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Article ; Online: Changes in Motor Competence of 4-8-Year-Old Children: A Longitudinal Study.

Koolwijk, Pim / de Jonge, Ester / Mombarg, Remo / Remmers, Teun / Van Kann, Dave / van Aart, Ingrid / Savelsbergh, Geert / de Vries, Sanne

International journal of environmental research and public health

2024 Volume 21, Issue 2

Abstract: Objectives: The development of children's motor competence (MC) from early to middle childhood can follow different courses. The purpose of this longitudinal study was to describe and quantify the prevalence of patterns of MC development from early to ... ...

Abstract	Objectives: The development of children's motor competence (MC) from early to middle childhood can follow different courses. The purpose of this longitudinal study was to describe and quantify the prevalence of patterns of MC development from early to middle childhood and to identify undesirable patterns. Design: The study used a longitudinal design. Data were collected in three consecutive years, between February 2020 (T0) and May 2022 (T2). Methods: A total of 1128 typically developing Dutch children (50.2% male) between 4 and 6 years old at baseline (M = 5.35 ± 0.69 years) participated in this study. MC was measured with the Athletic Skills Track and converted into Motor Quotient (MQ) scores. To convert all individual MQ scores into meaningful patterns of MC development, changes in MQ categories were analyzed between the different timepoints. Results: A total of 11 different developmental patterns were found. When grouping the different patterns, five undesirable patterns were found with 18.2% of the children, showing an undesirable pattern of MC development between T0 and T2. The patterns of motor development of the other children showed a normal or fluctuating course. Conclusions: There is a lot of variation in MC in early and middle childhood. A substantial percentage of young children showed undesirable MC developmental patterns emphasizing the need for early and targeted interventions.
MeSH term(s)	Humans ; Male ; Child ; Child, Preschool ; Female ; Longitudinal Studies ; Motor Skills ; Sports ; Ethnicity
Language	English
Publishing date	2024-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph21020190
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: Isolation and functional characterization of hybrid mouse monoclonal antibodies

Koolwijk, Pieter

= De isolatie en funktionele karakterisering van hybride muize monoklonale antilichamen

1990

Title variant	De isolatie en funktionele karakterisering van hybride muize monoklonale antilichamen
Author's details	door Pieter Koolwijk
Size	139 S. : graph. Darst.
Publishing country	Netherlands
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Utrecht, Rijksuniv., Diss., 1990
Note	Zsfassung in niederländ. Sprache
HBZ-ID	HT003935259
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Article ; Online: Prehospital coagulation measurement by a portable blood analyzer in a helicopter emergency medical service (HEMS).

Schober, Patrick / Bossers, Sebastiaan M / Koolwijk, Jasper / Terra, Maartje / Schwarte, Lothar A

The American journal of emergency medicine

2021 Volume 46, Page(s) 137–140

Abstract: In helicopter emergency medical services, HEMS, coagulopathy presents both in trauma (e.g. consumption of coagulation factors) and non-trauma cases (e.g. anticoagulant use). Therefore, in HEMS coagulation measurements appear promising and Prothrombin ... ...

Abstract	In helicopter emergency medical services, HEMS, coagulopathy presents both in trauma (e.g. consumption of coagulation factors) and non-trauma cases (e.g. anticoagulant use). Therefore, in HEMS coagulation measurements appear promising and Prothrombin Time (PT) and derived INR are attractive variables herein. We tested the feasibility of prehospital PT/INR coagulation measurements in HEMS. This study was performed at the Dutch HEMS, using a portable blood analyzer (i-Stat®1, Abbott). PT/INR measurements were performed on (hemodiluted) author's blood, and both trauma- and non-trauma HEMS patients. Device-related benefits of the i-Stat PT/INR system were portability, speed and ease of handling. Limitations included a rather narrow operational temperature range (16-30 °C). PT/INR measurements (n = 15) were performed on hemodiluted blood, and both trauma and non-trauma patients. The PT/INR results confirmed effects of hemodilution and anticoagulation, however, most measurement results were in the normal INR-range (0.9-1.2). We conclude that prehospital PT/INR measurements, although with limitations, are feasible in HEMS operations.
MeSH term(s)	Air Ambulances ; Aircraft ; Blood Chemical Analysis/instrumentation ; Blood Coagulation Disorders/diagnosis ; Emergency Medical Services ; Humans ; Netherlands ; Point-of-Care Testing
Language	English
Publishing date	2021-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2021.04.023
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Article ; Online: Executive function and extremely preterm children.

