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Article ; Online: Adolescents' Out-of-School Physical Activity Levels and Well-Being during the COVID-19 Restrictions in Greece: A Longitudinal Study.

Lazaridis, Alexandros / Syrmpas, Ioannis / Tsatalas, Themistoklis / Krommidas, Charalampos / Digelidis, Nikolaos

Journal of functional morphology and kinesiology

2023 Volume 8, Issue 2

Abstract: The present study aimed to identify the impact of social distancing measures on adolescents' physical activity (PA) levels and well-being during the implementation of COVID-19 restrictive measures. There were 438 participants (207 boys and 231 girls), ... ...

Abstract	The present study aimed to identify the impact of social distancing measures on adolescents' physical activity (PA) levels and well-being during the implementation of COVID-19 restrictive measures. There were 438 participants (207 boys and 231 girls), aged 12 to 15 years old (
Language	English
Publishing date	2023-05-04
Publishing country	Switzerland
Document type	Journal Article
ISSN	2411-5142
ISSN (online)	2411-5142
DOI	10.3390/jfmk8020055
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Book ; Thesis: Zum Krankheitsbild des Sinus Pilonidalis

Lazaridis, Charalampos

1977

Author's details	vorgelegt von Charalampos Lazaridis
Size	1 Mikrofiche
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Saarbrücken, Univ., Diss., 1978
Note	Mikroreprod. e. Ms. 73 Bl.: Ill., graph. Darst.
HBZ-ID	HT002604822
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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Article ; Online: The usability and effect of an mHealth disease management platform on the quality of life of patients with paroxysmal atrial fibrillation - The emPOWERD-AF study.

Lazaridis, Charalampos / Bakogiannis, Constantinos / Mouselimis, Dimitrios / Tsarouchas, Anastasios / Antoniadis, Antonios P / Triantafyllou, Konstantinos / Fragakis, Nikolaos / Vassilikos, Vassilios P

Health informatics journal

2022 Volume 28, Issue 4, Page(s) 14604582221139053

Abstract: Atrial fibrillation (AF) is the most common arrhythmia. myAlgos is an mHealth disease management system consisting of physician-oriented platform and patient-oriented smartphone app. Our purpose was to assess the usability of myAlgos by physicians and ... ...

Abstract	Atrial fibrillation (AF) is the most common arrhythmia. myAlgos is an mHealth disease management system consisting of physician-oriented platform and patient-oriented smartphone app. Our purpose was to assess the usability of myAlgos by physicians and patients and the effect of myAlgos on the quality of life (QoL) in patients with paroxysmal AF (PAF). Physicians rated the platform with the Post-Study System Usability Questionnaire (PSSUQ). Patients rated the app with the mHealth App Usability Questionnaire (MAUQ). The e-medicine Platform for Optimizing the Workflow in hEaRt Diseases (emPOWERD-AF) study investigated the effect of myAlgos in PAF patients randomized to full/control version. QoL was measured by the Atrial Fibrillation Effect on QualiTy-of-life (AFEQT) and 5-level EQ-5D (EQ-5D-5L) questionnaires. myAlgos got a PSSUQ score of 2.52 ± 0.36 by five physicians and a MAUQ score of 79.9% by 33 patients. In emPOWERD-AF, 80 patients were randomized 1:1 (58.1 ± 8.7 years, 66% male). The median AFEQT change at 6 months was +2.63% in full version users and -1.63% in controls (
MeSH term(s)	Humans ; Male ; Female ; Atrial Fibrillation/therapy ; Quality of Life ; Surveys and Questionnaires ; Telemedicine ; Disease Management
Language	English
Publishing date	2022-05-25
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2213115-2
ISSN	1741-2811 ; 1460-4582
ISSN (online)	1741-2811
ISSN	1460-4582
DOI	10.1177/14604582221139053
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Article ; Online: The role of patient-oriented mHealth interventions in improving heart failure outcomes: A systematic review of the literature.

Mouselimis, Dimitrios / Tsarouchas, Anastasios / Vassilikos, Vassilios P / Mitsas, Angelos C / Lazaridis, Charalampos / Androulakis, Emmanuel / Briasoulis, Alexandros / Kampaktsis, Polydoros / Papadopoulos, Christodoulos E / Bakogiannis, Constantinos

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

2023

Abstract: Heart failure (HF) is a debilitating disease with 26 million patients worldwide. Consistent and complex self-care is required on the part of patients to adequately adhere to medication and to the lifestyle changes that the disease necessitates. Mobile ... ...

