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  1. Article: m

    Gao, Yuan / Yu, Miao / Liu, Zengyuan / Liu, Yi / Kong, Zhijun / Zhu, Chunfu / Qin, Xihu / Li, Yan / Tang, Liming

    Translational oncology

    2024  Volume 41, Page(s) 101858

    Abstract: ALKBH5 plays critical roles in various cellular processes via post-transcriptional regulation of oncogenes or tumor suppressors in an N6-methyladenosine (m6A)-dependent manner. However, its function in intrahepatic cholangiocarcinoma (ICC) remains ... ...

    Abstract ALKBH5 plays critical roles in various cellular processes via post-transcriptional regulation of oncogenes or tumor suppressors in an N6-methyladenosine (m6A)-dependent manner. However, its function in intrahepatic cholangiocarcinoma (ICC) remains unclear. In the present study, bioinformatic analyses of The Cancer Genome Atlas (TCGA) data were performed, and the association of ALKBH5 in predicting overall survival in patients with ICC was investigated. Then, the clinical data of patients from The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University (Changzhou, China) was used to reveal the overall survival of patients with ICC with different ALKBH5 expression levels by Kaplan-Meier survival analysis. Subsequently, in vitro and in vivo studies were conducted to explore and verify the downstream genes regulated by ALKBH5. The results from TCGA data demonstrated that ALKBH5 expression is elevated in ICC and that patients with high ALKBH5 expression exhibited poor survival compared with patients with low expression. In addition, in vitro assays demonstrated that ALKBH5 promoted cell viability and maintained the stemness of ICC cells, leading to ICC progression. The present study also demonstrated that BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) is the downstream gene regulated by ALKBH5 and targeting BUB1B suppressed cell growth. The in vitro and vivo experiments revealed that ALKBH5 might function through BUB1B to maintain the stemness of ICC and that altering BUB1B may suppress ICC progression.
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2443840-6
    ISSN 1936-5233
    ISSN 1936-5233
    DOI 10.1016/j.tranon.2023.101858
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: m

    Li, Kexin / Shu, Shanrong / Zou, Jiahua / Li, Manmei / Liu, Zhong

    Genes & diseases

    2023  Volume 10, Issue 6, Page(s) 2278–2281

    Language English
    Publishing date 2023-03-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2821806-1
    ISSN 2352-3042 ; 2352-3042
    ISSN (online) 2352-3042
    ISSN 2352-3042
    DOI 10.1016/j.gendis.2023.01.021
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  3. Article ; Online: m

    Guan, Hua / Tian, Kun / Luo, Wei / Li, Mingfei

    Cell death & disease

    2023  Volume 14, Issue 2, Page(s) 120

    Abstract: Emerging evidence indicates the critical roles of ... ...

    Abstract Emerging evidence indicates the critical roles of N
    MeSH term(s) Humans ; RNA, Circular/genetics ; B7-H1 Antigen/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; RNA, Messenger/genetics ; Gene Expression Regulation, Neoplastic ; Myosin Type I/genetics ; Methyltransferases/genetics ; Methyltransferases/metabolism ; RNA-Binding Proteins/genetics ; Pancreatic Neoplasms
    Chemical Substances RNA, Circular ; B7-H1 Antigen ; RNA, Messenger ; MYO1C protein, human (EC 3.6.1.3) ; Myosin Type I (EC 3.6.1.-) ; METTL3 protein, human (EC 2.1.1.62) ; Methyltransferases (EC 2.1.1.-) ; IGF2BP2 protein, human ; RNA-Binding Proteins
    Language English
    Publishing date 2023-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-023-05570-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: M

    Wang, Ruixi / Cheng, Xingyuan / Chi, Dongmei / Liu, Shiliang / Li, Qiaoqiao / Chen, Baoqing / Xi, Mian

    Discover. Oncology

    2023  Volume 14, Issue 1, Page(s) 99

    Abstract: ... has explored methylation modifications in m: Methods: Public gene-expression data and clinical ... were analyzed to identify potential consensus clusters of m: Results: Consensus clustering analysis ... based on m: Conclusions: Transcriptomic prognostic signatures based on m ...

