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Article ; Online: Five genes identified as prognostic markers for colorectal cancer through the integration of genome-wide association study and expression quantitative trait loci data.

Zhang, Cuizhen / Huang, Wenjie / Niu, Wanjie / Yang, Huiying / Zheng, Yingyi / Gao, Xuan / Qiu, Xiaoyan

2024

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2299146-3
ISSN	1744-828X ; 1741-0541
ISSN (online)	1744-828X
ISSN	1741-0541
DOI	10.2217/pme-2023-0103
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Zs.A 6549: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: LMX and employee turnover intention: A social identity approach.

Niu, Wanjie / Wu, Wenjing / Ma, Jianfeng

Scandinavian journal of psychology

2022 Volume 63, Issue 3, Page(s) 219–228

Abstract: This study explored how leader-member exchange (LMX) affects employee turnover intention through the mediation of relational and organizational identification, and through the moderating role of leader competence in the relationship between LMX and ... ...

Abstract	This study explored how leader-member exchange (LMX) affects employee turnover intention through the mediation of relational and organizational identification, and through the moderating role of leader competence in the relationship between LMX and relational identification. Study 1 explores the indirect effect of LMX on employee turnover intention through relational and organizational identification by analyzing data collected from 210 employees in China at two points in time. Study 2 explores the moderating role of leader competence in the relationship between LMX and relational identification by analyzing data collected from 872 employees in China. The results show that LMX affected employee turnover intention through the serial mediation of relational and organizational identification, and that leader competence moderated the relationship between LMX and relational identification. Our findings provide implications for research on employee turnover intention and identification. Limitations and future research directions are also discussed.
MeSH term(s)	China ; Humans ; Intention ; Leadership ; Personnel Turnover ; Social Identification
Language	English
Publishing date	2022-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	219197-0
ISSN	1467-9450 ; 0036-5564
ISSN (online)	1467-9450
ISSN	0036-5564
DOI	10.1111/sjop.12800
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Article ; Online: Donor and recipient polymorphisms of MAPK signaling pathway genes influence post-transplant liver function in Chinese liver transplant patients taking tacrolimus.

Niu, Wanjie / Zheng, Xinyi / Li, Ziran / Wu, Zhuo / Zhong, Mingkang / Qiu, Xiaoyan

Gene

2023 Volume 857, Page(s) 147190

Abstract: Tacrolimus (TAC) is an immunosuppressive drug that is widely used for patients who underwent liver transplantation. In addition to inhibiting the action of calcineurin, TAC also exerts its immunosuppressive effects by interfering with mitogen activated ... ...

Abstract	Tacrolimus (TAC) is an immunosuppressive drug that is widely used for patients who underwent liver transplantation. In addition to inhibiting the action of calcineurin, TAC also exerts its immunosuppressive effects by interfering with mitogen activated protein kinase (MAPK) pathway. In this study, we investigated the impact of both recipient and donor genetic polymorphisms of MAPK kinase kinase (MAP3K) genes on clinical events in Han Chinese liver transplantation recipients taking TAC. Fifty-seven tag SNPs of 11 genes (MEKK1, MEKK2, MEKK4, MLK1, MLK3, ASK1, TAO1, TAO2, Tpl2, TAK1 and ZAK1) in the MAPK pathway were detected by MALDI-TOF MS assay in 175 TAC-treated liver transplant recipients. The associations of SNPs with incidence of acute rejection, TAC-induced acute nephrotoxicity, and post-transplantation liver and kidney function were explored using Kaplan-Meier survival analysis, Cox-proportional hazard model and linear mixed model, respectively. For the sites significantly associated with clinical events, the dual-luciferase reporter gene system was used to perform preliminary function verification. The results showed that (1) Donor-recipient combinational (D-R) MEKK1 rs62355944 and D-R MLK1 rs8006424 genotypes were significant influence factors of post-transplantation γ-glutamyl transpeptidase (GGT) level (P < 0.0001); (2) D-R MLK1 rs8006424 genotypes were found to significantly affect the alkaline phosphatase (ALP) level after transplantation (P < 0.0001). The results of the dual luciferase reporter gene system demonstrated that the luciferase activity of the pGL3-rs8006424A was significantly higher than that of pGL3-rs8006424G (3.47 ± 0.10 vs 2.97 ± 0.08, P = 0.002). Therefore, MEKK1 rs62355944 and MLK1 rs8006424 might serve as biomarkers to predict post-transplant liver function in liver transplant patients.
MeSH term(s)	Humans ; Tacrolimus/therapeutic use ; Liver Transplantation ; East Asian People ; Immunosuppressive Agents/therapeutic use ; Polymorphism, Single Nucleotide ; Genotype ; Signal Transduction ; Liver ; Cytochrome P-450 CYP3A/genetics ; Graft Rejection/genetics
Chemical Substances	Tacrolimus (WM0HAQ4WNM) ; Immunosuppressive Agents ; Cytochrome P-450 CYP3A (EC 1.14.14.1)
Language	English
Publishing date	2023-01-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2023.147190
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Article ; Online: Contrastive Learning Network Based on Causal Attention for Fine-Grained Ship Classification in Remote Sensing Scenarios

