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  1. Article ; Online: Holmium laser with MOSES technology (MoLEP) vs Thulium fiber laser enucleation of the prostate (ThuFLEP) in a real-world setting. Mid-term outcomes from a multicenter propensity score analysis.

    Castellani, Daniele / Di Rosa, Mirko / Gómez Sancha, Fernando / Rodríguez Socarrás, Moisés / Mahajan, Abhay / Taif Bendigeri, Mohammed / Taratkin, Mark / Enikeev, Dmitry / Dellabella, Marco / Gadzhiev, Nariman / Somani, Bhaskar Kumar / Herrmann, Thomas R W / Gauhar, Vineet

    World journal of urology

    2023  Volume 41, Issue 11, Page(s) 2915–2923

    Abstract: Purpose: To compare Holmium laser with MOSES technology (MoLEP) and Thulium fiber laser ...

    Abstract Purpose: To compare Holmium laser with MOSES technology (MoLEP) and Thulium fiber laser enucleation of the prostate (ThuFLEP) in terms of surgical and functional outcomes.
    Methods: We performed a retrospective analysis of all patients who underwent either procedure in five centers (January 2020-January 2022).
    Exclusion criteria: previous urethral/prostatic surgery, radiotherapy, concomitant surgery. Propensity score matching (PSM) analysis was performed to adjust for the bias inherent to the different characteristics at baseline. Differences between procedures were estimated using Firth Penalized Likelihood regression for International prostate symptom score (IPSS), quality of life (QL), maximum flow rate (Qmax).
    Results: PSM retrieved 118 patients in each group. Baseline characteristics were similar except for PSA and number of men on indwelling catheter (higher in MoLEP group). Median surgical time was significantly longer in the MoLEP group despite the enucleation and morcellation times being similar. Median catheter dwelling time and postoperative length of stay were similar. Most of the early complications were Clavien ≤ 2 grade. There were only two Clavien grade 3 complications (one for each group), one grade 4 in MoLEP group. Rate and type of early and persistent incontinence (> 3 months) were similar. At 12-month, proportion of patients reaching a decrease (Δ) of IPSS ≥ 18 from baseline was significantly larger in MoLEP group, with no significant difference in ΔQmax > 12 ml/sec and ΔQL ≥ -3.
    Conclusion: MoLEP and ThuFLEP were safe and efficacious procedures with similar short-term operative and functional outcomes. At 1-year, MoLEP patients had a sustained reduction of IPPS score.
    MeSH term(s) Male ; Humans ; Prostate/surgery ; Lasers, Solid-State/therapeutic use ; Thulium/therapeutic use ; Prostatic Hyperplasia/surgery ; Quality of Life ; Retrospective Studies ; Propensity Score ; Treatment Outcome ; Laser Therapy/methods
    Chemical Substances Thulium (8RKC5ATI4P)
    Language English
    Publishing date 2023-07-29
    Publishing country Germany
    Document type Multicenter Study ; Journal Article
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-023-04524-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1832: Show issues Location:
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  2. Article ; Online: En Bloc enucleation with early apical release technique using MOSES (En Bloc MoLEP) vs. classic En Bloc HoLEP: a single arm study comparing intra- and postoperative outcomes.

    Socarrás, Moisés Rodríguez / Del Álamo, Julio Fernández / Espósito, Fabio / Elbers, Javier Reinoso / Monsalve, Diego Carrión / Rivas, Juan Gómez / Greco, Isabella / González, Luis LLanes / Rivera, Vanesa Cuadros / Sancha, Fernando Gómez

    World journal of urology

    2022  Volume 41, Issue 1, Page(s) 159–165

    Abstract: Background and purpose: We aimed to describe the technique and outcomes of En-Bloc MOSES laser ... enucleation of the prostate (En-Bloc MoLEP) with early apical release comparing it to En-Bloc HoLEP (non-MOSES ... treated by En Bloc HoLEP (non-MOSES), in total n = 217 patients.: Results: En-Bloc MoLEP, showed ...