Abstract	Heart failure (HF) is a debilitating disease with 26 million patients worldwide. Consistent and complex self-care is required on the part of patients to adequately adhere to medication and to the lifestyle changes that the disease necessitates. Mobile health (mHealth) is being increasingly incorporated in patient interventions in HF, as smartphones prove to be ideal platforms for patient education and self-help assistance. This systematic review aims to summarize and report on all studies that have tested the effect of mHealth on HF patient outcomes. Our search yielded 17 studies, namely 11 randomized controlled trials and six non-randomized prospective studies. In these, patients with the assistance of an mHealth intervention regularly measured their blood pressure and/or body weight and assessed their symptoms. The outcomes were mostly related to hospitalizations, clinical biomarkers, patients' knowledge about HF, quality of life (QoL) and quality of self-care. QoL consistently increased in patients who received mHealth interventions, while study results on all other outcomes were not as ubiquitously positive. The first mHealth interventions in HF were not universally successful in improving patient outcomes but provided valuable insights for patient-oriented application development. Future trials are expected to build on these insights and deploy applications that measurably assist HF patients.
Language	English
Publishing date	2023-11-04
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2215027-4
ISSN	2241-5955 ; 1109-9666
ISSN (online)	2241-5955
ISSN	1109-9666
DOI	10.1016/j.hjc.2023.11.001
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Article: P-Wave Beat-to-Beat Analysis to Predict Atrial Fibrillation Recurrence after Catheter Ablation.

Tachmatzidis, Dimitrios / Tsarouchas, Anastasios / Mouselimis, Dimitrios / Filos, Dimitrios / Antoniadis, Antonios P / Lysitsas, Dimitrios N / Mezilis, Nikolaos / Sakellaropoulou, Antigoni / Giannopoulos, Georgios / Bakogiannis, Constantinos / Triantafyllou, Konstantinos / Fragakis, Nikolaos / Letsas, Konstantinos P / Asvestas, Dimitrios / Efremidis, Michael / Lazaridis, Charalampos / Chouvarda, Ioanna / Vassilikos, Vassilios P

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 4

Abstract: The identification of patients prone to atrial fibrillation (AF) relapse after catheter ablation is essential for better patient selection and risk stratification. The current prospective cohort study aims to validate a novel P-wave index based on beat- ... ...

Abstract	The identification of patients prone to atrial fibrillation (AF) relapse after catheter ablation is essential for better patient selection and risk stratification. The current prospective cohort study aims to validate a novel P-wave index based on beat-to-beat (B2B) P-wave morphological and wavelet analysis designed to detect patients with low burden AF as a predictor of AF recurrence within a year after successful catheter ablation. From a total of 138 consecutive patients scheduled for AF ablation, 12-lead ECG and 10 min vectorcardiogram (VCG) recordings were obtained. Univariate analysis revealed that patients with higher B2B P-wave index had a two-fold risk for AF recurrence (HR: 2.35, 95% CI: 1.24-4.44,
Language	English
Publishing date	2022-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12040830
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Article ; Online: Clinical frailty, and not features of acute infection, is associated with late mortality in COVID-19: a retrospective cohort study.

Vlachogiannis, Nikolaos I / Baker, Kenneth F / Georgiopoulos, Georgios / Lazaridis, Charalampos / van der Loeff, Ina Schim / Hanrath, Aidan T / Sopova, Kateryna / Tual-Chalot, Simon / Gatsiou, Aikaterini / Spyridopoulos, Ioakim / Stamatelopoulos, Kimon / Duncan, Christopher J A / Stellos, Konstantinos

