Article ; Online: Effect of glycotoxicity and lipotoxicity on carbohydrate antigen 19 - 9 in the patients with diabetes.
2024 Volume 24, Issue 1, Page(s) 51
Abstract: Objectives: In comparison to the subjects without diabetes, a greater concentration of serum carbohydrate antigen 19 - 9 (CA 19 - 9) was observed in the subjects with diabetes. Nevertheless, since the occurrence of abnormal CA 19 - 9 is not widespread ... ...
| Abstract | Objectives: In comparison to the subjects without diabetes, a greater concentration of serum carbohydrate antigen 19 - 9 (CA 19 - 9) was observed in the subjects with diabetes. Nevertheless, since the occurrence of abnormal CA 19 - 9 is not widespread among the whole diabetic population, this phenomenon has not attracted enough attention. The prevalence of abnormal CA 19 - 9 in hospitalized patients with diabetes was the focus of our research. Method: A total of 385 subjects with diabetes and 200 controls were enrolled and all had been tested the CA19-9 levels. Cases of cancers were excluded through examination and followup for 1 year. Results: We found that the rate of patients with abnormal CA19-9 level was 8.3%. The rate of patients with abnormal CA19-9 level was 14.0% in the HbA1c ≥ 9% group, and 3.0% in the HbA1c < 9% group, 2.5% in the control group. There was no significant difference in the HbA1c < 9% group and the control group. A significant correlation between serum CA19-9 and both HbA1c and total cholesterol was observed, yet no difference in CRP level was observed between subjects with normal CA19-9 level and subjects with abnormal CA19-9 level. However, a significant difference in fasting C-peptide levels was observed between the two groups, p = 0.039. Conclusion: The percentage of patients with diabetes exhibiting elevated CA19-9 level is 14% in the HbA1c ≥ 9% diabetic patients, much higher than expected. The underlying mechanism may be related to islet injury caused by glycotoxicity and lipotoxicity. Strengths and limitations of the study: We studied the rate of hospitalized diabetic patients with elevated CA 19 - 9 which were characterized with poorly controlled blood glucose. We found that the elevation of CA 19 - 9 was unexpectedly high in diabetic inpatients without development to cancer. The limitation of this study is that the underlying mechanism is not sufficiently studied. |
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| MeSH term(s) | Humans ; Male ; Female ; Middle Aged ; Glycated Hemoglobin/analysis ; CA-19-9 Antigen/blood ; Case-Control Studies ; Aged ; Diabetes Mellitus/blood ; Diabetes Mellitus/epidemiology ; Follow-Up Studies ; Blood Glucose/analysis ; Blood Glucose/metabolism ; Adult ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Prognosis ; Biomarkers/blood |
| Chemical Substances | Glycated Hemoglobin ; CA-19-9 Antigen ; Blood Glucose ; hemoglobin A1c protein, human ; Biomarkers |
| Language | English |
| Publishing date | 2024-04-24 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2091323-0 |
| ISSN | 1472-6823 ; 1472-6823 |
| ISSN (online) | 1472-6823 |
| ISSN | 1472-6823 |
| DOI | 10.1186/s12902-024-01578-5 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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