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Article: Short stature and

Capkova, Pavlina / Capkova, Zuzana / Rohon, Peter / Adamová, Katerina / Zapletalova, Jirina

2020 Volume 8, Page(s) e10236

Abstract: Background: SHOX: Methods: Targeted screening for variants in : Results: In total, 27 and 15 variants ... ...

Abstract	Background: SHOX Methods: Targeted screening for variants in Results: In total, 27 and 15 variants influencing
Language	English
Publishing date	2020-11-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.10236
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A comprehensive analysis of CD47 expression in various histological subtypes of soft tissue sarcoma: exploring novel opportunities for macrophage-directed treatments.

Benesova, Iva / Capkova, Linda / Ozaniak, Andrej / Pacas, Pavel / Kopeckova, Katerina / Galova, Dominika / Lischke, Robert / Buchler, Tomas / Ozaniak Strizova, Zuzana

Journal of cancer research and clinical oncology

2024 Volume 150, Issue 3, Page(s) 134

Abstract: Purpose: The CD47 molecule, often referred to as the "do not eat me" signal, is frequently overexpressed in tumor cells. This signaling pathway limits phagocytosis by macrophages. Our objective was to determine CD47 abundance in various soft tissue ... ...

Abstract	Purpose: The CD47 molecule, often referred to as the "do not eat me" signal, is frequently overexpressed in tumor cells. This signaling pathway limits phagocytosis by macrophages. Our objective was to determine CD47 abundance in various soft tissue sarcomas (STS) to investigate whether it could serve as a potential evasion mechanism for tumor cells. Additionally, we aimed to assess the prognostic value of CD47 expression by examining its association with different clinicopathological factors. This study aimed to elucidate the significance of CD47 in the context of emerging anti-tumor targeting approaches. Methods: In this retrospective study, formalin-fixed paraffine-embedded (FFPE) tumor tissues of 55 treatment-naïve patients were evaluated by immunohistochemistry for the abundance of CD47 molecule on tumor cells. The categorization of CD47 positivity was as follows: 0 (no staining of tumor cells), 1 + (less than 1/3 of tumor area positive), 2 + (between 1/3 and 2/3 of tumor area positive), and 3 + (more than 2/3 of tumor area positive for CD47). Next, we compared CD47 abundance between different tumor grades (G1-3). We used Kaplan-Meier survival curves with log-rank test to analyze the differences in survival between patients with different CD47 expression. Moreover, we performed Cox proportional hazards regression model to evaluate the clinical significance of CD47. Results: CD47 is widely prevalent across distinct STS subtypes. More than 80% of high grade undifferentiated pleiomorphic sarcoma (UPS), 70% of myxofibrosarcoma (MFS) and more than 60% of liposarcoma (LPS) samples displayed a pattern of moderate-to-diffuse positivity. This phenomenon remains consistent regardless of the tumor grade. However, there was a tendency for higher CD47 expression levels in the G3 group compared to the combined G1 + G2 groups when all LPS, MFS, and UPS were analyzed together. No significant associations were observed between CD47 abundance, death, and metastatic status. Additionally, high CD47 expression was associated with a statistically significant increase in progression-free survival in the studied cohort of patients. Conclusion: This study highlights the potential of the CD47 molecule as a promising immunotherapeutic target in STS, particularly given its elevated expression levels in diverse sarcoma types. Our data showed a notable trend linking CD47 expression to tumor grade, while also suggesting an interesting correlation between enhanced abundance of CD47 expression and a reduced hazard risk of disease progression. Although these findings shed light on different roles of CD47 in STS, further research is crucial to assess its potential in clinical settings.
MeSH term(s)	Humans ; Adult ; CD47 Antigen/metabolism ; Retrospective Studies ; Lipopolysaccharides ; Sarcoma/therapy ; Macrophages/pathology ; Soft Tissue Neoplasms/pathology ; Prognosis
Chemical Substances	CD47 Antigen ; Lipopolysaccharides ; CD47 protein, human
Language	English
Publishing date	2024-03-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-024-05661-1
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Article ; Online: Duplication of 9p24.3 in three unrelated patients and their phenotypes, considering affected genes, and similar recurrent variants.