Chaofan Pan / Runsheng Li / Qing Hu / Chaoyang Niu / Wei Liu / Wanjie Lu

Remote Sensing, Vol 15, Iss 3393, p

2023 Volume 3393

Abstract: Fine-grained classification of ship targets is an important task in remote sensing, having numerous applications in military reconnaissance and sea surveillance. Due to the influence of various imaging factors, ship targets in remote sensing images have ... ...

Abstract	Fine-grained classification of ship targets is an important task in remote sensing, having numerous applications in military reconnaissance and sea surveillance. Due to the influence of various imaging factors, ship targets in remote sensing images have considerable inter-class similarity and intra-class difference, which brings significant challenges to fine-grained classification. In response, we developed a contrastive learning network based on causal attention (C2Net) to improve the model’s fine-grained identification ability from local details. The asynchronous feature learning mode of “decoupling + aggregation” is adopted to reduce the mutual influence between local features and improve the quality of local features. In the decoupling stage, the feature vectors of each part of the ship targets are de-correlated using a decoupling function to prevent feature adhesion. Considering the possibility of false associations between results and features, the decoupled part is designed based on the counterfactual causal attention network to enhance the model’s predictive logic. In the aggregation stage, the local attention weight learned in the decoupling stage is used to carry out feature fusion on the trunk feature weight. Then, the proposed feature re-association module is used to re-associate and integrate the target local information contained in the fusion feature to obtain the target feature vector. Finally, the aggregation function is used to complete the clustering process of the target feature vectors and fine-grained classification is realized. Using two large-scale datasets, the experimental results show that the proposed C2Net method had better fine-grained classification than other methods.
Keywords	ship targets ; fine-grained classification ; remote sensing images ; causal attention ; comparative learning ; Science ; Q
Subject code	004
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Unveiling the nature of Pt-induced anti-deactivation of Ru for alkaline hydrogen oxidation reaction.

Fang, Yanyan / Wei, Cong / Bian, Zenan / Yin, Xuanwei / Liu, Bo / Liu, Zhaohui / Chi, Peng / Xiao, Junxin / Song, Wanjie / Niu, Shuwen / Tang, Chongyang / Liu, Jun / Ge, Xiaolin / Xu, Tongwen / Wang, Gongming

Nature communications

2024 Volume 15, Issue 1, Page(s) 1614

Abstract: While Ru owns superior catalytic activity toward hydrogen oxidation reaction and cost advantages, the catalyst deactivation under high anodic potential range severely limits its potential to replace the Pt benchmark catalyst. Unveiling the deactivation ... ...

Abstract	While Ru owns superior catalytic activity toward hydrogen oxidation reaction and cost advantages, the catalyst deactivation under high anodic potential range severely limits its potential to replace the Pt benchmark catalyst. Unveiling the deactivation mechanism of Ru and correspondingly developing protection strategies remain a great challenge. Herein, we develop atomic Pt-functioned Ru nanoparticles with excellent anti-deactivation feature and meanwhile employ advanced operando characterization tools to probe the underlying roles of Pt in the anti-deactivation. Our studies reveal the introduced Pt single atoms effectively prevent Ru from oxidative passivation and consequently preserve the interfacial water network for the critical H* oxidative release during catalysis. Clearly understanding the deactivation nature of Ru and Pt-induced anti-deactivation under atomic levels could provide valuable insights for rationally designing stable Ru-based catalysts for hydrogen oxidation reaction and beyond.
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45873-0
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Article ; Online: Effect of a Novel Flame Retardant on the Mechanical, Thermal and Combustion Properties of Poly(Lactic Acid).

