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Article: Wheat germ, a byproduct of the wheat milling industry, as a beneficial source of anti-aging polyamines: A quantitative comparison of various forms.

Mohajeri, Maryam / Ayatollahi, Seyed Abdulmajid / Kobarfard, Farzad / Goli, Mohammad / Khandan, Maryam / Mokhtari, Shaya / Khodadoost, Mahmoud

Food science & nutrition

2023 Volume 11, Issue 11, Page(s) 7242–7254

Abstract: Polyamines have received a lot of attention since the 1990s because of their anti-aging, anti-chronic disease, and proliferative effects. Wheat germ was reported as one of the natural sources of high polyamine, especially spermidine. The current study ... ...

Abstract	Polyamines have received a lot of attention since the 1990s because of their anti-aging, anti-chronic disease, and proliferative effects. Wheat germ was reported as one of the natural sources of high polyamine, especially spermidine. The current study used three types of wheat germ: group A was industrially separated germ from whole grain, group B was the commercially available germinated wheat germ, and group C was manually separated wheat germ from germinated grain. The polyamine content of putrescine, spermidine, and spermine has been determined using a simplified isocratic LC-MS/MS method. An optimized extraction procedure was performed on all seven samples for obtaining a polyamine-enriched extract. The three dominant carbomylated polyamines were identified by analyzing the extracted samples in order to determine their relative abundance. Wheat germ powders contain the highest amount of polyamines (220-337 μg/g) of which spermidine is one of the most important. Germinated wheat grains, on the other hand, contain the least amount of this polyamine. The commercially available separated wheat germs are suggested as a good nutrition source of these polyamines.
Language	English
Publishing date	2023-09-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.3650
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Article: Investigating the human protein-host protein interactome of SARS-CoV-2 infection in the small intestine.

Khodadoost, Mahmoud / Niknam, Zahra / Farahani, Masoumeh / Razzaghi, Mohammadreza / Norouzinia, Mohsen

Gastroenterology and hepatology from bed to bench

2020 Volume 13, Issue 4, Page(s) 374–387

Abstract: Aim: The present study aimed to identify human protein-host protein interactions of SARS-CoV-2 infection in the small intestine to discern the potential mechanisms and gain insights into the associated biomarkers and treatment strategies.: Background!# ...

Abstract	Aim: The present study aimed to identify human protein-host protein interactions of SARS-CoV-2 infection in the small intestine to discern the potential mechanisms and gain insights into the associated biomarkers and treatment strategies. Background: Deciphering the tissue and organ interactions of the SARS-CoV-2 infection can be important to discern the potential underlying mechanisms. In the present study, we investigated the human protein-host protein interactions in the small intestine. Methods: Public databases and published works were used to collect data related to small intestine tissue and SARS-CoV-2 infection. We constructed a human protein-protein interaction (PPI) network and showed interactions of host proteins in the small intestine. Associated modules, biological processes, functional pathways, regulatory transcription factors, disease ontology categories, and possible drug candidates for therapeutic targets were identified. Results: Thirteen primary protein neighbors were found for the SARS-CoV-2 receptor ACE2. ACE2 and its four partners were observed in a highly clustered module; moreover, 8 host proteins belonged to this module. The protein digestion and absorption as a significant pathway was highlighted with enriched genes of ACE2, MEP1A, MEP1B, DPP4, and XPNPEP2. The HNF4A, HNF1A, and HNF1B transcription factors were found to be regulating the expression of ACE2. A significant association with 12 diseases was deciphered and 116 drug-target interactions were identified. Conclusion: The protein-host protein interactome revealed the important elements and interactions for SARS-CoV-2 infection in the small intestine, which can be useful in clarifying the mechanisms of gastrointestinal symptoms and inflammation. The results suggest that antiviral targeting of these interactions may improve the condition of COVID-19 patients.
Language	English
Publishing date	2020-09-18
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2569124-7
ISSN	2008-4234 ; 2008-2258
ISSN (online)	2008-4234
ISSN	2008-2258
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Article ; Online: Baseline levels determine magnitude of increment in 25 hydroxy vitamin D following vitamin D3 prescription in healthy subjects.

Kaykhaei, Mahmoud Ali / Khodadoost, Mahdieh / Dashipour, Ali Reza / Haidari, Zahra / Karimkoshteh, Azra / Sandoughi, Mahnaz

Endocrine

2019 Volume 64, Issue 2, Page(s) 378–383

Abstract: Introduction: Vitamin D deficiency is a major health problem which affects about one billion people in the world. Although, vitamin D supplementation is recommended as standard treatment of vitamin D deficiency, there are controversies on dose response ... ...

