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Article: Mechanisms of Diabetic Nephropathy Not Mediated by Hyperglycemia.

Viggiano, Davide

2023 Volume 12, Issue 21

Abstract: Diabetes mellitus (DM) is characterized by the appearance of progressive kidney damage, which may progress to end-stage kidney disease. The control of hyperglycemia is usually not sufficient to halt this progression. The kidney damage is quantitatively ... ...

Abstract	Diabetes mellitus (DM) is characterized by the appearance of progressive kidney damage, which may progress to end-stage kidney disease. The control of hyperglycemia is usually not sufficient to halt this progression. The kidney damage is quantitatively and qualitatively different in the two forms of diabetes; the typical nodular fibrosis (Kimmelstiel Wilson nodules) appears mostly in type 1 DM, whereas glomerulomegaly is primarily present in type 2 obese DM. An analysis of the different metabolites and hormones in type 1 and type 2 DM and their differential pharmacological treatments might be helpful to advance the hypotheses on the different histopathological patterns of the kidneys and their responses to sodium/glucose transporter type 2 inhibitors (SGLT2i).
Language	English
Publishing date	2023-10-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12216848
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Article ; Online: Temperature-dependent kinetic measurements and quasi-classical trajectory studies for the OH(+) + H2/D2 → H2O(+)/HDO(+) + H/D reactions.

Martinez, Oscar / Ard, Shaun G / Li, Anyang / Shuman, Nicholas S / Guo, Hua / Viggiano, Albert A

The Journal of chemical physics

2015 Volume 143, Issue 11, Page(s) 114310

Abstract: ... a selected ion flow tube apparatus. Reaction occurs via atom abstraction to result in H2O(+)/HDO(+) + H/D ...

Abstract	We have measured the temperature-dependent kinetics for the reactions of OH(+) with H2 and D2 using a selected ion flow tube apparatus. Reaction occurs via atom abstraction to result in H2O(+)/HDO(+) + H/D. Room temperature rate coefficients are in agreement with prior measurements and resulting temperature dependences are T(0.11) for the hydrogen and T(0.25) for the deuterated reactions. This work is prompted in part by recent theoretical work that mapped a full-dimensional global potential energy surface of H3O(+) for the OH(+) + H2 → H + H2O(+) reaction [A. Li and H. Guo, J. Phys. Chem. A 118, 11168 (2014)], and reported results of quasi-classical trajectory calculations, which are extended to a wider temperature range and initial rotational state specification here. Our experimental results are in excellent agreement with these calculations which accurately predict the isotope effect in addition to an enhancement of the reaction rate constant due to the molecular rotation of OH(+). The title reaction is of high importance to astrophysical models, and the temperature dependence of the rate coefficients determined here should now allow for better understanding of this reaction at temperatures more relevant to the interstellar medium.
Language	English
Publishing date	2015-09-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/1.4931109
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Article ; Online: A Reanalysis of Historical Figures With Depression and Dropsy.

Viggiano, Davide / Widmer, David

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

2023 Volume 21, Issue Suppl 2, Page(s) 33–37

Abstract: Objectives: Recent studies suggest a link between chronic kidney disease and brain dysfunctions such as depression and cognitive problems. A review of medieval and early-modern historical figures with aspects of both kidney disease (gout and edema [ ... ...

Abstract	Objectives: Recent studies suggest a link between chronic kidney disease and brain dysfunctions such as depression and cognitive problems. A review of medieval and early-modern historical figures with aspects of both kidney disease (gout and edema [dropsy]) and depression (melancholia) shows that these conditions were observed together in the past. Materials and methods: References to the diseases of gout, dropsy, and melancholia were compared in literature on historical subjects. Case studies are reported to detail a previously unremarked com-bination of current kidney disease and depression comorbidity in historical writings. Results: The poet Boccaccio had gout and melancholia, and some descendants of the Portuguese Avis and Spanish Trastàmara dynasties, known for melancholia and madness, also had gout and dropsy. Historical case series of causes of death for sultans of the Ottoman Empire suggest an association among dropsy, gout, and melancholia. Conclusions: In this article, we reviewed the medical research on the comorbidity of kidney disease and depression and shared case studies of historical figures with these conditions and posit not previously noted data supporting comorbidity observations in historical writings.
MeSH term(s)	Humans ; Depression/diagnosis ; Depression/epidemiology ; Depressive Disorder/epidemiology ; Edema ; Comorbidity ; Gout
Language	English
Publishing date	2023-07-26
Publishing country	Turkey
Document type	Review ; Journal Article
ZDB-ID	2396778-X
ISSN	2146-8427 ; 1304-0855
ISSN (online)	2146-8427
ISSN	1304-0855
DOI	10.6002/ect.IAHNCongress.08
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Article: Wall Tension and Tubular Resistance in Kidney Cystic Conditions.

