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Article ; Online: Assessment of the quality of service in the field of real estate transactions

N. M. Kalinina / E. V. Khrapova

Омский научный вестник: Серия "Общество. История. Современность", Vol 8, Iss 3, Pp 131-

modern methodological approaches

2023 Volume 137

Abstract: This article discusses topical issues related to the assessment of the quality of service in the field of real estate transactions, in particular, the theoretical and methodological approaches to determining the quantitative value of the service quality ... ...

Abstract	This article discusses topical issues related to the assessment of the quality of service in the field of real estate transactions, in particular, the theoretical and methodological approaches to determining the quantitative value of the service quality indicator. The authors summarized the existing methods for determining the estimated value of the service quality indicator, and outlined the subjective aspects of the considered methods. The author’s vision of the methodological support for establishing the estimated values of service quality indicators in the field of real estate transactions is proposed.
Keywords	service ; real estate ; quality of service ; methodology ; evaluation criteria ; efficiency ; History (General) and history of Europe ; D ; Economics as a science ; HB71-74 ; Newspapers ; AN
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Omsk State Technical University, Federal State Budgetary Educational Institution of Higher Education
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prognostic Significance of Tumor-Associated Inflammation in Renal Cell Carcinoma.

Kovaleva, O V / Podlesnaya, P A / Mochalnikova, V V / Kushlinskii, N E / Khromykh, L M / Kalinina, A A / Kazansky, D B / Gratchev, A N

Bulletin of experimental biology and medicine

2024 Volume 176, Issue 3, Page(s) 382–385

Abstract: This study analyzed tumor-associated inflammation by assessing the expression of cyclophilin A (CypA) and TNF in samples of kidney tumors of various histological types. It was shown that different histological types of renal cell carcinoma differed by ... ...

Abstract	This study analyzed tumor-associated inflammation by assessing the expression of cyclophilin A (CypA) and TNF in samples of kidney tumors of various histological types. It was shown that different histological types of renal cell carcinoma differed by the expression of these proteins. Thus, the highest expression of CypA and TNF was observed in papillary and chromophobe kidney cancer, although no correlation with overall bacterial load was found for these tumors. In the case of clear cell renal cell carcinoma, the expression of proinflammatory factors was observed in only half of the cases and directly correlated with the presence of resident bacteria, serving as a favorable prognostic factor for the disease.
MeSH term(s)	Humans ; Carcinoma, Renal Cell/complications ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Prognosis ; Kidney Neoplasms/pathology
Language	English
Publishing date	2024-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	390407-6
ISSN	1573-8221 ; 0007-4888 ; 0365-9615
ISSN (online)	1573-8221
ISSN	0007-4888 ; 0365-9615
DOI	10.1007/s10517-024-06028-9
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Article ; Online: Glutathione Synthesis in Cancer Cells.

Kalinina, E V / Gavriliuk, L A

Biochemistry. Biokhimiia

2020 Volume 85, Issue 8, Page(s) 895–907

Abstract: Tripeptide GSH is associated not only with the control and maintenance of redox cell homeostasis, but also with the processes of detoxification, proliferation, cell differentiation, and regulation of cell death. Disruptions in GSH synthesis and changes ... ...

Abstract	Tripeptide GSH is associated not only with the control and maintenance of redox cell homeostasis, but also with the processes of detoxification, proliferation, cell differentiation, and regulation of cell death. Disruptions in GSH synthesis and changes in the GSH/GSSG ratio are common for many pathological conditions, including malignant neoplasms. Numerous data indicate the importance of GSH and the GSH/GSSG ratio in the regulation of tumor cell viability, in the initiation of tumor development, progression, and drug resistance. However, control of the mechanism of GSH synthesis in malignant tumors remains poorly understood. This review discusses the features of GSH synthesis and its regulation in tumor cells. The role of GSH in the mechanisms of apoptosis, necroptosis, ferroptosis, and autophagy is considered.
MeSH term(s)	Animals ; Apoptosis ; Autophagy ; Cell Differentiation ; Cell Survival ; Gene Expression Regulation, Neoplastic ; Glutathione/biosynthesis ; Humans ; MicroRNAs/genetics ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Oligopeptides/biosynthesis ; Oxidation-Reduction ; Tumor Microenvironment
Chemical Substances	MicroRNAs ; Oligopeptides ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2020-10-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1109-5
ISSN	1608-3040 ; 0006-2979 ; 0320-9717
ISSN (online)	1608-3040
ISSN	0006-2979 ; 0320-9717
DOI	10.1134/S0006297920080052
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Article ; Online: Application of deep learning for bronchial asthma diagnostics using respiratory sound recordings.