Capkova, Zuzana / Capkova, Pavlina / Srovnal, Josef / Adamova, Katerina / Prochazka, Martin / Hajduch, Marian

Molecular genetics & genomic medicine

2021 Volume 9, Issue 3, Page(s) e1592

Abstract: Background: Recent studies suggest that duplication of the 9p24.3 chromosomal locus, which includes the DOCK8 and KANK1 genes, is associated with autism spectrum disorders (ASD), intellectual disability/developmental delay (ID/DD), learning problems, ... ...

Abstract	Background: Recent studies suggest that duplication of the 9p24.3 chromosomal locus, which includes the DOCK8 and KANK1 genes, is associated with autism spectrum disorders (ASD), intellectual disability/developmental delay (ID/DD), learning problems, language disorders, hyperactivity, and epilepsy. Correlation between this duplication and the carrier phenotype needs further discussion. Methods: In this study, three unrelated patients with ID/DD and ASD underwent SNP aCGH and MLPA testing. Similarities in the phenotypes of patients with 9p24.3, 15q11.2, and 16p11.2 duplications were also observed. Results: All patients with ID/DD and ASD carried the 9p24.3 duplication and showed intragenic duplication of DOCK8. Additionally, two patients had ADHD, one was hearing impaired and obese, and one had macrocephaly. Inheritance of the 9p24.3 duplication was confirmed in one patient and his sibling. In one patient KANK1 was duplicated along with DOCK8. Carriers of 9p24.3, 15q11.2, and 16p11.2 duplications showed several phenotypic similarities, with ID/DD more strongly associated with duplication of 9p24.3 than of 15q11.2 and 16p11.2. Conclusion: We concluded that 9p24.3 is a likely cause of ASD and ID/DD, especially in cases of DOCK8 intragenic duplication. DOCK8 is a likely causative gene, and KANK1 aberrations a modulator, of the clinical phenotype observed. Other modulators were not excluded.
MeSH term(s)	Adaptor Proteins, Signal Transducing/genetics ; Child ; Child, Preschool ; Chromosome Disorders/genetics ; Chromosome Disorders/pathology ; Chromosome Duplication ; Chromosomes, Human, Pair 9/genetics ; Cytoskeletal Proteins/genetics ; Developmental Disabilities/genetics ; Developmental Disabilities/pathology ; Female ; Guanine Nucleotide Exchange Factors/genetics ; Humans ; Male ; Phenotype
Chemical Substances	Adaptor Proteins, Signal Transducing ; Cytoskeletal Proteins ; DOCK8 protein, human ; Guanine Nucleotide Exchange Factors ; KANK1 protein, human
Language	English
Publishing date	2021-01-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2734884-2
ISSN	2324-9269 ; 2324-9269
ISSN (online)	2324-9269
ISSN	2324-9269
DOI	10.1002/mgg3.1592
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Article ; Online: Short stature and SHOX (Short stature homeobox) variants—efficacy of screening using various strategies

Pavlina Capkova / Zuzana Capkova / Peter Rohon / Katerina Adamová / Jirina Zapletalova

PeerJ, Vol 8, p e

2020 Volume 10236

Abstract: Background SHOX mutations have previously been described as causes of Léri-Weill dyschondrosteosis (LWD), Langer mesomelic dysplasia (LMD), and idiopathic short stature. The loss of X chromosome—Turner syndrome or mosaic 45,X/46,XX or 46,XY—also leads to ...

