ; Fungemia/microbiology ; Fungi/drug effects ; Humans ; Mycoses/drug therapy ; Mycoses/epidemiology ; Mycoses/microbiology
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2009-07
Publishing country	England
Document type	Editorial ; Introductory Journal Article
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1111/j.1469-0691.2009.02914.x
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 284: Show issues

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Article ; Online: How to interpret MICs of antifungal compounds according to the revised clinical breakpoints v. 10.0 European committee on antimicrobial susceptibility testing (EUCAST).

Arendrup, M C / Friberg, N / Mares, M / Kahlmeter, G / Meletiadis, J / Guinea, J

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2020 Volume 26, Issue 11, Page(s) 1464–1472

Abstract: ... been revised or established for Candida species: micafungin against C. albicans (ATU = 0.03 ... S ≤/> R = 0.06/0.06) and voriconazole (S ≤/> R = 0.06/0.25) against C. dubliniensis; fluconazole ... against C. glabrata (S ≤/> R = 0.001/16); and anidulafungin (S ≤/> R = 4/4) and micafungin (S ≤/> R = 2/2 ...

Abstract	Background: EUCAST has revised the definition of the susceptibility category I from 'Intermediate' to 'Susceptible, Increased exposure'. This implies that I can be used where the drug concentration at the site of infection is high, either because of dose escalation or through other means to ensure efficacy. Consequently, I is no longer used as a buffer zone to prevent technical factors from causing misclassifications and discrepancies in interpretations. Instead, an Area of Technical Uncertainty (ATU) has been introduced for MICs that cannot be categorized without additional information as a warning to the laboratory that decision on how to act has to be made. To implement these changes, the EUCAST-AFST (Subcommittee on Antifungal Susceptibility Testing) reviewed all, and revised some, clinical antifungal breakpoints. Objectives: The aim was to present an overview of the current antifungal breakpoints and supporting evidence behind the changes. Sources: This document is based on the ten recently updated EUCAST rationale documents, clinical breakpoint and breakpoint ECOFF documents. Content: The following breakpoints (in mg/L) have been revised or established for Candida species: micafungin against C. albicans (ATU = 0.03); amphotericin B (S ≤/> R = 1/1), fluconazole (S ≤/> R = 2/4), itraconazole (S ≤/> R = 0.06/0.06), posaconazole (S ≤/> R = 0.06/0.06) and voriconazole (S ≤/> R = 0.06/0.25) against C. dubliniensis; fluconazole against C. glabrata (S ≤/> R = 0.001/16); and anidulafungin (S ≤/> R = 4/4) and micafungin (S ≤/> R = 2/2) against C. parapsilosis. For Aspergillus, new or revised breakpoints include itraconazole (ATU = 2) and isavuconazole against A. flavus (S ≤/> R = 1/2, ATU = 2); amphotericin B (S ≤/> R = 1/1), isavuconazole (S ≤ /> R = 1/2, ATU = 2), itraconazole (S ≤/> R = 1/1, ATU = 2), posaconazole (ATU = 0.25) and voriconazole (S ≤/> R = 1/1, ATU = 2) against A. fumigatus; itraconazole (S ≤/> R = 1/1, ATU = 2) and voriconazole (S ≤/> R = 1/1, ATU = 2) against A. nidulans; amphotericin B against A. niger (S ≤/> R = 1/1); and itraconazole (S ≤/> R = 1/1, ATU = 2) and posaconazole (ATU = 0.25) against A. terreus. Implications: EUCAST-AFST has released ten new documents summarizing existing and new breakpoints and MIC ranges for control strains. A failure to adopt the breakpoint changes may lead to misclassifications and suboptimal or inappropriate therapy of patients with fungal infections.
MeSH term(s)	Amphotericin B/pharmacology ; Antifungal Agents/pharmacology ; Aspergillus/drug effects ; Candida/drug effects ; Fluconazole/pharmacology ; Itraconazole/pharmacology ; Microbial Sensitivity Tests ; Practice Guidelines as Topic ; Triazoles/pharmacology ; Voriconazole/pharmacology
Chemical Substances	Antifungal Agents ; Triazoles ; Itraconazole (304NUG5GF4) ; posaconazole (6TK1G07BHZ) ; Amphotericin B (7XU7A7DROE) ; Fluconazole (8VZV102JFY) ; Voriconazole (JFU09I87TR)
Language	English
Publishing date	2020-06-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2020.06.007
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 284: Show issues

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Article ; Online: Comparative Pharmacodynamics of Echinocandins against Aspergillus fumigatus Using an

Siopi, Maria / Perlin, David S / Arendrup, Maiken C / Pournaras, Spyros / Meletiadis, Joseph

Antimicrobial agents and chemotherapy

2021 Volume 65, Issue 4

Abstract: Echinocandins have been used as primary therapy of invasive aspergillosis (IA), with suboptimal results at standard dosing. Here, we explored the efficacy of dose escalation in a ... ...

