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  1. Article: Thyroid Disease-Induced Hepatic Dysfunction: A Clinical Puzzle.

    Anugwom, Chimaobi M / Leventhal, Thomas M

    ACG case reports journal

    2021  Volume 8, Issue 4, Page(s) e00555

    Abstract: The diagnostic evaluation of an individual with clinical and laboratory evidence of thyroid dysfunction in the setting of acute liver injury is crucial. There is a complex relationship between the thyroid and the liver, and so, it requires a careful ... ...

    Abstract The diagnostic evaluation of an individual with clinical and laboratory evidence of thyroid dysfunction in the setting of acute liver injury is crucial. There is a complex relationship between the thyroid and the liver, and so, it requires a careful elucidation of the inciting disease process before instituting a treatment plan. We discuss a patient who had presented with coagulopathy, encephalopathy, and laboratory evidence of acute liver injury, hence adjudged to have developed drug-induced acute liver failure and transferred for liver transplant evaluation. She was found to have liver dysfunction from uncontrolled thyroid disease, with immediate and rapid improvement after controlling severe hyperthyroidism.
    Language English
    Publishing date 2021-04-14
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2814825-3
    ISSN 2326-3253
    ISSN 2326-3253
    DOI 10.14309/crj.0000000000000555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Protein-losing Enteropathy Due to Inferior Vena Cava Stenosis in a Liver Transplant Recipient.

    Anugwom, Chimaobi M / Lake, John R / Lim, Nicholas

    Transplantation direct

    2021  Volume 7, Issue 2, Page(s) e660

    Language English
    Publishing date 2021-01-26
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8731
    ISSN 2373-8731
    DOI 10.1097/TXD.0000000000001117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Understanding immune perspectives and options for the use of checkpoint immunotherapy in HCC post liver transplant.

    Anugwom, Chimaobi M / Leventhal, Thomas M / Debes, Jose D

    Hepatoma research

    2022  Volume 8

    Abstract: Treatment modalities for hepatocellular carcinoma (HCC) vary from surgical techniques and interventional radiologic strategies to systemic therapy. For the latter, the use of immune checkpoint inhibitors (ICIs) has gained popularity due to successful ... ...

    Abstract Treatment modalities for hepatocellular carcinoma (HCC) vary from surgical techniques and interventional radiologic strategies to systemic therapy. For the latter, the use of immune checkpoint inhibitors (ICIs) has gained popularity due to successful trials showing increased survival. In patients who have undergone liver transplantation, recurrence of HCC poses a significant challenge. There is indeed considerable debate on the efficacy and safety of ICI use in liver transplant recipients due to competing immune interests in maintaining a healthy graft and combating the tumor. Recent reports and case series have highlighted a role for the type of immune therapy, timing of therapy, tissue expression of PD-1 and modulation of immunosuppression, in the understanding of the efficacy and risks of ICIs for HCC in liver transplant. In this article, we appraise the available literature on the usage of ICIs for HCC in liver transplant recipients and provide perspectives on immune concerns as well as potential recommendations to consider during the management of such complex cases.
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2819886-4
    ISSN 2394-5079
    ISSN 2394-5079
    DOI 10.20517/2394-5079.2021.123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: L-Asparaginase-Induced Hepatotoxicity Treated Successfully With L-Carnitine and Vitamin B Infusion.

    Lee, Christina / Leventhal, Thomas M / Anugwom, Chimaobi M

    Cureus

    2021  Volume 13, Issue 8, Page(s) e16917

    Abstract: Asparaginase plays an integral role in chemotherapy for acute lymphoblastic leukemia (ALL). We present a 69-year old woman with refractory ALL, who developed asparaginase-induced hepatotoxicity and cholangiopathy after starting intravenous PEG-L- ... ...

    Abstract Asparaginase plays an integral role in chemotherapy for acute lymphoblastic leukemia (ALL). We present a 69-year old woman with refractory ALL, who developed asparaginase-induced hepatotoxicity and cholangiopathy after starting intravenous PEG-L-asparaginase-based chemotherapy. The patient was ultimately treated with the combination of L-carnitine and vitamin B complex, resulting in normalization of liver enzymes levels. This case highlights the consideration of PEG-L asparaginase chemotherapy-induced liver steatosis, injury, and cholangiopathy as well as the role of L-carnitine and vitamin B complex as treatment.
    Language English
    Publishing date 2021-08-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.16917
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Inverse Association Between Chronic Hepatitis B Infection and Coronavirus Disease 2019 (COVID-19): Immune Exhaustion or Coincidence?

    Anugwom, Chimaobi M / Aby, Elizabeth S / Debes, Jose D

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 72, Issue 1, Page(s) 180–182

    MeSH term(s) Antibody Formation ; COVID-19 ; Coinfection ; HIV-1 ; Hepacivirus ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/epidemiology ; Humans ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  6. Article: A Case of Infiltrative Hepatocellular Carcinoma With Vascular Invasion Into the Heart.