Chung, Paul J / Opipari, Valerie P / Koolwijk, Irene

Pediatric research

2017 Volume 82, Issue 4, Page(s) 565–566

MeSH term(s)	Child ; Cognition ; Executive Function ; Humans ; Infant, Extremely Premature ; Infant, Newborn ; Neuropsychological Tests
Language	English
Publishing date	2017-08-30
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/pr.2017.184
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Article ; Online: Applying an ecosystem approach to explore modifiable factors related to the risk for low motor competence in young children.

Van Kann, D H H / Koolwijk, P / de Kok, T / Vos, S B / de Vries, S I / Mombarg, R / van Aart, I / Savelsbergh, G J P / Hoeboer, J J M M / Remmers, T

Journal of science and medicine in sport

2022 Volume 25, Issue 11, Page(s) 890–895

Abstract: Objectives: Early childhood is a crucial phase for motor development in which differences between children can manifest. These differences might be related to factors in ecosystems in which children are raised, of which little is currently known. The ... ...

Abstract	Objectives: Early childhood is a crucial phase for motor development in which differences between children can manifest. These differences might be related to factors in ecosystems in which children are raised, of which little is currently known. The current study's purpose was to explore which modifiable factors in children's ecosystems are associated with the odds for low versus higher motor competence (MC) in 4- to 6-year-old children. Design: A cross-sectional study design was conducted to investigate which modifiable social and physical factors in the home environment and direct living environment were associated with differences in MC. Methods: Children's MC was measured through the Athletic Skills Track in 612 4- to 6-year-olds, from 10 primary schools in Eindhoven, the Netherlands. Parenting practices, characteristics of the home environment, and perceptions of the direct living environment were assessed through parental questionnaires. Hierarchical logistic regression analyses were conducted to evaluate factors associated with low MC in children. Results: The presence of a garden at home and higher perceived sports facilities in the direct living environment decreased the likelihood of children being classified as low MC. Moreover, stronger parental active transportation routines and more discouraging physical activity parenting practices resulted in lower odds of low MC. In addition, girls were more at risk for low MC. Conclusions: Characteristics of the social and physical home environment and direct living environment were associated with MC disparities during early childhood. Both parenting practices and parental physical activity-involved behaviours are relevant modifiable factors related to differences in children's MC.
MeSH term(s)	Child ; Female ; Child, Preschool ; Humans ; Ecosystem ; Cross-Sectional Studies ; Exercise ; Parents ; Sports
Language	English
Publishing date	2022-08-29
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1437829-2
ISSN	1878-1861 ; 1440-2440
ISSN (online)	1878-1861
ISSN	1440-2440
DOI	10.1016/j.jsams.2022.08.014
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Article ; Online: Therapeutic Potential of Human-Derived Endothelial Colony-Forming Cells in Animal Models.

Tasev, Dimitar / Koolwijk, Pieter / van Hinsbergh, Victor W M

Tissue engineering. Part B, Reviews

2016 Volume 22, Issue 5, Page(s) 371–382

Abstract: Purpose of review: Tissue regeneration requires proper vascularization. In vivo studies identified that the endothelial colony-forming cells (ECFCs), a subtype of endothelial progenitor cells that can be isolated from umbilical cord or peripheral blood, ...