Aptekarev, Theodore / Sokolovsky, Vladimir / Furman, Evgeny / Kalinina, Natalia / Furman, Gregory

PeerJ. Computer science

2023 Volume 9, Page(s) e1173

Abstract: Methods of computer-assisted diagnostics that utilize deep learning techniques on recordings of respiratory sounds have been developed to diagnose bronchial asthma. In the course of the study an anonymous database containing audio files of respiratory ... ...

Abstract	Methods of computer-assisted diagnostics that utilize deep learning techniques on recordings of respiratory sounds have been developed to diagnose bronchial asthma. In the course of the study an anonymous database containing audio files of respiratory sound recordings of patients suffering from different respiratory diseases and healthy volunteers has been accumulated and used to train the software and control its operation. The database consists of 1,238 records of respiratory sounds of patients and 133 records of volunteers. The age of tested persons was from 18 months to 47 years. The sound recordings were captured during calm breathing at four points: in the oral cavity, above the trachea, at the chest, the second intercostal space on the right side, and at the point on the back. The developed software provides binary classifications (diagnostics) of the type: "sick/healthy" and "asthmatic patient/non-asthmatic patient and healthy". For small test samples of 50 (control group) to 50 records (comparison group), the diagnostic sensitivity metric of the first classifier was 88%, its specificity metric -86% and accuracy metric -87%. The metrics for the classifier "asthmatic patient/non-asthmatic patient and healthy" were 92%, 82%, and 87%, respectively. The last model applied to analyze 941 records in asthmatic patients indicated the correct asthma diagnosis in 93% of cases. The proposed method is distinguished by the fact that the trained model enables diagnostics of bronchial asthma (including differential diagnostics) with high accuracy irrespective of the patient gender and age, stage of the disease, as well as the point of sound recording. The proposed method can be used as an additional screening method for preclinical bronchial asthma diagnostics and serve as a basis for developing methods of computer assisted patient condition monitoring including remote monitoring and real-time estimation of treatment effectiveness.
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Journal Article
ISSN	2376-5992
ISSN (online)	2376-5992
DOI	10.7717/peerj-cs.1173
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Article ; Online: Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin.

Hasan, Aseel Ali / Tatarskiy, Victor / Kalinina, Elena

International journal of molecular sciences

2022 Volume 23, Issue 22

Abstract: Polyphenols are considered popular ingredients in the pharmaceutical and medical fields due to their preventive and therapeutic properties. However, the potential effects and mechanisms of action of individual polyphenols remain largely unknown. Herein, ... ...

Abstract	Polyphenols are considered popular ingredients in the pharmaceutical and medical fields due to their preventive and therapeutic properties. However, the potential effects and mechanisms of action of individual polyphenols remain largely unknown. Herein, we analyzed recent data on the synthetic pathways, features, and similarity of the properties of quercetin, as the most famous flavonoid, and curcumin, a representative of curcuminoids that despite their anti-oxidant activity, also have a pro-oxidant effect, depending on the concentration and the cellular environment. This review focuses on an analysis of their anti-cancer efficacy against various cancer cell lines via cell cycle arrest (regulation of p53/p21 and CDK/cyclins) and by triggering the mitochondrial intrinsic (Bcl-2/Bax/caspase 9) apoptotic pathway, as well as through the modulation of the signaling pathways (PI3K/Akt, Wnt/β-catenin, JAK/STAT, MAPK, p53, and NF-ĸB) and their influence on the non-coding RNAs involved in angiogenesis, invasion, migration, and metastasis. The therapeutic potential of quercetin and curcumin is discussed not only on the basis of their anti-cancer effects, but also with regard to their anti-diabetic, anti-obesity, anti-inflammatory, and anti-bacterial actions.
MeSH term(s)	Humans ; Curcumin/pharmacology ; Curcumin/therapeutic use ; Quercetin/pharmacology ; Quercetin/therapeutic use ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Apoptosis ; Neoplasms/drug therapy
Chemical Substances	Curcumin (IT942ZTH98) ; Quercetin (9IKM0I5T1E) ; Tumor Suppressor Protein p53 ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
Language	English
Publishing date	2022-11-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232214413
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Article ; Online: Determination of quality criteria for candidate standard for anti-D immunoglobulin

E. N. Kalinina / N. S. Vildanova / E. S. Kormshchikova / A. V. Yovdiy / M. V. Smolnikova

Сибирский научный медицинский журнал, Vol 43, Iss 6, Pp 90-

2024 Volume 100

Abstract: Quality control of medicines is an integral part of the technological cycle, obligatory for the release of products into public distribution. Both in Russia and abroad, when carrying out of laboratory testing of the preparations, it is prescribed to use ... ...