Journal of cachexia, sarcopenia and muscle

2022 Volume 13, Issue 3, Page(s) 1502–1513

Abstract: Background: Coronavirus disease 2019 (COVID-19) is associated with excess mortality after hospital discharge. Identification of patients at increased risk of death following hospital discharge is needed to guide clinical monitoring and early ... ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) is associated with excess mortality after hospital discharge. Identification of patients at increased risk of death following hospital discharge is needed to guide clinical monitoring and early intervention. Herein, we aimed to identify predictors of early vs. late mortality in COVID-19 patients. Methods: A total of 471 patients with polymerase chain reaction-confirmed COVID-19 were followed up for 9 months [median (inter-quartile range) of follow-up time: 271 (14) days] after hospital admission. COVID-19-related signs and symptoms, laboratory features, co-morbidities, Coronavirus Clinical Characterisation Consortium (4C) mortality and Clinical Frailty Scale (CFS) scores were analysed by logistic regression for association with early (28 day) vs. late mortality. Receiver operating characteristic (ROC) analysis was used to determine the discriminative value of 4C and CFS scores for early vs. late mortality. Results: A total of 120 patients died within 28 days from hospital admission. Of the remaining 351 patients, 41 died within the next 8 months. Respiratory failure, systemic inflammation, and renal impairment were associated with early mortality, while active cancer and dementia were associated with late mortality, after adjustment for age and sex. 4C mortality score and CFS were associated with both early [odds ratio (OR) (95% confidence interval-CI): 4C: 1.34 (1.25-1.45); CFS: 1.49 (1.33-1.66)] and late [OR (95% CI): 4C: 1.23 (1.12-1.36); CFS: 2.04 (1.62-2.56)] mortality. After adjustment for CFS, the association between 4C and late mortality was lost. By ROC analysis, 4C mortality score was superior to CFS for 28 day mortality [area under the curve (AUC) (95% CI): 0.779 (0.732-0.825) vs. 0.723 (0.673-0.773), respectively; P = 0.039]. In contrast, CFS had higher predictive value for late mortality compared with 4C mortality score [AUC (95% CI): 0.830 (0.776-0.883) vs. 0.724 (0.650-0.798), respectively; P = 0.007]. Conclusions: In our cohort, late mortality in COVID-19 patients is more strongly associated with premorbid clinical frailty than with severity of the acute infection phase.
MeSH term(s)	COVID-19 ; Cohort Studies ; Frailty/diagnosis ; Humans ; Retrospective Studies
Language	English
Publishing date	2022-03-07
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2586864-0
ISSN	2190-6009 ; 2190-5991
ISSN (online)	2190-6009
ISSN	2190-5991
DOI	10.1002/jcsm.12966
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Article ; Online: Involvement of cardiovascular system as the critical point in coronavirus disease 2019 (COVID-19) prognosis and recovery.

Lazaridis, Charalampos / Vlachogiannis, Nikolaos I / Bakogiannis, Constantinos / Spyridopoulos, Ioakim / Stamatelopoulos, Kimon / Kanakakis, Ioannis / Vassilikos, Vassilios / Stellos, Konstantinos

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

2020 Volume 61, Issue 6, Page(s) 381–395

Abstract: The novel coronavirus disease 2019 (COVID-19) pandemic has already caused more than 300,000 deaths worldwide. Several studies have elucidated the central role of cardiovascular complications in the disease course. Herein, we provide a concise review of ... ...

Abstract	The novel coronavirus disease 2019 (COVID-19) pandemic has already caused more than 300,000 deaths worldwide. Several studies have elucidated the central role of cardiovascular complications in the disease course. Herein, we provide a concise review of current knowledge regarding the involvement of cardiovascular system in the pathogenesis and prognosis of COVID-19. We summarize data from 21 studies involving in total more than 21,000 patients from Asia, Europe, and the USA indicating that severe disease is associated with the presence of myocardial injury, heart failure, and arrhythmias. Additionally, we present the clinical and laboratory differences between recovered and deceased patients highlighting the importance of cardiac manifestations. For the infected patients, underlying cardiovascular comorbidities and particularly existing cardiovascular disease seem to predispose to the development of cardiovascular complications, which are in turn associated with higher mortality rates. We provide mechanistic insights into the underlying mechanisms including direct myocardial damage by the virus and the consequences of the hyperinflammatory syndrome developed later in the disease course. Finally, we summarize current knowledge on therapeutic modalities and recommendations by scientific societies and experts regarding the cardiovascular management of patients with COVID-19.
MeSH term(s)	COVID-19/complications ; COVID-19/diagnosis ; COVID-19/mortality ; COVID-19/physiopathology ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/therapy ; Cardiovascular Diseases/virology ; Cardiovascular System/immunology ; Cardiovascular System/physiopathology ; Cardiovascular System/virology ; Comorbidity ; Disease Management ; Humans ; Mortality ; Prognosis ; SARS-CoV-2/pathogenicity
Keywords	covid19
Language	English
Publishing date	2020-06-10
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2215027-4
ISSN	2241-5955 ; 1109-9666
ISSN (online)	2241-5955
ISSN	1109-9666
DOI	10.1016/j.hjc.2020.05.004
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Article ; Online: Syncope without prodromes is associated with excessive plasma release of adenosine at the time of syncope during head-up tilt table test.

Fragakis, Nikolaos / Antoniadis, Antonios P / Sotiriadou, Melani / Virgiliou, Christina / Ballauri, Iris / Gika, Helen G / Bougiouklis, Dimitrios / Gerou, Spyros / Lazaridis, Charalampos / Vergopoulos, Stavros / Bakogiannis, Constantinos / Giannopoulos, Georgios / Theodoridis, Georgios A / Papadopoulos, Christodoulos E / Karamitsos, Theodoros D / Vassilikos, Vassilios

International journal of cardiology

2022 Volume 363, Page(s) 43–48

Abstract: Background: In syncopal patients without underlying structural disease, we sought to investigate the association of Adenosine Plasma Levels (ADP) with the clinical presentation of neurally mediated syncope (NMS) and the outcomes of Head-Up Tilt Table ... ...

