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Book: Organofluorine compounds in biology and medicine

Reddy, V. Prakash

2015

Author's details	V. Prakash Reddy
Keywords	Organofluorine compounds ; Organofluorine compounds--Therapeutic use.
Subject code	615.31
Language	English
Size	XVII, 312 S. : Ill., graph. Darst., 23 cm
Publisher	Elsevier
Publishing place	Amsterdam u.a.
Publishing country	Netherlands
Document type	Book
HBZ-ID	HT018556364
ISBN	978-0-444-53748-5 ; 0-444-53748-1
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2015 A 804	available for loan (reading room)	Lesesaal EG

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Article: Oxidative Stress in Health and Disease.

Reddy, V Prakash

Biomedicines

2023 Volume 11, Issue 11

Abstract: Oxidative stress, resulting from the excessive intracellular accumulation of reactive oxygen species (ROS), reactive nitrogen species (RNS), and other free radical species, contributes to the onset and progression of various diseases, including diabetes, ...

Abstract	Oxidative stress, resulting from the excessive intracellular accumulation of reactive oxygen species (ROS), reactive nitrogen species (RNS), and other free radical species, contributes to the onset and progression of various diseases, including diabetes, obesity, diabetic nephropathy, diabetic neuropathy, and neurological diseases, such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and Parkinson's disease (PD). Oxidative stress is also implicated in cardiovascular disease and cancer. Exacerbated oxidative stress leads to the accelerated formation of advanced glycation end products (AGEs), a complex mixture of crosslinked proteins and protein modifications. Relatively high levels of AGEs are generated in diabetes, obesity, AD, and other I neurological diseases. AGEs such as N
Language	English
Publishing date	2023-10-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11112925
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Special Issue: Microbiota-Gut-Brain Axis.

Obrenovich, Mark / Reddy, V Prakash

Microorganisms

2022 Volume 10, Issue 2

Abstract: There is emerging evidence that human health and disease are modulated by the microbiota and their various metabolites, formed through intestinal and gut bacterial metabolism [ ... ]. ...

Abstract	There is emerging evidence that human health and disease are modulated by the microbiota and their various metabolites, formed through intestinal and gut bacterial metabolism [...].
Language	English
Publishing date	2022-01-28
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10020309
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Photocatalyst-free visible-light triggered amination of benzo[

Murugesh, V / Reddy, Patlolla Ravinder / Singh, Surya Prakash

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 8, Page(s) 1034–1037

Abstract: The photoredox amination of arene protocols mostly comprises photocatalyst-mediated transformations. Herein, we presented the photocatalyst-free, visible-light promoted, direct conversion of C( ... ...

Abstract	The photoredox amination of arene protocols mostly comprises photocatalyst-mediated transformations. Herein, we presented the photocatalyst-free, visible-light promoted, direct conversion of C(sp
MeSH term(s)	Amination ; Catalysis ; Molecular Structure ; Amines/chemistry ; Thiadiazoles
Chemical Substances	Amines ; Thiadiazoles
Language	English
Publishing date	2023-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d2cc05811a
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Development of an ammonia-biodiesel dual fuel combustion engine's injection strategy map using response surface optimization and artificial neural network prediction.

Elumalai, R / Ravi, K / Elumalai, P V / Sreenivasa Reddy, M / Prakash, E / Sekar, Prabhakar

Scientific reports

2024 Volume 14, Issue 1, Page(s) 543

Abstract: The study intends to calibrate the compression ignition (CI) engine split injection parameters as efficiently. The goal of the study is to find the best split injection parameters for a dual-fuel engine that runs on 40% ammonia and 60% biodiesel at 80% ... ...

Abstract	The study intends to calibrate the compression ignition (CI) engine split injection parameters as efficiently. The goal of the study is to find the best split injection parameters for a dual-fuel engine that runs on 40% ammonia and 60% biodiesel at 80% load and a constant speed of 1500 rpm with the CRDi system. To optimize and forecast split injection settings, the RSM and an ANN model are created. Based on the experimental findings, the RSM optimization research recommends a per-injection timing of 54 °CA bTDC, a main injection angle of 19 °CA bTDC, and a pilot mass of 42%. As a result, in comparison to the unoptimized map, the split injection optimized calibration map increases BTE by 12.33% and decreases BSEC by 6.60%, and the optimized map reduces HC, CO, smoke, and EGT emissions by 15.68%, 21.40%, 18.82, and 17.24%, while increasing NOx emissions by 15.62%. RSM optimization with the most desirable level was selected for map development, and three trials were carried out to predict the calibrated map using ANN. According to the findings, the ANN predicted all responses with R > 0.99, demonstrating the real-time reproducibility of engine variables in contrast to the RSM responses. The experimental validation of the predicted data has an error range of 1.03-2.86%, which is acceptable.
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-51023-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: RAGE Inhibitors in Neurodegenerative Diseases.