Abstract	Background SHOX mutations have previously been described as causes of Léri-Weill dyschondrosteosis (LWD), Langer mesomelic dysplasia (LMD), and idiopathic short stature. The loss of X chromosome—Turner syndrome or mosaic 45,X/46,XX or 46,XY—also leads to the heterozygous loss of SHOX in patients with short stature only or with features similar to LWD. The aim of this study was to assess the efficacy of the targeted screening for SHOX variants, which involved different methods in the laboratory analysis of short stature. We determined the significance and positive predictive value of short stature for the detection of SHOX variants. Methods Targeted screening for variants in SHOX involving MLPA, sequencing, karyotyping and FISH was performed in the short stature cohort (N = 174) and control cohort (N = 91). The significance of short stature and particular characteristics for the detection of SHOX variants was determined by Fisher’s exact test, and the probability of SHOX mutation occurrence was calculated using a forward/stepwise logistic regression model. Results In total, 27 and 15 variants influencing SHOX were detected in the short stature and control cohorts, respectively (p > 0.01). Sex chromosome aberrations and pathogenic CNV resulting in diagnosis were detected in eight (4.6%) and five (2.9%) patients of the short stature group and three (3.3%) and one (1.1%) individuals of the control group. VUS variants were discovered in 14 (8.0%) and 11 (12.1%) individuals of the short stature and control groups, respectively. MLPA demonstrated the detection rate of 13.22%, and it can be used as a frontline method for detection of aberrations involving SHOX. However, only mosaicism of monosomy X with a higher frequency of monosomic cells could be reliably discovered by this method. Karyotyping and FISH can compensate for this limitation; their detection rates in short stature group were 3.55% and 13.46% (N = 52), respectively. FISH proved to be more effective than karyotyping in the study as it could reveal ...
Keywords	SHOX ; Short stature ; Leri-Weill dyschondrosteosis ; Turner syndrome ; Screening for mutations ; Idiopathic short stature ; Medicine ; R
Subject code	630
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Contrasting biomass allocations explain adaptations to cold and drought in the world's highest-growing angiosperms.

Dolezal, Jiri / Chondol, Thinles / Chlumska, Zuzana / Altman, Jan / Capkova, Katerina / Dvorsky, Miroslav / Fibich, Pavel / Korznikov, Kirill A / Ruka, Adam T / Kopecky, Martin / Macek, Martin / Rehakova, Klara

Annals of botany

2024

Abstract: Background and aims: Understanding biomass allocation among plant organs is crucial for comprehending plant growth optimization, survival and responses to global change drivers. Yet, mechanisms governing mass allocation in vascular plants from extreme ... ...

Abstract	Background and aims: Understanding biomass allocation among plant organs is crucial for comprehending plant growth optimization, survival and responses to global change drivers. Yet, mechanisms governing mass allocation in vascular plants from extreme elevations exposed to cold and drought stresses remain poorly understood. Methodology: We analyzed organ mass weights and fractions in 258 Himalayan herbaceous species across diverse habitats (wetland, steppe, alpine), growth forms (annual, perennial taprooted, rhizomatous, cushiony), and climatic gradients (3500-6150 m elevation) to explore whether biomass distribution adhered to fixed allometric or optimal partitioning rules, and how variation in size, phylogeny, and ecological preferences influence their strategies for resource allocation. Key findings: Following the optimal partitioning theory, Himalayan plants distribute more biomass to key organs vital for acquiring and preserving limited resources necessary for their growth and survival. Allocation strategies are mainly influenced by plant growth forms and habitat conditions, notably temperature, water availability, and evaporative demands. Alpine plants primarily invest in belowground stem bases for storage and regeneration, reducing aboveground stems while increasing leaf mass fraction to maximize carbon assimilation in their short growing season. Conversely, arid steppe plants prioritize deep roots over leaves to secure water and minimize transpiration. Wetland plants allocate resources to aboveground stems and belowground rhizomes, enabling them to resist competition and grazing in fertile environments. Conclusions: Himalayan plants from extreme elevations optimize their allocation strategies to acquire scarce resources under specific conditions, efficiently investing carbon from supportive to acquisitive and protective functions with increasing cold and drought. Intraspecific variation and shared ancestry did not significantly alter Himalayan plants' biomass allocation strategies. Despite diverse evolutionary histories, plants from similar habitats have developed comparable phenotypic structures to adapt to their specific environments. This study offers new insights into plant adaptations in diverse Himalayan environments and underscores the importance of efficient resource allocation for survival and growth in challenging conditions.
Language	English
Publishing date	2024-02-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1461328-1
ISSN	1095-8290 ; 0305-7364
ISSN (online)	1095-8290
ISSN	0305-7364
DOI	10.1093/aob/mcae028
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Article: Raum und Zeit als Faktoren der nationalen Identifikation der Prager Juden