Abstract	Introduction: Vitamin D deficiency is a major health problem which affects about one billion people in the world. Although, vitamin D supplementation is recommended as standard treatment of vitamin D deficiency, there are controversies on dose response relationship. In this regard, the present study aimed to determine the impact of vitamin D3 supplement on raising of serum 25 hydroxyvitamin D[25(OH)D] in healthy subjects with varying degrees of vitamin D deficiency. Materials and methods: In this clinical trial 114 subjects with varying degrees of vitamin D deficiency were entered and divided into three groups: serum levels of 25(OH) D less than 10 ng/ml, 10-20 ng/ml, and 20-30 ng/ml. All of the participants were given 50,000 units vitamin D3 per week for 8 weeks, thereafter, changes in serum levels of vitamin D and PTH were evaluated at week twelve. The results were analyzed using SPSS version 16 and P < 0.05 was considered to be significant. Results: Of the 114 vitamin D deficient subjects, serum level of vitamin D was below 10 ng/ml in 22 persons (19.3%), 10-20 ng/ml in 52 persons (45.6%) and 20-30 ng/ml in 40 persons (35.1%). Following vitamin D prescription all people with varying degrees of vitamin D deficiency obtained a favorable serum level. The increase in vitamin D levels were 26.4, 18.5, and 8.3 ng/ml, in individuals with baseline vitamin D levels below 10 ng/ml, 10-20 ng/ml and 20-30 ng/ml, respectively. The changes in 25(OH) vitamin D in all three groups were significant (P < 0.05), nonetheless no significant alterations in serum levels of PTH were observed (P > 0.05). Conclusion: Our results indicated an inverse relationship between baseline serum levels of 25(OH) D and its increment following treatment with vitamin D3. Therefore, the magnitude of increments in serum 25(OH) D is greater in subjects with lower baseline levels of 25(OH) D.
MeSH term(s)	Adult ; Cholecalciferol/administration & dosage ; Cholecalciferol/therapeutic use ; Dose-Response Relationship, Drug ; Female ; Healthy Volunteers ; Humans ; Male ; Treatment Outcome ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/drug therapy ; Young Adult
Chemical Substances	Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2019-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-019-01881-5
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Article ; Online: Effects of Compound Honey Syrup (Ma-ol-asal) on Polycystic Ovary Syndrome (PCOS) Induced by Estradiol Valerate in Female Rats

Mojgan Tansaz / Maryam Bahman / Mahmoud Khodadoost / Seyyed Shamsadin Athari / Saadat Ghafarzadeh / Hanieh Kashafroodi / Rasool Choopani

Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, Vol 23, Iss 12, Pp 13-

2021 Volume 24

Abstract: Introduction: Polycystic ovary syndrome affects 5-10% of women of reproductive age and is characterized by irregular menstruation, hyperandrogenism, and ovarian cysts. Iranian traditional medicine products can be effective in treatment of this syndrome. ... ...

Abstract	Introduction: Polycystic ovary syndrome affects 5-10% of women of reproductive age and is characterized by irregular menstruation, hyperandrogenism, and ovarian cysts. Iranian traditional medicine products can be effective in treatment of this syndrome. This study was performed with aim to evaluate the effect of compound honey syrup on the polycystic ovary syndrome induced by estradiol valerate in female rats. Methods: In this experimental study conducted by traditional medicine and matria medica research center of Shahid Beheshti University of Medical Sciences in animal laboratory of Shahid Beheshti University of Medical Sciences on female rats in 2017, the compound honey syrup (Ma-ol-asal) (containing honey, cinnamon, ginger, saffron, cardamom, galangal, nutmeg, mace and mastic) was used. Thirty female rats were classified into five groups of cases: negative control, positive control, and three treatment groups (receiving two doses of compound honey syrup (1ml/kg and 2ml/kg) and metformin). Polycystic ovary syndrome was induced by injection of Estradiol valerate. At the end of intervention, the rats were euthanized, hormones were measured, and the ovarian histology was examined. Data were analyzed by SPSS software (version 24) and Kruskal-Wallis and Dunn-Bonferroni tests. p < 0.05 was considered statistically significant. Results: At the end of the study, weights of ovaries in the metformin and Ma-ol-asal 2 groups were higher than the untreated group. There was no change in body weight or abdominal fat. There was a significant increase in levels of progesterone in three treatment groups (P=0.002) and significant reduction of estrogen in the metformin group compared to the untreated group (P=0.021). There was significant reduction of number of ovary cysts in Ma-ol-asal 1 group (P=0.001), and significant increase in the number of Corpus luteum, and antral follicles in Ma-ol-asal 1 and 2 groups compared to the untreated group (P=0.010). The number of graph follicles did not differ significantly in the groups ...
Keywords	compound honey syrup ; metabolic syndrome ; polycystic ovary syndrome ; traditional persian medicine ; Gynecology and obstetrics ; RG1-991
Subject code	630
Language	Persian
Publishing date	2021-02-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
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Article ; Online: Efficacy of topical Linum usitatissimum L. (flaxseed) oil in knee osteoarthritis: A double-blind, randomized, placebo-controlled clinical trial.

