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Article ; Online: Nucleos(t)ide Analogue Treatment Cessation in Hepatitis B e Antigen-negative Chronic Hepatitis B Patients

Figen SARIGÜL / Ülkü USER

Mediterranean Journal of Infection, Microbes and Antimicrobials, Vol 9, Iss

A Retrospective Single-center Study

2020 Volume 1

Abstract: Introduction: The optimal duration of nucleos(t)ide analogues (NAs) therapy is unknown for hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) patients. The European Association for the Study of the Liver (EASL) recommends the cessation of ... ...

Abstract	Introduction: The optimal duration of nucleos(t)ide analogues (NAs) therapy is unknown for hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) patients. The European Association for the Study of the Liver (EASL) recommends the cessation of NAs in selected non-cirrhotic HBeAg-negative patients achieving long-term (at least three years) virological suppression under treatment if close monitoring can be guaranteed after the cessation of NAs. This study aimed to test this “cut-off rule” in HBeAg-negative CHB patients treated with NAs. Materials and Methods: Seventy-one non-cirrhotic patients were treated with NAs for an average of nine (3-14) years before treatment was discontinued, and patients’ hepatitis B virus (HBV) DNAs were negative for an average of seven (3-13) years. After treatment cessation, serum HBV-DNA and alanine aminotransferase levels were monitored every four weeks for the first six months and every three months from six months to 12 months. The patients were followed-up for 48 weeks after treatment cessation. Results: In 48 weeks after NA treatment cessation, 30 of 71 patients (42.3%) experienced relaps. Hepatitis B e antigen seroreversion in two consecutive visits was observed in one patient (3.4%), HBV-DNA >20,000 IU/ml twice was observed in 23 patients (76.6%), and both virological and biochemical relapses were observed in six patients (20%). Median retreatment time was 21.6 (4-48) weeks. There were no significant differences between relapsers and non-relapsers in terms of baseline features. Conclusion: Although the viral suppression time in NA treatment of HBeAg-negative CHB patients was longer than the EASL recommendation, the relapse rate was found to be similar to that in other studies. Our study has shown that applying EASL recommendations in patients meeting the suitable criteria who can be closely followed up is appropriate.
Keywords	chronic hepatitis b ; hepatitis b e antigen ; treatment cessation ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
Subject code	610
Language	Turkish
Publishing date	2020-12-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
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Article: Real-Life Experience With Bictegravir/Emtricitabine/Tenofovir Alafenamide in Turkey.

Balcı, Umay / Üser, Ülkü / Tahmaz, Alper / Sarigul Yildirim, Figen

Cureus

2023 Volume 15, Issue 10, Page(s) e47253

Abstract: Introduction: Single-tablet regimens (STRs) can increase treatment success and even improve the quality of life of human immunodeficiency virus (HIV) patients. In this study, we aim to analyze the real-life efficacy and tolerability data of people ... ...

Abstract	Introduction: Single-tablet regimens (STRs) can increase treatment success and even improve the quality of life of human immunodeficiency virus (HIV) patients. In this study, we aim to analyze the real-life efficacy and tolerability data of people living with HIV (PLWH) initiated on or switched to bictegravir/emtricitabine/tenofovir alafenamide fumarate (BIC/FTC/TAF) as first-line treatment. Materials and methods: This retrospective analysis was performed in HIV-1-positive patients who were initiated BIC/FTC/TAF in the HIV clinic between June 2020 and June 2022. Patients who received BIC/FTC/TAF for at least 12 months were included in this study. Virological suppression, laboratory parameters, side effects, and immunological response were analyzed at one, three, six, nine, and 12 months. Results: A total of 116 patients, 66 (56.9%) treatment-experienced and 50 (43.1%) naive, were evaluated within the scope of the study. In the naive patient group, baseline HIV-RNA, CD4+ and CD8+ T cell counts, CD4/CD8 ratio, and estimated glomerular filtration rate (eGFR) values were significantly different in different follow-up months. The number of patients with HIV-1 RNA levels below 50 copies/mL was 55.9% in the first month, 73.7% in the third month, 90.2% in the sixth month, and 100% in the ninth and 12th months. Conclusion: In our real-life observational study, BIC/FTC/TAF treatment achieved rapid viral suppression, maintained viral suppression in virally suppressed patients, and was effective for immunological recovery in both treatment-experienced and naive HIV patients. No serious side effects were observed. Our study has proved the potential of BIC/FTC/TAF as an important option in the treatment of HIV patients.
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.47253
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Article: Investigation of compatibility of severe acute respiratory syndrome coronavirus 2 reverse transcriptase-PCR kits containing different gene targets during coronavirus disease 2019 pandemic.