Čapková, Katerina

Praha - Prag 1900 - 1945 : Literaturstadt zweier Sprachen , p. 21-30

2010 , Page(s) 21–30

Author's details	Katerina Capková
Language	German
Publisher	Stutz
Publishing place	Passau
Document type	Article
ISBN	978-388-84915-0-4 ; 388-84915-0-9
Database	Former special subject collection: coastal and deep sea fishing

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Book: Češi, Němci, Židé?

Čapková, Kateřina

národní identita Žid°u v Čechách 1918 až 1938

2013

Author's details	Kateřina Čapková
Keywords	Jews/History ; Jews/Identity ; Jews/Social conditions ; Bohemia (Czech Republic)
Language	Czech
Size	367 S., zahlr. Ill., graph. Darst.
Edition	2., přeprac. vyd.
Publisher	Nakl. Paseka
Publishing place	Praha u.a.
Document type	Book
ISBN	9788074322945 ; 8074322947
Database	Former special subject collection: coastal and deep sea fishing

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Article: Die "Judenfrage" in der Frühphase der tschechischen Nationalbewegung

Čapková, Kateřina

Die "Judenfrage" - ein europäisches Phänomen? , p. 247-266

2013 , Page(s) 247–266

Author's details	Kateřina Čapková
Language	German
Publisher	Metropol
Publishing place	Berlin
Document type	Article
ISBN	978-3-86331-125-4 ; 3-86331-125-6
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Littoral periphyton dynamics in newly established post-mining lakes [Correction: Apr. 2023, 85(2), p. 40]

Besta, Tomáš / Mareš, Jan / Čapková, Kateřina / Janeček, Emil / Štenclová, Lenka / Kust, Andreja / Říha, Milan / Konopáčová, Eliška / Řeháková, Klára

Aquat Sci. 2023 Jan., v. 85, no. 1, p. 21

2023 , Page(s) 21

Abstract: Hydric recultivation-flooding of abandoned mining pits-creates a completely new, underexplored habitat for a wide range of aquatic organisms. Periphyton, dominated by algae and cyanobacteria, is frequently a key component of newly established aquatic ... ...

Abstract	Hydric recultivation-flooding of abandoned mining pits-creates a completely new, underexplored habitat for a wide range of aquatic organisms. Periphyton, dominated by algae and cyanobacteria, is frequently a key component of newly established aquatic ecosystems. Periphyton and its response to abiotic factors were studied in the littoral zone of three post-mining lakes with different ages of foundation situated in the Czech Republic. The microbial diversity of phototrophs as a major component of periphyton is largely unknown in such localities. The studied habitat proved to harbour a huge periphytic diversity-25% of diatom species found in the respective watershed (~ 5500 km²) inhabited exlusively the studied lakes. Species composition of phototrophic microorganisms varied significantly (Permutational Multivariate Analysis of Variance) among the studied lakes, seasons, and sampling years. However, the sampling depths and sampling site of the studied lake have not shown a significant impact on the diversity, indicating the homogeneous composition of the littoral periphyton within a particular lake and growing season. The seasonal dynamics of periphyton were unique for each lake, documenting three distinct successional patterns. The proportion of diatoms in the periphytic community decreases with the higher trophic state and flooding age of the post-mining lakes. Cyanobacteria and mobile diatom forms prevailed later in the growing season, suggesting that they could utilise nutrients released from the accumulated periphyton biomass. Calcium ions were one of the best correlates of species data among other abiotic variables tested, offering the intriguing question of the role of calcium in the formation of periphytic mats for future research.
Keywords	Bacillariophyceae ; Cyanobacteria ; autotrophs ; biomass ; calcium ; habitats ; lakes ; littoral zone ; multivariate analysis ; periphyton ; species diversity ; watersheds ; Czech Republic
Language	English
Dates of publication	2023-01
Size	p. 21
Publishing place	Springer International Publishing
Document type	Article ; Online
ZDB-ID	1464021-1
ISSN	1420-9055 ; 1015-1621
ISSN (online)	1420-9055
ISSN	1015-1621
DOI	10.1007/s00027-022-00914-y
Database	NAL-Catalogue (AGRICOLA)