Abstract	Echinocandins have been used as primary therapy of invasive aspergillosis (IA), with suboptimal results at standard dosing. Here, we explored the efficacy of dose escalation in a validated
MeSH term(s)	Anidulafungin ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Aspergillus fumigatus ; Caspofungin ; Echinocandins/pharmacology ; Humans ; Lipopeptides ; Microbial Sensitivity Tests
Chemical Substances	Antifungal Agents ; Echinocandins ; Lipopeptides ; Anidulafungin (9HLM53094I) ; Caspofungin (F0XDI6ZL63)
Language	English
Publishing date	2021-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.01618-20
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Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Einzelsignatur: Show issues

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Article ; Online: Evaluation of the in vitro activity of isavuconazole and comparator voriconazole against 2635 contemporary clinical Candida and Aspergillus isolates.

Astvad, K M T / Hare, R K / Arendrup, M C

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2017 Volume 23, Issue 11, Page(s) 882–887

Abstract: ... displayed broad in vitro activity, similar to that of voriconazole. Up to 15% of C. glabrata, C. tropicalis ...

Abstract	Objective: The in vitro activity of isavuconazole was determined for 1677 Candida and 958 Aspergillus isolates from 2012 to 2014 with voriconazole as comparator. Methods: Aspergillus isolates were screened for resistance using azole-agar. Aspergillus isolates that screened positive and all Candida isolates underwent EUCAST broth microdilution testing. Isolates were categorized as wild-type (wt) or non-wt, adopting EUCAST epidemiological cut-off values (ECOFFs) (where available) or wt upper limits (wtULs; two two-fold dilutions above the MIC Results: Isavuconazole MIC Conclusion: Isavuconazole displayed broad in vitro activity, similar to that of voriconazole. Up to 15% of C. glabrata, C. tropicalis and A. fumigatus isolates were non-wt, reflecting increased resistance at a reference centre and technical issues. Significant CYP51A alterations were reliably detected applying the isavuconazole breakpoint.
Language	English
Publishing date	2017-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2017.03.023
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Zs.MO 284: Show issues

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Article ; Online: Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms.

Ryder, Laura / Arendrup, Frederic Schrøder / Martínez, José Francisco / Snieckute, Goda / Pecorari, Chiara / Shah, Riyaz Ahmad / Lund, Anders H / Blasius, Melanie / Bekker-Jensen, Simon

Cell death & disease

2023 Volume 14, Issue 7, Page(s) 467

Abstract: Impairment of protein translation can cause stalling and collision of ribosomes and is a signal for the activation of ribosomal surveillance and rescue pathways. Despite clear evidence that ribosome collision occurs stochastically at a cellular and ... ...

Abstract	Impairment of protein translation can cause stalling and collision of ribosomes and is a signal for the activation of ribosomal surveillance and rescue pathways. Despite clear evidence that ribosome collision occurs stochastically at a cellular and organismal level, physiologically relevant sources of such aberrations are poorly understood. Here we show that a burst of the cellular signaling molecule nitric oxide (NO) reduces translational activity and causes ribosome collision in human cell lines. This is accompanied by activation of the ribotoxic stress response, resulting in ZAKα-mediated activation of p38 and JNK kinases. In addition, NO production is associated with ZNF598-mediated ubiquitination of the ribosomal protein RPS10 and GCN2-mediated activation of the integrated stress response, which are well-described responses to the collision of ribosomes. In sum, our work implicates a novel role of NO as an inducer of ribosome collision and activation of ribosomal surveillance mechanisms in human cells.
MeSH term(s)	Humans ; Nitric Oxide/metabolism ; Ribosomes/metabolism ; Protein Biosynthesis ; Ribosomal Proteins/genetics ; Ribosomal Proteins/metabolism ; Ubiquitination ; Carrier Proteins/metabolism
Chemical Substances	Nitric Oxide (31C4KY9ESH) ; Ribosomal Proteins ; ZNF598 protein, human ; Carrier Proteins
Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-023-05997-5
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Article: Re-examination of species limits in

Sklenář, F / Jurjević, Ž / Houbraken, J / Kolařík, M / Arendrup, M C / Jørgensen, K M / Siqueira, J P Z / Gené, J / Yaguchi, T / Ezekiel, C N / Silva Pereira, C / Hubka, V

Studies in mycology

2021 Volume 99, Page(s) 100120

Abstract: Since the last revision in 2015, the taxonomy of ... ...

Abstract	Since the last revision in 2015, the taxonomy of section
Language	English
Publishing date	2021-12-16
Publishing country	Netherlands
Document type	Journal Article
ISSN	0166-0616
ISSN	0166-0616
DOI	10.1016/j.simyco.2021.100120
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