Sarıgül, Figen / Doluca, Osman / Akhan, Sıla / Sayan, Murat

Future virology

2020 Volume 15, Issue 8, Page(s) 515–524

Abstract: Aim: In the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), reverse transcriptase-PCR (RT-PCR) technique is often used. We evaluated the compatibility of SARS-CoV-2 RT-PCR kits containing different gene targets during the ... ...

Abstract	Aim: In the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), reverse transcriptase-PCR (RT-PCR) technique is often used. We evaluated the compatibility of SARS-CoV-2 RT-PCR kits containing different gene targets during the pandemic. Materials & methods: Samples were tested by Bio-Speddy Results: Diagnovital PCR kit showed amplification in a narrow Ct range and conveniently sharper exponential amplification curves than Bio-Speedy PCR kit. While the correlation between the findings of the two kits was apparent even with single gene target, this correlation increased when a secondary biomarker was added to the correlation calculations. Conclusion: We have observed high correlation between different PCR kits, however, using different PCR kits during the pandemic may provide a more accurate diagnosis of SARS-CoV-2, since despite correlation there are a number of patients showing contradicting diagnosis.
Keywords	covid19
Language	English
Publishing date	2020-09-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2254606-6
ISSN	1746-0808 ; 1746-0794
ISSN (online)	1746-0808
ISSN	1746-0794
DOI	10.2217/fvl-2020-0169
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Article ; Online: Bibliometric Analysis of HIV and Exercise Literature based on Scientific Studies from 1990-2020.

Köse, Elif / Seyman, Derya / Sarigül-Yildirim, Figen / Yerlisu-Lapa, Tennur / Tercan-Kaas, Evren

Iranian journal of public health

2022 Volume 50, Issue 12, Page(s) 2397–2410

Abstract: Background: Exercise is believed to play an important role in maintaining functionality in patients with HIV and it is thought that researchers are increasingly interested in this field. We aimed to shed light on the historical development of research ... ...

Abstract	Background: Exercise is believed to play an important role in maintaining functionality in patients with HIV and it is thought that researchers are increasingly interested in this field. We aimed to shed light on the historical development of research on HIV and exercise by utilizing visual mapping method. Methods: Overall, 1051 articles retrieved from Web of Science (WoS) core database were analyzed according to the publication year and language, number of issues, citation, country collaborations, co-citation networks and concept-topic trends by using CiteSpace software. Results: The United States played a key role in country collaborations, and had the highest citation burst. The most cited studies were meta-analysis studies. The studies gathered mainly around the clusters named "physical activity" and "metabolic abnormalities" meanwhile, the recent topics of research were heart failure, metabolism, comorbidity, Ethiopia, muscle, cardiovascular event and drug user. Conclusion: The reason why USA was found to be one of the key actors in the network is supposed to be the financial resources it can allocate for the studies conducted. It appears that the majority of the studies in the field dwell upon the impact of exercise on the physical parameters in HIV patients, whereas there are only a limited number of studies focusing on the impact of exercise on HIV-induced psychological and cognitive problems. Recent studies on neurocognitive impairment, on the other hand, are predictive of possible future popularity of such topics among researchers.
Language	English
Publishing date	2022-10-22
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	2240935-X
ISSN	2251-6093 ; 2251-6093
ISSN (online)	2251-6093
ISSN	2251-6093
DOI	10.18502/ijph.v50i12.7923
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Article: Türkiye’deki Bir Hastanede Dokuzuncu Ayda Uzamış Koronavirüs Hastalığı Belirtilerinin Değerlendirilmesi.

Tahmaz, Alper / Çetin, Eda / Balcı, Umay / Sarıgül Yıldırım, Figen / Seyman, Derya / Gürgen, Atila

Mikrobiyoloji bulteni

2022 Volume 56, Issue 4, Page(s) 657–666

Abstract: Long COVID is defined as symptoms related to various organs following COVID-19. There is currently very little information available about the prevalence of these symptoms and their long-term recovery time. The aim of this study was to describe the ... ...