    Abstract Background: Esophageal squamous cell carcinoma (ESCC) is the most common esophageal malignancy, and RNA methylation has been reported to be involved in the tumorigenesis of ESCC. However, no study has explored methylation modifications in m
    Methods: Public gene-expression data and clinical annotation of 254 patients obtained from The Cancer Genome Atlas and the Gene Expression Omnibus databases were analyzed to identify potential consensus clusters of m
    Results: Consensus clustering analysis based on m
    Conclusions: Transcriptomic prognostic signatures based on m
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article
    ISSN 2730-6011
    ISSN (online) 2730-6011
    DOI 10.1007/s12672-023-00710-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: m

    Fan, Wenwen / Wang, Ling / Lei, Zhen / Li, Hui / Chu, Jie / Yan, Mengxiao / Wang, Yuqin / Wang, Hongxia / Yang, Jun / Cho, Jungnam

    Science advances

    2023  Volume 9, Issue 48, Page(s) eadf3292

    Abstract: ... that transposon RNA is marked by m ...

    Abstract Transposons are mobile and ubiquitous DNA molecules that can cause vast genomic alterations. In plants, it is well documented that transposon mobilization is strongly repressed by DNA methylation; however, its regulation at the posttranscriptional level remains relatively uninvestigated. Here, we suggest that transposon RNA is marked by m
    MeSH term(s) Arabidopsis/genetics ; Retroelements/genetics ; RNA ; Hot Temperature ; DNA Methylation ; Terminal Repeat Sequences/genetics ; Gene Expression Regulation, Plant
    Chemical Substances Retroelements ; RNA (63231-63-0)
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adf3292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: m

    Shan, Ting / Liu, Feiyan / Wen, Miaomiao / Chen, Zonggui / Li, Shaopeng / Wang, Yafen / Cheng, Hong / Zhou, Yu

    Molecular cell

    2023  Volume 83, Issue 24, Page(s) 4494–4508.e6

    Abstract: ... but the mechanism for this regulation has largely remained elusive. Here, we report that m ...

    Abstract In the cytoplasm, mRNAs are dynamically partitioned into translating and non-translating pools, but the mechanism for this regulation has largely remained elusive. Here, we report that m
    MeSH term(s) Humans ; Chromatography, Liquid ; HeLa Cells ; Polyribosomes/genetics ; Processing Bodies ; Proteomics ; RNA, Messenger/genetics ; Tandem Mass Spectrometry ; Adenine/analogs & derivatives ; Adenine/metabolism ; RNA-Binding Proteins/metabolism ; Protein Biosynthesis
    Chemical Substances RNA, Messenger ; 6-methyladenine (W7IBY2BGAX) ; Adenine (JAC85A2161) ; IGF2BP3 protein, human ; RNA-Binding Proteins
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2023.10.040
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5055: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: M

    Li, Miao / Guo, Qianwen / Shi, Qian / Rao, Yanzhi / Dong, Yixin / Chen, Fangjie / Qi, Xun

    Discover. Oncology

    2023  Volume 14, Issue 1, Page(s) 175

    Abstract: Human Hox genes (Homeobox) play a crucial role in embryonic development and cancer. The HOXC10 gene, a member of the HOX family, has been reported abnormally expressed in several cancers. However, the association between HOXC10 and hepatocellular ... ...

    Abstract Human Hox genes (Homeobox) play a crucial role in embryonic development and cancer. The HOXC10 gene, a member of the HOX family, has been reported abnormally expressed in several cancers. However, the association between HOXC10 and hepatocellular carcinoma (HCC) remains to be elucidated. In the present study, tissue microarray cohort data showed that high levels of HOXC10 expression predicted a poor survival in HCC patients. Meanwhile, HOXC10 was significantly upregulated in the Huh7 cell line compared with the well differentiated cell line HepG2 and human normal liver cells. Functionally, silencing HOXC10 in Huh7 cells inhibited cell proliferation, increased apoptosis, and inhibited invasion and migration of HCC cells. HOXC10 overexpression in HepG2 cells increased cell proliferation, decreased apoptosis, and increased invasion and migration of HCC cells. In the HepG2 xenograft models, HOXC10 increased the tumor volume and weight compared with control. Mechanistically, the m6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. Both the in vitro and in vivo results showed that overexpressed HOXC10 activated the PTEN/AKT/mTOR pathway. In summary, the findings highlight the importance of HOXC10 in the regulation of HCC progression. HOXC10 is potentially a future therapeutic target for HCC treatment.
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Journal Article
    ISSN 2730-6011
    ISSN (online) 2730-6011
    DOI 10.1007/s12672-023-00786-0
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  8. Article ; Online: m