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Article: Contrasting Patterns of Soil Chemistry and Vegetation Cover Determine Diversity Changes of Soil Phototrophs Along an Afrotropical Elevation Gradient

Řeháková, Klára / Čapková, Kateřina / Altman, Jan / Dančák, Martin / Majeský, Ľuboš / Doležal, Jiří

Ecosystems. 2022 Aug., v. 25, no. 5

2022

Abstract: Soil phototrophic microbes play key roles in many ecosystem functions, including nutrient cycling, water absorption and retention, substrate weathering and soil stabilization, as well as colonization and persistence of other organisms. Knowledge about ... ...

Abstract	Soil phototrophic microbes play key roles in many ecosystem functions, including nutrient cycling, water absorption and retention, substrate weathering and soil stabilization, as well as colonization and persistence of other organisms. Knowledge about the diversity and biomass of soil phototrophs remains limited, especially in tropical forests and savannas. Here, we investigate changes in the diversity and abundance of soil phototrophs across the 4-km elevation gradient on Mt. Cameroon, Africa, from tropical forests (0–2300 m) to treeless savanna (2300–3600 m) and afroalpine vegetation (3600–4000 m). We evaluated the role of soil chemistry and vegetation cover in shaping phototrophic diversity patterns using soil, tree and herb census data from 224 permanent plots. Cyanobacteria from Chroococcales accounted for 65% of the species richness and > 70% of the biovolume. The highest phototrophic diversity and biovolume were recorded in treeless savanna and afroalpine vegetation, and lowest values in mid-elevation tropical forests with dense understory vegetation and hence limited light availability. Higher diversity and biovolume of soil phototrophs were associated with less productive, well-illuminated soils with lower organic matter and nitrogen content and higher pH, phosphorus and cation content. Changes in microbial richness and biovolume across tropical forests showed a U-shaped elevation pattern, with higher values recorded in coastal and lowland forests up to 1000 m elevation, the lowest values in the mid-elevation open-canopy forests with dense understory vegetation caused by disturbances of forest elephants and higher values again in montane forests between 1800 and 2200 m. Above the tree line, soil phototrophic biovolume also showed a U-shaped elevation pattern, with lower richness recorded in compact grasslands between 2700 and 3400 m. At lower-elevation savanna, soil phototrophs are indirectly supported by regular fires during the dry season, which reduces plant cover and increases soil phosphorus and cations, while barren lava fields at higher elevations around the summit support soil phototrophs directly via increased soil P and K content and indirectly by inhibiting plant growth and vegetation cover. Our results shed light on an overlooked part of soil biodiversity in major tropical ecosystems and uncover the role of various ecological filters in structuring phototrophic microbial communities in tropical soils.
Keywords	Afrotropical region ; Chroococcales ; altitude ; autotrophs ; biomass ; cations ; census data ; dry season ; ecosystems ; lava ; nitrogen content ; organic matter ; pH ; phosphorus ; plant growth ; savannas ; soil chemistry ; soil stabilization ; species richness ; treeline ; trees ; understory ; vegetation cover ; water uptake ; Cameroon
Language	English
Dates of publication	2022-08
Size	p. 1020-1036.
Publishing place	Springer US
Document type	Article
ZDB-ID	1428921-0
ISSN	1435-0629 ; 1432-9840
ISSN (online)	1435-0629
ISSN	1432-9840
DOI	10.1007/s10021-021-00698-6
Database	NAL-Catalogue (AGRICOLA)

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