Della Corte, Michele / Viggiano, Davide

Biomedicines

2023 Volume 11, Issue 6

Abstract: The progressive formation of single or multiple cysts accompanies several renal diseases. Specifically, (i) genetic forms, such as adult dominant polycystic kidney disease (ADPKD), and (ii) acquired cystic kidney disease (ACKD) are probably the most ... ...

Abstract	The progressive formation of single or multiple cysts accompanies several renal diseases. Specifically, (i) genetic forms, such as adult dominant polycystic kidney disease (ADPKD), and (ii) acquired cystic kidney disease (ACKD) are probably the most frequent forms of cystic diseases. Adult dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by multiple kidney cysts and systemic alterations. The genes responsible for the condition are known, and a large amount of literature focuses on the molecular description of the mechanism. The present manuscript shows that a multiscale approach that considers supramolecular physical phenomena captures the characteristics of both ADPKD and acquired cystic kidney disease (ACKD) from the pathogenetic and therapeutical point of view, potentially suggesting future treatments. We first review the hypothesis of cystogenesis in ADPKD and then focus on ACKD, showing that they share essential pathogenetic features, which can be explained by a localized obstruction of a tubule and/or an alteration of the tubular wall tension. The consequent tubular aneurysms (cysts) follow Laplace's law. Reviewing the public databases, we show that ADPKD genes are widely expressed in various organs, and these proteins interact with the extracellular matrix, thus potentially modifying wall tension. At the kidney and liver level, the authors suggest that altered cell polarity/secretion/proliferation produce tubular regions of high resistance to the urine/bile flow. The increased intratubular pressure upstream increases the difference between the inside (Pi) and the outside (Pe) of the tubules (∆P) and is counterbalanced by lower wall tension by a factor depending on the radius. The latter is a function of tubule length. In adult dominant polycystic kidney disease (ADPKD), a minimal reduction in the wall tension may lead to a dilatation in the tubular segments along the nephron over the years. The initial increase in the tubule radius would then facilitate the progressive expansion of the cysts. In this regard, tubular cell proliferation may be, at least partially, a consequence of the progressive cysts' expansion. This theory is discussed in view of other diseases with reduced wall tension and with cysts and the therapeutic effects of vaptans, somatostatin, SGLT2 inhibitors, and potentially other therapeutic targets.
Language	English
Publishing date	2023-06-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11061750
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Article ; Online: Experimental and theoretical kinetics for the H2O+ + H2/D2 → H3O+/H2DO+ + H/D reactions: observation of the rotational effect in the temperature dependence.

Ard, Shaun G / Li, Anyang / Martinez, Oscar / Shuman, Nicholas S / Viggiano, Albert A / Guo, Hua

The journal of physical chemistry. A

2014 Volume 118, Issue 49, Page(s) 11485–11489

Abstract: Thermal rate coefficients for the title reactions computed using a quasi-classical trajectory method on an accurate global potential energy surface fitted to ∼81,000 high-level ab initio points are compared with experimental values measured between 100 ... ...