Abstract	Background: In syncopal patients without underlying structural disease, we sought to investigate the association of Adenosine Plasma Levels (ADP) with the clinical presentation of neurally mediated syncope (NMS) and the outcomes of Head-Up Tilt Table Test (HUTT) and Adenosine test (ADT). Methods: We studied 124 patients with different clinical types of NMS, i.e., Vasovagal (VVS, n=58), non-prodromes (NPS, n=18), or situational syncope (SS, n=48), using a standard protocol including HUTT and ADT. During HUTT, ADP was measured in the supine position, at table tilting and in syncope. Results: Baseline ADP did not differ among groups. ADP at syncope were higher in NPS (n=5) compared to VVS (n=20): 0.23 vs. 0.12 μΜ, p=0.03, and SS (n=22): 0.04 μΜ, p=0.02. In NPS, ADP increased from supine to syncope (n=5): 0.15 vs. 0.23 μΜ, p=0.04. In VVS, ADP increased only from supine to tilt position: 0.11 vs. 0.14 μΜ, p=0.02. In SS, ADP did not change during HUTT. In positive vasodepressor HUTT, ADP increased from supine to tilt position (p=0.002) and at syncope (p=0.01). In SS, 20.0% exhibited cardioinhibitory HUTT vs. 6.8% in other forms of syncope (p=0.04). In SS, 22.9% manifested positive ADT vs 6.6% in other types of syncope (p=0.012). Conclusion: The subset of NPS patients with positive HUTT, show excessive ADP release at the time of syncope. This may explain the lack of prodromes in this form of syncope. Such observations contribute to the understanding of distinct profiles of clinical forms of syncope and may differentiate the management approach accordingly.
MeSH term(s)	Adenosine ; Adenosine Diphosphate ; Humans ; Syncope/diagnosis ; Syncope, Vasovagal/diagnosis ; Tilt-Table Test/methods
Chemical Substances	Adenosine Diphosphate (61D2G4IYVH) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2022-06-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2022.06.045
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Article: Beat-to-Beat P-Wave Analysis Outperforms Conventional P-Wave Indices in Identifying Patients with a History of Paroxysmal Atrial Fibrillation during Sinus Rhythm.

Tachmatzidis, Dimitrios / Filos, Dimitrios / Chouvarda, Ioanna / Tsarouchas, Anastasios / Mouselimis, Dimitrios / Bakogiannis, Constantinos / Lazaridis, Charalampos / Triantafyllou, Konstantinos / Antoniadis, Antonios P / Fragakis, Nikolaos / Efthimiadis, Georgios / Maglaveras, Nicos / Tsalikakis, Dimitrios G / Vassilikos, Vassilios P

Diagnostics (Basel, Switzerland)

2021 Volume 11, Issue 9

Abstract: Early identification of patients at risk for paroxysmal atrial fibrillation (PAF) is essential to attain optimal treatment and a favorable prognosis. We compared the performance of a beat-to-beat (B2B) P-wave analysis with that of standard P-wave indices ...

Abstract	Early identification of patients at risk for paroxysmal atrial fibrillation (PAF) is essential to attain optimal treatment and a favorable prognosis. We compared the performance of a beat-to-beat (B2B) P-wave analysis with that of standard P-wave indices (SPWIs) in identifying patients prone to PAF. To this end, 12-lead ECG and 10 min vectorcardiogram (VCG) recordings were obtained from 33 consecutive, antiarrhythmic therapy naïve patients, with a short history of low burden PAF, and from 56 age- and sex-matched individuals with no AF history. For both groups, SPWIs were calculated, while the VCG recordings were analyzed on a B2B basis, and the P-waves were classified to a primary or secondary morphology. Wavelet transform was used to further analyze P-wave signals of main morphology. Univariate analysis revealed that none of the SPWIs performed acceptably in PAF detection, while five B2B features reached an AUC above 0.7. Moreover, multivariate logistic regression analysis was used to develop two classifiers-one based on B2B analysis derived features and one using only SPWIs. The B2B classifier was found to be superior to SPWIs classifier; B2B AUC: 0.849 (0.754-0.917) vs. SPWIs AUC: 0.721 (0.613-0.813),
Language	English
Publishing date	2021-09-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics11091694
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Article ; Online: Involvement of cardiovascular system as the critical point in coronavirus disease 2019 (COVID-19) prognosis and recovery

Lazaridis, Charalampos / Vlachogiannis, Nikolaos I. / Bakogiannis, Constantinos / Spyridopoulos, Ioakim / Stamatelopoulos, Kimon / Kanakakis, Ioannis / Vassilikos, Vassilios / Stellos, Konstantinos

Hellenic Journal of Cardiology ; ISSN 1109-9666

2020

Keywords	Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.1016/j.hjc.2020.05.004
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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