Niu, Mingjun / Zhang, Zhongzhou / Wei, Zizhen / Wang, Wanjie

Polymers

2020 Volume 12, Issue 10

Abstract: Poly(lactic) acid (PLA) is one of the most promising biobased materials, but its inherent flammability limits its applications. A novel flame retardant hexa-(DOPO-hydroxymethylphenoxy-dihydroxybiphenyl)-cyclotriphosphazene (HABP-DOPO) for PLA was ... ...

Abstract	Poly(lactic) acid (PLA) is one of the most promising biobased materials, but its inherent flammability limits its applications. A novel flame retardant hexa-(DOPO-hydroxymethylphenoxy-dihydroxybiphenyl)-cyclotriphosphazene (HABP-DOPO) for PLA was prepared by bonding 9,10-dihydro-9-oxy-10-phosphaphenanthrene-10-oxide (DOPO) to cyclotriphosphazene. The morphologies, mechanical properties, thermal stability and burning behaviors of PLA/HABP-DOPO blends were investigated using a scanning electron microscope (SEM), a universal mechanical testing machine, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), limiting oxygen index (LOI), vertical burning (UL-94) and a cone calorimeter test (CCT). The LOI value reached 28.5% and UL-94 could pass V-0 for the PLA blend containing 25 wt% HABP-DOPO. A significant improvement in fire retardant performance was observed for PLA/HABP-DOPO blends. PLA/HABP-DOPO blends exhibited balanced mechanical properties. The flame retardant mechanism of PLA/HABP-DOPO blends was evaluated.
Language	English
Publishing date	2020-10-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym12102407
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Article ; Online: Effect of a Novel Flame Retardant on the Mechanical, Thermal and Combustion Properties of Poly(Lactic Acid)

Mingjun Niu / Zhongzhou Zhang / Zizhen Wei / Wanjie Wang

Polymers, Vol 12, Iss 2407, p

2020 Volume 2407

Abstract	Poly(lactic) acid (PLA) is one of the most promising biobased materials, but its inherent flammability limits its applications. A novel flame retardant hexa-(DOPO-hydroxymethylphenoxy-dihydroxybiphenyl)-cyclotriphosphazene (HABP-DOPO) for PLA was prepared by bonding 9,10-dihydro-9-oxy-10-phosphaphenanthrene-10-oxide (DOPO) to cyclotriphosphazene. The morphologies, mechanical properties, thermal stability and burning behaviors of PLA/HABP-DOPO blends were investigated using a scanning electron microscope (SEM), a universal mechanical testing machine, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), limiting oxygen index (LOI), vertical burning (UL-94) and a cone calorimeter test (CCT). The LOI value reached 28.5% and UL-94 could pass V-0 for the PLA blend containing 25 wt% HABP-DOPO. A significant improvement in fire retardant performance was observed for PLA/HABP-DOPO blends. PLA/HABP-DOPO blends exhibited balanced mechanical properties. The flame retardant mechanism of PLA/HABP-DOPO blends was evaluated.
Keywords	flame retardant ; poly(lactic acid) ; mechanical properties ; blends ; Organic chemistry ; QD241-441
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: TLR10 genotypes affect long-term graft function in tacrolimus-treated solid organ transplant recipients.

Xu, Qinxia / Dong, Yue / Niu, Wanjie / Zheng, Xinyi / Li, Ruidong / Zhang, Ming / Wang, Zhengxin / Qiu, Xiaoyan

International immunopharmacology

2022 Volume 111, Page(s) 109160

Abstract: The present study was conducted to investigate the relationship between single nucleotide polymorphisms (SNPs) in TLR10 and the clinical outcomes of renal transplant patients who took tacrolimus (TAC) as an immunosuppressant, and further confirmed the ... ...