    Peng, Chen / Xiong, Fen / Pu, Xi / Hu, Zhangmin / Yang, Yufei / Qiao, Xuehan / Jiang, Yuchun / Han, Miao / Wang, Deqiang / Li, Xiaoqin

    Frontiers in immunology

    2023  Volume 14, Page(s) 1326031

    Abstract: ... ...

    Abstract N
    MeSH term(s) Humans ; Catalytic Domain ; Gastrointestinal Neoplasms/genetics ; Gastrointestinal Neoplasms/therapy ; Immunotherapy ; Immune Checkpoint Inhibitors ; Methylation ; Tumor Microenvironment/genetics ; Methyltransferases/genetics
    Chemical Substances Immune Checkpoint Inhibitors ; METTL3 protein, human (EC 2.1.1.62) ; Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2023-12-15
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1326031
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  9. Article ; Online: m

    Yang, Xia / Bai, Qiaorui / Chen, Weizhong / Liang, Jiaer / Wang, Fang / Gu, Weiqi / Liu, Lei / Li, Quanfeng / Chen, Zishuo / Zhou, Anni / Long, Jianting / Tian, Han / Wu, Jueheng / Ding, Xiaofan / Zhou, Ningning / Li, Mengfeng / Yang, Yi / Cai, Junchao

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 20, Page(s) e2206744

    Abstract: The importance of mRNA N6-methyladenosine (m ...

    Abstract The importance of mRNA N6-methyladenosine (m
    MeSH term(s) Humans ; Adenocarcinoma ; Adenocarcinoma of Lung ; Adenosine ; Cell Cycle Proteins ; Lung Neoplasms/genetics ; RNA, Messenger
    Chemical Substances Adenosine (K72T3FS567) ; Cell Cycle Proteins ; MCM5 protein, human ; RNA, Messenger ; IGF2BP3 protein, human
    Language English
    Publishing date 2023-05-12
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202206744
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  10. Article ; Online: m

    Wang, Shiguan / Chen, Shanze / Sun, Jianfeng / Han, Pan / Xu, Bowen / Li, Xinying / Zhong, Youquan / Xu, Zaichao / Zhang, Peng / Mi, Ping / Zhang, Cuijuan / Li, Lixiang / Zhang, Haiyan / Xia, Yuchen / Li, Shiyang / Heikenwalder, Mathias / Yuan, Detian

    Nature metabolism

    2023  Volume 5, Issue 5, Page(s) 842–860

    Abstract: ... adenosine (m ...

    Abstract Different organs undergo distinct transcriptional, epigenetic and physiological alterations that guarantee their functional maturation after birth. However, the roles of epitranscriptomic machineries in these processes have remained elusive. Here we demonstrate that expression of RNA methyltransferase enzymes Mettl3 and Mettl14 gradually declines during postnatal liver development in male mice. Liver-specific Mettl3 deficiency causes hepatocyte hypertrophy, liver injury and growth retardation. Transcriptomic and N6-methyl-adenosine (m
    MeSH term(s) Mice ; Male ; Animals ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Liver/metabolism ; Hepatocytes/metabolism ; Ceramides ; Endoplasmic Reticulum Stress ; Adenosine/metabolism ; Sphingomyelin Phosphodiesterase/genetics ; Sphingomyelin Phosphodiesterase/metabolism
    Chemical Substances Methyltransferases (EC 2.1.1.-) ; Ceramides ; Adenosine (K72T3FS567) ; Smpd3 protein, mouse (EC 3.1.4.12) ; Sphingomyelin Phosphodiesterase (EC 3.1.4.12)
    Language English
    Publishing date 2023-05-15
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-023-00808-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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