Mosavat, Seyed Hamdollah / Masoudi, Nematollah / Hajimehdipoor, Homa / Emami Meybodi, Mohammad Kazem / Niktabe, Zahra / Tabarrai, Malihe / Ghorat, Fereshteh / Khodadoost, Mahmoud

Complementary therapies in clinical practice

2018 Volume 31, Page(s) 302–307

Language	English
Publishing date	2018
Publishing country	England
Document type	Journal Article
ZDB-ID	2182834-9
ISSN	1873-6947 ; 1744-3881
ISSN (online)	1873-6947
ISSN	1744-3881
DOI	10.1016/j.ctcp.2018.03.003
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Article: The Role of Syndrome Differentiation in the Clinical Efficacy of Punica Granatum on Patients with Ulcerative Colitis.

Kamali, Mohammadali / Khodadoost, Mahmoud / Tavakoli, Hamid / Kamalinejad, Mohammad / Gachkar, Latif / Adibi, Payman / Heydari, Mojtaba

Iranian journal of medical sciences

2015 Volume 41, Issue 3 Suppl, Page(s) S15

Abstract: Background: The present study investigated the difference between therapeutic responses of hot and cold temperament patients (based on traditional Persian medicine) with ulcerative colitis to pomegranate peel extract.: Methods: Seventy-eight patients ...

Abstract	Background: The present study investigated the difference between therapeutic responses of hot and cold temperament patients (based on traditional Persian medicine) with ulcerative colitis to pomegranate peel extract. Methods: Seventy-eight patients with moderate ulcerative colitis based on Lichtiger Colitis Activity Index (LCAI) criteria were randomized to receive an aqueous extract of the Punica granatum peel (6 gram per day) or placebo for four weeks. They were assessed before and after the intervention in terms of symptoms by LCAI scoring system. The results were compared in two therapeutic groups based on the patient s' temperament (cold and hot) which were diagnosed based on a previously validated questionnaire. Results: Therapeutic response was significantly higher in patients with hot temperament compared to patients with cold temperament in the P. granatum group (1.91±0.492 vs. -0.500±0.500, P=0.029). Conclusion: This study showed the importance of considering syndrome differentiation and temperament in interpreting the effect of P. granatum peel extract on ulcerative colitis.
Language	English
Publishing date	2015-03-05
Publishing country	Iran
Document type	Journal Article
ZDB-ID	603872-4
ISSN	1735-3688 ; 0253-0716
ISSN (online)	1735-3688
ISSN	0253-0716
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Article ; Online: Efficacy of the Punica granatum peels aqueous extract for symptom management in ulcerative colitis patients. A randomized, placebo-controlled, clinical trial.

Kamali, Mohammadali / Tavakoli, Hamid / Khodadoost, Mahmoud / Daghaghzadeh, Hamed / Kamalinejad, Mohammad / Gachkar, Latif / Mansourian, Marjan / Adibi, Payman

Complementary therapies in clinical practice

2015 Volume 21, Issue 3, Page(s) 141–146

Abstract: Objective: To investigate the effects of the Punica granatum peel extract on symptoms of patients with ulcerative colitis (UC).: Method: Patients with UC were randomized to receive an aqueous extract of the P. granatum peel (6 g of dry peel/day) or ... ...