Abstract	The present study was conducted to investigate the relationship between single nucleotide polymorphisms (SNPs) in TLR10 and the clinical outcomes of renal transplant patients who took tacrolimus (TAC) as an immunosuppressant, and further confirmed the results in liver transplant patients. A total of 172 renal transplant patients and 145 pairs of liver transplant recipients and donors were included. Nineteen SNPs of TLR10 gene were detected by matrix-assisted laser desorption ionization-time-of-flight-mass spectrometry (MALDI-TOF-MS). The associations of recipient SNPs with TAC-related clinical outcomes were explored in renal transplant recipients. The relationship between recipient and donor SNPs and the clinical outcomes of liver transplant patients were investigated to confirm the results. Three SNPs (rs28393318, rs11466655 and rs11096957) in renal transplant recipients were found to influence the graft function after transplantation (P = 0.00003, 0.001 and 0.000003, respectively). The recipient rs11096957 was also found to affect the TBil, and DBil levels in liver transplant recipients (P = 0.001 and 0.002). In this study, we identified significant association signals from TLR10 polymorphisms with clinical outcomes in TAC-treated transplant patients in a Chinese Han-based sample. We provide some evidence for the effect between rs11096957 in TLR10 gene on the graft functions in both renal and liver transplantation.
MeSH term(s)	Cytochrome P-450 CYP3A/genetics ; Genotype ; Humans ; Immunosuppressive Agents/therapeutic use ; Liver Transplantation ; Polymorphism, Single Nucleotide ; Tacrolimus/therapeutic use ; Toll-Like Receptor 10/genetics
Chemical Substances	Immunosuppressive Agents ; TLR10 protein, human ; Toll-Like Receptor 10 ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2022-08-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2022.109160
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Article: Effects of Different Management Practices on the Increase in Phytolith-Occluded Carbon in Moso Bamboo Forests.

Lv, Wanjie / Zhou, Guomo / Chen, Guangsheng / Zhou, Yufeng / Ge, Zhipeng / Niu, Zhengwen / Xu, Lin / Shi, Yongjun

Frontiers in plant science

2020 Volume 11, Page(s) 591852

Abstract: Phytolith-occluded carbon (PhytOC), a promising long-term biogeochemical carbon sequestration mode, plays a crucial role in the global carbon cycle and the regulation of atmospheric ... ...

Abstract	Phytolith-occluded carbon (PhytOC), a promising long-term biogeochemical carbon sequestration mode, plays a crucial role in the global carbon cycle and the regulation of atmospheric CO
Language	English
Publishing date	2020-12-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711035-7
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2020.591852
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Article: Effect of Protein Binding on Exposure of Unbound and Total Mycophenolic Acid: A Population Pharmacokinetic Analysis in Chinese Adult Kidney Transplant Recipients.

Sheng, Changcheng / Zhao, Qun / Niu, Wanjie / Qiu, Xiaoyan / Zhang, Ming / Jiao, Zheng

Frontiers in pharmacology

2020 Volume 11, Page(s) 340

Abstract: Objectives: The population pharmacokinetic (popPK) characteristics of total mycophenolic acid (tMPA) have been investigated in various ethnic populations. However, investigations of popPK of unbound MPA (uMPA) are few. Thus, a popPK analysis was ... ...

Abstract	Objectives: The population pharmacokinetic (popPK) characteristics of total mycophenolic acid (tMPA) have been investigated in various ethnic populations. However, investigations of popPK of unbound MPA (uMPA) are few. Thus, a popPK analysis was performed to: (1) characterize the PK of uMPA and tMPA and its 7-O-mycophenolic acid glucuronide (MPAG) metabolite in kidney transplant patients cotreated with cyclosporine (CsA), and (2) identify the clinically significant covariates that explain variability in the dose-exposure relationship. Methods: A total of 740 uMPA, 741 tMPA, and 734 total MPAG (tMPAG) concentration-time data from 58 Chinese kidney transplant patients receiving MPA in combination with CsA were analyzed using NONMEM Results: The PK of uMPA and unbound MPAG (uMPAG) were characterized by a two- and one-compartment model with first-order elimination, respectively. A linear protein binding model was used to link uMPA and tMPA. Apparent clearance (CL/F) and central volume of distribution (V Conclusions: The established model adequately described the popPK characteristics of the uMPA, tMPA, and MPAG. The estimated CL
Language	English
Publishing date	2020-03-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.00340
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