Abstract	Quality control of medicines is an integral part of the technological cycle, obligatory for the release of products into public distribution. Both in Russia and abroad, when carrying out of laboratory testing of the preparations, it is prescribed to use the reference materials – the certified standard samples. Currently, it is important for the Russian pharmaceutical industry to provide the methods for evaluating the specific activity of human anti-D immunoglobulin with a national standard sample. Its production is impossible without the production of stabilized concentrate of anti-D antibodies and verifying the suitability of each batch for sale. This requires the establishment of specification requirements and the development of regulatory documentation.Aim is to define the quality criteria for candidate standard for anti-D immunoglobulin.Material and methods. The national and foreign normative bases in the field of quality control of blood products, manufacturing and application of biological standards of medicines were analyzed. Three series of lyophilized concentrate of anti-D antibodies were obtained and a laboratory-experimental study of their properties was carried out.Results and discussion. As a result of the work done, technical specifications were approved, including a list of consumer characteristics, a description of the methods for their assessment and relevant norms.Conclusions. The established requirements can become the basis for the releasing quality control of the candidate standard for anti-D immunoglobulin during its serial production.
Keywords	human anti-d immunoglobulin ; specific activity ; anti-d antibodies ; standard sample ; Medicine ; R
Subject code	670
Language	Russian
Publishing date	2024-01-01T00:00:00Z
Publisher	Russian Academy of Sciences, Siberian Branch Publishing House
Document type	Article ; Online
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Article: Stimulyator reparatsii al'fa-glutamil-triptofan v kompleksnoi terapii khronicheskogo atroficheskogo gastrita: rezul'taty gistologicheskogo issledovaniya.

Baryshnikova, N V / Uspensky, Yu P / Fominykh, Yu A / Kalinina, E Yu / Krylova, Yu S / Krasnov, A A / Petlenko, S V / Apryatina, V A

Arkhiv patologii

2023 Volume 85, Issue 3, Page(s) 54–63

Abstract: Objective: To study the effect of the repair stimulator alpha-glutamyl-tryptophan on the morphological characteristics of the gastric mucosa and the expression of CXCL-12 and CDX-2 in chronic atrophic gastritis associated with : Material and methods: ...

Title translation	Repair stimulator alpha-glutamyl-tryptophan in the complex therapy of chronic atrophic gastritis: results of histological examination.
Abstract	Objective: To study the effect of the repair stimulator alpha-glutamyl-tryptophan on the morphological characteristics of the gastric mucosa and the expression of CXCL-12 and CDX-2 in chronic atrophic gastritis associated with Material and methods: Biopsy samples of 116 patients with a verified diagnosis of chronic atrophic gastritis associated with Results: In patients taking the studied drug, a statistically significant increase in the number of glands per 1 mm Conclusion: A statistically significant positive effect of the study drug on regenerative mechanisms leading to stabilization and/or improvement of the histological picture in the atrophic area of the gastric mucosa was found in comparison with the control of the initial state and with placebo. The results of an immunohistochemical study to increase CDX-2 expression while taking the study drug can also be regarded as an indicator of improvement in reparative processes.
MeSH term(s)	Humans ; Gastritis, Atrophic/drug therapy ; Gastritis, Atrophic/genetics ; Gastritis, Atrophic/complications ; Tryptophan/analysis ; Tryptophan/metabolism ; Tryptophan/therapeutic use ; Helicobacter Infections/complications ; Helicobacter Infections/drug therapy ; Helicobacter Infections/pathology ; Gastric Mucosa/pathology ; Metaplasia/pathology ; Helicobacter pylori ; Stomach Neoplasms/pathology
Chemical Substances	Tryptophan (8DUH1N11BX)
Language	Russian
Publishing date	2023-06-05
Publishing country	Russia (Federation)
Document type	Randomized Controlled Trial ; Multicenter Study ; English Abstract ; Journal Article
ZDB-ID	127285-8
ISSN	0004-1955
ISSN	0004-1955
DOI	10.17116/patol20238503154
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Article ; Online: Serum Biomarkers of Vascular Involvement in Childhood Uveitis.

Kouwenberg, Carlyn V / Kuiper, Jonas J W / de Boer, Joke H / Kalinina Ayuso, Viera

Translational vision science & technology

2024 Volume 13, Issue 4, Page(s) 9

Abstract: ... noninflammatory pediatric controls. Data on retinal vascular involvement (i.e., papillitis, cystoid macular edema ...