Reddy, V Prakash / Aryal, Puspa / Soni, Pallavi

Biomedicines

2023 Volume 11, Issue 4

Abstract: Nonenzymatic reactions of reducing sugars with primary amino groups of amino acids, proteins, and nucleic acids, followed by oxidative degradations would lead to the formation of advanced glycation endproducts (AGEs). The AGEs exert multifactorial ... ...

Abstract	Nonenzymatic reactions of reducing sugars with primary amino groups of amino acids, proteins, and nucleic acids, followed by oxidative degradations would lead to the formation of advanced glycation endproducts (AGEs). The AGEs exert multifactorial effects on cell damage leading to the onset of neurological disorders. The interaction of AGEs with the receptors for advanced glycation endproducts (RAGE) contribute to the activation of intracellular signaling and the expression of the pro-inflammatory transcription factors and various inflammatory cytokines. This inflammatory signaling cascade is associated with various neurological diseases, including Alzheimer's disease (AD), secondary effects of traumatic brain injury (TBI), amyotrophic lateral sclerosis (ALS), and diabetic neuropathy, and other AGE-related diseases, including diabetes and atherosclerosis. Furthermore, the imbalance of gut microbiota and intestinal inflammation are also associated with endothelial dysfunction, disrupted blood-brain barrier (BBB) and thereby the onset and progression of AD and other neurological diseases. AGEs and RAGE play an important role in altering the gut microbiota composition and thereby increase the gut permeability and affect the modulation of the immune-related cytokines. The inhibition of the AGE-RAGE interactions, through small molecule-based therapeutics, prevents the inflammatory cascade of events associated with AGE-RAGE interactions, and thereby attenuates the disease progression. Some of the RAGE antagonists, such as Azeliragon, are currently in clinical development for treating neurological diseases, including AD, although currently there have been no FDA-approved therapeutics based on the RAGE antagonists. This review outlines the AGE-RAGE interactions as a leading cause of the onset of neurological diseases and the current efforts on developing therapeutics for neurological diseases based on the RAGE antagonists.
Language	English
Publishing date	2023-04-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11041131
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Special Issue: Microbiota–Gut–Brain Axis

Obrenovich, Mark / Reddy, V. Prakash

Microorganisms. 2022 Jan. 28, v. 10, no. 2

2022

Abstract: There is emerging evidence that human health and disease are modulated by the microbiota and their various metabolites, formed through intestinal and gut bacterial metabolism [ ... ] ...

Abstract	There is emerging evidence that human health and disease are modulated by the microbiota and their various metabolites, formed through intestinal and gut bacterial metabolism [...]
Keywords	human health ; intestines ; metabolism ; metabolites ; microorganisms
Language	English
Dates of publication	2022-0128
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10020309
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Development of an ammonia-biodiesel dual fuel combustion engine's injection strategy map using response surface optimization and artificial neural network prediction

R. Elumalai / K. Ravi / P. V. Elumalai / M. Sreenivasa Reddy / E. Prakash / Prabhakar Sekar

Scientific Reports, Vol 14, Iss 1, Pp 1-

2024 Volume 18

Abstract: Abstract The study intends to calibrate the compression ignition (CI) engine split injection parameters as efficiently. The goal of the study is to find the best split injection parameters for a dual-fuel engine that runs on 40% ammonia and 60% biodiesel ...

Abstract	Abstract The study intends to calibrate the compression ignition (CI) engine split injection parameters as efficiently. The goal of the study is to find the best split injection parameters for a dual-fuel engine that runs on 40% ammonia and 60% biodiesel at 80% load and a constant speed of 1500 rpm with the CRDi system. To optimize and forecast split injection settings, the RSM and an ANN model are created. Based on the experimental findings, the RSM optimization research recommends a per-injection timing of 54 °CA bTDC, a main injection angle of 19 °CA bTDC, and a pilot mass of 42%. As a result, in comparison to the unoptimized map, the split injection optimized calibration map increases BTE by 12.33% and decreases BSEC by 6.60%, and the optimized map reduces HC, CO, smoke, and EGT emissions by 15.68%, 21.40%, 18.82, and 17.24%, while increasing NOx emissions by 15.62%. RSM optimization with the most desirable level was selected for map development, and three trials were carried out to predict the calibrated map using ANN. According to the findings, the ANN predicted all responses with R > 0.99, demonstrating the real-time reproducibility of engine variables in contrast to the RSM responses. The experimental validation of the predicted data has an error range of 1.03–2.86%, which is acceptable.
Keywords	Medicine ; R ; Science ; Q
Subject code	600
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Advanced Glycation End Products in Health and Disease.