Title translation	The Evaluation of Long Coronavirus Disease Symptoms at Ninth Month from a Hospital in Türkiye.
Abstract	Long COVID is defined as symptoms related to various organs following COVID-19. There is currently very little information available about the prevalence of these symptoms and their long-term recovery time. The aim of this study was to describe the symptoms that persisted nine months after COVID-19. This cross-sectional study was conducted in Antalya, Türkiye, between November 1 and 30, 2020 on COVID-19 patients. Patients were contacted approximately nine months later by two infectious diseases physicians, and the questionnaire which included 27 symptoms was completed. Of the 390 patients who met the criteria, 329 agreed to participate in the study. Patients' average age was 48.9 ± 14.4 years, and 51.7% were male. 79.3% of the people still had at least one symptom at the end of the ninth month. The most common symptoms were weakness-fatigue (54.7%), forgetfulness (45.3%), effort loss (35.0%), sleep disturbance (34.3%), joint pain (27.4%), and hair loss (23.4%). According to analysis performed in terms of sex; hair loss, diarrhea, nausea, dizziness, sore throat, loss of taste and smell were more common in women than in men (p= 0.042, p= 0.047, p= 0.050, p= 0.026, p= 0.016, p= 0.036, p= 0.027, respectively). Individuals aged 65 years and over had a significantly lower number of symptoms (p= 0.029) than all other age groups. Furthermore, the number of symptoms was higher in patients who used steroids (p= 0.049). This study is an important source of information on the long-term symptoms of COVID-19. Our results have shown that the symptoms associated with COVID-19 do not completely resolve even after nine months, which explains why long COVID requires continuous monitoring.
MeSH term(s)	Humans ; Female ; Male ; Adult ; Middle Aged ; Coronavirus ; COVID-19 ; Cross-Sectional Studies ; Coronavirus Infections ; Hospitals ; Alopecia
Language	Turkish
Publishing date	2022-05-31
Publishing country	Turkey
Document type	English Abstract ; Journal Article
ZDB-ID	985146-x
ISSN	0374-9096
ISSN	0374-9096
DOI	10.5578/mb.20229604
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Zs.A 3943: Show issues

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Article ; Online: Assessment of Microcirculation in HIV-Positive Patients with a Noninvasive Method: Nailfold Videocapillaroscopy.

Sarigul Yildirim, Figen / Balkarli, Ayse

AIDS research and human retroviruses

2019 Volume 36, Issue 1, Page(s) 8–12

Abstract: Chronic inflammation that contributes to the deterioration of the mechanical form of both the vascular wall and the function of endothelial has been shown to cause vascular dysfunction in patients with human immunodeficiency virus (HIV). Nailfold ... ...

Abstract	Chronic inflammation that contributes to the deterioration of the mechanical form of both the vascular wall and the function of endothelial has been shown to cause vascular dysfunction in patients with human immunodeficiency virus (HIV). Nailfold videocapillaroscopy (NVC) is a noninvasive and simple technique used to analyze dermal microvasculature. The aims of our study were to detect the morphological and functional properties of microcirculation in HIV-positive patients utilizing NVC and to compare the results with those obtained from healthy individuals and investigate whether these changes had supported any correlation with HIV. In this prospective study, 51 male HIV-positive patients were the subjects and 59 male healthy individuals made up the control group. Capillaroscopic findings, obtained from both groups by NVC, were evaluated. Tortuosity, a capillaroscopic finding, was significantly higher in the group with HIV (
MeSH term(s)	Adult ; Aged ; Capillaries/diagnostic imaging ; Capillaries/physiopathology ; Female ; HIV Infections/diagnosis ; HIV Infections/physiopathology ; Humans ; Male ; Microcirculation ; Microscopic Angioscopy ; Middle Aged ; Prospective Studies ; Young Adult
Language	English
Publishing date	2019-10-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	639130-8
ISSN	1931-8405 ; 0889-2229
ISSN (online)	1931-8405
ISSN	0889-2229
DOI	10.1089/aid.2019.0107
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Zs.A 1928: Show issues

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Article ; Online: Bibliometric Analysis of HIV and Exercise Literature Based on Scientific Studies from 1990-2020

Elif Köse / Derya Seyman / Figen Sarıgül Yıldırım / Tennur Yerlisu Lapa / Evren Tercan Kaas