    Anugwom, Chimaobi M / Kayandabila, Johnstone / Flanagan, Siobhan / Debes, Jose D

    Cureus

    2021  Volume 13, Issue 9, Page(s) e17859

    Abstract: Hepatocellular carcinoma (HCC) represents a major cause of morbidity and mortality in the world, but this problem is especially significant in low-resource countries where HCC screening recommendations and strategies are limited. We describe a rare ... ...

    Abstract Hepatocellular carcinoma (HCC) represents a major cause of morbidity and mortality in the world, but this problem is especially significant in low-resource countries where HCC screening recommendations and strategies are limited. We describe a rare complication of newly diagnosed HCC in a patient with untreated hepatitis B virus (HBV) infection, underscoring the importance of improving screening strategies and promoting early diagnosis of HCC in Sub-Saharan Africa.
    Language English
    Publishing date 2021-09-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.17859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Systematic analysis of acute liver injury during SARS-CoV-2 infection.

    Debes, Jose D / Anugwom, Chimaobi M / Aby, Elizabeth S

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2020  Volume 52, Issue 9, Page(s) 953–955

    MeSH term(s) Acute Disease ; Alanine Transaminase/metabolism ; Aspartate Aminotransferases/metabolism ; Betacoronavirus ; Bilirubin/metabolism ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/metabolism ; Coronavirus Infections/physiopathology ; Diarrhea/physiopathology ; Humans ; Intensive Care Units/statistics & numerical data ; Liver Diseases/epidemiology ; Liver Diseases/metabolism ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/physiopathology ; SARS-CoV-2 ; Vomiting/physiopathology
    Chemical Substances Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2) ; Bilirubin (RFM9X3LJ49)
    Keywords covid19
    Language English
    Publishing date 2020-05-19
    Publishing country Netherlands
    Document type Letter ; Systematic Review
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2020.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1134: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: The Role of Cytokines in the Different Stages of Hepatocellular Carcinoma.

    Rico Montanari, Noe / Anugwom, Chimaobi M / Boonstra, Andre / Debes, Jose D

    Cancers

    2021  Volume 13, Issue 19

    Abstract: Hepatocellular carcinoma (HCC) is the primary form of liver cancer and a leading cause of cancer-related death worldwide. Early detection remains the most effective strategy in HCC management. However, the spectrum of underlying liver diseases preceding ... ...

    Abstract Hepatocellular carcinoma (HCC) is the primary form of liver cancer and a leading cause of cancer-related death worldwide. Early detection remains the most effective strategy in HCC management. However, the spectrum of underlying liver diseases preceding HCC, its genetic complexity, and the lack of symptomatology in early stages challenge early detection. Regardless of underlying etiology, unresolved chronic inflammation is a common denominator in HCC. Hence, many inflammatory molecules, including cytokines, have been investigated as potential biomarkers to predict different stages of HCC. Soluble cytokines carry cell-signaling functions and are easy to detect in the bloodstream. However, its biomarkers' role remains limited due to the dysregulation of immune parameters related to the primary liver process and their ability to differentiate carcinogenesis from the underlying disease. In this review, we discuss and provide insight on cytokines with clinical relevance for HCC differentiating those implicated in tumor formation, early detection, advanced disease, and response to therapy.
    Language English
    Publishing date 2021-09-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13194876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Assessment of STAT4 Variants and Risk of Hepatocellular Carcinoma in Latin Americans and Europeans.

    Ayoub, Alan / Anugwom, Chimaobi M / Prieto, Jhon / Balderramo, Domingo / Ferrer, Javier Diaz / Mattos, Angelo Z / Arrese, Marco / Carrera, Enrique / Groothuismink, Zwier M A / Oliveira, Jeffrey / Boonstra, Andre / Debes, Jose D

    Cancers

    2023  Volume 15, Issue 18

    Abstract: Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. ... ...

    Abstract Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. The
    Language English
    Publishing date 2023-09-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15184530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Aceruloplasminemia: A Case Report and Review of a Rare and Misunderstood Disorder of Iron Accumulation.

    Anugwom, Chimaobi M / Moscoso, Carlos G / Lim, Nicholas / Hassan, Mohamed

    Cureus

    2020  Volume 12, Issue 11, Page(s) e11648

    Abstract: Aceruloplasminemia is a rare disorder of iron accumulation inherited in an autosomal recessive fashion. It commonly presents as chronic microcytic anemia, and then progresses to signs and symptoms that are due to the accumulation of iron in multiple ... ...

    Abstract Aceruloplasminemia is a rare disorder of iron accumulation inherited in an autosomal recessive fashion. It commonly presents as chronic microcytic anemia, and then progresses to signs and symptoms that are due to the accumulation of iron in multiple organs such as the brain, liver, pancreas, and thyroid. We present an asymptomatic patient with a history of microcytic anemia, who was evaluated for abnormal liver enzymes, and ultimately diagnosed with aceruloplasminemia.
    Language English
    Publishing date 2020-11-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.11648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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