Abstract	Purpose of review: Tissue regeneration requires proper vascularization. In vivo studies identified that the endothelial colony-forming cells (ECFCs), a subtype of endothelial progenitor cells that can be isolated from umbilical cord or peripheral blood, represent a promising cell source for therapeutic neovascularization. ECFCs not only are able to initiate and facilitate neovascularization in diseased tissue but also can, by acting in a paracrine manner, contribute to the creation of favorable conditions for efficient and appropriate differentiation of tissue-resident stem or progenitor cells. This review outlines the progress in the field of in vivo regenerative and tissue engineering studies and surveys why, when, and how ECFCs can be used for tissue regeneration. Recent findings: Reviewed literature that regard human-derived ECFCs in xenogeneic animal models implicates that ECFCs should be considered as an endothelial cell source of preference for induction of neovascularization. Their neovascularization and regenerative potential is augmented in combination with other types of stem or progenitor cells. Biocompatible scaffolds prevascularized with ECFCs interconnect faster and better with the host vasculature. The physical incorporation of ECFCs in newly formed blood vessels grants prolonged release of trophic factors of interest, which also makes ECFCs an interesting cell source candidate for gene therapy and delivery of bioactive compounds in targeted area. Summary: ECFCs possess all biological features to be considered as a cell source of preference for tissue engineering and repair of blood supply. Investigation of regenerative potential of ECFCs in autologous settings in large animal models before clinical application is the next step to clearly outline the most efficient strategy for using ECFCs as treatment.
Language	English
Publishing date	2016-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2420584-9
ISSN	1937-3376 ; 1937-3368
ISSN (online)	1937-3376
ISSN	1937-3368
DOI	10.1089/ten.TEB.2016.0050
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Article ; Online: Extracorporeal cardiopulmonary resuscitation for refractory OHCA: lessons from three randomized controlled trials-the trialists' view.

Ubben, Johannes F H / Heuts, Samuel / Delnoij, Thijs S R / Suverein, Martje M / van de Koolwijk, Anina F / van der Horst, Iwan C C / Maessen, Jos G / Bartos, Jason / Kavalkova, Petra / Rob, Daniel / Yannopoulos, Demetris / Bělohlávek, Jan / Lorusso, Roberto / van de Poll, Marcel C G

European heart journal. Acute cardiovascular care

2023 Volume 12, Issue 8, Page(s) 540–547

Abstract: Extracorporeal cardiopulmonary resuscitation is a promising treatment for refractory out-of-hospital cardiac arrest. Three recent randomized trials (ARREST trial, Prague OHCA study, and INCEPTION trial) that addressed the clinical benefit of ... ...

Abstract	Extracorporeal cardiopulmonary resuscitation is a promising treatment for refractory out-of-hospital cardiac arrest. Three recent randomized trials (ARREST trial, Prague OHCA study, and INCEPTION trial) that addressed the clinical benefit of extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest yielded seemingly diverging results. The evidence for extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest, derived from three recent randomized controlled trials, is not contradictory but rather complementary. Excellent results can be achieved with a very high level of dedication, provided that strict selection criteria are applied. However, pragmatic implementation of extracorporeal cardiopulmonary resuscitation does not necessarily lead to improved outcome of refractory out-of-hospital cardiac arrest. Centres that are performing extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest or aspire to do so should critically evaluate whether they are able to meet the pre-requisites that are needed to conduct an effective extracorporeal cardiopulmonary resuscitation programme.
MeSH term(s)	Humans ; Cardiopulmonary Resuscitation ; Out-of-Hospital Cardiac Arrest/therapy ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-07-21
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2663340-1
ISSN	2048-8734 ; 2048-8726
ISSN (online)	2048-8734
ISSN	2048-8726
DOI	10.1093/ehjacc/zuad071
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Article ; Online: Endothelial cells enhance adipose mesenchymal stromal cell-mediated matrix contraction via ALK receptors and reduced follistatin: Potential role of endothelial cells in skin fibrosis.

Monsuur, Hanneke N / van den Broek, Lenie J / Koolwijk, Pieter / Niessen, Frank B / Gibbs, Susan

Journal of cellular physiology

2018 Volume 233, Issue 10, Page(s) 6714–6722

Abstract: Abnormal cutaneous wound healing can lead to formation of fibrotic hypertrophic scars. Although several clinical risk factors have been described, the cross-talk between different cell types resulting in hypertrophic scar formation is still poorly ... ...