    Abstract Background and purpose: We aimed to describe the technique and outcomes of En-Bloc MOSES laser enucleation of the prostate (En-Bloc MoLEP) with early apical release comparing it to En-Bloc HoLEP (non-MOSES).
    Patients and methods: This is a single-arm prospective study, using a historical control. n = 80 patients were enrolled to the En Bloc MoLEP group and compared to a retrospective group of n = 137 patients treated by En Bloc HoLEP (non-MOSES), in total n = 217 patients.
    Results: En-Bloc MoLEP, showed to significantly improve the surgical time by 32% compared to non-MOSES HoLEP (32.16 ± 14.46 min, 47.58 ± 21.32, respectively; P = 0.003). Enucleation time, ablation rate and hemostasis time were also significantly improved (P < 0.001, for all three parameters). Enucleation time was 22.10 ± 9.27 min and 31.46 ± 14.85 min (P < 0.001), ablation rate 4.11 ± 2.41 and 2.54 ± 1.31 gr/min (P < 0.001), Hemostasis time 3.01 ± 2.50 and 8.35 ± 5.38 min (P < 0.001), for En Bloc MoLEP and En Bloc HoLEP, respectively. Q-max, PVR, PSA and IPSS showed significant improvement, however, at 12 months no significant differences were observed comparing both groups.
    Conclusions: En-Bloc MoLEP was significantly better than En-Bloc HoLEP in terms of surgical time, enucleation time, ablation rate and hemostasis time. However, large comparative RCT with long-term follow-up are needed.
    MeSH term(s) Humans ; Male ; Holmium ; Laser Therapy/methods ; Lasers, Solid-State/therapeutic use ; Prospective Studies ; Prostatic Hyperplasia/surgery ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Holmium (W1XX32SQN1)
    Language English
    Publishing date 2022-11-05
    Publishing country Germany
    Document type Clinical Trial ; Journal Article
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-022-04205-x
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    Zs.A 1832: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: En bloc MoLEP (MOSES HoLEP) with early apical dissection and preservation of the sphincter's mucosa. Surgical technique and technology developments that allow a new paradigm of endoscopic prostate enucleation.

    Rodríguez Socarrás, Moisés / Fernández Del Álamo, Julio / Gómez Rivas, Juan / Gómez Sancha, Fernando

    Archivos espanoles de urologia

    2020  Volume 73, Issue 8, Page(s) 689–698

    Abstract: ... of pulse modulation for Holmium generators (MOSES) as well as high-speed morcellators. Second ...

    Title translation MoLEP (MOSES HoLEP) en bloque con liberación apical precoz y preservación de la mucosa esfinteriana. Evolución de la técnica quirúrgica y la tecnológica que permiten un nuevo paradigma de enucleación endoscópica anatómica de próstata.
    Abstract Endoscopic enucleation of the prostate was first described by Hiraoka in 1986, using a monopolar resectoscope. His contribution was largely ignored until Gilling and Fraundorfer published their three-lobe enucleation technique with the Holmium laser in 1998 ,that ended establishing itself as a reliable option for the treatment of HBP, backed by ample scientific evidence. Later on, enucleation performed with other lasers, as well as bipolar energy, have shown concordance in their clinical results. As a result, the term AEEP (anatomic endoscopic enucleation of the prostate) emerged to encompass all these techniques. During the last few years there have been significant advances in two areas: first, technology, with the development of pulse modulation for Holmium generators (MOSES) as well as high-speed morcellators. Second, the development of new surgical techniques that recognize the importance of the early release of the sphincter from the apex of the adenoma during the operation as well as the careful preservation of the external sphincter's mucosa, to avoid early stress incontinence. In this paper,we review the recent evolution of both technology and surgical technique. AEEP has been risen to a new level, reducing operative time significantly, usually under one hour, and radically reducing the incidence of early temporary stress incontinence, and maybe also facilitating the learning curve of AEEP.
    MeSH term(s) Endoscopy/instrumentation ; Humans ; Industrial Development ; Lasers, Solid-State/therapeutic use ; Male ; Prostatectomy ; Prostatic Hyperplasia/surgery
    Language Spanish
    Publishing date 2020-10-07
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 211673-x
    ISSN 0004-0614
    ISSN 0004-0614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Advances in multiple sclerosis and experimental demyelinating diseases

    Rodriguez, Moses

    (Current topics in microbiology and immunology ; 318)

    2008  

    Author's details Moses Rodriguez, ed
    Series title Current topics in microbiology and immunology ; 318
    Collection
    Keywords Multiple Sklerose ; Entmarkungskrankheit ; Tiermodell
    Subject Demyelinisierungskrankheit ; Encephalomyelitis disseminata
    Language English
    Size XIV, 360 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT015385730
    ISBN 978-3-540-73676-9 ; 9783540736776 ; 3-540-73676-X ; 3540736778
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Ud II Zs 24 -318- verfügbar in Königswinter Königswinter

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  5. Book: Multiple sclerosis

    Rodriguez, Moses / Kantarci, Orhun H. / Pirko, Istvan

    (Contemporary neurology series ; 84)

    2013  

    Author's details Moses Rodriguez ; Orhun H. Kantarci ; Istvan Pirko
    Series title Contemporary neurology series ; 84
    Collection
    Keywords Multiple Sclerosis
    Language English
    Size XIII, 199 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT017726591
    ISBN 978-0-19-974046-8 ; 978-0-19-997019-3 ; 0-19-974046-1 ; 0-19-997019-X
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2013 A 2011 available for loan (reading room) Lesesaal EG

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  6. Article ; Online: Alectinib-induced rash unresponsive to desensitization: a case report and literature review.

    Rodriguez, Robin Raquel / Dindak, Jessie / Kline, Janet / Raj, Moses S

    BMC pulmonary medicine

    2023  Volume 23, Issue 1, Page(s) 261

    Abstract: Background: Since the inception of targeted therapies in treating lung cancer, providers have had to be aware of a new host of side effects when selecting management options for patients. Although targeted therapies are creating increased hope for ... ...