Abstract	Thermal rate coefficients for the title reactions computed using a quasi-classical trajectory method on an accurate global potential energy surface fitted to ∼81,000 high-level ab initio points are compared with experimental values measured between 100 and 600 K using a variable temperature selected ion flow tube instrument. Excellent agreement is found across the entire temperature range, showing a subtle, but unusual temperature dependence of the rate coefficients. For both reactions the temperature dependence has a maximum around 350 K, which is a result of H2O(+) rotations increasing the reactivity, while kinetic energy is decreasing the reactivity. A strong isotope effect is found, although the calculations slightly overestimate the kinetic isotope effect. The good experiment-theory agreement not only validates the accuracy of the potential energy surface but also provides more accurate kinetic data over a large temperature range.
Language	English
Publishing date	2014-12-11
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/jp510399v
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Article ; Online: Good shrink bad shrink by Kluft, Richard P.

Viggiano, Darlene

The American journal of clinical hypnosis

2017 Volume 59, Issue 3, Page(s) 316–317

Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	219387-5
ISSN	2160-0562 ; 0002-9157
ISSN (online)	2160-0562
ISSN	0002-9157
DOI	10.1080/00029157.2016.1169725
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Article ; Online: Argon cluster-mediated isolation and vibrational spectra of peroxy and nominally D(3h) isomers of CO3(-) and NO3(-).

Relph, Rachael A / Bopp, Joseph C / Johnson, Mark A / Viggiano, A A

The Journal of chemical physics

2008 Volume 129, Issue 6, Page(s) 64305

Abstract: ... of a species with D(3h) structure. The spectrum of the peroxynitrite isomer, OONO(-), displays intermediate ...

Abstract	Vibrational predissociation spectra are reported for two isomeric forms of the gas-phase ions, CO(3)(-) and NO(3)(-). The peroxy forms, (OOCO(-) and OONO(-)) were isolated using an Ar-mediated synthetic scheme involving exchange of CO and NO for the more weakly bound Ar ligands in O(2)(-)Ar(m) clusters, while the forms based on a central heteroatom (CO(3)(-) and NO(3)(-)) were generated by electron impact on CO(2) and HNO(3) vapor. The simple two-band spectrum of OOCO(-) indicates that it is best described as the O(2)(-) x CO ion-molecule complex, whereas the covalently bound CO(3)(-) form yields a much more complicated vibrational spectrum with bands extending out to 4000 cm(-1). In contrast, the NO(3)(-) ion yields a simple spectrum with only one transition as expected for the antisymmetric NO stretching fundamental of a species with D(3h) structure. The spectrum of the peroxynitrite isomer, OONO(-), displays intermediate complexity that can be largely understood in the context of fundamentals associated with its cis and trans structures previously characterized in an Ar matrix.
Language	English
Publishing date	2008-08-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/1.2958223
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Article ; Online: Activation of pre-synaptic M-type K+ channels inhibits [3H]D-aspartate release by reducing Ca2+ entry through P/Q-type voltage-gated Ca2+ channels.

Luisi, Rosa / Panza, Elisabetta / Barrese, Vincenzo / Iannotti, Fabio Arturo / Viggiano, Davide / Secondo, Agnese / Canzoniero, Lorella Maria Teresa / Martire, Maria / Annunziato, Lucio / Taglialatela, Maurizio

Journal of neurochemistry

2009 Volume 109, Issue 1, Page(s) 168–181

Abstract: ... activator retigabine (RT, 10 microM) inhibited [(3)H]D-aspartate ([(3)H]D-Asp) release and caused membrane ... omega-agatoxin IVA prevented RT-induced inhibition of depolarization-induced [Ca(2+)](i) increase and [(3)H]D-Asp ... modify the increase of [Ca(2+)](i) and the resulting enhancement of [(3)H]D-Asp release induced by [Ca(2+ ...

