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  1. Article ; Online: Invasive mechanical ventilation in a former preterm infant with COVID-19.

    Nyholm, Silvia / Edner, Ann / Myrelid, Åsa / Janols, Helena / Dörenberg, Rainer / Diderholm, Barbro

    Acta paediatrica (Oslo, Norway : 1992)

    2020  Volume 109, Issue 10, Page(s) 2141–2143

    MeSH term(s) COVID-19/therapy ; Female ; Humans ; Infant, Newborn ; Infant, Premature ; Male ; Respiration, Artificial ; Twins
    Keywords covid19
    Language English
    Publishing date 2020-07-06
    Publishing country Norway
    Document type Case Reports ; Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.15437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Experimental and numerical investigation of a latent heat thermal energy storage unit with ellipsoidal macro-encapsulation

    Xu, Tianhao / Humire, Emma Nyholm / Trevisan, Silvia / Ignatowicz, Monika / Sawalha, Samer / Chiu, Justin NW.

    Energy. 2022 Jan. 01, v. 238

    2022  

    Abstract: This paper investigates ellipsoid-shaped macro-encapsulated phase change material (PCM) on a component scale. The selected PCM is a paraffin-based commercial material, namely ATP60; differential scanning calorimetry and transient plane source method are ... ...

    Abstract This paper investigates ellipsoid-shaped macro-encapsulated phase change material (PCM) on a component scale. The selected PCM is a paraffin-based commercial material, namely ATP60; differential scanning calorimetry and transient plane source method are used to measure ATP60's thermo-physical properties. A 0.382 m³ latent heat thermal energy storage (LHTES) component has been built and experimentally characterized. The temperature measurement results indicate that a thermocline was retained in the packed bed region during charging/discharging processes. The experimental characterization shows that increasing the temperature difference between the heat transfer fluid (HTF) inlet temperature and phase-change temperature by 20 K can shorten the completion time of discharge by 65%, and increasing HTF inlet flowrate from 0.15 m³/h (Re = 77) to 0.5 m³/h (Re = 256) can shorten the completion time of charge by 51%. Furthermore, a one-dimensional packed bed model using source-based enthalpy method was developed and validated by comparison to experimental results, showing discrepancies in the accumulated storage capacity within 6.6% between simulation and experiment when the Reynolds number of the HTF inlet flow ranges between 90 and 922. Compared with a conventional capsule shaped in 69-mm-diameter and 750-mm-long cylinders, the ellipsoidal capsule shows 60% less completion time of discharge but 23% lower storage capacity. Overall, this work demonstrates a combined experimental and numerical characterization approach for applying novel macro-encapsulated PCM geometries for heating-oriented LHTES.
    Keywords Reynolds number ; enthalpy ; heat transfer ; latent heat ; models ; phase transition ; temperature ; thermal energy
    Language English
    Dates of publication 2022-0101
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2019804-8
    ISSN 0360-5442 ; 0360-5442
    ISSN (online) 0360-5442
    ISSN 0360-5442
    DOI 10.1016/j.energy.2021.121828
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Robust treatment planning of dose painting for prostate cancer based on ADC-to-Gleason score mappings - what is the potential to increase the tumor control probability?

    Grönlund, Eric / Almhagen, Erik / Johansson, Silvia / Traneus, Erik / Nyholm, Tufve / Thellenberg, Camilla / Ahnesjö, Anders

    Acta oncologica (Stockholm, Sweden)

    2020  Volume 60, Issue 2, Page(s) 199–206

    Abstract: Background and purpose: The aim of this study was to evaluate the potential to increase the tumor control probability (TCP) with 'dose painting by numbers' (DPBN) plans optimized in a treatment planning system (TPS) compared to uniform dose plans. The ... ...

    Abstract Background and purpose: The aim of this study was to evaluate the potential to increase the tumor control probability (TCP) with 'dose painting by numbers' (DPBN) plans optimized in a treatment planning system (TPS) compared to uniform dose plans. The DPBN optimization was based on our earlier published formalism for prostate cancer that is driven by dose-responses of Gleason scores mapped from apparent diffusion coefficients (ADC).
    Material and methods: For 17 included patients, a set of DPBN plans were optimized in a TPS by maximizing the TCP for an equal average dose to the prostate volume (CTVT) as for a conventional uniform dose treatment. For the plan optimizations we applied different photon energies, different precisions for the ADC-to-Gleason mappings, and different CTVT positioning uncertainties. The TCP increasing potential was evaluated by the DPBN efficiency, defined as the ratio of TCP increases for DPBN plans by TCP increases for ideal DPBN prescriptions (optimized without considering radiation transport phenomena, uncertainties of the CTVT positioning, and uncertainties of the ADC-to-Gleason mapping).
    Results: The median DPBN efficiency for the most conservative planning scenario optimized with a low precision ADC-to-Gleason mapping, and a positioning uncertainty of 0.6 cm was 10%, meaning that more than half of the patients had a TCP gain of at least 10% of the TCP for an ideal DPBN prescription. By increasing the precision of the ADC-to-Gleason mapping, and decreasing the positioning uncertainty the median DPBN efficiency increased by up to 40%.
    Conclusions: TCP increases with DPBN plans optimized in a TPS were found more likely with a high precision mapping of image data into dose-responses and a high certainty of the tumor positioning. These findings motivate further development to ensure precise mappings of image data into dose-responses and to ensure a high spatial certainty of the tumor positioning when implementing DPBN clinically.
    MeSH term(s) Humans ; Male ; Neoplasm Grading ; Probability ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/radiotherapy ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted
    Language English
    Publishing date 2020-09-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 896449-x
    ISSN 1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
    ISSN (online) 1651-226X
    ISSN 0349-652X ; 0284-186X ; 1100-1704
    DOI 10.1080/0284186X.2020.1817547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Invasive mechanical ventilation in a former preterm infant with COVID-19