Iranian Journal of Public Health, Vol 50, Iss

2021 Volume 12

Abstract	Background: Exercise is believed to play an important role in maintaining functionality in patients with HIV and it is thought that researchers are increasingly interested in this field. We aimed to shed light on the historical development of research on HIV and exercise by utilizing visual mapping method. Methods: Overall, 1051 articles retrieved from Web of Science (WoS) core database were analyzed according to the publication year and language, number of issues, citation, country collaborations, co-citation networks and concept–topic trends by using CiteSpace software. Results: The United States played a key role in country collaborations, and had the highest citation burst. The most cited studies were meta-analysis studies. The studies gathered mainly around the clusters named “physical activity” and “metabolic abnormalities” meanwhile, the recent topics of research were heart failure, metabolism, comorbidity, Ethiopia, muscle, cardiovascular event and drug user. Conclusion: The reason why USA was found to be one of the key actors in the network is supposed to be the financial resources it can allocate for the studies conducted. It appears that the majority of the studies in the field dwell upon the impact of exercise on the physical parameters in HIV patients, whereas there are only a limited number of studies focusing on the impact of exercise on HIV-induced psychological and cognitive problems. Recent studies on neurocognitive impairment, on the other hand, are predictive of possible future popularity of such topics among researchers.
Keywords	Bibliometric ; Social network analysis ; Exercise ; Public aspects of medicine ; RA1-1270
Subject code	001
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
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Article ; Online: Evaluation of the Effect of Oral Corticosteroid Treatment on Clinical Course, Hospitalization and Mortality in COVID-19 Patients

Umay Balcı / Figen Sarıgül / Derya Seyman / Alper Tahmaz / Ayşegül Seremet Keskin / Kübra Demir Önder / Hande Berk / Ulku User / Filiz Kizilates

Van Tip Dergisi, Vol 29, Iss 3, Pp 290-

2022 Volume 296

Abstract: INTRODUCTION: It has been reported that short-term and low-dose intravenous corticosteroids prevent the progression of the disease and reduce mortality during the hyperinflammation period caused by the virus in COVID-19 disease. The aim of our study is ... ...

Abstract	INTRODUCTION: It has been reported that short-term and low-dose intravenous corticosteroids prevent the progression of the disease and reduce mortality during the hyperinflammation period caused by the virus in COVID-19 disease. The aim of our study is to evaluate the clinical course, hospital readmission and mortality rates of patients with mild to moderate COVID-19 pneumonia, who do not need oxygen and for whom we started outpatient corticosteroid treatment. METHODS: Patients over the age of 18 who applied to our hospital with the diagnosis of mild-to-moderate COVID-19 pneumonia and were treated with outpatient oral systemic corticosteroid were included in the study.Inclusion criteria were pneumonia finding consistent with mild to moderate COVID-19 involvement in lung computerized tomography, seven days or more from symptom onset, and oxygen saturation of 93 and above. The patients were given dexamethasone 8 milligrams (mg) methylprednisolone 32 mg, methylprednisolone 40 mg as oral systemic corticosteroid. RESULTS: The median age (min-max) of the patients was 49.24 (22-91), and 60% of them were male. The median steroid duration was 6.6 (1-10) days. Due to ongoing symptoms, 56% of the patients were admitted to the hospital again, 12% were hospitalized due to clinical and laboratory deterioration, the intensive care hospitalization rate was 3% and the mortality rate was 2% (2/100). DISCUSSION AND CONCLUSION: As a result, the effectiveness of oral corticosteroids on mortality and morbidity has not been demonstrated in mild to moderate COVID-19 pneumonia. Well-designed randomized controlled studies are needed on this subject.
Keywords	covid-19 ; corticosteroid ; sars-cov-2 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	Van Yuzuncu Yil University, School of Medicine
Document type	Article ; Online
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Article: Comparison of Immunological and Virological Recovery with Rapid, Early, and Late Start of Antiretroviral Treatment in Naive Plwh: Real-World Data.

Sarıgül Yıldırım, Figen / Candevir, Aslıhan / Akhan, Sıla / Kaya, Selçuk / Çabalak, Mehmet / Ersöz, Gülden / İnan, Dilara / Ceren, Nurgül / Karaoğlan, İlkay / Damar Çakırca, Tuba / Özer Balin, Şafak / Alkan, Sevil / Kandemir, Özlem / Üser, Ülkü / Karabay, Oğuz / Çelen, Mustafa Kemal

International journal of general medicine

2023 Volume 16, Page(s) 1867–1877

Abstract: Background: Rapid initiation of antiretroviral therapy (ART) reduces the transmission of HIV infection in the community. This study aimed to determine whether rapid ART initiation is effective compared to standard ART treatment in our country.: ... ...