Abstract	In this study, the functional consequences of the pharmacological modulation of the M-current (I(KM)) on cytoplasmic Ca(2+) intracellular Ca(2+)concentration ([Ca(2+)](i)) changes and excitatory neurotransmitter release triggered by various stimuli from isolated rat cortical synaptosomes have been investigated. K(v)7.2 immunoreactivity was identified in pre-synaptic elements in cortical slices and isolated glutamatergic cortical synaptosomes. In cerebrocortical synaptosomes exposed to 20 mM [K(+)](e), the I(KM) activator retigabine (RT, 10 microM) inhibited [(3)H]D-aspartate ([(3)H]D-Asp) release and caused membrane hyperpolarization; both these effects were prevented by the I(KM) blocker XE-991 (20 microM). The I(KM) activators RT (0.1-30 microM), flupirtine (10 microM) and BMS-204352 (10 microM) inhibited 20 mM [K(+)](e)-induced synaptosomal [Ca(2+)](i) increases; XE-991 (20 microM) abolished RT-induced inhibition of depolarization-triggered [Ca(2+)](i) transients. The P/Q-type voltage-sensitive Ca(2+)channel (VSCC) blocker omega-agatoxin IVA prevented RT-induced inhibition of depolarization-induced [Ca(2+)](i) increase and [(3)H]D-Asp release, whereas the N-type blocker omega-conotoxin GVIA failed to do so. Finally, 10 microM RT did not modify the increase of [Ca(2+)](i) and the resulting enhancement of [(3)H]D-Asp release induced by [Ca(2+)](i) mobilization from intracellular stores, or by store-operated Ca(2+)channel activation. Collectively, the present data reveal that the pharmacological activation of I(KM) regulates depolarization-induced [(3)H]D-Asp release from cerebrocortical synaptosomes by selectively controlling the changes of [Ca(2+)](i) occurring through P/Q-type VSCCs.
MeSH term(s)	Animals ; CHO Cells ; Calcium ; Calcium Channels, P-Type/metabolism ; Calcium Channels, Q-Type/metabolism ; Cricetinae ; Cricetulus ; D-Aspartic Acid/antagonists & inhibitors ; D-Aspartic Acid/metabolism ; Ion Channel Gating/physiology ; KCNQ2 Potassium Channel/metabolism ; Male ; Presynaptic Terminals/metabolism ; Rats ; Rats, Wistar ; Tritium/metabolism
Chemical Substances	Calcium Channels, P-Type ; Calcium Channels, Q-Type ; KCNQ2 Potassium Channel ; Tritium (10028-17-8) ; D-Aspartic Acid (4SR0Q8YD1X) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2009-02-02
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80158-6
ISSN	1471-4159 ; 0022-3042 ; 1474-1644
ISSN (online)	1471-4159
ISSN	0022-3042 ; 1474-1644
DOI	10.1111/j.1471-4159.2009.05945.x
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Article ; Online: How much time does it take to get cognitive impairment in kidney disease?

Viggiano, Davide / Capasso, Giovambattista

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2021 Volume 37, Issue 2, Page(s) 203–204

MeSH term(s)	Cognitive Dysfunction/etiology ; Humans ; Kidney Failure, Chronic
Language	English
Publishing date	2021-08-04
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfab220
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Article: Complex Sleeve Lobectomy Has Lower Postoperative Major Complications Than Pneumonectomy in Patients with Centrally Located Non-Small-Cell Lung Cancer.

Voltolini, Luca / Viggiano, Domenico / Gonfiotti, Alessandro / Borgianni, Sara / Mugnaini, Giovanni / Salvicchi, Alberto / Bongiolatti, Stefano

Cancers

2024 Volume 16, Issue 2

Abstract: Background: Standard sleeve lobectomies are recommended over pneumonectomy (PN), but the efficacy and oncological proficiency of complex sleeve lobectomies (CSLs) have not been completely investigated. The aim of this study was to report our experience ... ...

Abstract	Background: Standard sleeve lobectomies are recommended over pneumonectomy (PN), but the efficacy and oncological proficiency of complex sleeve lobectomies (CSLs) have not been completely investigated. The aim of this study was to report our experience in CSL in patients affected by a centrally located non-small-cell lung cancer (NSCLC), comparing all the variables and outcomes with PN. Methods: From 2014 to 2022, we collected the data of patients who underwent PN and CSL for NSCLC, excluding neuroendocrine tumors, salvage surgery or carinal resection. Regression analysis was used to assess the association between procedures and complications; the Kaplan-Meier method and Cox regression analysis were used to evaluate survival and risk factors of reduced survival. Results: We analyzed Conclusions: Considering that major complications are often associated with mortality after surgery for centrally located NSCLC, CSLs could be considered an alternative to PN while also ensuring comparable survival.
Language	English
Publishing date	2024-01-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16020261
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