    Nyholm, Silvia / Edner, Ann / Myrelid, Åsa / Janols, Helena / Dörenberg, Rainer / Diderholm, Barbro

    Acta paediatr. scand

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #610824
    Database COVID19

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  5. Article ; Online: Invasive mechanical ventilation in a former preterm infant with COVID‐19

    Nyholm, Silvia / Edner, Ann / Myrelid, Åsa / Janols, Helena / Dörenberg, Rainer / Diderholm, Barbro

    Acta Paediatrica

    2020  Volume 109, Issue 10, Page(s) 2141–2143

    Keywords Pediatrics, Perinatology, and Child Health ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ISSN 0803-5253
    DOI 10.1111/apa.15437
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Dose painting of prostate cancer based on Gleason score correlations with apparent diffusion coefficients.

    Grönlund, Eric / Johansson, Silvia / Nyholm, Tufve / Thellenberg, Camilla / Ahnesjö, Anders

    Acta oncologica (Stockholm, Sweden)

    2017  Volume 57, Issue 5, Page(s) 574–581

    Abstract: Background: Gleason scores for prostate cancer correlates with an increased recurrence risk after radiotherapy (RT). Furthermore, higher Gleason scores correlates with decreasing apparent diffusion coefficient (ADC) data from diffusion weighted MRI (DWI- ...

    Abstract Background: Gleason scores for prostate cancer correlates with an increased recurrence risk after radiotherapy (RT). Furthermore, higher Gleason scores correlates with decreasing apparent diffusion coefficient (ADC) data from diffusion weighted MRI (DWI-MRI). Based on these observations, we present a formalism for dose painting prescriptions of prostate volumes based on ADC images mapped to Gleason score driven dose-responses.
    Methods: The Gleason score driven dose-responses were derived from a learning data set consisting of pre-RT biopsy data and post-RT outcomes for 122 patients treated with a homogeneous dose to the prostate. For a test data set of 18 prostate cancer patients with pre-RT ADC images, we mapped the ADC data to the Gleason driven dose-responses by using probability distributions constructed from published Gleason score correlations with ADC data. We used the Gleason driven dose-responses to optimize dose painting prescriptions that maximize the tumor control probability (TCP) with equal average dose as for the learning sets homogeneous treatment dose.
    Results: The dose painting prescriptions increased the estimated TCP compared to the homogeneous dose by 0-51% for the learning set and by 4-30% for the test set. The potential for individual TCP gains with dose painting correlated with increasing Gleason score spread and larger prostate volumes. The TCP gains were also found to be larger for patients with a low expected TCP for the homogeneous dose prescription.
    Conclusions: We have from retrospective treatment data demonstrated a formalism that yield ADC driven dose painting prescriptions for prostate volumes that potentially can yield significant TCP increases without increasing dose burdens as compared to a homogeneous treatment dose. This motivates further development of the approach to consider more accurate ADC to Gleason mappings, issues with delivery robustness of heterogeneous dose distributions, and patient selection criteria for design of clinical trials.
    MeSH term(s) Diffusion Magnetic Resonance Imaging/methods ; Humans ; Male ; Neoplasm Grading ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/radiotherapy ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods
    Language English
    Publishing date 2017-12-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 896449-x
    ISSN 1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
    ISSN (online) 1651-226X
    ISSN 0349-652X ; 0284-186X ; 1100-1704
    DOI 10.1080/0284186X.2017.1415457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Symbiotic organs shaped by distinct modes of genome evolution in cephalopods.

    Belcaid, Mahdi / Casaburi, Giorgio / McAnulty, Sarah J / Schmidbaur, Hannah / Suria, Andrea M / Moriano-Gutierrez, Silvia / Pankey, M Sabrina / Oakley, Todd H / Kremer, Natacha / Koch, Eric J / Collins, Andrew J / Nguyen, Hoan / Lek, Sai / Goncharenko-Foster, Irina / Minx, Patrick / Sodergren, Erica / Weinstock, George / Rokhsar, Daniel S / McFall-Ngai, Margaret /
    Simakov, Oleg / Foster, Jamie S / Nyholm, Spencer V

    Proceedings of the National Academy of Sciences of the United States of America

    2019  Volume 116, Issue 8, Page(s) 3030–3035

    Abstract: Microbes have been critical drivers of evolutionary innovation in animals. To understand the processes that influence the origin of specialized symbiotic organs, we report the sequencing and analysis of the genome ... ...

    Abstract Microbes have been critical drivers of evolutionary innovation in animals. To understand the processes that influence the origin of specialized symbiotic organs, we report the sequencing and analysis of the genome of
    MeSH term(s) Aliivibrio fischeri/genetics ; Aliivibrio fischeri/isolation & purification ; Animals ; Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Cephalopoda/genetics ; Cephalopoda/microbiology ; Decapodiformes/genetics ; Decapodiformes/microbiology ; Genome/genetics ; Host Microbial Interactions/genetics ; Octopodiformes/genetics ; Octopodiformes/microbiology ; Symbiosis/genetics
    Language English
    Publishing date 2019-01-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1817322116
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