    Abstract Background: Since the inception of targeted therapies in treating lung cancer, providers have had to be aware of a new host of side effects when selecting management options for patients. Although targeted therapies are creating increased hope for patients with non-small cell lung cancers (NSCLC), understanding their side effects presents a challenge for providers. Alectinib, a second-generation tyrosine kinase inhibitor, is a targeted therapy used in patients with non-small cell lung cancer found to have anaplastic lymphoma kinase (ALK) mutations. Alectinib is the focus of this case report and literature review as we seek to understand side effects providers may encounter when prescribing these therapies.
    Case presentation: We begin our report with the case of a 63-year-old Hispanic female with stage IIIA non-small cell lung cancer found to have the ALK genomic alteration. She was started on Alectinib, and on Day 11, she developed a severe maculopapular rash requiring hospitalization. After complete resolution, desensitization with Alectinib was attempted but unsuccessful.
    Conclusions: Despite the unsuccessful desensitization of this patient, it is important to report this rare side effect in order to better understand how providers can pursue management. Case reports such as this can aid providers in potentially preventing, treating, and rechallenging patients on targeted therapies in the future.
    MeSH term(s) Humans ; Female ; Middle Aged ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Receptor Protein-Tyrosine Kinases/genetics ; Receptor Protein-Tyrosine Kinases/therapeutic use ; Protein Kinase Inhibitors/adverse effects ; Exanthema/chemically induced ; Exanthema/drug therapy ; Drug-Related Side Effects and Adverse Reactions
    Chemical Substances alectinib (LIJ4CT1Z3Y) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Protein Kinase Inhibitors
    Language English
    Publishing date 2023-07-15
    Publishing country England
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-023-02558-6
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  7. Article: Using natural language from a smartphone pregnancy app to identify maternal depression.

    Krishnamurti, Tamar / Allen, Kristen / Hayani, Laila / Rodriguez, Samantha / Rothenberger, Scott / Moses-Kolko, Eydie / Simhan, Hyagriv

    Research square

    2023  

    Abstract: Depression is highly prevalent in pregnancy, yet it often goes undiagnosed and untreated. Language can be an indicator of psychological well-being. This longitudinal, observational cohort study of 1,274 pregnancies examined written language shared in a ... ...

    Abstract Depression is highly prevalent in pregnancy, yet it often goes undiagnosed and untreated. Language can be an indicator of psychological well-being. This longitudinal, observational cohort study of 1,274 pregnancies examined written language shared in a prenatal smartphone app. Natural language feature of text entered in the app (e.g. in a journaling feature) throughout the course of participants' pregnancies were used to model subsequent depression symptoms. Language features were predictive of incident depression symptoms in a 30-day window (AUROC = 0.72) and offer insights into topics most salient in the writing of individuals experiencing those symptoms. When natural language inputs were combined with self-reported current mood, a stronger predictive model was produced (AUROC = 0.84). Pregnancy apps are a promising way to illuminate experiences contributing to depression symptoms. Even sparse language and simple patient-reports collected directly from these tools may support earlier, more nuanced depression symptom identification.
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-2583296/v1
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  8. Article ; Online: Quality of Care in Family Planning Services: Differences Between Formal and Informal Settlements of Kira Municipality, Uganda.

    Lukyamuzi, Zubair / Tetui, Moses / Fonseca-Rodríguez, Osvaldo / Atuyambe, Lynn / Makumbi, Fredrick Edward / Baroudi, Mazen

    Frontiers in global women's health

    2021  Volume 2, Page(s) 656616

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-08-13
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-5059
    ISSN (online) 2673-5059
    DOI 10.3389/fgwh.2021.656616
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  9. Article ; Online: Remyelination therapies for multiple sclerosis: optimizing translation from animal models into clinical trials.

    Sutiwisesak, Rujapope / Burns, Terry C / Rodriguez, Moses / Warrington, Arthur E

    Expert opinion on investigational drugs

    2021  Volume 30, Issue 8, Page(s) 857–876

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Animals ; Disease Models, Animal ; Humans ; Multiple Sclerosis/physiopathology ; Multiple Sclerosis/therapy ; Myelin Sheath/metabolism ; Myelin Sheath/pathology ; Oligodendroglia/cytology ; Remyelination
    Language English
    Publishing date 2021-06-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2021.1942840
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    Zs.A 3739: Show issues Location:
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  10. Article ; Online: Glial cells as therapeutic targets in progressive multiple sclerosis.

    Wilbanks, Brandon / Maher, L J / Rodriguez, Moses

    Expert review of neurotherapeutics

    2019  Volume 19, Issue 6, Page(s) 481–494

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Animals ; Disease Progression ; Humans ; Multiple Sclerosis/drug therapy ; Neuroglia/drug effects ; Remyelination/drug effects
    Language English
    Publishing date 2019-05-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2112534-X
    ISSN 1744-8360 ; 1473-7175
    ISSN (online) 1744-8360
    ISSN 1473-7175
    DOI 10.1080/14737175.2019.1614443
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