Abstract	Purpose: Nonanterior uveitis frequently involves the retinal vasculature; however, no molecular markers associated with the retinal vascular disease are currently known. In this study, we aimed to identify serum biomarker signatures associated with retinal vascular involvement in noninfectious pediatric uveitis. Methods: We performed a 384-plex targeted proteomic analysis of serum samples of 154 noninfectious pediatric uveitis patients diagnosed with nonanterior uveitis (n = 74), idiopathic chronic anterior uveitis (iCAU, n = 36), or juvenile idiopathic arthritis-associated uveitis (JIA-U, n = 44), as well as 22 noninflammatory pediatric controls. Data on retinal vascular involvement (i.e., papillitis, cystoid macular edema, retinal vasculitis, or retinal capillary leakage on optical coherence tomography and/or fluorescein angiography) were used to stratify cases in the nonanterior uveitis group. Results: In the analysis of nonanterior uveitis, we identified nine proteins significantly associated with retinal vascular involvement, including F13B, MYOM3, and PTPN9. These proteins were enriched through pathway enrichment analysis for the coagulation cascade. Comparing cases and controls, we identified 63 differentially expressed proteins, notably proteins involved in platelet biology and complement cascades, which could be primarily attributed to differences in serum proteomes between anterior uveitis and nonanterior uveitis groups. Conclusions: Serum proteins related to the coagulation and complement cascade are associated with retinal vascular involvement in pediatric uveitis patients. Our results indicate involvement of mediators that could interact with the microcirculation in pediatric uveitis and might serve as potential biomarkers in personalized medicine in the future. Translational relevance: Our targeted proteomics analysis in serum of pediatric uveitis patients indicates involvement of mediators that could interact with the microcirculation in pediatric uveitis and might serve as potential biomarkers in personalized medicine in the future.
MeSH term(s)	Humans ; Child ; Proteomics ; Uveitis/diagnosis ; Uveitis, Anterior/diagnosis ; Retinal Diseases ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2674602-5
ISSN	2164-2591 ; 2164-2591
ISSN (online)	2164-2591
ISSN	2164-2591
DOI	10.1167/tvst.13.4.9
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Article: 100 let so dnya rozhdeniya Aleksandra Vsevolodovicha Tsinzerlinga.

Nasyrov, R A / Anichkov, N M / Krasnogorskaya, O L / Kalinina, E Yu

Arkhiv patologii

2023 Volume 85, Issue 4, Page(s) 78–79

Abstract: ... was a well-known scientist, corresponding member of the Russian Academy of Medical Sciences, prof. A.V ...

Title translation	100th anniversary of the birth of Alexander Vsevolodovich Zinserling.
Abstract	In December 2022, the Department of Pathological Anatomy of the St. Petersburg State Pediatric Medical University solemnly celebrated its 90th anniversary. At the meeting of the city scientific society of pathologists, dedicated to this event, the staff of the department, fellow professors, members of the society, as well as clinicians and invited guests, recalled the brilliant scientists-pathologists who led the specified department in different years. One of these scientists, who headed the department in 1965-1992, was a well-known scientist, corresponding member of the Russian Academy of Medical Sciences, prof. A.V. Zinzerling (1923-1995).
MeSH term(s)	Humans ; Child ; History, 20th Century ; Anniversaries and Special Events ; Russia ; Pathologists
Language	Russian
Publishing date	2023-08-02
Publishing country	Russia (Federation)
Document type	Historical Article ; English Abstract ; Journal Article
ZDB-ID	127285-8
ISSN	0004-1955
ISSN	0004-1955
DOI	10.17116/patol20238504178
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Article: Fibromuskulyarnaya displaziya arterii — odin iz faktorov vnezapnoi serdechnoi smerti lits molodogo vozrasta.

Yagmurov, O D / Fedotova, E P / Davydova, Z V / Kalinina, E Yu / Anichkov, N M

Sudebno-meditsinskaia ekspertiza

2022 Volume 65, Issue 4, Page(s) 57–60

Abstract: The objective of the study is to consider the problem of diagnostics of a rare vasculopathy, fibromuscular dysplasia of coronary arteries, by the case study of a 19-year-old serviceman, an athlete with sudden death occurred during slight physical ... ...

Title translation	Arterial fibromuscular dysplasia as a factor in sudden cardiac death in young adults.
Abstract	The objective of the study is to consider the problem of diagnostics of a rare vasculopathy, fibromuscular dysplasia of coronary arteries, by the case study of a 19-year-old serviceman, an athlete with sudden death occurred during slight physical exertion. After repeated histological examination as part of the forensic medical examination, the diagnosis was made: «multifocal fibromuscular dysplasia of the coronary arteries and ascending aortic arch, complicated by acute left ventricular failure.» This disease often manifests with the acute coronary syndrome in people of young age. Therefore, special attention was given to the macroscopic and histological features of fibromuscular dysplasia of arteries.
MeSH term(s)	Adult ; Coronary Vessels/pathology ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/pathology ; Fibromuscular Dysplasia/complications ; Fibromuscular Dysplasia/diagnosis ; Fibromuscular Dysplasia/pathology ; Humans ; Young Adult
Language	Russian
Publishing date	2022-08-01
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	41012-3
ISSN	0039-4521
ISSN	0039-4521
DOI	10.17116/sudmed20226504157
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