Abstract	Background: Rapid initiation of antiretroviral therapy (ART) reduces the transmission of HIV infection in the community. This study aimed to determine whether rapid ART initiation is effective compared to standard ART treatment in our country. Methods: Patients were grouped based on time to treatment initiation. HIV RNA levels, CD+4 T cell count, CD4/CD8 ratio, and ART regimens were recorded at baseline and follow-up visits for 12 months. Results: There were 368-ART naive adults (treatment initiated at the time of HIV diagnosis; 143 on the first day, 48 on the second-seventh day, and 177 after the seventh day). Although virological suppression rates at 12 Conclusion: Our findings support the broader application of recommendations for rapid ART initiation in HIV patients.
Language	English
Publishing date	2023-05-17
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S393370
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Article ; Online: Integrase Strand Transfer Inhibitor (INSTI) Genotypic Resistance Analysis in Treatment-Naive, INSTI Free Antiretroviral-Experienced and INSTI-Experienced Turkish Patients Infected with HIV-1.

Sayan, Murat / Yildirim, Figen Sarigul / Akhan, Sila / Karaoglan, Ilkay / Akalin, Halis

Current HIV research

2022 Volume 20, Issue 2, Page(s) 184–192

Abstract: Background and objective: Integrase strand transfer inhibitors (INSTIs) are currently the standard of practice for first-line HIV therapy for most patients. We evaluated the mutations associated with INSTI resistance in naive HIV-1 infected patients and ...

Abstract	Background and objective: Integrase strand transfer inhibitors (INSTIs) are currently the standard of practice for first-line HIV therapy for most patients. We evaluated the mutations associated with INSTI resistance in naive HIV-1 infected patients and treated them with antiretrovirals (ART). Methods: The study, conducted in the 2018 - 2020 period, included 50 ART-naïve patients, 69 INSTI free ART-experienced patients, and 82 INSTI-experienced patients. INSTI resistance mutations were interpreted using the Stanford University HIVdb Program algorithm. Results: INSTI resistance was not detected in ART naïve patients. At least one INSTI resistance mutation was detected in 10% of the INSTI-free patients and 29% of the INSTI-treated patients. Major INSTI-mutations E138K, Y143R, S147G, Q148R, N155H, and E157Q were found in raltegravir. Additional mutations, E92Q, E138K, G140A, S147G, and Q148R were found in elvitegravir; E192Q, E138K/T, G140A/S, S147G, Q148H/R, N155H, E157Q were found in dolutegravir (DTG) experienced patients. According to all drug classes, drug resistance mutation prevalences were determined at the rate of 60%, 46%, and 46% in the RAL, EVG, and DTG groups, respectively. Conclusion: Our findings provide data for treatment and resistance management of INSTIs and may provide feedback for INSTIs resistance surveillance consensus-building efforts. In viral rebound under INSTI treatment, INSTI-resistant mutations follow typical INSTI resistance pathways and high resistance rates. INSTI resistance genotypic analysis should be considered before any DTG-based regimes can be initiated in the future, and reduced DTG susceptibility should be carefully monitored and investigated.
MeSH term(s)	Anti-Retroviral Agents/therapeutic use ; Drug Resistance, Viral/genetics ; HIV Infections/drug therapy ; HIV Integrase/genetics ; HIV Integrase Inhibitors/pharmacology ; HIV Integrase Inhibitors/therapeutic use ; HIV Seropositivity/drug therapy ; HIV-1/genetics ; HIV-1/metabolism ; Heterocyclic Compounds, 3-Ring/pharmacology ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Humans ; Integrases/genetics ; Integrases/pharmacology ; Integrases/therapeutic use ; Mutation ; Raltegravir Potassium/therapeutic use
Chemical Substances	Anti-Retroviral Agents ; HIV Integrase Inhibitors ; Heterocyclic Compounds, 3-Ring ; Raltegravir Potassium (43Y000U234) ; HIV Integrase (EC 2.7.7.-) ; Integrases (EC 2.7.7.-)
Language	English
Publishing date	2022-03-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2192348-6
ISSN	1873-4251 ; 1570-162X
ISSN (online)	1873-4251
ISSN	1570-162X
DOI	10.2174/1570162X20666220303104509
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