Abstract	Objective: To investigate the effects of the Punica granatum peel extract on symptoms of patients with ulcerative colitis (UC). Method: Patients with UC were randomized to receive an aqueous extract of the P. granatum peel (6 g of dry peel/day) or placebo for four weeks complementary to standard medications. Symptoms were assessed using the Lichtiger Colitis Activity Index (LCAI) at baseline, week 4, and week 10 (follow-up). Clinical response was defined by ≥ 3 point decrease in LCAI. Results: The LCAI score was similarly reduced in both the P. granatum (-1.68 ± 3.85, P = 0.019) and placebo groups (-1.39 ± 2.41, P = 0.002). Clinical response was higher with P. granatum compared with placebo at week 4 (41.4% vs. 18.2%, P = 0.055), but not at week 10 (48.3% vs. 36.4%, P = 0.441). Conclusions: The P. granatum peel extract seems effective in complementary management of UC. Further studies in a larger sample of patients are warranted. IRCT2014040617156N1.
MeSH term(s)	Adult ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/physiopathology ; Female ; Fruit/chemistry ; Humans ; Male ; Middle Aged ; Phytotherapy ; Plant Extracts/adverse effects ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Punicaceae/chemistry
Chemical Substances	Plant Extracts
Language	English
Publishing date	2015-08
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2182834-9
ISSN	1873-6947 ; 1744-3881
ISSN (online)	1873-6947
ISSN	1744-3881
DOI	10.1016/j.ctcp.2015.03.001
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Article: Study of a polymerase chain reaction-based method for detection of herpes simplex virus type 1 DNA among Iranian patients with ocular herpetic keratitis infection.

Khodadoost, Mohammad Ali / Sabahi, Farzaneh / Behroz, Mahmoud Jabbarvand / Roustai, Mohammad Hassan / Saderi, Horieh / Amini-Bavil-Olyaee, Samad / Arzenani, Mohsen Karimi

Japanese journal of ophthalmology

2004 Volume 48, Issue 4, Page(s) 328–332

Abstract: Purpose: To study the presence of the herpes simplex virus type 1 (HSV-1) glycoprotein D gene in tear films of Iranian patients with herpetic keratitis.: Methods: Twenty-five tear film and eye swab specimens from 25 herpetic keratitis patients and 10 ...

Abstract	Purpose: To study the presence of the herpes simplex virus type 1 (HSV-1) glycoprotein D gene in tear films of Iranian patients with herpetic keratitis. Methods: Twenty-five tear film and eye swab specimens from 25 herpetic keratitis patients and 10 specimens from 10 healthy volunteers were collected in the Farabi Eye Hospital, Tehran, Iran. HSV-1 DNA was detected by using the nested polymerase chain reaction (nPCR) method. Viral isolation was done using conventional viral techniques. A monoclonal antibody-based enzyme-linked immunosorbent assay (ELISA) was used for confirmation of positive cytopathic effect cell culture. The results of a diagnosis by an ophthalmologist team were compared with those of nPCR. Results: HSV-1 DNA was identified in tear films of 88% (23/25) of suspected herpetic keratitis patients. All healthy controls (100%) had negative PCR results. HSV-1 was isolated in cell culture and confirmed by ELISA in 12% (3/25) of herpetic keratitis patients who had epithelial keratitis. The kappa value showed a high level of agreement between ophthalmologist team diagnosis and the PCR results (kappa = 0.86, P < 0.0001). Conclusions: nPCR is a sensitive, rapid, and powerful tool for detection of HSV-1 DNA in tear films of ocular herpetic keratitis patients and can serve as a supplemental method for diagnosis of herpetic keratitis infection.
MeSH term(s)	Animals ; Antibodies, Viral/analysis ; Cercopithecus aethiops ; Cytopathogenic Effect, Viral ; DNA, Viral/analysis ; Enzyme-Linked Immunosorbent Assay ; Female ; HeLa Cells ; Herpesvirus 1, Human/genetics ; Herpesvirus 1, Human/immunology ; Herpesvirus 1, Human/isolation & purification ; Humans ; Iran ; Keratitis, Herpetic/virology ; Male ; Polymerase Chain Reaction/methods ; Tears/virology ; Vero Cells ; Viral Envelope Proteins/genetics ; Virus Cultivation/methods
Chemical Substances	Antibodies, Viral ; DNA, Viral ; Viral Envelope Proteins ; glycoprotein D, Human herpesvirus 1
Language	English
Publishing date	2004-07
Publishing country	Japan
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	82032-5
ISSN	1613-2246 ; 0021-5155
ISSN (online)	1613-2246
ISSN	0021-5155
DOI	10.1007/s10384-004-0081-z
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