Abstract	Abnormal cutaneous wound healing can lead to formation of fibrotic hypertrophic scars. Although several clinical risk factors have been described, the cross-talk between different cell types resulting in hypertrophic scar formation is still poorly understood. The aim of this in vitro study was to investigate whether endothelial cells (EC) may play a role in skin fibrosis, for example, hypertrophic scar formation after full-thickness skin trauma. Using a collagen/elastin matrix, we developed an in vitro fibrosis model to study the interaction between EC and dermal fibroblasts or adipose tissue-derived mesenchymal stromal cells (ASC). Tissue equivalents containing dermal fibroblasts and EC displayed a normal phenotype. In contrast, tissue equivalents containing ASC and EC displayed a fibrotic phenotype indicated by contraction of the matrix, higher gene expression of ACTA2, COL1A, COL3A, and less secretion of follistatin. The contraction was in part mediated via the TGF-β pathway, as both inhibition of the ALK4/5/7 receptors and the addition of recombinant follistatin resulted in decreased matrix contraction (75 ± 11% and 24 ± 8%, respectively). In conclusion, our study shows that EC may play a critical role in fibrotic events, as seen in hypertrophic scars, by stimulating ASC-mediated matrix contraction via regulation of fibrosis-related proteins.
MeSH term(s)	Actins/genetics ; Activin Receptors, Type I/genetics ; Anaplastic Lymphoma Kinase/genetics ; Cell Line ; Cell Movement/genetics ; Cicatrix, Hypertrophic/genetics ; Cicatrix, Hypertrophic/pathology ; Endothelial Cells/metabolism ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Fibrosis/genetics ; Fibrosis/pathology ; Follistatin/pharmacology ; Humans ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cells/pathology ; Receptor, Transforming Growth Factor-beta Type I/genetics ; Skin/injuries ; Skin/metabolism ; Skin/pathology ; Wound Healing/genetics
Chemical Substances	ACTA2 protein, human ; Actins ; Follistatin ; Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; ACVR1B protein, human (EC 2.7.11.30) ; ACVR1C protein, human (EC 2.7.11.30) ; Activin Receptors, Type I (EC 2.7.11.30) ; Receptor, Transforming Growth Factor-beta Type I (EC 2.7.11.30) ; TGFBR1 protein, human (EC 2.7.11.30)
Language	English
Publishing date	2018-05-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.26494
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Article ; Online: IL-6 counteracts the inhibitory effect of IL-4 on osteogenic differentiation of human adipose stem cells.

Bastidas-Coral, Angela P / Hogervorst, Jolanda M A / Forouzanfar, Tymour / Kleverlaan, Cornelis J / Koolwijk, Pieter / Klein-Nulend, Jenneke / Bakker, Astrid D

Journal of cellular physiology

2019 Volume 234, Issue 11, Page(s) 20520–20532

Abstract: Fracture repair is characterized by cytokine production and hypoxia. To better predict cytokine modulation of mesenchymal stem cell (MSC)-aided bone healing, we investigated whether interleukin 4 (IL-4), IL-6, and their combination, affect osteogenic ... ...

Abstract	Fracture repair is characterized by cytokine production and hypoxia. To better predict cytokine modulation of mesenchymal stem cell (MSC)-aided bone healing, we investigated whether interleukin 4 (IL-4), IL-6, and their combination, affect osteogenic differentiation, vascular endothelial growth factor (VEGF) production, and/or mammalian target of rapamycin complex 1 (mTORC1) activation by MSCs under normoxia or hypoxia. Human adipose stem cells (hASCs) were cultured with IL-4, IL-6, or their combination for 3 days under normoxia (20% O
MeSH term(s)	Adipose Tissue/cytology ; Adult ; Bone Development/drug effects ; Cell Differentiation/drug effects ; Cell Differentiation/physiology ; Cell Proliferation ; Female ; Gene Expression Regulation/drug effects ; Humans ; Interleukin-4/pharmacology ; Interleukin-6/pharmacology ; Middle Aged ; Osteogenesis/drug effects ; Osteogenesis/physiology ; Oxygen ; Stem Cells/drug effects ; Stem Cells/physiology ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	IL4 protein, human ; Interleukin-6 ; Vascular Endothelial Growth Factor A ; Interleukin-4 (207137-56-2) ; Oxygen (S88TT14065)
Language	English
Publishing date	2019-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.28652
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Book: Floh & Pieks

Koolwijk, Pieter / Faas, Linde / Hachmeister, Sylke

allerbeste Freunde

2013

Title translation	Vlo en Stiekel <dt.>
Author's details	Pieter Koolwijk. Dt. von Sylke Hachmeister. Mit Bildern von Linde Faas
Keywords	Mädchen ; Junge ; Verschiedenheit ; Freundschaft ; Selbstbehauptung
Language	German
Size	134 S., Ill., 210 mm x 145 mm
Publisher	Oetinger
Publishing place	Hamburg
Document type	Book
ISBN	3789140562 ; 9783789140563
Database	Former special subject collection: coastal and deep sea fishing

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