Reddy, V Prakash / Aryal, Puspa / Darkwah, Emmanuel K

Microorganisms

2022 Volume 10, Issue 9

Abstract: Advanced glycation end products (AGEs), formed through the nonenzymatic reaction of reducing sugars with the side-chain amino groups of lysine or arginine of proteins, followed by further glycoxidation reactions under oxidative stress conditions, are ... ...

Abstract	Advanced glycation end products (AGEs), formed through the nonenzymatic reaction of reducing sugars with the side-chain amino groups of lysine or arginine of proteins, followed by further glycoxidation reactions under oxidative stress conditions, are involved in the onset and exacerbation of a variety of diseases, including diabetes, atherosclerosis, and Alzheimer's disease (AD) as well as in the secondary stages of traumatic brain injury (TBI). AGEs, in the form of intra- and interprotein crosslinks, deactivate various enzymes, exacerbating disease progression. The interactions of AGEs with the receptors for the AGEs (RAGE) also result in further downstream inflammatory cascade events. The overexpression of RAGE and the AGE-RAGE interactions are especially involved in cases of Alzheimer's disease and other neurodegenerative diseases, including TBI and amyotrophic lateral sclerosis (ALS). Maillard reactions are also observed in the gut bacterial species. The protein aggregates found in the bacterial species resemble those of AD and Parkinson's disease (PD), and AGE inhibitors increase the life span of the bacteria. Dietary AGEs alter the gut microbiota composition and elevate plasma glycosylation, thereby leading to systemic proinflammatory effects and endothelial dysfunction. There is emerging interest in developing AGE inhibitor and AGE breaker compounds to treat AGE-mediated pathologies, including diabetes and neurodegenerative diseases. Gut-microbiota-derived enzymes may also function as AGE-breaker biocatalysts. Thus, AGEs have a prominent role in the pathogenesis of various diseases, and the AGE inhibitor and AGE breaker approach may lead to novel therapeutic candidates.
Language	English
Publishing date	2022-09-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10091848
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Advanced Glycation End Products in Health and Disease

Reddy, V. Prakash / Aryal, Puspa / Darkwah, Emmanuel K.

Microorganisms. 2022 Sept. 15, v. 10, no. 9

2022

Abstract	Advanced glycation end products (AGEs), formed through the nonenzymatic reaction of reducing sugars with the side-chain amino groups of lysine or arginine of proteins, followed by further glycoxidation reactions under oxidative stress conditions, are involved in the onset and exacerbation of a variety of diseases, including diabetes, atherosclerosis, and Alzheimer’s disease (AD) as well as in the secondary stages of traumatic brain injury (TBI). AGEs, in the form of intra- and interprotein crosslinks, deactivate various enzymes, exacerbating disease progression. The interactions of AGEs with the receptors for the AGEs (RAGE) also result in further downstream inflammatory cascade events. The overexpression of RAGE and the AGE-RAGE interactions are especially involved in cases of Alzheimer’s disease and other neurodegenerative diseases, including TBI and amyotrophic lateral sclerosis (ALS). Maillard reactions are also observed in the gut bacterial species. The protein aggregates found in the bacterial species resemble those of AD and Parkinson’s disease (PD), and AGE inhibitors increase the life span of the bacteria. Dietary AGEs alter the gut microbiota composition and elevate plasma glycosylation, thereby leading to systemic proinflammatory effects and endothelial dysfunction. There is emerging interest in developing AGE inhibitor and AGE breaker compounds to treat AGE-mediated pathologies, including diabetes and neurodegenerative diseases. Gut-microbiota-derived enzymes may also function as AGE-breaker biocatalysts. Thus, AGEs have a prominent role in the pathogenesis of various diseases, and the AGE inhibitor and AGE breaker approach may lead to novel therapeutic candidates.
Keywords	amyotrophic lateral sclerosis ; arginine ; atherosclerosis ; brain damage ; crosslinking ; diabetes ; digestive system ; disease progression ; glycosylation ; intestinal microorganisms ; longevity ; lysine ; oxidative stress ; pathogenesis ; therapeutics
Language	English
Dates of publication	2022-0915
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10091848
Database	NAL-Catalogue (AGRICOLA)

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